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WO2023012652A3 - Hypoallergenic peanut allergens, production and use thereof - Google Patents

Hypoallergenic peanut allergens, production and use thereof Download PDF

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Publication number
WO2023012652A3
WO2023012652A3 PCT/IB2022/057144 IB2022057144W WO2023012652A3 WO 2023012652 A3 WO2023012652 A3 WO 2023012652A3 IB 2022057144 W IB2022057144 W IB 2022057144W WO 2023012652 A3 WO2023012652 A3 WO 2023012652A3
Authority
WO
WIPO (PCT)
Prior art keywords
ara
production
hypoallergenic
peanut allergens
hypoallergenic peanut
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2022/057144
Other languages
French (fr)
Other versions
WO2023012652A2 (en
Inventor
Yanay OFRAN
Moshe BEN DAVID
Orly MARCU GARBER
Si NAFTALY KIROS
Gil DIAMANT
Almog BREGMAN COHEN
Maayan KORMAN
Anna CHUPRIN
Zohar BIRON SOREK
Lior ROSENFELD SHLAMKOVICH
Etai ROTEM
Yair GAT
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ukko Inc
Original Assignee
Ukko Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ukko Inc filed Critical Ukko Inc
Priority to EP22852444.3A priority Critical patent/EP4380957A4/en
Priority to CA3226900A priority patent/CA3226900A1/en
Priority to AU2022323847A priority patent/AU2022323847A1/en
Priority to CN202280063732.8A priority patent/CN117979981A/en
Priority to JP2024506789A priority patent/JP2024530926A/en
Priority to US18/292,959 priority patent/US20240390485A1/en
Publication of WO2023012652A2 publication Critical patent/WO2023012652A2/en
Publication of WO2023012652A3 publication Critical patent/WO2023012652A3/en
Priority to US18/522,706 priority patent/US20240117020A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/16—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from plants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/35—Allergens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Botany (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

In one embodiment, the present disclosure provides hypoallergenic peanut allergens Ara h 1 or Ara h 2 variants lacking at least one epitope recognized by anti-Ara h 1 antibodies or anti-Ara h 2 antibodies, thereby having reduced or abolished antibody binding to the peanut allergen variants. These hypoallergenic peanut allergen variants may be used in methods of inducing desensitization to peanuts in a subject allergic to peanuts.
PCT/IB2022/057144 2021-08-03 2022-08-02 Hypoallergenic peanut allergens, production and use thereof Ceased WO2023012652A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
EP22852444.3A EP4380957A4 (en) 2021-08-03 2022-08-02 HYPOALLERGENIC PEANUT ALLERGENS, THEIR PRODUCTION AND USE
CA3226900A CA3226900A1 (en) 2021-08-03 2022-08-02 Hypoallergenic peanut allergens, production and use thereof
AU2022323847A AU2022323847A1 (en) 2021-08-03 2022-08-02 Hypoallergenic peanut allergens, production and use thereof
CN202280063732.8A CN117979981A (en) 2021-08-03 2022-08-02 Hypoallergenic peanut allergens, production thereof and use thereof
JP2024506789A JP2024530926A (en) 2021-08-03 2022-08-02 Hypoallergenic peanut allergen, its preparation method and use
US18/292,959 US20240390485A1 (en) 2021-08-03 2022-08-02 Hypoallergenic peanut allergens, production and use thereof
US18/522,706 US20240117020A1 (en) 2021-08-03 2023-11-29 Hypoallergenic peanut allergens, production and use thereof

Applications Claiming Priority (14)

Application Number Priority Date Filing Date Title
US202163228606P 2021-08-03 2021-08-03
US202163228604P 2021-08-03 2021-08-03
US63/228,604 2021-08-03
US63/228,606 2021-08-03
US202163284108P 2021-11-30 2021-11-30
US63/284,108 2021-11-30
US202163292441P 2021-12-22 2021-12-22
US63/292,441 2021-12-22
US202263311117P 2022-02-17 2022-02-17
US63/311,117 2022-02-17
US202263319394P 2022-03-14 2022-03-14
US202263319393P 2022-03-14 2022-03-14
US63/319,393 2022-03-14
US63/319,394 2022-03-14

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US18/522,706 Continuation-In-Part US20240117020A1 (en) 2021-08-03 2023-11-29 Hypoallergenic peanut allergens, production and use thereof

Publications (2)

Publication Number Publication Date
WO2023012652A2 WO2023012652A2 (en) 2023-02-09
WO2023012652A3 true WO2023012652A3 (en) 2023-04-06

Family

ID=85155450

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2022/057144 Ceased WO2023012652A2 (en) 2021-08-03 2022-08-02 Hypoallergenic peanut allergens, production and use thereof

Country Status (6)

Country Link
US (2) US20240390485A1 (en)
EP (1) EP4380957A4 (en)
JP (1) JP2024530926A (en)
AU (1) AU2022323847A1 (en)
CA (1) CA3226900A1 (en)
WO (1) WO2023012652A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2024224738A1 (en) * 2023-02-23 2025-09-18 The General Hospital Corporation, D/B/A Massachusetts General Hospital Mutant ara h 2 and ara h 6 proteins and uses thereof
WO2024256749A1 (en) 2023-06-12 2024-12-19 Desentum Oy Hypoallergenic variants of major peanut allergen, ara h 2

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080075725A1 (en) * 2004-06-10 2008-03-27 Monash University Novel Immunointeractive Molecules and uses Thereof
WO2013171268A1 (en) * 2012-05-15 2013-11-21 Biomay Ag Allergen variants
WO2019222281A1 (en) * 2018-05-15 2019-11-21 Immunomic Therapeutics, Inc Improved lamp constructs comprising allergens
US20200124615A1 (en) * 2016-12-29 2020-04-23 Ukko Inc. Methods for identifying and de-epitoping allergenic polypeptides

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002074250A2 (en) * 2001-03-16 2002-09-26 Panacea Pharmaceuticals Methods and reagents for decreasing clinical reaction to allergy

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080075725A1 (en) * 2004-06-10 2008-03-27 Monash University Novel Immunointeractive Molecules and uses Thereof
WO2013171268A1 (en) * 2012-05-15 2013-11-21 Biomay Ag Allergen variants
US20200124615A1 (en) * 2016-12-29 2020-04-23 Ukko Inc. Methods for identifying and de-epitoping allergenic polypeptides
WO2019222281A1 (en) * 2018-05-15 2019-11-21 Immunomic Therapeutics, Inc Improved lamp constructs comprising allergens

Also Published As

Publication number Publication date
EP4380957A4 (en) 2025-09-03
US20240117020A1 (en) 2024-04-11
US20240390485A1 (en) 2024-11-28
JP2024530926A (en) 2024-08-27
WO2023012652A2 (en) 2023-02-09
CA3226900A1 (en) 2023-02-09
EP4380957A2 (en) 2024-06-12
AU2022323847A1 (en) 2024-02-15

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