[go: up one dir, main page]

WO2023024518A1 - Cornée artificielle de type bouton-collier de type ii - Google Patents

Cornée artificielle de type bouton-collier de type ii Download PDF

Info

Publication number
WO2023024518A1
WO2023024518A1 PCT/CN2022/084455 CN2022084455W WO2023024518A1 WO 2023024518 A1 WO2023024518 A1 WO 2023024518A1 CN 2022084455 W CN2022084455 W CN 2022084455W WO 2023024518 A1 WO2023024518 A1 WO 2023024518A1
Authority
WO
WIPO (PCT)
Prior art keywords
gasket
type
skirt
artificial cornea
front plate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CN2022/084455
Other languages
English (en)
Chinese (zh)
Inventor
翟嘉洁
翟舒平
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Guangdong Jiayue Meishi Biotechnology Co Ltd
Original Assignee
Guangdong Jiayue Meishi Biotechnology Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guangdong Jiayue Meishi Biotechnology Co Ltd filed Critical Guangdong Jiayue Meishi Biotechnology Co Ltd
Publication of WO2023024518A1 publication Critical patent/WO2023024518A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses or corneal implants; Artificial eyes
    • A61F2/142—Cornea, e.g. artificial corneae, keratoprostheses or corneal implants for repair of defective corneal tissue

Definitions

  • the invention relates to a type II collar button artificial cornea.
  • Type II artificial cornea The indications for the collar button artificial cornea are patients with high risk of rejection of corneal transplantation. However, for patients with severe dry eyes who cannot undergo collar button artificial corneal implantation, Type II artificial cornea is the only solution. Type II artificial cornea has no similar products in China at present, and it is an important supplement to collar button artificial cornea. Boston Type II artificial cornea in the United States is designed according to the eye anatomy structure of Europeans. The eyelid structure and eyelid thickness of Europeans are similar to those of Chinese. Huge difference.
  • the object of the present invention is to provide a type II collar button artificial cornea.
  • the type II collar button artificial cornea is more suitable for Asian eyelids.
  • a type II collar button artificial cornea including a front plate with an optical lens column, the outer surface of the optical lens column is provided with a skirt, and the outer surface of the optical lens column is A spacer is also arranged around the side, the spacer is located between the front plate and the skirt, and the spacer is attached to the skirt.
  • the length of the part of the optical mirror column between the front plate and the spacer is 1.3-1.7mm.
  • the front surface of the gasket is designed with a convex arc
  • the rear surface of the gasket is designed with a concave arc
  • the rear surface of the gasket is in contact with the front surface of the skirt and bonding.
  • the diameter of the outer ring of the gasket is the same as that of the front plate.
  • the diameter of the outer ring of the gasket is 4.5-4.7mm
  • the diameter of the inner ring of the gasket is 3-3.5mm
  • the thickness of the inner ring of the gasket (the gasket The distance between the inner ring of the front surface and the inner ring of the rear surface in the direction of the centerline of the gasket) is 0.5-0.9mm
  • the thickness of the gasket (the distance between the inner ring of the front surface of the gasket and the outer ring of the rear surface in the direction of the centerline of the gasket) is 0.6-1.0mm
  • the thickness of the skirt The thickness (the distance between the inner circle of the front surface of the skirt and the outer circle of the rear surface in the direction of the center line of the skirt) is 0.6-1.0 mm.
  • the front surface of the front plate is designed with a convex arc
  • the rear surface of the front plate is flat
  • the optical mirror column is located at the center of the rear surface of the front plate.
  • the diameter of the front plate is 4.5-4.7mm
  • the distance between the front surface edge and the rear surface edge of the front plate is 0.5-0.7mm
  • the diameter of the optical mirror column is 3.3-3.5mm .
  • the front plate, the optical mirror column and the skirt are of an integrated structure, and the materials of the front plate, the optical mirror column, the skirt and the gasket are all PMMA (polymethyl methacrylate).
  • it also includes a rear plate with a middle hole matched with the optical mirror column, and an end ring on the outer surface of the optical mirror column away from the front plate is provided with a ring for clamping the rear plate.
  • An annular groove, the skirt is located between the annular groove and the front plate, and a plurality of side holes are arranged on the rear plate.
  • the back plate is a disc
  • the back plate is provided with 16 side holes, and the centers of 8 side holes in the 16 side holes are located on the first circumference, and the first The center line of the circumference coincides with the center line of the disc, and the distances between the centers of the adjacent side holes in the 8 side holes are equal; the centers of the other 8 side holes in the 16 side holes are located at the first
  • the centerline of the second circle coincides with the centerline of the disc, and the center distances between the adjacent side holes in the eight side holes are equal, and the second circle and the first circle are the same.
  • the diameters corresponding to a circle are not equal.
  • the present invention considers that the eyelids of Asians are thinner, and the mirror column is too long to easily fix the eye. Therefore, a spacer is added on the basis of the American Type II artificial cornea sheet to obtain the Type II collar button artificial cornea of the present invention.
  • the use of the type II collar button artificial cornea of the present invention can better clamp the eyelids, reduce the shedding rate of the artificial cornea, and can be better fixed in the eye.
  • Fig. 1 is a schematic structural view of an embodiment of the type II collar button artificial cornea of the present invention.
  • Fig. 2 is a schematic structural view of an embodiment of the rear plate of the present invention.
  • a type II collar button artificial cornea comprises a front plate 1 with an optical lens column 2, the outer surface of the optical lens column 2 is provided with a skirt 3, and the outer surface of the optical lens column 2 is A spacer 4 is also arranged around the side, the spacer 4 is located between the front plate 1 and the skirt 3 , and the spacer 4 is attached to the skirt 3 . Due to the existence of the spacer, the gap between the front plate 1 and the skirt 3 is reduced, resulting in the change of the operation method.
  • the Boston type II artificial cornea needs to be fixed through the eyelid, and the use of the type II collar button artificial cornea of the present invention is not necessary. To open the eyelids, just put an ear cartilage or conjunctival flap inside.
  • the length (L1-L3) of the part of the optical mirror column 2 between the front plate 1 and the gasket 4 is preferably 1.3-1.7 mm.
  • L1 is the distance between the rear surface 9 of the front plate 1 and the outer ring of the front surface 5 of the gasket 4 in the centerline direction of the gasket 4
  • L3 is the distance between the inner ring of the front surface 5 of the gasket 4 and the outer ring of the front surface 5 of the gasket 4. The distance of the outer ring in the direction of the centerline of the gasket 4.
  • the front surface 5 of the gasket 4 is designed with a convex arc
  • the rear surface of the gasket 4 is designed with a concave arc
  • the rear surface of the gasket 4 is in line with the The front surface 6 of the skirt 3 is conformed and bonded.
  • the diameter of the outer ring of the gasket 4 is the same as that of the front plate 1 .
  • the diameter of the outer ring of the gasket 4 is 4.5-4.7mm
  • the diameter of the inner ring of the gasket 4 is 3-3.5mm
  • the thickness of the inner ring of the gasket 4 (the gasket The distance between the inner ring of the front surface 5 of 4 and the inner ring of the rear surface in the direction of the center line of the gasket 4) is 0.5-0.9mm
  • the inner ring and the outer ring of the front surface 5 of the gasket 4 are in the direction of the gasket 4
  • the distance L3 in the direction of the centerline is 0.1-0.2mm
  • the thickness of the gasket 4 (the distance between the inner ring of the front surface 5 of the gasket 4 and the outer ring of the rear surface in the direction of the centerline of the gasket 4) (L3+L2) is 0.6-1.0mm
  • the thickness of the skirt 3 (the distance between the inner circle of the front surface 6 of the skirt 3 and the outer circle of the rear surface 7 in the direction of the center line of the skirt 3) is 0.6
  • the front surface 8 of the front panel 1 is designed with a convex arc
  • the rear surface 9 of the front panel 1 is flat
  • the optical mirror column 2 is located at the center of the rear surface 9 of the front panel 1 .
  • the diameter d1 of the front plate 1 is 4.5-4.7 mm
  • the distance L4 between the edge of the front surface 8 of the front plate 1 and the edge of the rear surface 9 is 0.5-0.7 mm
  • the diameter of the optical mirror column 2 is 3.3-3.5mm.
  • the front plate 1, the optical mirror column 2 and the skirt 3 are of an integrated structure, and the materials of the front plate 1, the optical mirror column 2, the skirt 3 and the spacer 4 are all PMMA (polymethyl Methyl acrylate).
  • the materials of the front plate 1, the optical mirror column 2, the skirt 3 and the spacer 4 are all medical PMMA (polymethyl methacrylate).
  • the type II collar button artificial cornea also includes a rear plate 10 with a middle hole 11 matching the optical mirror column 2, and the outer surface of the optical mirror column 2 is away from the front plate
  • One end ring of 1 is provided with an annular groove 12 for clamping the rear plate 10
  • the skirt 3 is located between the annular groove 12 and the front plate 1
  • the rear plate 10 is provided with a plurality of edges Hole 13.
  • the purpose of setting side holes is to facilitate the penetration of aqueous humor.
  • the back plate 10 is a disc, and the back plate 10 is provided with 16 side holes 13, and the centers of 8 side holes in the 16 side holes 13 are located on the first circumference, and the second side holes 13 are located on the first circumference.
  • the center line of a circle coincides with the center line of the disc, and the distances between the centers of the adjacent side holes in the 8 side holes are equal; the centers of the other 8 side holes in the 16 side holes are located at
  • the center line of the second circumference coincides with the center line of the disc, and the distances between the centers of the adjacent side holes in the eight side holes are equal, and the second circumference is the same as the center line of the disc.
  • the diameters corresponding to the first circles are not equal.
  • the diameter corresponding to the first circle is 4.7-4.9 mm
  • the diameter corresponding to the second circle is 6.55-6.85 mm
  • the diameters of the 16 side holes 13 are all 1.0-1.2 mm
  • the diameter of the second circle is 1.0-1.2 mm.
  • the included angle between a circle and the line formed by the centers of the two adjacent side holes on the second circle and the center of the middle hole of the rear plate is 22.5°.
  • the inner diameter of the rear plate 10 is 2.7-2.9 mm, and the outer diameter of the rear plate 10 is 8.4-8.6 mm.
  • the back plate 10 is an arc-shaped disc, and the front and rear surfaces of the back plate 10 are both arc-shaped.
  • the arc radius of the front surface of the rear plate 10 is 7.75 mm
  • the arc radius of the rear surface of the rear plate 10 is 7.9-8.1 mm
  • the distance between the front surface and the rear surface of the rear plate 10 is Using arc transition
  • the arc radius of the arc between the front surface and the rear surface of the back plate 10 is 0.12-0.15mm
  • the thickness of the back plate 10 (the inner ring on the back surface of the back plate 10 and The distance between the outer circle on the front surface and the centerline direction of the rear plate 10) is 1.25-1.35mm.
  • the rear panel 10 is provided with a circular ridge 14 , and the centerline of the circular ridge 14 coincides with the centerline of the rear panel 10 .
  • the inner diameter of the circular ridge 14 is 2.7-2.9 mm
  • the outer diameter of the circular ridge 14 is 3.35-3.65 mm
  • the thickness of the circular ridge 14 is 0.25-0.45 mm.
  • the back plate 10 is a medical titanium disc
  • the circular ridge 14 is a metal ridge
  • Ear cartilage preparation A 15 mm vertical skin incision was made on the upper and dorsal 1/4 of the ipsilateral ear, and the subcutaneous tissue was dissected to expose the cartilage. Then, 12 x 10 mm ear cartilage was harvested for later use.
  • Type II collar button artificial cornea of the present invention Implantation of type II collar button artificial cornea of the present invention: Trephination is performed on the host cornea, and the lens is taken out if necessary. Anterior vitrectomy was performed by pars plana vitrectomy (PPV) with the 25G system. At the same time, a clinical assessment of the fundus (including the macula and optic disc) was performed. As in standard penetrating keratoplasty, the assembled Type II collar-and-button keratoplasty device is attached to the implant bed with interrupted sutures. According to glaucoma diagnosis and postoperative prognosis, Ahmed Glaucoma Drainage Devices (GDDs) can be implanted at the same time.
  • GDDs Ahmed Glaucoma Drainage Devices
  • Cartilage reinforcement The autologous auricular cartilage is trimmed to the desired shape to fit the surface of the eye, and a hole with a diameter of 3 mm is drilled in the center to fix the mirror column. A radial incision was made on the autogenous auricular cartilage to wrap the mirror column, and then the incision was closed with sutures. Afterwards, the cartilage is further secured to the ocular surface using 7-0 sutures. In order to achieve better results, it is recommended to cover the edge of the auricle cartilage with a corneoscleral allograft ring, which is further sutured on the patient's sclera.
  • fascia sac and conjunctiva are sutured layer by layer to further cover and reinforce the cartilage. If the conjunctival sac is insufficient, tarsus-free eyelid skin can be used, allowing the prosthetic keratomileus to protrude through the closed eyelid skin.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Transplantation (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Prostheses (AREA)
  • Lenses (AREA)

Abstract

Une cornée artificielle de type bouton-collier de type II, comprenant une plaque avant (1) qui a une colonne de lentille optique (2), une jupe (3) est disposée autour de la surface latérale externe de la colonne de lentille optique (2), un joint d'étanchéité (4) est en outre disposé autour de la surface latérale externe de la colonne de lentille optique (2), le joint d'étanchéité (4) est situé entre la plaque avant (1) et la jupe (3), et le joint d'étanchéité (4) est équipé de la jupe (3). L'utilisation de la cornée artificielle de type bouton-collier de type II permet une meilleure fixation à la paupière, ce qui réduit le taux de chute de la cornée artificielle, de sorte que celle-ci peut être mieux fixée dans l'œil.
PCT/CN2022/084455 2021-08-27 2022-03-31 Cornée artificielle de type bouton-collier de type ii Ceased WO2023024518A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN202110996491.XA CN113786268B (zh) 2021-08-27 2021-08-27 一种ⅱ型领扣型人工角膜
CN202110996491.X 2021-08-27

Publications (1)

Publication Number Publication Date
WO2023024518A1 true WO2023024518A1 (fr) 2023-03-02

Family

ID=79182321

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2022/084455 Ceased WO2023024518A1 (fr) 2021-08-27 2022-03-31 Cornée artificielle de type bouton-collier de type ii

Country Status (2)

Country Link
CN (1) CN113786268B (fr)
WO (1) WO2023024518A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113786268B (zh) * 2021-08-27 2025-06-27 广东佳悦美视生物科技有限公司 一种ⅱ型领扣型人工角膜

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6106552A (en) * 1996-01-30 2000-08-22 Corneal Industrie Corneal prosthesis device having anterior and posterior annular skirts
CN201029958Y (zh) * 2007-04-19 2008-03-05 同济大学 非穿透一体式人工角膜
WO2014039495A1 (fr) * 2012-09-05 2014-03-13 University Of Miami Nouvelle kératoprothèse et système et procédé de réparation de la cornée l'utilisant
CN208725957U (zh) * 2018-03-19 2019-04-12 翟嘉洁 人工角膜后板
CN210130973U (zh) * 2018-08-01 2020-03-10 黄一飞 一种人工角膜
CN112372005A (zh) * 2020-04-13 2021-02-19 广东佳悦美视生物科技有限公司 一种领扣型人工角膜的制备方法
CN113786268A (zh) * 2021-08-27 2021-12-14 广东佳悦美视生物科技有限公司 一种ⅱ型领扣型人工角膜

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6755858B1 (en) * 2000-04-07 2004-06-29 Thomas C. White Prosthetic corneal graft and method
CN108784888A (zh) * 2018-08-01 2018-11-13 黄飞 一种人工角膜
CN110025402B (zh) * 2019-05-21 2021-09-24 王丽强 含生物材料的人工角膜
US10994051B2 (en) * 2019-08-28 2021-05-04 Liqiang Wang Keratoprosthesis implanting method
CN111419471A (zh) * 2020-03-05 2020-07-17 姚晓明 一种人工角膜
CN216439371U (zh) * 2021-08-27 2022-05-06 广东佳悦美视生物科技有限公司 一种ⅱ型领扣型人工角膜

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6106552A (en) * 1996-01-30 2000-08-22 Corneal Industrie Corneal prosthesis device having anterior and posterior annular skirts
CN201029958Y (zh) * 2007-04-19 2008-03-05 同济大学 非穿透一体式人工角膜
WO2014039495A1 (fr) * 2012-09-05 2014-03-13 University Of Miami Nouvelle kératoprothèse et système et procédé de réparation de la cornée l'utilisant
CN208725957U (zh) * 2018-03-19 2019-04-12 翟嘉洁 人工角膜后板
CN210130973U (zh) * 2018-08-01 2020-03-10 黄一飞 一种人工角膜
CN112372005A (zh) * 2020-04-13 2021-02-19 广东佳悦美视生物科技有限公司 一种领扣型人工角膜的制备方法
CN113786268A (zh) * 2021-08-27 2021-12-14 广东佳悦美视生物科技有限公司 一种ⅱ型领扣型人工角膜

Also Published As

Publication number Publication date
CN113786268B (zh) 2025-06-27
CN113786268A (zh) 2021-12-14

Similar Documents

Publication Publication Date Title
ES2821423T3 (es) Córnea artificial deformable de forma reversible
US5201762A (en) Intraocular archromatic lens
US4738680A (en) Laser edge lens
US4966452A (en) Contact lens for laser surgery
US5098438A (en) Procedures for intraocular surgery
JP5705529B2 (ja) 嚢内保持具
US6156042A (en) Retinal tissue implantation instrument
US7713228B2 (en) Surgical method
US11360327B1 (en) Scleral lens with fenestration and pockets
CN109199637B (zh) 一种人工角膜
US6641589B2 (en) Ophthalmic surgical lens
WO2023024518A1 (fr) Cornée artificielle de type bouton-collier de type ii
CN216439371U (zh) 一种ⅱ型领扣型人工角膜
Morales-Wong et al. Femtosecond laser applications in corneal surgery
CN113599020A (zh) 一种集晶状体屈光功能的人工角膜
CN112656544B (zh) 一种双光学区的人工晶状体
JP3747386B2 (ja) 後部被膜の混濁化抑制装置
CN220069927U (zh) 一种集晶状体屈光功能的人工角膜
CN218792739U (zh) 一种房水引流器
CN216168088U (zh) 一种固定于后囊膜孔的人工晶状体
RU2691857C1 (ru) Способ хирургического лечения заболеваний роговицы при дисфункции лимбальной ростковой зоны
RU2168965C1 (ru) Способ шунтирования передней камеры глаза при антиглаукоматозных операциях
RU2733319C1 (ru) Способ коррекции высокой степени миопии у пациентов с тонкой роговицей
CN214586281U (zh) 具有开窗和凹袋的巩膜镜
LU503932B1 (en) A large-diameter artificial corneal endothelial sheet and application thereof

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 22859872

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 22859872

Country of ref document: EP

Kind code of ref document: A1

32PN Ep: public notification in the ep bulletin as address of the adressee cannot be established

Free format text: NOTING OF LOSS OF RIGHTS PURSUANT TO RULE 112(1) EPC (EPO FORM 1205A DATED 25/09/2024)

122 Ep: pct application non-entry in european phase

Ref document number: 22859872

Country of ref document: EP

Kind code of ref document: A1