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WO2023090708A1 - Composition comprenant du sirop de grains d'avoine ou un extrait de celui-ci pour l'hydratation de la peau, la réduction des rides et l'antioxydation - Google Patents

Composition comprenant du sirop de grains d'avoine ou un extrait de celui-ci pour l'hydratation de la peau, la réduction des rides et l'antioxydation Download PDF

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Publication number
WO2023090708A1
WO2023090708A1 PCT/KR2022/017154 KR2022017154W WO2023090708A1 WO 2023090708 A1 WO2023090708 A1 WO 2023090708A1 KR 2022017154 W KR2022017154 W KR 2022017154W WO 2023090708 A1 WO2023090708 A1 WO 2023090708A1
Authority
WO
WIPO (PCT)
Prior art keywords
grain syrup
oat grain
extract
oat
skin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2022/017154
Other languages
English (en)
Korean (ko)
Inventor
배수지
경서연
이은정
유정진
강승현
박명삼
이해신
정다은
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cosmax Inc
Original Assignee
Cosmax Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cosmax Inc filed Critical Cosmax Inc
Publication of WO2023090708A1 publication Critical patent/WO2023090708A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L7/00—Cereal-derived products; Malt products; Preparation or treatment thereof
    • A23L7/20—Malt products
    • A23L7/25—Fermentation of cereal malt or of cereal by malting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9794—Liliopsida [monocotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/007—Preparations for dry skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2200/00—Function of food ingredients
    • A23V2200/30—Foods, ingredients or supplements having a functional effect on health
    • A23V2200/318—Foods, ingredients or supplements having a functional effect on health having an effect on skin health and hair or coat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/52—Stabilizers
    • A61K2800/522—Antioxidants; Radical scavengers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine

Definitions

  • It relates to a process for concentrating an oat grain syrup component and a composition for improving skin using the same.
  • Grain Syrup is a vegetable ingredient made from grain and has no irritation issues, so it can be used as a substitute for honey, which continues to be controversial about the safety of pesticide residues and pesticides.
  • Oats have been selected as one of the world's top 10 foods because they contain unsaturated fatty acids, minerals, and vitamins. Although studies on the skin efficacy of oats are active, in the cosmetics field, simple oat extracts are only studied and used, and no example of application of oat-derived grain syrup components has been reported yet.
  • One aspect provides a composition comprising oat grain syrup or an extract thereof.
  • oat honey means grain syrup made from oats as a raw material.
  • the manufacturing method of the oat grain syrup is not limited to a specific type.
  • the oat grain syrup may be prepared using oats as a raw material using a grain syrup manufacturing method commonly used in the art.
  • the oat grain syrup may be prepared by a method for preparing oat grain syrup according to another aspect of the present specification.
  • the composition may include oat grain syrup itself or an extract of oat grain syrup.
  • the extraction solvent may be selected from water, organic solvents, or mixtures thereof.
  • the water may be distilled water or purified water.
  • the organic solvent may include one or more of C1 to C6 alcohol, acetone, ether, ethyl acetate, diethyl ether, ethyl methyl ketone, and chloroform, but is not limited thereto.
  • the extraction solvent of the extract may be water, C1 to C4 alcohol, or a mixture thereof. In another embodiment, the extraction solvent of the extract may be a mixture of water and C1 to C4 alcohol. In another embodiment, the extraction solvent of the extract may be water, butylene glycol, or a mixture thereof. In another embodiment, the extraction solvent of the extract may be a mixture of water and butylene glycol.
  • the extraction temperature is 10 to 150 °C, 10 to 120 °C, 10 to 100 °C, 10 to 80 °C, 20 to 150 °C, 20 to 120 °C, 20 to 100 °C, 20 to 80 °C, 20 to 60 °C, 20 to 40 ° C., or room temperature, but may be appropriately selected according to other conditions such as extraction solvent and extraction time.
  • the composition may include oat grain syrup or an extract thereof as an active ingredient.
  • the "included as an active ingredient” means that oat grain syrup or an extract thereof is added to the extent that it can exhibit the effects mentioned in this specification, and formulated in various forms by adding various ingredients as subcomponents for drug delivery and stabilization ( It means that it includes being formulated.
  • composition containing oat grain syrup or an extract thereof may be used for moisturizing skin, enhancing skin elasticity, improving skin wrinkles, improving skin aging, or antioxidant.
  • moistureturizing the skin can refer to any action that maintains skin moisture or prevents moisture loss.
  • skin elasticity enhancement may refer to any action of increasing skin elasticity reduced by causes such as aging or preventing a decrease in skin elasticity.
  • improvement of skin wrinkles is interpreted to mean not only an action of reducing the number or depth of wrinkles on the skin, but also includes suppression of skin aging through wrinkle improvement.
  • the aging may be photoaging.
  • photoaging is a phenomenon caused by external environmental factors, and the most representative factor is ultraviolet rays.
  • UVB ultraviolet B
  • antioxidation means inhibition of oxidation, and may include an action of removing free radicals that attack normal cells in the body and act as a cause of aging or various diseases.
  • the content of the oat grain syrup or extract thereof may be appropriately selected within a conventional range in comprehensive consideration of the use of the composition, desired effects, and the like.
  • the oat grain syrup or extract thereof is present in an amount of 0.0001 wt% to 20.0 wt%, 0.0001 wt% to 10.0 wt%, 0.0001 wt% to 5.0 wt%, 0.0001 wt% to 1.0 wt%, 0.001 wt% to 20.0 wt%, based on the total composition.
  • % 0.001% to 10.0%, 0.001% to 5.0%, 0.001% to 1.0%, 0.01% to 20.0%, 0.01% to 10.0%, 0.01% to 5.0%, Or it may be included in 0.01% by weight to 1.0% by weight, but is not limited thereto.
  • the composition may be a cosmetic composition.
  • the cosmetic composition may further include ingredients commonly used in cosmetic compositions, functional additives, etc., in addition to the active ingredients disclosed herein, such as antioxidants, stabilizers, solubilizers, surfactants, dispersants, thickeners, Conventional adjuvants such as preservatives, vitamins, pigments, fragrances, and the like, and cosmetically acceptable carriers may be included.
  • ingredients commonly used in cosmetic compositions, functional additives, etc. such as antioxidants, stabilizers, solubilizers, surfactants, dispersants, thickeners, Conventional adjuvants such as preservatives, vitamins, pigments, fragrances, and the like, and cosmetically acceptable carriers may be included.
  • the composition may be an external composition for skin.
  • the binder may be polyvinylpyrrolidone, low-substituted hydroxypropylcellulose, hydroxypropylcellulose, or a combination thereof.
  • the lubricant may be magnesium stearate, silicon dioxide, talc, or a combination thereof.
  • the pharmaceutical composition may be formulated for oral or parenteral administration.
  • Oral dosage forms may be granules, powders, solutions, tablets, capsules, dry syrups, or combinations thereof.
  • Parenteral dosage forms may be injections.
  • the composition may be a health functional food composition.
  • the health functional food composition may be used alone or in combination with the oat grain syrup or extract thereof, or other foods or food ingredients, and may be appropriately used according to conventional methods.
  • the mixing amount of the active ingredient may be appropriately determined depending on the purpose of use (prevention, health or therapeutic treatment).
  • beverage compositions may contain various flavoring agents or natural carbohydrates as additional components, like conventional beverages.
  • the natural carbohydrates include monosaccharides such as glucose and fructose, disaccharides such as maltose and sucrose, polysaccharides such as dextrin and cyclodextrin, and sugar alcohols such as xylitol, sorbitol, and erythritol.
  • the sweetener natural sweeteners such as thaumatin and stevia extract, or synthetic sweeteners such as saccharin and aspartame may be used.
  • the health functional food composition may also contain nutrients, vitamins, electrolytes, flavors, colorants, pectic acid and its salts, alginic acid and its salts, organic acids, protective colloidal thickeners, pH adjusters, stabilizers, preservatives, glycerin, alcohol, carbonated beverages It may contain a carbonation agent used for, or a combination thereof.
  • the health functional food composition may also contain natural fruit juice, fruit juice beverages, fruit flesh for preparing vegetable beverages, or a combination thereof.
  • Another aspect provides a method of making oat grain syrup.
  • the method may be a concentration process of oat grain syrup.
  • an amount of water sufficient to soak oats may be used.
  • the steaming process means cooking or heating with hot steam.
  • steamed oats may be used in a high-quality form such as godubap.
  • the weight ratio of water and malt may be appropriately selected so that the malt can be sufficiently dissolved in water.
  • the weight ratio of water and malt is 5-10:1, 5-9:1, 6-10:1, 6-9:1, 7-10:1, or 7-9:1, for example 8 : can be 1.
  • the fermentation time may be appropriately selected in consideration of other conditions such as fermentation temperature.
  • the fermentation is 1 to 12 hours, 1 to 10 hours, 1 to 8 hours, 1 to 6 hours, 2 to 12 hours, 2 to 10 hours, 2 to 8 hours, 2 to 6 hours, 4 to 12 hours hour, 4 to 10 hours, 4 to 8 hours, or 4 to 6 hours.
  • a step of filtering the aqueous saccharification solution may be further included.
  • the filtration may be performed according to a conventional method, and may be performed using, for example, a mesh.
  • the unit of the mesh is expressed as the number of nets included in a square having a side of 1 inch (25.4 mm). For example, 100 mesh means a particle diameter of 0.149 ⁇ m.
  • the concentration may be performed at 80 to 100 °C.
  • the heating may be performed for 5 to 10 hours, 6 to 10 hours, 7 to 10 hours, 5 to 9 hours, or 6 to 9 hours, 7 to 9 hours, for example 8 hours. By the heating, oat grain syrup with more nutrients can be obtained.
  • the sugar concentration of the oat grain syrup may be 65 to 75 Brix. Therefore, the concentration temperature and time of step (3) may be appropriately adjusted so that the sugar concentration of oat grain syrup is 65 to 75 Brix.
  • the oat grain syrup prepared by the above method may have an excellent antioxidant effect due to a higher polyphenol content than that of the oat extract.
  • the oat grain syrup prepared by the above method is superior in HAS3 expression increasing ability, AQP3 expression increasing ability, and COL1A1 expression increasing ability compared to oat extract, it has effects of moisturizing skin, enhancing skin elasticity, improving skin wrinkles, and improving skin aging.
  • Redundant content is omitted in consideration of the complexity of the present specification, and terms not defined otherwise in the present specification have meanings commonly used in the technical field to which the present invention belongs.
  • the composition according to one aspect may have skin moisturizing, skin elasticity enhancement, skin wrinkle improvement, skin aging improvement, and antioxidant effects by including oat grain syrup or an extract thereof. Since the oat grain syrup or its extract has superior skin improvement efficacy compared to the oat extract, it can be used as a cosmetic composition or a health functional food composition.
  • Example 1 is a graph showing the effect of oat grain syrup according to an embodiment on the expression of HAS3. None: Pure distilled water added group; Control: retinoic acid addition group as a positive control group; EGCG: EGCG addition group as a positive control group; Oat EXTRACT: oat extract addition group of Comparative Example 1; and Oat Honey: the oat grain syrup extract addition group of Example 1.
  • Figure 2 is a graph showing the effect of oat grain syrup according to an embodiment on the expression of AQP3. None: Pure distilled water added group; Control: retinoic acid addition group as a positive control group; EGCG: EGCG addition group as a positive control group; Oat EXTRACT: oat extract addition group of Comparative Example 1; and Oat Honey: the oat grain syrup extract addition group of Example 1.
  • a group containing pure distilled water was used as a negative control group, and a group containing 1 ⁇ M retinoic acid and 1 ⁇ M EGCG (Epigallocatechin gallate) were used as positive controls. Thereafter, cells in each medium were obtained, washed with chilled PBS, RNA was isolated using an RNAprep kit (Monarch® Total RNAprep Kit, NEB, USA), and RNA was quantified at 260 nm with a nanodrop. , cDNA was synthesized in an amplifier using 2 ⁇ g of RNA each (C1000 Thermal Cycler, Bio-Rad, USA).
  • 1 is a graph showing the effect of oat grain syrup according to an embodiment on the expression of HAS3.
  • a human dermal fibroblast cell line (Hs68) was cultured in DMEM (Dulbecco's modified Eagle's medium) containing 10% fetal bovine serum (FBS) and 1% penicillin, and the culture was carried out at 37°C, 5% CO2 and It was performed for 24 hours in an incubator at 95% humidity. Thereafter, the medium was removed, DPBS was added, and 20 mJ/cm 2 of UVB was irradiated or not irradiated.
  • DMEM Dynabecco's modified Eagle's medium
  • FBS fetal bovine serum
  • cDNA was synthesized in an amplifier using 2 ⁇ g of RNA each (C1000 Thermal Cycler, Bio-Rad, USA). Using the synthesized cDNA as a template, cybergreen (SYBR Green supermix, Applied Biosystems, USA) was added together with the primers and cDNA in Table 2 for the target gene, COL1A1, in a real-time PCR machine (Step One Plus, Applied Biosystems, USA). Real-time polymerase chain reaction was performed at Biosystems, USA). The real-time PCR reaction was performed by repeating 40 cycles of polymerase activation at 94°C for 5 minutes, followed by 95°C for 30 seconds, 55°C for 30 seconds, and 72°C for 30 seconds. The expression level of the COL1A1 gene was finally analyzed through correction for the ⁇ -actin gene, and the results are shown in FIG. 3 .
  • Figure 3 is a graph showing the effect of oat grain syrup according to one embodiment on the expression of COL1A1.
  • polyphenols are a class of chemicals found in plants and are characterized by having two or more phenolic groups in one molecule.
  • Polyphenols are generally classified as tannins and phenylpropanoids (e.g., flavonoids, lignins, etc.). Phenol is obtained by replacing one hydrogen atom of benzene with a hydroxyl group, and polyphenol is obtained by replacing two or more hydroxyl groups.
  • Polyphenols are known as antioxidants that remove the toxicity of harmful substances containing free radicals such as active oxygen.
  • a typical method for measuring total polyphenols is the Folin-Denis test method, which measures absorbance using general oxidation-reduction properties of phenolic substances.
  • the total polyphenol content ( ⁇ g gallic acid equivalent/g) was calculated using a standard curve obtained using gallic acid as a standard substance.
  • Figure 4 is a table showing the polyphenol content analyzed to confirm the antioxidant effect of the oat syrup extract according to one embodiment.
  • the oat grain syrup extract of Example 1 was expected to have a higher antioxidant effect than the general oat extract due to its high polyphenol content.

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Abstract

L'invention concerne une composition cosmétique et une composition d'aliment fonctionnel pour la santé, comprenant chacune du sirop de grains d'avoine ou un extrait de celui-ci, ainsi qu'un procédé de préparation de sirop de grains d'avoine. Dans un aspect, une composition contient du sirop de grains d'avoine ou un extrait de celui-ci, et présente des effets d'hydratation de la peau, d'augmentation de l'élasticité de la peau, de réduction des rides, d'atténuation du vieillissement cutané et d'antioxydation. En outre, un procédé de préparation de sirop de grains d'avoine selon un aspect permet de préparer un sirop de grains d'avoine doté d'une teneur élevée en polyphénols.
PCT/KR2022/017154 2021-11-16 2022-11-03 Composition comprenant du sirop de grains d'avoine ou un extrait de celui-ci pour l'hydratation de la peau, la réduction des rides et l'antioxydation Ceased WO2023090708A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2021-0157738 2021-11-16
KR1020210157738A KR102643886B1 (ko) 2021-11-16 2021-11-16 귀리 조청 또는 그의 추출물을 포함하는 피부 보습, 주름 개선 및 항산화용 조성물

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WO2023090708A1 true WO2023090708A1 (fr) 2023-05-25

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Publication number Priority date Publication date Assignee Title
KR20250048832A (ko) 2023-10-04 2025-04-11 김명희 수수조청의 제조방법

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160262433A1 (en) * 2014-09-19 2016-09-15 Xyleco, Inc. Saccharides and Saccharide Compositions and Mixtures
KR101791325B1 (ko) * 2016-01-11 2017-10-31 전주대학교 산학협력단 귀리 조청의 제조방법 및 그로부터 제조된 귀리 조청
KR101998804B1 (ko) * 2019-03-05 2019-07-10 에스앤에프 주식회사 항산화 및 항노화용 조성물

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160262433A1 (en) * 2014-09-19 2016-09-15 Xyleco, Inc. Saccharides and Saccharide Compositions and Mixtures
KR101791325B1 (ko) * 2016-01-11 2017-10-31 전주대학교 산학협력단 귀리 조청의 제조방법 및 그로부터 제조된 귀리 조청
KR101998804B1 (ko) * 2019-03-05 2019-07-10 에스앤에프 주식회사 항산화 및 항노화용 조성물

Non-Patent Citations (2)

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Title
ANONYMOUS: "Skin function of oat glucan and oat beta glucan ", 5 August 2019 (2019-08-05), XP093068237, Retrieved from the Internet <URL:http://www.underextract.com/info/the-function-of-oat-glucan-and-oat-beta-glucan-38011465.html> *
CHO, JEONG NAM: "The Effect of Cream with Avena Sativa Extracts on the Improvement of Facial Skin", REQUEST THESIS FOR A MASTER´S DEGREE, GRADUATE SCHOOL OF KONKUK UNIVERSITY, August 2015 (2015-08-01), pages 1 - 56, XP009546570 *

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KR20230071486A (ko) 2023-05-23

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