WO2023080143A1 - Biometric information measurement device - Google Patents

Abstract

[Problem] The present invention provides a biometric information measurement device that is capable of handling measurement subjects with a variety of arm thicknesses, and can increase detection accuracy of electrocardiographic waveforms. [Solution] This biometric information measurement device has at least a main body part that includes a first arm part and a second arm part each curving from the main body part top to the main body part bottom and extending to the left and right. The ends of the first arm part and the second arm part are separated from each other, and at least one end side of the first arm part and the second arm part includes an electrode for measuring biometric information. At least one among the first arm part and the second arm part extends offset outward in the front-rear direction at the main body part bottom. At least a portion of both ends of the first arm part and the second arm part extend to a length overlapping each other in the front-rear direction at the main body part bottom. At least one of the ends of the first arm part and the second arm part further curves toward the main body part top side from the main body part bottom side.

Description

Biological information measuring device

The present disclosure relates to a biological information measuring device for measuring biological information of a subject.

It is effective for health management to continuously measure blood pressure and detect disease early and detect changes in medical conditions from changes in blood pressure. Therefore, biological information measuring apparatuses have been proposed for continuously measuring biological information such as blood pressure without pressurizing the arm or the like with a cuff or the like.

For example, in Patent Document 1, an optical sensor module and a motion sensor are provided, and based on the reflected light detected by the optical sensor module, a wrist-worn device capable of measuring biological information such as the subject's heart rate, stress, blood oxygen saturation, etc. type wearable, a wearing configuration worn on the wrist by a belt-type strap is shown.

JP 2019-042500 A

However, it is difficult to wear, for example, when the hand is paralyzed, with a configuration that is worn on the wrist with a belt like a conventional wristwatch as exemplified in Patent Document 1, and an information measuring device that can be easily worn. is required.

On the other hand, as an idea for facilitating wearing, a bracelet-type information measuring device may be considered (Patent Document 1 also mentions only the term "bracelet-type"). In the case of such a bracelet type, it is necessary to create a gap between the attachment point and the measurement device so that the wrist can be easily passed through the bracelet part. The configuration and the desired configuration conflict with each other, and a more complicated mechanism is required to make them compatible.

Therefore, it is an object of the present invention to provide a biological information measuring device that can accommodate subjects with various arm thicknesses and that can improve the detection accuracy of electrocardiogram waveforms.

In order to solve the above problems, the biological information measuring device of the present invention is a biological information measuring device having at least a main body portion, wherein the main body portion is curved from the upper portion of the main portion to the lower portion of the main portion and left and right. including a first arm and a second arm extending, wherein ends of the first arm and the second arm are separated from each other, and at least one of the first arm and the second arm An electrode for measuring biological information is provided on the end side of the .

According to the above-described biological information measuring apparatus, it is possible to provide a biological information measuring apparatus that can be applied to subjects with various arm thicknesses and that can improve the detection accuracy of electrocardiographic waveforms.

FIG. 2 is a diagram for explaining the left arm of the person to be measured, the biological information measuring device, the electrodes of the measurement site, etc., according to the present embodiment; 1 is a perspective view of a biological information measuring device according to this embodiment; FIG. It is six views of the biological information measuring device according to the present embodiment. It is a figure for showing the example of composition which connects a thermistor to the electrode of the biological information measuring device concerning this embodiment. 1 is a schematic block diagram showing the configuration of a biological information measurement system according to this embodiment; FIG. FIG. 4 is a diagram for explaining an example of an electrocardiogram waveform and a pulse wave according to the embodiment; 4 is a flowchart for explaining the operation of the blood pressure information measurement system according to this embodiment;

The contents of the embodiments of the present invention are listed and explained. A biological information measuring device according to an embodiment of the present invention has the following configuration.
[Item 1]
A biological information measuring device having at least a main body,
The main body includes a first arm and a second arm that are curved from the upper part of the main body to the lower part of the main body and extend left and right,
ends of the first arm and the second arm are separated from each other;
An electrode for measuring biological information is provided on at least one end side of the first arm and the second arm,
A biological information measuring device characterized by:
[Item 2]
At least one of the first arm portion and the second arm portion extends outward in the front-rear direction at the lower portion of the main body portion,
The biological information measuring device according to claim 1, characterized in that:
[Item 3]
At least a part of both ends of the first arm and the second arm extends to a length that overlaps with each other in the front-rear direction at the lower part of the main body,
The biological information measuring device according to claim 2, characterized in that:
[Item 4]
At least one of the ends of the first arm portion and the second arm portion is further curved from the lower side of the main body toward the upper side of the main body,
4. The biological information measuring device according to any one of claims 1 to 3, characterized in that:
[Item 5]
The material of the first arm and the second arm includes a thermoplastic elastomer,
5. The biological information measuring device according to any one of claims 1 to 4, characterized in that:
[Item 6]
The thermoplastic elastomer contains at least a polyether block amide,
6. The biological information measuring device according to claim 5, characterized in that:
[Item 7]
The body portion does not have a display portion,
7. The biological information measuring device according to any one of claims 1 to 6, characterized in that:
[Item 8]
Two electrodes are provided on the same end side of the end sides of the first arm and the second arm,
7. The biological information measuring device according to any one of claims 1 to 6, characterized in that:
[Item 9]
One of the electrodes is provided on each of different end sides of the first arm and the second arm,
7. The biological information measuring device according to any one of claims 1 to 6, characterized in that:
[Item 10]
Two of the electrodes are provided on different end sides of the first arm and the second arm,
7. The biological information measuring device according to any one of claims 1 to 6, characterized in that:
[Item 11]
An amplifier that amplifies the potential difference between the two electrodes provided on the same end side,
11. The biological information measuring device according to any one of claims 1 to 10, characterized in that:
[Item 12]
The main body has a reference voltage terminal for acquiring a reference voltage on the upper part of the main body, and inputs the reference voltage to the amplifier.
The biological information measuring device according to claim 11, characterized in that:
[Item 13]
The reference voltage terminal is connected to a thermistor that measures the skin temperature of the person being measured.
13. The biological information measuring device according to claim 12, characterized in that:
[Item 14]
The main body includes an optical sensor module that measures the pulse wave of the subject.
14. The biological information measuring device according to any one of claims 1 to 13, characterized in that:
[Item 15]
The main unit includes a communication unit that outputs the measured biological information to the outside,
15. The biological information measuring device according to any one of claims 1 to 14, characterized in that:

The present embodiment will be described below. It should be noted that the embodiments described below do not unduly limit the content of the present invention described in the claims. Moreover, not all the configurations described in this embodiment are essential constituent elements of the present invention. Also, the features shown in each embodiment can be applied to other embodiments as long as they are not mutually contradictory.

<Configuration>
A biological information measuring device 100 according to the present embodiment and an arm, which is a measurement site of a subject, will be described with reference to FIGS. 1-3. FIG. 1A shows a state in which the biological information measuring device 100 is worn on the left arm of a person to be measured. FIG. 1B shows the radial artery and ulnar artery of the subject's left arm in perspective, and shows the positional relationship between the radial artery, the ulnar artery, and the electrodes of the biological information measurement device 100 . FIG. 1C is a diagram showing the positional relationship between the subject's arm, the electrodes of the biological information measuring device 100, and the optical sensor. FIG. 2 is a perspective view of the biological information measuring device 100. As shown in FIG. 3A and 3B are six views of the biological information measuring device 100. FIG. In FIG. 2, the direction in which the arm of the biological information measuring device 100 is inserted is the front-rear direction, the direction opposite to the upper surface portion 102 side and the arm is the vertical direction, and the first arm portion 131 and the second arm portion 131 from the upper portion of the main body portion 101. The direction in which the arm portion 132 extends is defined as the left-right direction for the sake of convenience.

As shown in FIG. 1-3, the biological information measurement device 100 consists of a main body portion 101 and an upper surface portion 102. The body portion 101 includes a first arm portion 131 and a second arm portion 132 extending from the upper portion of the body portion 101 on the back side of the hand to the lower portion of the body portion 101 while curving along the wrist of the subject. The ends of the first arm 131 and the second arm 132 are separated from each other and have a non-toroidal configuration (i.e., the first arm 131 and the second arm separated from each other). This does not preclude a shape that can be called an annular shape when the surfaces of both ends of the portion 132 are in contact with each other). At least one of the ends of the first arm portion 131 and the second arm portion 132 (both ends in FIGS. 2 and 3) may extend outward in the front-rear direction at the lower portion of the main body portion 101, In particular, as shown in the bottom view of FIG. 3, at least a portion of both end portions of the first arm portion 131 and the second arm portion 132 may extend to such a length as to overlap each other in the front-rear direction. Furthermore, at least one of the ends of the first arm portion 131 and the second arm portion 132 (the end portion of the first arm portion 131 in FIGS. 2 and 3) extends toward the inner side of the inserted arm (main body portion 101). It may be curved (from the lower side to the upper side of the main body 101). A part or all of the material (particularly the material of the first arm 131 and the second arm 132) constituting the biological information measuring device 100 is not particularly limited, but has elasticity and excellent workability. Thermoplastic elastomers are preferred, particularly polyether block amides (PEBA). Then, for example, at least a portion of at least one of the main body portion 101, the upper surface portion 102, the first arm portion 131, and the second arm portion 132 may be formed by a molding process using the above materials. The biometric information measuring device 100 may be configured by connecting the created members to each other.

With such a configuration, when the subject's arm is inserted between the first arm portion 131 and the second arm portion 132 of the body portion 101, the first arm portion 131 and the second arm portion 132 move at least in the horizontal direction. By elastically deforming and expanding, it is possible to support various arm sizes with one size, and it is also possible to configure so that fasteners (fixtures) such as belts and hook-and-loop fasteners are not required. Therefore, even if the hand is paralyzed, it is easy to wear. In addition, since the ends of the first arm portion 131 and the second arm portion 132 are shifted outward in the front-rear direction and extend to a length sufficient to overlap each other in the front-rear direction, the ring-like shape of a bracelet can be obtained. Therefore, even when a thick arm is inserted through the biological information measuring device 100, the arm 131 and the second arm 132 are provided at the ends of the arm 131 and 132, respectively. Each electrode (described later) can be placed near the artery without being too far from the artery. Furthermore, since the end portions of the first arm portion 131 and the second arm portion 132 are curved inward, which is the side of the inserted arm (from the lower side of the main body portion 101 to the upper side of the main body portion 101), the first arm portion Even when the arms 131 and 132 are elastically deformed and expanded at least in the left-right direction, the arms of the person to be measured can easily be caught. It is possible to bring each electrode provided on the end side into sufficient contact with the surface of the arm.

The upper surface portion 102 is provided outside the upper portion of the main body portion 101 and may serve as a lid portion when a circuit board, a battery, etc. are stored in the main body portion 101 . Further, the upper surface portion 102 may have a display function, such as a time display function or a biological information display function. However, if the upper surface portion 102 has a display function, the number of required components increases and the body portion 101 becomes large. In this case, when the subject wishes to confirm his/her own biological information, the biological information measuring apparatus 100 communicates with the external terminal device 200 (see FIG. 5), and the terminal device display section 214 of the terminal device 200 It may be possible to display biological information.

The body portion 101 has a first electrode 121 and a second electrode 122 on the end side of the second arm portion 132, and has a third electrode 123 and a fourth electrode 124 on the end portion side of the first arm portion 131. , a fifth electrode 125, a sixth electrode 126, an optical sensor module 111, and the like are provided on the inner upper portion of the body portion 101. As shown in FIG. For example, the sixth electrode 126 may be provided as a terminal for charging a battery, may be provided as a terminal for communication with an external device, or may serve both purposes. , may be provided for uses other than these.

As shown in FIG. 1(B), a radial artery 911 and an ulnar artery 912 pass through the subject's arm. The radial artery 911 runs between the radius and the skin on the wrist surface, and the ulnar artery 912 runs between the ulna and the skin on the wrist surface. A radial artery 911 and an ulnar artery 912 branch from the brachial artery (not shown) in the upper arm.

As shown in FIGS. 1B, 2, and 3, the first electrode 121 and the second electrode 122 are arranged side by side in the circumferential direction of the wrist in the vicinity of the radial artery 911 on the palm side of the wrist, Electrocardiogram-linked potential is detected from the radial artery 911 . The third electrode 123 and the fourth electrode 124 are arranged side by side in the circumferential direction of the wrist near the ulnar artery 912 on the palm side of the wrist, and detect electrocardiographic potential from the ulnar artery 912 . As shown in FIGS. 1C, 2, and 3, the fifth electrode 125 is arranged on the back side of the wrist, and detects the biological reference potential. With such a configuration, the potential detected by at least one of the first electrode 121 or the second electrode 122 or at least one of the third electrode 123 or the fourth electrode 124 is amplified using the fifth electrode 125 as a reference potential. An electrocardiogram can be obtained with high accuracy by performing measurement over time using an operational amplifier (for example, an operational amplifier), and the electrocardiogram waveform can be measured. In addition, the fifth electrode 125 may be, for example, a ground potential, and by using this, it is possible to suppress the deviation of the reference potential for measurement, so that the T wave or the like detected by at least one of the first to fourth electrodes It is possible to improve the detection accuracy of an electrocardiographic waveform that accompanies a minute change (inflection point) in .

Here, the number of electrodes for obtaining an electrocardiogram is not limited to five as described above, and may be increased or decreased as necessary. With regard to this, a modification of the electrodes will be described below.

<Modification 1 of the electrode>
For example, if an electrocardiogram waveform accompanied by a minute change (inflection point) such as a T wave can be sufficiently detected from at least one of the first electrode 121 to the fourth electrode 124, the fifth electrode 125 is not provided. There may be.

<Modifications 2 and 3 of electrodes>
The first electrode 121 to the fourth electrode 124 can be appropriately placed near either the radial artery 911 or the ulnar artery 912 of the subject, for example, the biometric information measuring device 100 can be made in various sizes. If there is, a configuration (modification 2) including any one of the first electrode 121 to the fourth electrode 124, or one for the radial artery 911 and one for the radial artery 911 by either the first electrode 121 or the second electrode 122 There may be one for the ulnar artery 912 with either three electrodes 123 or a fourth electrode 124 (variant 3).

<Modification 4 of the electrode>
Either one set of the first electrode 121 and the second electrode 122 for the radial artery 911, or one set of the third electrode 123 and the fourth electrode 124 for the ulnar artery 912 (total two) may be configured.

Here, in the configuration in which one set is provided for at least one of the radial artery 911 and the ulnar artery 912 as in the above-described embodiment and the present modification 4, for example, the potential difference between both electrodes in one set is calculated. It may be configured to That is, for example, when the first arm portion 131 and the second arm portion 132 are elastically deformed at least in the left-right direction and spread out, or when the biological information measuring device 100 rotates in the circumferential direction of the wrist and is out of position, the artery is When the electrodes are separated, the value becomes extremely close to 0, and the influence of noise is more likely to appear. increase. On the other hand, by arranging one set of electrodes side by side in the circumferential direction of the wrist with respect to the artery, for example, even if one electrode is separated from the artery, the other electrode is arranged near the artery. Therefore, it is possible to improve the detection accuracy of an electrocardiographic waveform including a minute change (inflection point) such as a T-wave. Alternatively, instead of the potential difference, the electrocardiographic potential may be obtained by calculating the average value of the potentials from both electrodes of one set, although the detected potential may be small. In addition, although the determination configuration may be complicated, the potential of one of both electrodes in one set can be determined by comparing with a reference potential for determination or by comparing the potentials of both electrodes instead of the potential difference. may be selected as the electrocardiographic potential.

In addition, as in the above-described embodiment and modification 2, when obtaining two types of data for the radial artery 911 and the ulnar artery 912, the average value of both may be calculated as the electrocardiographic potential. Alternatively, the potential (potential difference) of one of the two types of electrodes may be employed for detection of the electrocardiographic waveform by comparing with a reference potential for determination or comparing the potentials (potential difference) between the two.

Also, by connecting a thermistor to at least one of the first electrode 121 to the sixth electrode 126, the skin temperature may be obtained. In particular, considering that the fifth electrode 125 is provided on the upper portion of the main body portion 101, it is more preferable than other electrodes as an electrode having a thermistor. FIG. 4 shows an example in which a thermistor 1252 is connected to the fifth electrode 125 provided on the back surface 103 of the main body 101. As shown in FIG. For example, the fifth electrode 125 may have a terminal 1251 connected to a reference potential (eg, ground potential GND), and the thermistor 1252 may have a ground terminal 1253 and an output terminal 1254, respectively. The thermistor 1252 may be connected to the fifth electrode 125 via a thermally conductive adhesive 1255 having high thermal conductivity, or directly connected to the fifth electrode 125, as illustrated in FIG. (particularly, a recess is made on the back side of the fifth electrode 125 and a part of the thermistor 1252 is inserted and fixed). As a result, skin heat is transmitted to the thermistor 1252 via the electrode (for example, the fifth electrode 125 illustrated in FIG. 4) that directly touches the subject's skin, so that the subject's skin temperature can be measured. .

The optical sensor module 111 includes a light emitting section 112 and a light receiving section 113, as shown in FIG. 1(C). The light emitting section 112 includes, for example, a green light emitting LED, and the light receiving section 113 is configured by a photodiode capable of receiving light emitted from the light emitting section 112 . The light emitting unit 112 is not limited to a green light emitting LED, and may be a red light emitting LED, a blue light emitting LED, an infrared LED, or the like. More specifically, for example, the light emitting unit 112 may be configured to have a total of four LEDs: two green LEDs, a red LED, and an infrared LED. Further, the number of light receiving units 113 may be provided corresponding to each LED included in the light emitting unit 112, or may be provided in common for several LEDs. Light emitted from the light emitting unit 112 to the wrist is reflected inside the wrist and received by the light receiving unit 113 . A pulse waveform can be measured based on a change in the intensity of the light received by the light receiving unit 113 over time and a change in the volume of blood vessels caused by the heartbeat of the subject. A pulse waveform that can be detected by this method is a photoelectric volume pulse waveform. The optical sensor module 111 is arranged on the back side of the wrist, and is arranged at a position facing the first electrode 121 and the like via the wrist. As a result, the electrocardiographic waveform measured by the first electrode 121 or the like can be separated from the photoelectric volume pulse waveform measured by the optical sensor module 111 . As a result, a ventricular systolic pulse wave transit time PTT_SYS (Pulse Transit Time_Diastolic) and a ventricular diastolic pulse wave transit time PTT_DIA, which will be described later, can be lengthened, and the reliability of measurement can be improved.

Next, with reference to FIG. 5, the configuration and outline of the biological information measuring system 1 including the server device 400 that calculates the biological information of the subject based on the information from the biological information measuring device 100 in the first embodiment. explain. In addition, FIG. 5 is a block diagram of the biological information measurement system 1 of this embodiment.

As shown in FIG. 5, the biological information measurement system 1 of the present embodiment includes a biological information measurement device 100, a terminal device 200, and a server device 400. The terminal device 200 and the server device 400 are connected to the Internet or LAN, for example. It is configured to be connectable to a network 300 such as. In addition, the biological information measuring device 100 and the server device may be configured by integrally configuring the biological information measuring device 100 and the terminal device 200, or by providing the biological information measuring device 100 with a network communication function that enables communication via the network 300. 400 may be configured to perform communication. Further, part or all of the calculation processing of the predetermined biological information (biometrically generated information) may be performed by the biological information measurement device 100 instead of the calculation by the server device 400 . However, if the calculation is performed by the biological information measuring device 100, the calculation processing load becomes high, so there is a possibility that the biological information measuring device 100 will become larger and the cost will increase. is more preferable.

The biological information measurement device 100 includes an electrocardiogram detection unit 110 , a pulse wave detection unit 120 , a measurement device control unit 140 , a measurement device storage unit 150 , a measurement device operation unit 160 and a measurement device communication unit 170 . These functional units are realized by executing a predetermined program for the biological information measuring device 100. FIG.

The biometric information is exemplified by electrocardiographic information and pulse wave information as biometric information, or blood pressure information as biometric information obtained from these, but not limited to these, biometric information can be obtained by a known method. includes, for example, the subject's skin temperature information (body temperature information), acceleration information, and angular velocity information, and biometric data obtained from these biometric information includes, for example, the subject's heartbeat information, blood Oxygen level information, maximum oxygen uptake information, blood sugar level information, respiratory rate, body temperature information, step count information, stride information, center of gravity position information, posture information, stress information, exercise amount information, exercise load information, travel distance information, travel speed It includes data such as information, activity information, motion information of a wearing part such as a hand or a leg.

The electrocardiogram detector 110 includes, for example, a first electrode 121 and a second electrode 122 for detecting an electrocardiogram of the radial artery, a third electrode 123 and a fourth electrode 124 for detecting the electrocardiogram of the ulnar artery, and a reference potential. It comprises a fifth electrode 125 for taking measurements.

The pulse wave detection unit 120 includes an optical sensor module 111 . The optical sensor module 111 is composed of the light emitting section 112 and the light receiving section 113 described above.

The measurement device control section 140 includes an electrocardiogram measurement control section 141 and a pulse wave measurement control section 142 . The electrocardiogram measurement control unit 141 detects, for example, at least one of a difference in potential detected from the first electrode 121 and the second electrode 122, or a difference in potential detected from the third electrode 123 and the fourth electrode 124. , is amplified using the reference potential of the fifth electrode 125, and time information is added to obtain an electrocardiographic waveform. The pulse wave measurement control unit 142 performs light emission control of the light emitting unit 112 of the pulse wave detecting unit 120 and receives a detection signal from the light receiving unit 113, for example.

The measuring device storage unit 150 stores, for example, electrocardiogram information received by the electrocardiogram measurement control unit 117 and pulse wave information received by the pulse wave measurement control unit 118 . The electrocardiogram information also includes electrocardiogram waveform information relating to electrocardiogram waveforms in which the electrocardiogram information received by the measuring device control unit 140 is continuously arranged, and measurement time information and the like of the electrocardiogram waveforms are added. The pulse wave information is information relating to a photoelectric volume pulse waveform in which the pulse wave information received by the pulse wave measurement control unit 142 is continuously arranged, and measurement time information and the like of the photoelectric volume pulse waveform are added. Electrocardiographic information and pulse wave information are transmitted to the terminal device 200 via the measuring device communication unit 170, which will be described later. Temporary storage is also possible for cases such as when the connection is broken.

The measurement device operation unit 160 is an operation unit for the subject or the like to operate the power source of the biological information measurement device 100 and to start and end the measurement.

The measuring device communication unit 170 is a communication interface for communicating between the biological information measuring device 100 and an external device such as the terminal device 200. The measuring device communication unit 170 receives, for example, the electrocardiographic information received by the electrocardiographic measurement control unit 141 and the pulse wave information received by the pulse wave measurement control unit 142, and the electrocardiographic information and pulse wave information stored in the measuring device storage unit 150. Wave information is transmitted to the terminal device 200 and information for operating the biological information measuring device 100 is received from the terminal device 200 . Bluetooth (registered trademark) is used as communication means in this embodiment. As other means of communication, near field radio communication (NFC), Afero (registered trademark), Zigbee (registered trademark), Z-Wave (registered trademark), wireless LAN, or the like may be used. Alternatively, a wired connection may be made using the sixth electrode 126 .

The terminal device 200 includes a terminal device control section 211 , a terminal device storage section 212 and a terminal device communication section 213 . A terminal device 200 is an information processing device such as a smart phone, a mobile phone, a PHS, or a PDA. Also, a terminal device dedicated to a biological information measurement device may be used instead of a general-purpose device such as a smart phone. These functional units are realized by executing a predetermined program of the terminal device 200 .

The terminal device control unit 211 controls storage of biological information such as electrocardiographic information and pulse wave information received by the terminal device communication unit 213 from the biological information measuring device 100 in the terminal device storage unit 212, or stores the terminal device storage unit 212 in the terminal device storage unit 212. Biological information such as electrocardiographic information and pulse wave information is transmitted from the unit 212 to the server device 400, and biological generation information calculated based on the biological measurement information is received by the server device 400. FIG.

The terminal device storage unit 212 stores biological information such as electrocardiogram information and pulse wave information received by the terminal device communication unit 213 .

The terminal device communication unit 213 is a communication interface for communicating with the biological information measurement device 100 and the server device 400 . It receives biological information such as electrocardiographic information and pulse wave information transmitted from the biological information measuring device 100, and also receives setting information for the biological information measuring device 100 and biological information such as electrocardiographic information and pulse wave information. request signal is sent. It also transmits biometric information such as electrocardiographic information and pulse wave information to the server device 400 and receives a request signal for biometric information such as electrocardiographic information and pulse wave information from the server device 400 . In this embodiment, the communication with the biological information measuring device 100 is the aforementioned Bluetooth (registered trademark), but other communication means may be used. Also, communication with the server apparatus 400 can be performed via a network 301 such as the Internet using a wireless LAN.

The terminal device display unit 214 displays biological information and abnormality notifications transmitted from the biological information measuring device 100 or the server device 400, for example, according to the rules of the application executed on the terminal device 200.

The server device 400 includes a server device control section 411 , a server device communication section 412 and a server device storage section 413 .

The server device control unit 411 includes a pulse wave propagation time calculation unit 421 as a first calculation unit and a biological information calculation unit 422 as a second calculation unit. The server device control unit 411 (third calculation unit) calculates second-order differential data from the photoelectric volume pulse waveform data. The pulse wave transit time calculation unit 421 detects R waves and T waves from the waveform profile in the electrocardiogram information described later, and detects P waves and D waves from the waveform profile in the photoelectric volume pulse waveform data, Based on the information, the ventricular systolic pulse wave transit time PTT_SYS and the ventricular diastolic pulse wave transit time PTT_DIA are calculated. In addition, the biological information calculation unit 422 calculates acceleration pulse wave characteristic information based on second-order differential data (described later) calculated by the server device control unit 411, ventricular systolic pulse wave transit time PTT_SYS, and ventricular diastolic pulse wave transit time PTT_DIA. , the blood pressure information is calculated. Furthermore, the server device control section 411 determines the health condition of the person to be measured based on the blood pressure information, and notifies the terminal device 200 of the abnormality. The pulse wave transit time calculator 421 may use first-order differential data or second-order differential data of the photoelectric volume pulse waveform data in detecting the R wave and the T wave.

In addition, the biological information calculation unit 422 calculates the intervals of the QRS waves in the electrocardiographic waveform data (for example, the electrocardiographic waveform data in FIG. 6, etc.) measured by the biological information measuring device 100 worn by the subject at rest, for example. heartbeat information can be obtained as biological information (biologically generated information).

Further, the biological information calculation unit 422 converts the temperature information from the subject's skin temperature information measured by a temperature sensor (such as a thermistor) of the biological information measuring device 100 worn by the subject, for example, to biological information (biologically generated information).

Further, the biometric information calculation unit 422 uses, for example, a known calculation method or the like from the waveform data of the acceleration data measured by the biometric information measuring device 100 worn on the wrist of the person to be measured, alone or in combination. Walking speed information can be obtained as biological information (biologically generated information) by (for example, averaging, weighting, etc.). generated information).

Further, the biometric information calculation unit 422 uses, for example, a known calculation method or the like from the waveform data of the acceleration data measured by the biometric information measuring device 100 worn on the wrist of the person to be measured, alone or in combination. By (for example, averaging, weighting, etc.), stride information can be obtained as biological information (biologically generated information). For example, the timing at which the acceleration component in the direction of travel is the smallest or the timing at which it switches to the opposite direction, the timing at which the acceleration component in the direction perpendicular to the direction of travel is the lowest, or the timing at which the vertical direction switches, etc.) can be determined, the stride information can be obtained as biometric information (biometric generation information) by using the time information. Alternatively, for example, when kicking off the ground, the acceleration component in the kicking direction is synthesized, so it is possible to determine the interval of one step at the timing of generation of the acceleration component in that direction.

In addition, the biological information calculation unit 422, for example, based on the acceleration data and the angular velocity data measured by the biological information measuring device 100 worn by the person to be measured, the part where the biological information measuring device 100 is worn (for example, the wrist, the Ankle, etc.) can be obtained as biological information (biologically generated information) about how fast and at what angle they move.

Further, the biometric information calculation unit 422 performs frequency analysis of acceleration data measured by the biometric information measuring device 100 that is worn on a daily basis, for example, and associates high and low frequencies with high and low activity frequencies. Activity amount information can be obtained as biological information (biological generation information) by calculating based on predetermined conditions such as what percentage of the day the above activities occupy.

In addition, the biological information calculation unit 422 can identify acceleration data during exercise including walking by a known calculation method or the like from acceleration data measured by the biological information measuring device 100 worn on a daily basis, for example. Therefore, it is possible to obtain the momentum information as biometric information (biologically generated information) by performing calculation under predetermined conditions using, for example, frequency analysis. Further, by using additional information such as angular velocity information, it is possible to obtain more accurate momentum information.

In addition, the biological information calculation unit 422 calculates, for example, the activity amount information and the exercise amount information derived from the acceleration data measured by the biological information measuring device 100 worn on a daily basis, for example, the heart rate that increases with the exercise load. By weighting the information, the exercise load amount information can be obtained as biological information (biologically generated information). In addition, for example, if vector information of acceleration data is added, state information such as walking environment (slope, stairs, etc.) and posture (standing position, sitting position, etc.) can be specified, so the state information may be further used. Further, by using additional information such as angular velocity information, it is possible to obtain more accurate exercise load amount information.

In addition, the biological information calculation unit 422, for example, using the above-described resting heart rate information, calculates the maximum oxygen uptake information in the biological body by a known formula such as VO ₂ max = 15 × (220-age) / resting heart rate. It can be obtained as information (biological generation information).

Further, by a known learning device, for example, biometric information, biometric information generated based on the biometric information (such as heart rate information and blood pressure information) and positive biometric information (for example, based on known medical equipment Heart rate information, blood pressure information, etc.), and a machine learning model is created in advance based on teacher data that is associated by a correspondence relationship (for example, information indicating the degree and range of error may be included), and biometric information The calculation unit 422 may generate the biometric information using the determination using the machine learning model as the predetermined calculation (analysis) described above.

The server device communication unit 412 is a communication interface for communicating with the terminal device 200 via the network 300 such as the Internet. Receives biological information such as electrocardiographic information and pulse wave information transmitted from the terminal device 200, and transmits a request signal for biological information such as electrocardiographic information and pulse wave information to the terminal device 200. . In addition, an abnormality notification is transmitted to the terminal device 200 .

The server device storage unit 413 stores biological information such as electrocardiogram information and pulse wave information received by the server device communication unit 412 . Also, the blood pressure information calculated by the biological information calculation unit 422 is stored.

<Electrocardiographic waveform, photoelectric volume pulse waveform, velocity pulse waveform, acceleration pulse waveform, blood pressure information calculation method>
FIG. 6 shows an electrocardiographic waveform and a photoelectric volume pulse waveform of a non-measuring person measured by the biological information measuring device 100, and a velocity pulse waveform and an acceleration pulse waveform calculated by the server device 400. FIG. In order from the top of FIG. 6, the electrocardiographic waveform, the photoelectric volume pulse waveform, the velocity pulse waveform, and the acceleration pulse waveform. The vertical axis indicates the intensity of each waveform, and the electrocardiogram waveform and photoelectric volume pulse waveform are expressed in mV, which indicates potential. The horizontal axis indicates the passage of time, from left to right.

An electrocardiogram is a waveform that shows periodic changes in electrical signals that cause a person's heart to beat. An electrocardiographic waveform is assigned names of P wave, Q wave, R wave, S wave, and T wave to the inflection points of its shape, and indicates one cycle of heartbeat. The P-wave represents atrial contraction, the Q-wave, R-wave, S-wave represents the state of ventricular contraction, and the T-wave represents the onset of ventricular dilation.

The photoelectric volume pulse waveform is a waveform that shows changes in blood pressure and volume in the peripheral vascular system accompanying the beating of the human heart. The photoelectric plethysmogram is assigned names of A wave, P wave, V wave, and D wave to the inflection points of its shape, and indicates one cycle of heartbeat. With the A wave as the reference point at which the arterial pulse wave occurs, the P wave is the percussion wave (shock wave) generated by left ventricular ejection, the V wave is the Valley wave (wave due to double uplift) generated when the aortic valve closes, and the D wave. indicates a Dicrotic wave (overlapping wave) which is a reflected oscillatory wave.

The velocity pulse waveform is the first derivative of the photoelectric volume pulse waveform with respect to time. The acceleration pulse waveform is obtained by first-order differentiation of the velocity pulse waveform with respect to time, that is, second-order differentiation of the photoelectric volume pulse waveform. As shown in FIG. 6, the acceleration pulse waveform has a wave (positive wave at the beginning of systole), wave b (negative wave at the beginning of systole), wave c (re-rising wave during the middle of systole), wave d (shock wave) at each peak of the waveform. late re-descending wave), e-wave (extended early positive wave), and f-wave (extended early negative wave). The ratio of the intensity of the b-wave to the intensity of the a-wave and the ratio of the intensity of the f-wave to the intensity of the e-wave are parameters indicating the stretchability or elasticity of the blood vessel, respectively. The main components of blood vessels are vascular endothelium (Endothelium), elastic fiber (Elastin), protein (Collagen), and smooth muscle (Smooth Muscle). Each of these components has different properties, and Collagen and Elastin have a strong influence on the elasticity of blood vessels at maximum blood pressure and minimum blood pressure, respectively. Therefore, the elasticity that varies depending on the blood pressure value is indicated by the parameters of (b/a), which is the ratio of the b-wave intensity to the a-wave intensity, and (f/e), which is the ratio of the f-wave intensity to the e-wave intensity. These values also fluctuate due to the effects of age, gender, and environmental variables (temperature, etc.). Therefore, the values of (b/a) and (f/e) can be calculated as characteristic information of the acceleration pulse waveform.

As shown in FIG. 6, the difference between the time Tr at which the R wave occurs and the time Tp at which the P wave occurs is the ventricular systolic pulse wave propagation time PTT_SYS. The difference between the time Tt at which the T wave occurs and the time Td at which the D wave occurs is the ventricular diastolic pulse wave propagation time PTT_DIA. That is, from the time Tr of the R wave and the time Tt of the T wave of the electrocardiographic waveform, and the time Tp of the T wave and the time Td of the D wave of the photoelectric volume pulse waveform, as shown in equations (1) and (2) Finally, the ventricular systolic pulse wave transit time PTT_SYS and the ventricular diastolic pulse wave transit time PTT_DIA can be calculated.

　PTT_SYS=Tp-Tr...(1)

　PTT_DIA=Td-Tt (2)

The first to fourth electrodes 121 to 124 for measuring the electrocardiogram waveform and the optical sensor module 111 for measuring the photoelectric volume pulse waveform are placed facing each other across the wrist, and the arrangement distance is separated to detect the electrocardiogram waveform. The site and the measurement site of the photoelectric volume pulse waveform are separated. Therefore, the absolute calculation time of the ventricular systolic pulse wave transit time PTT_SYS and the ventricular diastolic pulse wave transit time PTT_DIA can be lengthened by creating a time lag between the respective characteristic waveforms. Therefore, when obtaining change information of the ventricular systolic pulse wave transit time PTT_SYS and the ventricular diastolic pulse wave transit time PTT_DIA, the accuracy of the change information can be improved.

Here, the formula for calculating blood pressure will be explained.

The relationship between the pulse wave velocity and the longitudinal elastic modulus of the arterial wall is indicated by the following equation (3) of the pulse wave velocity (Moens-Korteweg equation).

　L/T_PTT=√(E·h/(2·r·ρ)) (3)

The parameters in equation (3) are L: distance between measurements, T_PTT: pulse wave transit time, r: inner diameter of blood vessel, E: longitudinal elastic modulus of blood vessel, h: thickness of blood vessel, and ρ: blood density.

　It is known that there is a correlation between the modulus of longitudinal elasticity and the blood pressure value,

E= _E0 ·exp(α·P) (4)

can be shown as Here, P: blood pressure value, α: constant, E ₀ : initial value.

　From formulas (3) and (4)

P=(−2·ln(T_PTT)+ln(2·r·ρ·L ² /(E ₀ ·h)))/α (5)

can be derived. ln indicates the natural logarithm. At this time, since "r·ρ" is proportional to the blood volume at the measurement site, it can be indicated by high values (Vp, Vd) indicated by the photoelectric volume pulse waveform. Also, since "E ₀ ·h" is a value proportional to the elasticity of the blood vessel, it can be replaced using the parameters (b/a) and (f/e) that indicate the elasticity.

Therefore, the systolic blood pressure BP_SYS (Blood Pressure_Systolic) and the diastolic blood pressure BP_DIA (Blood Pressure_Diastolic) can be expressed by the following formulas (6) and (7).

BP_SYS = A1 · ln (PTT_SYS) + A2 · ln (Vp) + A3 · ln (b/a) + A4 (6)

BP_DIA = A5 ln (PTT_DIA) + A6 ln (Vd) + A7 ln (f/e) + A8 (7)

A1 to A8 are constants determined by conditions. The systolic blood pressure BP_SYS that can be calculated by the formula (6) is obtained by multiplying the natural logarithm of the ventricular systolic pulse wave transit time PTT_SYS by a constant A1 and by multiplying the natural logarithm of the P-wave intensity Vp by a constant A2. and the sum of the natural logarithm of (b/a) multiplied by the constant A3 and the constant A4. The diastolic blood pressure BP_SYS that can be calculated by the formula (7) is obtained by multiplying the natural logarithm of the ventricular systolic pulse wave transit time PTT_DIA by a constant A5 and by multiplying the natural logarithm of the D wave intensity Vd by a constant A6. and the sum of the natural logarithm of (f/e) multiplied by the constant A7 and the constant A8. It is possible to obtain the systolic blood pressure BP_SYS and the diastolic blood pressure BP_DIA by obtaining each constant according to the characteristics of the device, the person to be measured, and the like. However, when confirming the change state of the systolic blood pressure BP_SYS and the diastolic blood pressure BP_DIA, it is not necessary to fix all the constants, and while substituting provisional values, the information on the systolic blood pressure BP_SYS and the diastolic blood pressure BP_DIA can be obtained. value can be obtained. The natural logarithm of the P-wave intensity Vp and the natural logarithm of the D-wave intensity Vd are terms that take into account the effect of blood density. Also, the natural logarithm of (b/a) and the natural logarithm of (f/e) are terms that take into account the effect of the longitudinal elastic modulus of the arterial wall. Therefore, depending on the measurement conditions, the information on the systolic blood pressure BP_SYS and the information on the diastolic blood pressure BP_DIA may be calculated by selecting one of the terms and making the other terms constant.

<Process flow>
Next, the operation of the biological information measurement system 1 according to the first embodiment of the present invention will be described with reference to the flowchart illustrated in FIG. The flowchart of FIG. 7 shows the related states of each operation of the biological information measuring device 100, the terminal device 200, and the server device 400. In FIG.

In step S101, the biological information measuring apparatus 100 loops until step S122 until the subject starts measurement and performs an end operation.

In step S102, the electrocardiogram measurement control unit 141 detects electrocardiograms from the first electrode 121 to the fourth electrode 124. Note that steps S102 and S104, and steps S103 and S105 are processed in parallel by parallel processing.

In step S103, the electrocardiogram measurement control unit 141 generates an electrocardiographic waveform from the time change of the electrocardiogram detected in step S102.

In step S104, the pulse wave measurement control unit 142 controls the optical sensor module 111 to detect pulse waves. Specifically, the light-emitting LED of the light-emitting unit 112 is caused to emit light to irradiate the wrist. The light receiving unit 113 receives light reflected from the wrist. The light receiving unit 113 converts the received light into an electric signal with a photodiode of the light receiving unit 113 and transmits the electric signal as pulse wave information to the pulse wave measurement control unit 142 .

In step S105, the pulse wave measurement control unit 142 generates a photoelectric volume pulse waveform from the temporal change in pulse wave information based on the pulse wave detected in step S104.

In step S106, the measurement device control unit 140 adds the detected times to the electrocardiogram waveform generated in step S103 and the photoelectric volume pulse waveform generated in step S105 as measurement times, thereby The information is stored in the measuring device storage unit 150 as wave information.

In step S107, the measuring device control section 140 determines whether or not there is a measuring device data transmission trigger. When the measurement device data transmission trigger is "yes", the process proceeds to step S107, and when "no", i.e., "n", the process proceeds to step S122. The measuring device data transmission trigger is an internal parameter in the biological information measuring device 100, and when the electrocardiogram information and the pulse wave information are constantly transmitted from the biological information measuring device 100 to the terminal device 200, the parameter is always " It is set to "present" or "1". When the electrocardiogram information and the pulse wave information are periodically transmitted from the biological information measuring device 100 to the terminal device 200, the internal counter sets the measuring device data communication trigger to "1" according to the set timing. set. Also, the measurement device data communication trigger may be set to “1” upon request from the terminal device 200 .

In step S<b>108 , the measuring device control unit 140 transmits the electrocardiographic information and pulse wave information stored in the measuring device storage unit 150 to the terminal device 200 .

In step S<b>109 , the terminal device control unit 211 stores the electrocardiographic information and pulse wave information received by the terminal device communication unit 213 in the terminal device storage unit 212 .

In step S110, the terminal device control unit 211 determines whether or not there is a terminal device data transmission trigger. When the terminal device data transmission trigger is "yes", the process proceeds to step S111, and when "no", i.e., "n", the process proceeds to step S121. The terminal device data transmission trigger is an internal parameter in the terminal device 200, and when the terminal device 200 constantly transmits the electrocardiogram information and the pulse wave information to the server device 400, the parameter is always "present", that is, " 1”. When periodically transmitting electrocardiogram information and pulse wave information from the terminal device 200 to the server device 400, the internal counter is set so that the terminal device data communication trigger becomes "1" according to the set timing. . In addition, the terminal device data communication trigger may be set to "1" according to a request from the server device 400. FIG.

In step S<b>111 , the terminal device control unit 211 transmits the electrocardiographic information and pulse wave information stored in the terminal device storage unit 212 to the server device 400 .

In step S<b>112 , the server device control unit 411 stores the electrocardiographic information and pulse wave information received by the server device communication unit 412 in the server device storage unit 413 .

In step S113, the server device control unit 411 calculates the pulse wave transit time from the electrocardiographic information and pulse wave information stored in the server device storage unit 413. A specific operating procedure will be described below. The pulse wave propagation time calculator 421 extracts a waveform profile in the electrocardiographic information and a waveform profile in the pulse wave information whose measurement timings are close. Next, the pulse wave transit time calculator 421 detects R waves and T waves from the waveform profile in the electrocardiographic information, and stores the time information when the detected R waves and T waves occur as Tr and Tt. Similarly, the pulse wave transit time calculation unit 421 detects the P wave and the D wave from the waveform profile in the photoelectric volume pulse waveform data, and sets the time information when the detected P wave and D wave occur as Tp and Td. make a memory. At the same time, the intensity Vp of the P wave and the intensity Vd of the D wave are detected and stored. As shown in FIG. 6, the pulse wave transit time computing unit 421 computes the difference between the time information Tr at which the R wave occurs and the time information Tp at which the P wave occurs, thereby computing the ventricular systolic pulse wave transit time PTT_SYS. . Similarly, the difference between the time information Tt at which the T wave occurred and the time information Td at which the D wave occurred is calculated to calculate the ventricular diastolic pulse wave propagation time PTT_DIA.

In step S<b>114 , the server device control unit 411 calculates second-order differential data from the photoelectric volume pulse waveform data stored in the server device storage unit 413 . Specifically, as shown in FIG. 6, the photoelectric volume pulse waveform data is first differentiated, and the first-differentiated data is further differentiated to obtain second-order differential data. A waveform obtained by second-order differentiation of a pulse wave is called an acceleration pulse waveform.

In step S115, the server device control unit 411 calculates the characteristic information of the acceleration pulse waveform from the second-order differential data obtained in step S114. The characteristic information of the acceleration pulse waveform is calculated from the intensities of the a-wave, b-wave, e-wave, and f-wave that indicate the peaks of the acceleration pulse waveform.

In step S116, the server device control unit 411 extracts blood pressure information from the ventricular systolic pulse wave transit time PTT_SYS and ventricular diastolic pulse wave transit time PTT_DIA obtained in step S113 and the characteristic information of the accelerated pulse waveform obtained in step S115. perform the calculation of Calculation of blood pressure information related to the maximum blood pressure is performed from the characteristic information of the ventricular systolic pulse wave transit time PTT_SYS and the accelerated pulse wave, and computation of blood pressure information related to the diastolic blood pressure from the ventricular diastolic pulse wave transit time PTT_DIA and the characteristic information of the accelerated pulse wave. conduct. The calculation is performed using the formulas (6) and (7) described above.

In step S<b>117 , the server device control unit 411 stores the blood pressure information calculated in step S<b>116 in the server device storage unit 413 .

In step S<b>118 , the server device control unit 411 analyzes the change state of the blood pressure information stored in the server device storage unit 413 . When it is determined that the change state is deterioration of the subject's health condition, the determination flag is set as "abnormal". The determination flag is an internal parameter of server device 400 .

In step S119, the server device control unit 411 determines whether the determination flag is "present". If "yes", the process proceeds to step S120, and if "no", the flow ends.

In step S120, the server device control unit 411 notifies the terminal device 200 of the abnormality via the server device communication unit 412.

In step S121, the terminal device control unit 211 controls the terminal device display unit 214 to perform display for notifying that there is an abnormality in the health condition based on the abnormality notification received by the terminal device communication unit 213. As a result, the terminal device 200 can notify the subject of an abnormality in the health condition.

In step S122, the biological information measuring apparatus 100 loops between step S101 and step S101 until the power of the biological information measuring apparatus 100 is turned off or the measuring apparatus control unit 140 performs a measurement end operation.

<Description of effect>
As described above, the biological information measuring device 100 of the present invention can accommodate subjects with various arm thicknesses by including the first arm 131 and the second arm 132 in particular. It is possible to improve the detection accuracy of the electrocardiographic waveform.

Although several embodiments of the present invention have been described above, these embodiments can be implemented in various other forms, and various omissions, replacements, and modifications are possible without departing from the scope of the invention. It can be performed. These embodiments and their modifications are intended to be included in the invention described in the claims and their equivalents as well as included in the scope and gist of the invention.

DESCRIPTION OF SYMBOLS 1... Biological information measuring system 100... Biological information measuring apparatus 200... Terminal device 300... Network 400... Server apparatus

Claims (15)

A biological information measuring device having at least a main body,
The main body includes a first arm and a second arm that are curved from the upper part of the main body to the lower part of the main body and extend left and right,
ends of the first arm and the second arm are separated from each other;
An electrode for measuring biological information is provided on at least one end side of the first arm and the second arm,
A biological information measuring device characterized by: At least one of the first arm portion and the second arm portion extends outward in the front-rear direction at the lower portion of the main body portion,
The biological information measuring device according to claim 1, characterized in that: At least a part of both ends of the first arm and the second arm extends to a length that overlaps with each other in the front-rear direction at the lower part of the main body,
The biological information measuring device according to claim 2, characterized in that: At least one of the ends of the first arm portion and the second arm portion is further curved from the lower side of the main body toward the upper side of the main body,
4. The biological information measuring device according to any one of claims 1 to 3, characterized in that: The material of the first arm and the second arm includes a thermoplastic elastomer,
5. The biological information measuring device according to any one of claims 1 to 4, characterized in that: The thermoplastic elastomer contains at least a polyether block amide,
6. The biological information measuring device according to claim 5, characterized in that: The body portion does not have a display portion,
7. The biological information measuring device according to any one of claims 1 to 6, characterized in that: Two electrodes are provided on the same end side of the end sides of the first arm and the second arm,
7. The biological information measuring device according to any one of claims 1 to 6, characterized in that: One of the electrodes is provided on each of different end sides of the first arm and the second arm,
7. The biological information measuring device according to any one of claims 1 to 6, characterized in that: Two of the electrodes are provided on different end sides of the first arm and the second arm,
7. The biological information measuring device according to any one of claims 1 to 6, characterized in that: An amplifier that amplifies the potential difference between the two electrodes provided on the same end side,
11. The biological information measuring device according to any one of claims 1 to 10, characterized in that: The main body has a reference voltage terminal for acquiring a reference voltage on the upper part of the main body, and inputs the reference voltage to the amplifier.
The biological information measuring device according to claim 11, characterized in that: The reference voltage terminal is connected to a thermistor that measures the skin temperature of the subject.
13. The biological information measuring device according to claim 12, characterized in that: The main body includes an optical sensor module that measures the pulse wave of the subject.
14. The biological information measuring device according to any one of claims 1 to 13, characterized in that: The main unit includes a communication unit that outputs the measured biological information to the outside,
15. The biological information measuring device according to any one of claims 1 to 14, characterized in that:

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