[go: up one dir, main page]

WO2023093514A1 - Circuit et procédé de mise en œuvre de technologie de champ électrique pulsé - Google Patents

Circuit et procédé de mise en œuvre de technologie de champ électrique pulsé Download PDF

Info

Publication number
WO2023093514A1
WO2023093514A1 PCT/CN2022/130460 CN2022130460W WO2023093514A1 WO 2023093514 A1 WO2023093514 A1 WO 2023093514A1 CN 2022130460 W CN2022130460 W CN 2022130460W WO 2023093514 A1 WO2023093514 A1 WO 2023093514A1
Authority
WO
WIPO (PCT)
Prior art keywords
switch
capacitor
output
circuit
electric field
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CN2022/130460
Other languages
English (en)
Chinese (zh)
Inventor
杨勇
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chengdu Kelaifu Life Technology Co Ltd
Original Assignee
Chengdu Kelaifu Life Technology Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chengdu Kelaifu Life Technology Co Ltd filed Critical Chengdu Kelaifu Life Technology Co Ltd
Publication of WO2023093514A1 publication Critical patent/WO2023093514A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Images

Classifications

    • H—ELECTRICITY
    • H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
    • H02M—APPARATUS FOR CONVERSION BETWEEN AC AND AC, BETWEEN AC AND DC, OR BETWEEN DC AND DC, AND FOR USE WITH MAINS OR SIMILAR POWER SUPPLY SYSTEMS; CONVERSION OF DC OR AC INPUT POWER INTO SURGE OUTPUT POWER; CONTROL OR REGULATION THEREOF
    • H02M11/00—Power conversion systems not covered by the preceding groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • H—ELECTRICITY
    • H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
    • H02M—APPARATUS FOR CONVERSION BETWEEN AC AND AC, BETWEEN AC AND DC, OR BETWEEN DC AND DC, AND FOR USE WITH MAINS OR SIMILAR POWER SUPPLY SYSTEMS; CONVERSION OF DC OR AC INPUT POWER INTO SURGE OUTPUT POWER; CONTROL OR REGULATION THEREOF
    • H02M3/00—Conversion of DC power input into DC power output
    • H02M3/02—Conversion of DC power input into DC power output without intermediate conversion into AC
    • H02M3/04—Conversion of DC power input into DC power output without intermediate conversion into AC by static converters
    • H02M3/06—Conversion of DC power input into DC power output without intermediate conversion into AC by static converters using resistors or capacitors, e.g. potential divider
    • H02M3/07—Conversion of DC power input into DC power output without intermediate conversion into AC by static converters using resistors or capacitors, e.g. potential divider using capacitors charged and discharged alternately by semiconductor devices with control electrode, e.g. charge pumps
    • H—ELECTRICITY
    • H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
    • H02M—APPARATUS FOR CONVERSION BETWEEN AC AND AC, BETWEEN AC AND DC, OR BETWEEN DC AND DC, AND FOR USE WITH MAINS OR SIMILAR POWER SUPPLY SYSTEMS; CONVERSION OF DC OR AC INPUT POWER INTO SURGE OUTPUT POWER; CONTROL OR REGULATION THEREOF
    • H02M7/00—Conversion of AC power input into DC power output; Conversion of DC power input into AC power output
    • H02M7/42—Conversion of DC power input into AC power output without possibility of reversal
    • H02M7/44—Conversion of DC power input into AC power output without possibility of reversal by static converters
    • H02M7/48—Conversion of DC power input into AC power output without possibility of reversal by static converters using discharge tubes with control electrode or semiconductor devices with control electrode
    • H02M7/53—Conversion of DC power input into AC power output without possibility of reversal by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a triode or transistor type requiring continuous application of a control signal
    • H02M7/537—Conversion of DC power input into AC power output without possibility of reversal by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a triode or transistor type requiring continuous application of a control signal using semiconductor devices only, e.g. single switched pulse inverters
    • H02M7/5387—Conversion of DC power input into AC power output without possibility of reversal by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a triode or transistor type requiring continuous application of a control signal using semiconductor devices only, e.g. single switched pulse inverters in a bridge configuration
    • H02M7/53871—Conversion of DC power input into AC power output without possibility of reversal by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a triode or transistor type requiring continuous application of a control signal using semiconductor devices only, e.g. single switched pulse inverters in a bridge configuration with automatic control of output voltage or current
    • H—ELECTRICITY
    • H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
    • H02M—APPARATUS FOR CONVERSION BETWEEN AC AND AC, BETWEEN AC AND DC, OR BETWEEN DC AND DC, AND FOR USE WITH MAINS OR SIMILAR POWER SUPPLY SYSTEMS; CONVERSION OF DC OR AC INPUT POWER INTO SURGE OUTPUT POWER; CONTROL OR REGULATION THEREOF
    • H02M7/00—Conversion of AC power input into DC power output; Conversion of DC power input into AC power output
    • H02M7/42—Conversion of DC power input into AC power output without possibility of reversal
    • H02M7/44—Conversion of DC power input into AC power output without possibility of reversal by static converters
    • H02M7/48—Conversion of DC power input into AC power output without possibility of reversal by static converters using discharge tubes with control electrode or semiconductor devices with control electrode
    • H02M7/53—Conversion of DC power input into AC power output without possibility of reversal by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a triode or transistor type requiring continuous application of a control signal
    • H02M7/537—Conversion of DC power input into AC power output without possibility of reversal by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a triode or transistor type requiring continuous application of a control signal using semiconductor devices only, e.g. single switched pulse inverters
    • H02M7/539—Conversion of DC power input into AC power output without possibility of reversal by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a triode or transistor type requiring continuous application of a control signal using semiconductor devices only, e.g. single switched pulse inverters with automatic control of output wave form or frequency
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
    • A61B2018/00613—Irreversible electroporation

Definitions

  • the invention relates to the field of medical pulse ablation technology, in particular to a circuit and method for realizing pulse electric field technology.
  • thermal ablation methods mainly use radiofrequency and cryotechniques. However, during the use of this thermal ablation technique, it is often difficult to achieve full-thickness penetration due to the limitation of the thermal pool effect. At the same time, these thermal ablation techniques are not cell-selective, so non-target cells will be destroyed together.
  • Pulsed electric field ablation technology releases extremely high energy in a short time by generating a high-voltage pulsed electric field with a pulse width of milliseconds, microseconds or even nanoseconds, which can make cell membranes and even intracellular organelles such as endoplasmic reticulum, Mitochondria, nucleus, etc. will produce a large number of irreversible micropores. And then cause the apoptosis of diseased cells, so as to achieve the expected therapeutic purpose.
  • pulsed electric field ablation technology is expected to become an ideal surgical ablation technology.
  • This patent proposes a realization circuit and method of pulsed electric field technology in view of the problem that the high-voltage pulse waveform in the prior art is single and cannot meet the clinical needs.
  • a circuit for realizing pulsed electric field technology including a DC power supply, a full-bridge topology switch circuit and an output interface, the DC power supply is connected in parallel to the input end of the full-bridge topology switch circuit, and the full-bridge topology switch circuit is used to convert high-voltage The pulse signal is output through the output interface.
  • Capacitor pools are connected in parallel at both ends of each switch module in the full-bridge topology switch circuit, and one end of each capacitor pool is connected in parallel with the output end of the DC power supply.
  • a plurality of capacitor branches are connected in parallel in the capacitor pool, and the capacitor switch array and the capacitor group are connected in series in the capacitor pool, and the capacitor switch array is formed by a plurality of switch units connected in series, each Inside the switch unit, a plurality of switch subunits are connected in parallel.
  • the switches in the capacitive switch array all have body diodes, and the body diodes of the switches located in the upper half are opposite to the body diodes of the switches located in the lower half.
  • the present invention also includes a plurality of diode array groups, and a diode array group is connected in series between the input end of each capacitor pool and the output end of the DC power supply, and a plurality of diodes are connected in series to form a plurality of diode branches, and more Two diode branches are connected in parallel to form the diode array group, the direction of the diodes is consistent, the anode of the diode in the diode array group is connected to the output terminal of the DC power supply, and the cathode of the diode array group is connected to the capacitor. Pool connections.
  • an output switch group is also provided at the output end of the DC power supply, the output switch group is connected in series between the output end of the DC power supply and the diode array group, and multiple power switches are connected in series to form a plurality of power supply Switch branches, and a plurality of power switch branches are connected in parallel to form the output switch group, wherein each power switch is connected in parallel with a body diode, the anode of the body diode faces one end of the diode array group, and the cathode of the body diode faces the DC output terminal of the power supply.
  • the band-pass filter circuit includes a band-pass filter sub-circuit and a band-pass filter selector, through which the full-bridge topology switch circuit outputs
  • the pulse waveform is filtered by different band-pass filter sub-circuits to output a combination of sinusoidal waveform and pulse waveform.
  • a method for realizing pulsed electric field technology is also proposed, and a realization circuit of any one of the above-mentioned pulsed electric field technologies is constructed, and a body diode charging mode is realized, and the charging process of the body diode charging mode is as follows: : Turn on the capacitor switch array ((Kxq111...K1x11n)...(Kxq211...K1x21n)...(Kxq1n1...Kx11nn)...(Kxq2n1...Kxq2nn)) of the capacitor bank that needs to be charged, and turn on the full bridge topology switch circuit
  • the second switch module to the switch of the fourth area in the nth switch module (((S2411...S241n)...(S24n1...S24nn))...((Sn411...Sn41n)...(Sn4n1...Sn4nn))), and finally The switches (Sn31n...Sn3nn) in the
  • the capacitor switch array For the capacitor pool to be used, turn on the capacitor switch array corresponding to the capacitor bank used ((Kxq111...K1x11n)...(Kxq211...K1x21n)...(Kxq1n1...Kx11nn)...(Kxq2n1...Kxq2nn)); The second area switch ((Sx211...Sx21n)...(Sx2n1...Sx2nn)) of the switch module corresponding to the capacitor pool and the third area switch ((Sx311...Sx31n)...(Sx3n1...Sx3nn)) of the switch module, the remaining The total number of unused capacitor pools is n-p, and the first area and the second area of the switch module corresponding to the unused capacitor pool are switched on, or the third area and the second area of the switch module corresponding to the unused capacitor pool are switched on.
  • the switch in the fourth area When the switch in the fourth area is turned on, a positive pulse is output
  • the negative pulse output method is:
  • the capacitor switch array For the capacitor pool to be used, turn on the capacitor switch array corresponding to the capacitor bank used ((Kxq111...K1x11n)...(Kxq211...K1x21n)...(Kxq1n1...Kx11nn)...(Kxq2n1...Kxq2nn)); The first area switch ((Sx111...Sx21n)...(Sx1n1...Sx2nn)) and the fourth area switch ((Sx411...Sx41n)...(Sx4n1...Sx4nn)) of the switch module corresponding to the capacitor pool, leaving unused capacitors
  • the total number of pools is n-p, switch on the first area and the second area of the switch module corresponding to the unused capacitor pool, or switch on the third area and the fourth area of the switch module corresponding to the unused capacitor pool When it is turned on, a negative pulse is output, and the voltage amplitude of the negative pulse is -V*p.
  • circuit structure of the present invention there are n groups of full-bridge topologies. By controlling the conduit and shut-off of the switch of the full-bridge topology, the output of the high-voltage pulse signal can be realized while the charging of the capacitance of the capacitor bank can be realized. Based on the circuit structure of the present invention, High-voltage pulse signal output and capacitor bank charging are carried out relatively independently, which greatly improves the safety of the system.
  • the present invention has multiple groups of capacitor pools to realize energy storage of capacitors during output and provide energy for output.
  • Each capacitor pool is composed of multiple groups of capacitors, which form the capacitors of the capacitor group. The number is arbitrary.
  • the charging and discharging process is realized through the bidirectional switch group. At the same time, the bidirectional switch can ensure that the capacitors that do not need to participate in the process will not affect the charging and discharging process during the charging and discharging process.
  • the present invention is powered by a single power supply to realize unified charging, and at the same time, through switches and diodes, it is ensured that the capacitance of the capacitor bank will not be reversely charged during discharge, so as to reduce unnecessary energy loss in the capacitor bank capacitor.
  • the present invention can realize the output requirements of different combinations, different directions, different voltages, and different pulse widths in the corresponding pulse group through the control of the full bridge topology and the bidirectional switch of the capacitor group.
  • the present invention can realize the combined output of sinusoidal signal and pulse signal through the control of the full-bridge topology and the bidirectional switch of the capacitor bank, and cooperate with the band-pass filter at the same time.
  • Fig. 1 is the circuit that realizes the pulse electric field realization method of diode charging mode and whole charging mode simultaneously in embodiment 1 of the present invention
  • Fig. 2 is the full-bridge topology switch circuit diagram of prior art in embodiment 1 of the present invention.
  • FIG. 3 is a schematic diagram of dividing areas of the switch module in Embodiment 1 of the present invention.
  • Fig. 4 is a simplified diagram of Fig. 2 after the switch module is divided into regions in Embodiment 1 of the present invention
  • Fig. 5 is a simplified diagram of Fig. 1 after the switch module is divided into regions in Embodiment 1 of the present invention
  • Fig. 6 is the waveform diagram 1 after the pulse combination of the switch module
  • Fig. 7 is the waveform diagram 2 after the pulse combination of the switch module in Embodiment 1 of the present invention.
  • Fig. 8 is the waveform diagram 3 after the pulse combination of the switch module in Embodiment 1 of the present invention.
  • FIG. 9 is a waveform diagram 4 after pulse combination of the switch module in Embodiment 1 of the present invention.
  • Fig. 10 is a waveform diagram five after pulse combination of the switch module in Embodiment 1 of the present invention.
  • Fig. 11 is a waveform diagram 6 after pulse combination of the switch module in Embodiment 1 of the present invention.
  • Fig. 12 is the waveform diagram 7 after the pulse combination of the switch module in Embodiment 1 of the present invention.
  • Fig. 13 is a waveform diagram 8 after pulse combination of the switch module in Embodiment 1 of the present invention.
  • Fig. 14 is a waveform diagram 9 after pulse combination of the switch module in Embodiment 1 of the present invention.
  • Fig. 15 is a waveform diagram ten after pulse combination of the switch module in Embodiment 1 of the present invention.
  • Fig. 16 is the eleventh waveform diagram after pulse combination of the switch module in embodiment 1 of the present invention.
  • Fig. 17 is a waveform diagram twelve after pulse combination of the switch module in Embodiment 1 of the present invention.
  • Fig. 18 is a circuit diagram of a method for implementing a pulsed electric field that can only realize a full-range charging mode in Embodiment 1 of the present invention
  • Fig. 19 is the first pulse output waveform in Embodiment 1 of the present invention.
  • Fig. 20 is the second pulse output waveform in Embodiment 1 of the present invention.
  • Fig. 21 is the third pulse output waveform in Embodiment 1 of the present invention.
  • Fig. 22 is the fourth pulse output waveform in Embodiment 1 of the present invention.
  • Fig. 23 is the fifth pulse output waveform in Embodiment 1 of the present invention.
  • Fig. 24 is a circuit for implementing the diode charging mode and the full-range charging mode and the pulse electric field implementation method with a band-pass filter in Embodiment 1 of the present invention
  • Fig. 25 is a circuit of the implementation method of the pulsed electric field that can only realize the full charging mode and has a band-pass filter in Embodiment 1 of the present invention
  • Fig. 26 is a schematic diagram of the waveform generated by the first sinusoidal pulse in Embodiment 1 of the present invention.
  • Fig. 27 is a schematic diagram of the waveform generated by the second sinusoidal pulse in Embodiment 1 of the present invention.
  • Fig. 28 is a schematic diagram of the combined pulse waveform in Embodiment 1 of the present invention.
  • Fig. 29 is a discharge circuit formed during charging of adjacent capacitor cells if there is no diode array group in Embodiment 2 of the present invention.
  • FIG. 1 it is a circuit diagram for realizing the pulsed electric field technology.
  • the circuit includes multiple capacitor pools, a diode array group corresponding to each capacitor pool, a DC power supply, an output switch group at the output of the DC power supply, a full-bridge topology switch circuit, and an output interface.
  • the high-voltage pulse circuit in the prior art is mainly a full-bridge topology switch circuit, and does not use a capacitor pool, an output switch group and a diode array group.
  • the high-voltage pulse circuit in the prior art is shown in FIG. 2 .
  • the present invention is an improvement made on the basis of Fig. 2 .
  • switches S1111, ... S111(n-1), S111n in series form the first switch branch
  • the switches S1121, ... S112(n-1), S112n form the second switch branch
  • the switches S11n1, ... S11n(n-1), S111n form the nth switch branch
  • the n switch branches are connected in parallel to form the S11 switch module.
  • switches S1311, ... S131(n-1), S131n are connected in series to form a first switch branch
  • switches S1321, ... S132(n-1), S132n form a second switch branch
  • S13n(n-1), S131n form the nth switch branch, and the n switch branches are connected in parallel to form the S13 switch module, and the S11 switch module and the S13 switch module are connected in series to form the first branch.
  • S12 The switch module and the S14 switch module are connected in series to form the second branch, and the first branch and the second branch are connected in parallel to form the first module of the full-bridge topology.
  • the second module and the third module are formed... N modules, etc.
  • the S11 switch module of the first module is defined as the first area of the first module
  • the S13 switch module of the first module is defined as the third area of the first module
  • the S12 switch module of the first module is defined as the third area of the first module.
  • the switch module is defined as the second area of the first module
  • the S14 switch module of the first module is defined as the fourth area of the first module, as shown in FIG. 3 .
  • the corresponding positions of other modules are also designated as the first area, the second area, the third area and the fourth area.
  • the modules of the full-bridge topology switch circuit in Figure 1 are also named after the same switch area. After dividing the area, Figure 2 can be simplified to Figure 4, and Figure 1 can be simplified to Figure 5.
  • the midpoint A1 of the first branch of the first module is connected with the midpoint B2 of the second branch of the second module, and the midpoint A2 of the first branch of the second module is connected with the second branch of the third module.
  • the midpoint B3 is connected, and so on.
  • a full-bridge topology is formed, and the front end of each module is connected in parallel with capacitors.
  • Capacitor 1, capacitor 2... One end of capacitor n is connected in parallel to the input terminal K of the DC power supply.
  • capacitor 1, capacitor 2...the other end of capacitor n is respectively connected to the terminal Ji of each module.
  • the middle point B1 of the second branch of the first module and the midpoint An of the first branch of the Nth module are used as the two end points of the output.
  • the states of the switches of the branches are respectively controlled, and the high-voltage positive pulse, negative pulse, zero pulse, zero pulse and zero charging pulse can be output.
  • the pulse combination of multiple switch modules constitutes the combined pulse as shown in Figure 6-17. Since this circuit is used in medical equipment, no matter what combination or pulse the output high-voltage pulse has, it will act on the human body. Therefore, it is necessary to improve the safety performance of the circuit, so the reverse connection switch is used to realize charging protection, as shown in Figure 2 As shown, the switches S141n...S14nn in the last row of the second branch of the first module, and the switches Sn31n...Sn3nn in the last row of the first branch of the last module must be connected in reverse, so that the post-charging current is set Will not flow through the patient. Since each switch has a body diode, such a reverse connection makes the circuit realize zero charging pulse without using a charging protection switch. The capacitor in the circuit is in a charging state, and the output is a zero pulse. , the charging current will not flow to the patient through the output port.
  • the remaining branches Can be constructed in two ways. One is the forward connection as shown in Figure 1, and the other is the reverse connection as shown in Figure 18.
  • each switch module is equipped with a capacitor pool connected in parallel; each capacitor pool is connected with a diode array group in series before being connected to the DC power supply; the output terminal of the DC power supply is connected in series output switch group.
  • Each capacitor pool is composed of n sets of capacitor groups, and the number of capacitors forming the capacitor group can be set arbitrarily according to application requirements.
  • Each capacitor bank is equipped with a bidirectional switch to ensure the charging and discharging of the capacitor bank that needs to be used.
  • a plurality of capacitor branches are connected in parallel in the capacitor pool, and the capacitor branch is connected in series with a capacitor switch array and a capacitor group.
  • the capacitor switch array is formed by a plurality of switch units connected in series, and each switch unit is composed of a plurality of switch subunits connected in parallel.
  • the switches in the capacitive switch array all have body diodes, and the body diodes of the switches in the upper half are opposite to the body diodes of the switches in the lower half.
  • the reason why the body diodes are oppositely set is that if the body diodes of the switches are all in one direction, for example, the cathodes of the body diodes are all facing up, although the entire capacitor switch array of this branch is turned off and does not charge the capacitor bank, but due to the body diode Negatives all pointing up will cause adjacent capacitor banks to charge that capacitor bank through their body diodes.
  • the switches in the capacitive switch array are designed to have body diodes, and the body diodes of the switches in the upper half are in the opposite direction to the body diodes of the switches in the lower half. No matter charging or discharging, there are body diodes that act as resistance. The function of turning off makes the entire capacitor switch array of this branch only control the charging and discharging of the capacitor bank of this branch by turning on and off, without affecting or being affected by the adjacent capacitor banks.
  • the power supply adopts a DC power supply.
  • a diode is arranged on the charging circuit of each group of full-bridge topology, and an output switch group is configured.
  • the configuration of this switch group and the diode ensures that the capacitance of the capacitor group will not be reversed during the discharge process. Discharging ensures that the capacitance in the capacitor pool will not generate unnecessary losses.
  • the charging process of the body diode charging mode is as follows: firstly, the output voltage of the DC power supply is set to V. The total number of capacitor pools to be charged is p, x represents the capacitor pools to be charged, and the corresponding capacitor bank is q. Turn on the switch group ((M11...M1n)...(Mn1...Mnn)) connected to the DC power supply, and at the same time turn on the switch ((Kxq111...K1x11n)...(Kxq211...K1x21n)...(Kxq1n1... Kx11nn)...(Kxq2n1...Kxq2nn)).
  • the full-bridge topology needs to be turned on (((S2411...S241n)...(S24n1...S24nn))...((Sn411...Sn41n)...(Sn4n1...Sn4nn))), and the last group of switches of the full-bridge topology (Sn31n ...Sn3nn).
  • the switching tubes of all other parts remain closed. In this way, the energy of the DC power supply can flow through the capacitor to be charged to realize charging.
  • the current path of the full-bridge topology is realized by flowing through the body diodes of the third region of each set of full-bridge topology.
  • the charging process of the full control charging mode is as follows: firstly, the output voltage of the DC power supply is set to V1.
  • the total number of capacitor pools to be charged is p, x represents the capacitor pools to be charged, and the corresponding capacitor bank is q.
  • the full-bridge topology needs to be turned on by the switches in the third region (((S1311...S131n)...(S13n1...S13nn))...((Sn311...Sn31n)...(Sn3n1...Sn3nn))), and the switches in the fourth region Switch tube (((S2411...S241n)...(S24n1...S24nn))...((Sn411...Sn41n)...(Sn4n1...Sn4nn))).
  • the switching tubes of all other parts remain closed. In this way, the energy of the DC power supply can flow through the capacitor to be charged to realize charging.
  • the switch tube in the third region of the full-bridge topology is turned on, the path of the charging current is guaranteed not to pass through the body diode of the third region of the full-bridge topology, especially the last region of the third region of the full-bridge topology shown in Figure 18
  • the reverse connection of the switch tubes in the row makes the topology of the structure only realize the way of full control of charging.
  • the advantage of this charging method is that the body diode will produce a fixed voltage drop, and the on-resistance of the switch tube is often small. Therefore, adopting the full control charging mode can greatly reduce the influence of the body diode voltage drop on the charging voltage of the capacitor.
  • the above two charging modes can be used during the output pulse period to achieve zero pulse output.
  • the positive pulse output method is: when the positive pulse needs to be output, set the output voltage of the pre-charged DC power supply to V.
  • the total number of capacitor pools to be used for positive pulse output is p, x refers to the capacitor pools used, and the capacitor bank to be used is q.
  • switch off the switch tube ((M11...M1n)...(Mn1...Mnn)).
  • For the capacitor pool circuit to be used turn on the switch tube corresponding to the capacitor bank used ((Kxq111...K1x11n)...(Kxq211...K1x21n)...(Kxq1n1...Kx11nn)...(Kxq2n1...Kxq2nn)).
  • the switch module corresponding to the used capacitor pool For the full-bridge topology, for the switch module corresponding to the used capacitor pool, turn on the second zone switch ((Sx211...Sx21n)...(Sx2n1...Sx2nn)) and the third zone switch ((Sx311...Sx31n) of the switch module )...(Sx3n1...Sx3nn)).
  • the total number of remaining unused capacitor pools is n-p, which can be turned on by turning on the first area and the second area switch of the corresponding switch module, or turning on the third area and the fourth area switch of the corresponding switch module.
  • Disconnecting the switch group ((M11...M1n)...(Mn1...Mnn)) at the output of the DC power supply and disconnecting the diode array group ((D111...D11n)...(D1n1...D1nn)) can ensure that no individual
  • the cascade circuit of the output capacitors forms the mutual charge and discharge between the energy storage capacitors, resulting in unnecessary loss of energy of the energy storage capacitors.
  • the negative pulse output method is: when it is necessary to output negative pulses, set the output voltage of the pre-charged DC power supply to V.
  • the total number of capacitor pools to be used for positive pulse output is p
  • x refers to the capacitor pools used
  • the capacitor bank to be used is q.
  • Disconnect the diode array groups ((M11...M1n)...(Mn1...Mnn)).
  • For the capacitor pool circuit to be used turn on the switch tube corresponding to the capacitor bank used ((Kxq111...K1x11n)...(Kxq211...K1x21n)...(Kxq1n1...Kx11nn)...(Kxq2n1...Kxq2nn)).
  • the first zone switch ((Sx111...Sx21n)...(Sx1n1...Sx2nn)) and the fourth zone switch ((Sx411... Sx41n)...(Sx4n1...Sx4nn)).
  • the total number of remaining unused capacitor pools is n-p, which can be turned on by turning on the first area and the second area switch of the corresponding switch module, or turning on the third area and the fourth area switch of the corresponding switch module.
  • Disconnecting the switch group ((M11...M1n)...(Mn1...Mnn)) at the output of the DC power supply and disconnecting the diode array group ((D111...D11n)...(D1n1...D1nn)) can ensure that no individual pulses are formed during the negative pulse output.
  • the cascade circuit of the output capacitors forms the mutual charge and discharge between the energy storage capacitors, resulting in unnecessary loss of energy of the energy storage capacitors.
  • the above positive pulse and negative pulse output methods can be used.
  • the parameters such as the corresponding pulse width, pulse interval, and number of pulses are taken into consideration.
  • the capacitors in the capacitor bank can be configured according to the usage.
  • FIG. 19- Figure 23 briefly lists several output pulse waveforms. The actual output waveforms are not limited to these types, and can be combined arbitrarily.
  • Sine pulse output The sine pulse can be output by applying a band-pass filter to the output pulse signal through the circuit topology shown in Figure 24 and Figure 25 to realize the output of the sine pulse.
  • Figure 26- Figure 27 briefly lists several output pulse waveforms. The actual pulse waveforms that can be output are not limited to these types, and can be combined arbitrarily.
  • Figure 28 shows a schematic diagram of the combined pulse.
  • the actual pulse waveforms that can be output are not limited to these types, and can be combined arbitrarily.
  • Each full-bridge topology will have a corresponding capacitor pool.
  • the main function of the capacitor pool is to store energy, and then load the capacitor bank in the corresponding capacitor pool according to different output requirements to achieve pulses with different pulse widths, pulse amplitudes, and pulse numbers. energy output.
  • the capacitor pool 1 is composed of n capacitor groups. Assuming that the total capacity of the capacitors in the capacitor bank 11 is 100mF and the withstand voltage is 1000V, the highest voltage value of the energy that the capacitor bank 11 can store is 1000V. Assuming that the total capacity of the capacitors in the capacitor bank 1n is 10uF and the withstand voltage is 20KV, the highest voltage value of the two points that the capacitor bank 1n can store is 20KV.
  • the higher the capacitance the longer the pulse output can maintain the high voltage when the number of outputs and the pulse width are larger.
  • the example of the above capacitor group can show that for different output requirements, such as pulse amplitude 60KV, pulse width 2us, and pulse number 3, at this time, you can switch to the capacitor group 1n, so that you can output pulse energy that meets its output requirements. For example, 3000V, 100us, 5, at this time, you can switch to the capacitor bank 11, so that the pulse energy that meets its output can be output.
  • each capacitor pool will conduct the required capacitor bank for output.
  • capacitor bank 1 needs to be used at this time, so that capacitor pool 1-capacitor pool n will turn on their capacitor banks 11-n1 respectively, so that the desired high voltage can be output through the superposition of capacitor banks.
  • Diodes ((D111...D11n)...(D1n1...D1nn)) are used here, and their function is to prevent the influence of the capacitor group between the battery packs. For example, the voltage and stored energy of the capacitor group 11 and the capacitor group n1 cannot be exactly the same, and the energy consumption during the discharge process cannot be exactly the same. If there is no diode function, it is assumed that in the adjacent capacitor pool 2 and capacitor pool 3, the energy of the capacitor group 11 of the capacitor pool 3 is higher than the energy of the capacitor group n1 in the capacitor pool 2, and the corresponding switch module of the capacitor pool 2 The switch in the third area in the switch is turned on, and the switch in the fourth area in the switch module corresponding to the capacitor pool 3 is turned on.
  • One function of the switches ((M11....M1n)...(Mn1 VietnameseMnn)) is to ensure that the DC power supply is disconnected from the full-bridge path of the discharge during discharge. If the switch ((S1211...S121n, S12n1...S12nn)) of the second bridge arm of the full-bridge topology is turned on at this time, the DC power will be loaded on the load at this time, which does not match the actual output voltage. At the same time, if the load organization Very small and very likely to tax the DC power supply.

Landscapes

  • Engineering & Computer Science (AREA)
  • Power Engineering (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Electromagnetism (AREA)
  • Medical Informatics (AREA)
  • Otolaryngology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Charge And Discharge Circuits For Batteries Or The Like (AREA)
  • Inverter Devices (AREA)

Abstract

La présente invention concerne un circuit et un procédé de mise en œuvre de technologie de champ électrique pulsé. Le circuit de mise en œuvre de technologie de champ électrique pulsé comprend une source d'alimentation en courant continu, un circuit de commutation de topologie en pont complet et une interface de sortie, la source d'alimentation en courant continu étant connectée en parallèle à une extrémité d'entrée du circuit de commutation de topologie en pont complet, un signal d'impulsion haute tension étant délivré par l'intermédiaire de l'interface de sortie au moyen du circuit de commutation de topologie en pont complet, deux extrémités de chaque module de commutation dans le circuit de commutation de topologie en pont complet étant connectées en parallèle à des groupes de condensateurs, et une extrémité de chaque groupe de condensateurs étant connectée en parallèle à une extrémité d'entrée de la source d'alimentation en courant continu ; et des tensions de charge différentes sont fournies pour les modules de commutation au moyen du réglage des états de mise sous tension-hors tension des réseaux de commutateurs de condensateur dans les groupes de condensateurs. Afin de réaliser différentes sorties de tension dans le même groupe d'impulsions, le circuit comporte n groupements de groupes de condensateurs pour réaliser un stockage d'énergie des condensateurs pendant la sortie, fournissant ainsi de l'énergie pour la sortie.
PCT/CN2022/130460 2021-11-23 2022-11-08 Circuit et procédé de mise en œuvre de technologie de champ électrique pulsé Ceased WO2023093514A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN202111397612.5A CN114094869B (zh) 2021-11-23 2021-11-23 一种脉冲电场技术的实现电路及方法
CN202111397612.5 2021-11-23

Publications (1)

Publication Number Publication Date
WO2023093514A1 true WO2023093514A1 (fr) 2023-06-01

Family

ID=80303531

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2022/130460 Ceased WO2023093514A1 (fr) 2021-11-23 2022-11-08 Circuit et procédé de mise en œuvre de technologie de champ électrique pulsé

Country Status (2)

Country Link
CN (1) CN114094869B (fr)
WO (1) WO2023093514A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12186011B2 (en) 2019-10-21 2025-01-07 Endogenex, Inc. Devices, systems, and methods for pulsed electric field treatment of the duodenum
US12239365B2 (en) 2015-10-07 2025-03-04 Mayo Foundation For Medical Education And Research Electroporation for obesity or diabetes treatment

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114094869B (zh) * 2021-11-23 2024-01-09 融和医疗科技(浙江)有限公司 一种脉冲电场技术的实现电路及方法
CN116492043B (zh) * 2022-10-18 2024-05-24 广州星际悦动股份有限公司 脉冲光控制方法、电路、设备及脱毛仪、存储介质

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018108143A1 (fr) * 2016-12-16 2018-06-21 台达电子企业管理（上海）有限公司 Système d'alimentation électrique modulaire
CN111053975A (zh) * 2020-01-03 2020-04-24 创领心律管理医疗器械（上海）有限公司 心脏起搏装置、存储介质、电源设备及输出电压控制方法
CN111345889A (zh) * 2020-03-30 2020-06-30 四川锦江电子科技有限公司 一种应用于脉冲电场消融技术的脉冲产生电路及控制方法
CN111419383A (zh) * 2020-03-30 2020-07-17 四川锦江电子科技有限公司 一种应用于脉冲电场消融技术的组合脉冲产生电路及方法
CN114094869A (zh) * 2021-11-23 2022-02-25 成都科莱弗生命科技有限公司 一种脉冲电场技术的实现电路及方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05283780A (ja) * 1992-04-02 1993-10-29 Mitsubishi Electric Corp パルス発生回路
CN101312330A (zh) * 2008-05-09 2008-11-26 合肥雷科电子科技有限公司 谐振变换器高压电源装置
CN201199674Y (zh) * 2008-05-09 2009-02-25 合肥雷科电子科技有限公司 谐振变换器高压电源装置
US7903435B2 (en) * 2008-08-05 2011-03-08 System General Corp. Switching controller having switching frequency hopping for power converter
CN102332920A (zh) * 2011-07-18 2012-01-25 复旦大学 一种高sfdr多通道时间交错逐次逼近型模数转换器
CN103490661A (zh) * 2013-09-12 2014-01-01 复旦大学 具有正负脉冲输出的全固态高压脉冲电流源
WO2016151796A1 (fr) * 2015-03-25 2016-09-29 国立大学法人長岡技術科学大学 Dispositif de génération d'impulsions haute tension et dispositif laser à gaz
CN105207516B (zh) * 2015-09-14 2017-10-20 上海交通大学 电除尘用高频高压直流叠加高压脉冲电源
CN106059376A (zh) * 2016-06-03 2016-10-26 山东航天电子技术研究所 一种适用于高重复频率脉冲负载的供电系统
WO2018236883A1 (fr) * 2017-06-19 2018-12-27 Stangenes Industries, Inc. Systèmes et procédé pour générateurs de marx identiques parallèles
CN207573258U (zh) * 2017-10-31 2018-07-03 北方智能装备有限公司 一种具有单电源的级联型多电平逆变器
EP3749238B1 (fr) * 2018-02-08 2023-08-16 Farapulse, Inc. Appareil d'application contrôlée d'une énergie d'ablation à champ électrique pulsé sur un tissu
CN111464010A (zh) * 2020-04-24 2020-07-28 湖南大学 负载滤波电容可变的轨道交通用车载充电机及控制方法
CN112468011B (zh) * 2020-10-28 2022-10-14 南京工业大学 一种应用于高压微秒脉冲电源的限压整形电路

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018108143A1 (fr) * 2016-12-16 2018-06-21 台达电子企业管理（上海）有限公司 Système d'alimentation électrique modulaire
CN111053975A (zh) * 2020-01-03 2020-04-24 创领心律管理医疗器械（上海）有限公司 心脏起搏装置、存储介质、电源设备及输出电压控制方法
CN111345889A (zh) * 2020-03-30 2020-06-30 四川锦江电子科技有限公司 一种应用于脉冲电场消融技术的脉冲产生电路及控制方法
CN111419383A (zh) * 2020-03-30 2020-07-17 四川锦江电子科技有限公司 一种应用于脉冲电场消融技术的组合脉冲产生电路及方法
CN114094869A (zh) * 2021-11-23 2022-02-25 成都科莱弗生命科技有限公司 一种脉冲电场技术的实现电路及方法

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12239365B2 (en) 2015-10-07 2025-03-04 Mayo Foundation For Medical Education And Research Electroporation for obesity or diabetes treatment
US12426948B2 (en) 2015-10-07 2025-09-30 Mayo Foundation For Medical Education And Research Electroporation for obesity or diabetes treatment
US12186011B2 (en) 2019-10-21 2025-01-07 Endogenex, Inc. Devices, systems, and methods for pulsed electric field treatment of the duodenum

Also Published As

Publication number Publication date
CN114094869A (zh) 2022-02-25
CN114094869B (zh) 2024-01-09

Similar Documents

Publication Publication Date Title
WO2023093514A1 (fr) Circuit et procédé de mise en œuvre de technologie de champ électrique pulsé
CN111345889B (zh) 一种应用于脉冲电场消融技术的脉冲产生电路及控制方法
KR102410532B1 (ko) 모듈형 펄스 전원 장치
WO2011032149A2 (fr) Générateur de marx bipolaire à semi-conducteurs
CN111419383B (zh) 一种应用于脉冲电场消融技术的组合脉冲产生电路及方法
CN108321871A (zh) 一种串联电池组的主动均衡电路及其均衡方法
CN106787724B (zh) 一种开关零电压关断双路输入高增益dc/dc变换器
KR20210035899A (ko) 흐름전지 및 충전상태(soc)의 평형을 유지하는 방법
RU2018128391A (ru) Устройство подачи мощности
CN113824431A (zh) 协同脉冲发生电路、发生装置及其发生方法
CN109755960A (zh) 一种单相并网开关电容九电平逆变器拓扑结构
CN116781043A (zh) 脉冲发生电路、装置、设备及方法
CN113749759A (zh) 用于不可逆电穿孔的脉冲发生设备及其方法、系统
Elserougi et al. Multi-module high voltage pulse generator based on DC-DC boost converter and CDVMs for drinking water purification
JP7728439B2 (ja) シナジーパルス発生回路、発生装置及びその発生方法
CN114744987A (zh) 一种关断器及光伏系统
CN106655773B (zh) 一种含有软开关的双端口输入高增益dc/dc变换器
CN107834655A (zh) 一种基于多绕组变压器的自动的电池均衡电路及实现方法
Jiang et al. A multilevel pulse generator based on series capacitor structure for cell electroporation
CN110011382A (zh) 一种电池组热插拔保护电路及保护方法
CN114448396A (zh) 一种协同脉冲的产生设备和方法
CN114520604A (zh) 带有直流偏置的高压脉冲源
CN101807804B (zh) 电池共用的不间断电源系统
CN206412442U (zh) 一种电池能量均衡电路
RU2824806C1 (ru) Устройство формирования импульса дефибрилляции с регулируемой формой

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 22897597

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 22897597

Country of ref document: EP

Kind code of ref document: A1