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WO2023079196A1 - Matériel médical de vérification et de contrôle de qualité de radiothérapie 4d - Google Patents

Matériel médical de vérification et de contrôle de qualité de radiothérapie 4d Download PDF

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Publication number
WO2023079196A1
WO2023079196A1 PCT/ES2022/070600 ES2022070600W WO2023079196A1 WO 2023079196 A1 WO2023079196 A1 WO 2023079196A1 ES 2022070600 W ES2022070600 W ES 2022070600W WO 2023079196 A1 WO2023079196 A1 WO 2023079196A1
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WO
WIPO (PCT)
Prior art keywords
wheels
displacement
linked
move
transversal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/ES2022/070600
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English (en)
Spanish (es)
Inventor
Antonio LEAL PLAZA
Carlos Manuel DE SEQUEIRA RIBEIRO NUNES
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universidad de Sevilla
Original Assignee
Universidad de Sevilla
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universidad de Sevilla filed Critical Universidad de Sevilla
Publication of WO2023079196A1 publication Critical patent/WO2023079196A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1048—Monitoring, verifying, controlling systems and methods
    • A61N5/1075—Monitoring, verifying, controlling systems and methods for testing, calibrating, or quality assurance of the radiation treatment apparatus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/1048—Monitoring, verifying, controlling systems and methods
    • A61N5/1075—Monitoring, verifying, controlling systems and methods for testing, calibrating, or quality assurance of the radiation treatment apparatus
    • A61N2005/1076—Monitoring, verifying, controlling systems and methods for testing, calibrating, or quality assurance of the radiation treatment apparatus using a dummy object placed in the radiation field, e.g. phantom

Definitions

  • the object of the invention is a device, associated with the field of medicine, for verification and verification software for the quality control of 4D radiotherapy.
  • Stereotaxic cranial radiosurgery has been used successfully for years for the treatment of intracranial lesions, as it can precisely deliver a high dose to the tumor while maintaining sufficiently low values in irradiation-compromised healthy tissue and risk organs.
  • the good results have led to the development of stereotaxy for extracranial lesions, coining the term SBRT (Stereotactic Body Radiation Therapy).
  • the step to initiate a clinical SBRT program involves determining the requirements for patient positioning, treatment delivery, and verification of radiation dose delivery. This scenario is especially complex in the case of lesions that are in motion during irradiation, mainly due to the patient's breathing.
  • the information provided by the 4D image can be used in dose planning algorithms. These generate openings of the collimation systems, such as the MLC (muitileaf collmimator) for the application of modulated intensity, capable of managing fluence maps previously generated from a planning reverse weighted by a mathematical calculation with respect to a static image in each calculation, even considering the displacements.
  • MLC microfilileaf collmimator
  • the fluence maps are generated from global information regarding the problem faced by each incident, so if something moves, the calculation has to be done again, which delays treatments and makes adaptive radiotherapy difficult. .
  • Algorithms that generate MLC apertures based on anatomy can address the problem more realistically, relating each collimation segment in the plan to projections of the volumes of interest, and thus more efficiently with the possible modifications of these projections in time.
  • the Monte Carlo method is a preventive analysis method in cases where experimentation is hardly possible, providing theoretical solutions to complex mathematical problems after sampling random numbers to sample the probability distribution functions that govern the physical phenomenon.
  • the image segmentation process for the delimitation of the disease is a factor to take into account in the management of uncertainties, so the use of automatic or semi-automatic algorithms plays a relevant role in terms of the reproducibility of the process, which will allow direct planning with the processed image.
  • Image guided during treatment (IGRT) techniques such as gatting or tracking, are appropriate methods to control possible changes in the treatment image, as well as other techniques that do not require fiduciary marks, resulting in less invasive procedures on the patient. . Compression systems to reduce movement of the lesion in certain directions can also help to control these movements to some extent during irradiation.
  • the document WO2016058898 presents a method for the construction of a mannequin from volumes designed in CAD from an image of a patient.
  • Document W02017019809A1 exposes a method based on chambers that can accommodate different fluids, and which are insufflated by a pumping system controlled according to the specific respiratory mechanics, and inside which finds a target that simulates the tumor and that moves with the flow dynamics.
  • US6697451 B2 presents a dynamic dummy in which the central section of the dummy moves to imitate cardiac movements.
  • Document US7699522B2 shows a dynamic dummy in which the sensor is inserted into the dummy by means of a radio-transparent cylinder and allows linear movements in a single direction and rotational movements.
  • the present invention corresponds to medical equipment and 4D radiotherapy quality control and verification software, which comprises an anterior fixed structure and a posterior fixed structure, with a cylindrical axis, where an ionizing radiation detection device is located, fixed to displacement mechanisms, front and rear, that move the axis based on the orders received from a control unit.
  • the front and rear fixed structures are configured from structural profiles and vertical guide profiles, joined together by fixing elements, so that the geometry of the fixed structures will be parallelepiped.
  • some supports are located to support an anthropomorphic mannequin inside which the axis with the detection device will run.
  • the radiotherapy medical equipment is designed to be coupled to the geometry of the anthropomorphic mannequin that is traversed by the cylindrical axis, achieving that the movement of the cylindrical axis where the ionizing radiation detection device is located is carried out inside the mannequin to to emulate the movement of the lesion inside the patient.
  • the equipment also includes some radiological protection casings that are fixed to the structures by means of joining elements, said casings having an opening with a determined geometry to allow the movement of the axis.
  • the control unit makes it possible to calculate and transmit the movement that must be carried out by the displacement mechanisms in order to be able to place the axis and, therefore, the detection device that is located on it, in suitable positions to perform a simulation of the movement of a lesion. during radiotherapy treatment or any other movement in which you want to verify the dose during irradiation.
  • the displacement mechanisms move vertically, transversely, and longitudinally; and they are built from some internal elements, whose configuration guarantees that these movements take place.
  • a transversal, front and rear displacement carriage made up of a plate to which wheels are attached and which move by the action of a motor.
  • the front transversal displacement carriage is linked to a longitudinal displacement carriage, by means of a transversal guide profile, fixed at its ends to a lower support that has wheels, which move the support longitudinally and whose movement is determined by a engine and a transmission element.
  • the front longitudinal displacement carriage is adapted to a front vertical displacement carriage, from front longitudinal guide profiles, which are attached to a horizontal tray that has plates, motors, transmission belts and wheels that they allow the previous vertical movement carriage to move vertically through the vertical guide profiles of the previous fixed structure.
  • the rear transversal displacement carriage additionally has a hollow part that allows the longitudinal displacement of the axis when passing through said hollow part.
  • the rear transverse slider is linked to a rear vertical slider through a rear transversal guide profile that is fixed to the vertical slider at both ends of the profile.
  • the rear transversal displacement carriage comprises, in addition to the transversal guide profile, some plates, motors and wheels that allow the vertical displacement of the carriage with the help of the vertical guide profiles of the rear fixed structure and transmission belts associated with the engines.
  • Figure 1. Shows a perspective view of the radiotherapy medical equipment.
  • Figure 2. Shows a perspective view of the anterior displacement mechanism of the radiotherapy medical equipment.
  • Figure 3. Shows a detailed view of the rear displacement mechanism of the radiotherapy medical equipment.
  • Figure 1 shows a radiotherapy medical equipment, which comprises an anterior fixed structure (1) equipped with structural profiles (2) and vertical guide profiles (3) fixed to each other by fastening elements and a posterior fixed structure ( 4) also provided with structural profiles (2) and vertical guide profiles (3) joined together in the same way by fastening elements.
  • Figure 1 shows some supports (5) that are fixed to the lower area of the vertical guide profiles (3) of the fixed structures (1, 4) and that are facing each other and are intended to support a anthropomorphic mannequin (6).
  • the radiotherapy medical equipment comprises an axis (7) in which an ionizing radiation detection device (8) is located, intended to move through the internal area of the anthropomorphic mannequin (6), thus modifying its location according to the trace of movement that you want to verify.
  • the radiotherapy medical equipment comprises a front displacement mechanism (9) fixed to one end of the shaft (7) and which moves in a transversal, longitudinal and vertical direction with respect to the front fixed structure (1), occurring also with a rear displacement mechanism (10) fixed to the other end of the shaft (7) and which also moves in the transversal, longitudinal and vertical direction with respect to the rear fixed structure (4), in a synchronized manner with the front displacement mechanism (9).
  • the medical radiation equipment comprises radiological protection casings (33) that fit into the structural profiles (2) and vertical guide profiles (3) of the fixed structures (1, 4), and they are facing each other.
  • FIG. 2 shows the front displacement mechanism (9) comprising a front transversal displacement carriage (12) that is linked to one end of the shaft (7).
  • Said front transversal displacement carriage additionally comprises a first plate (13), first wheels (14) that are mounted on said first plate (13), a first motor (15) mounted on the first plate (13) intended to transmit the movement to the first wheels (14) through the use of transmission belts (35) associated with said first motor (15).
  • Figure 2 shows a front longitudinal displacement carriage (16) comprising a front transverse guide profile (17) on which the first wheels (14) of the front transverse displacement carriage (12) move. It also includes a lower support (18) linked to both ends of the front transverse profile (17), second wheels (19) that are mounted on the aforementioned lower support (18) and a fourth motor (20), associated with an element of transmission (21) and some transmission belts (35), which cause the movement of longitudinal displacement of the lower support (18) and the elements related to it.
  • a front longitudinal displacement carriage (16) comprising a front transverse guide profile (17) on which the first wheels (14) of the front transverse displacement carriage (12) move. It also includes a lower support (18) linked to both ends of the front transverse profile (17), second wheels (19) that are mounted on the aforementioned lower support (18) and a fourth motor (20), associated with an element of transmission (21) and some transmission belts (35), which cause the movement of longitudinal displacement of the lower support (18) and the elements related to it.
  • the front displacement mechanism (9) incorporates a front vertical displacement carriage (22) that includes longitudinal guide profiles
  • FIG. 3 shows the rear displacement mechanism (10) comprising a rear transversal displacement carriage (28) linked to the other end of the shaft (7), and comprising a first plate (13), first wheels (14) mounted on said first plate (13), a first motor (15) also mounted on the first plate (13) and which drives the first wheels (14) by using transmission belts (35) linked to the first motor (15). ) previously mentioned.
  • the rear transversal displacement carriage (28) also comprises a hollow part (34), mounted on the first plate (13) and which allows the shaft (7) to slide inside it.
  • a rear vertical displacement carriage (29) comprising a rear transversal guide profile (30) on which the first wheels (14) of the rear transversal displacement carriage (29) move. , some respective second plates (31) opposite and unique to the ends of the rear transversal guide profile (30), some second wheels (19) mounted on said second plates (31) and, finally, some second motors (32) mounted on the second plates (31) that drive the second wheels (19) that move on the vertical guide profiles (3) of the rear fixed structure (4) thanks to transmission belts (35) connected to the second motors (32).

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Radiation-Therapy Devices (AREA)
  • Electrotherapy Devices (AREA)

Abstract

Le matériel médical comprend une structure fixe antérieure (1), une structure fixe postérieure (4), un axe (7) qui abrite un dispositif de détection de rayonnement ionisant (8), des supports (5) destinés à soutenir un mannequin anthropomorphique (6), des mécanismes de déplacement antérieur (9) et un mécanisme de déplacement postérieur (10) auxquels l'axe (7) se joint et qui sont chargés de réaliser les mouvements dudit axe, des carcasses de protection radiologique (33) et une unité de commande (1) qui configure les mouvements de l'axe (7), paramétrés au préalable par le logiciel qui traite les images cliniques 3D/4D provenant de dispositifs d'acquisition d'image clinique.
PCT/ES2022/070600 2021-11-04 2022-09-21 Matériel médical de vérification et de contrôle de qualité de radiothérapie 4d Ceased WO2023079196A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ESP202131034 2021-11-04
ES202131034A ES2940533A1 (es) 2021-11-04 2021-11-04 Equipo medico de verificacion y control de calidad radioterapica 4d

Publications (1)

Publication Number Publication Date
WO2023079196A1 true WO2023079196A1 (fr) 2023-05-11

Family

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Family Applications (1)

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PCT/ES2022/070600 Ceased WO2023079196A1 (fr) 2021-11-04 2022-09-21 Matériel médical de vérification et de contrôle de qualité de radiothérapie 4d

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ES (1) ES2940533A1 (fr)
WO (1) WO2023079196A1 (fr)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7193220B1 (en) * 2006-06-28 2007-03-20 Daniel Navarro Modular radiation bean analyzer
WO2017158634A1 (fr) * 2016-03-18 2017-09-21 Ospedale Pediatrico Bambino Gesu' Système et procédé de détermination expérimentale de quantités dosimétriques avec des scanners ct

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7193220B1 (en) * 2006-06-28 2007-03-20 Daniel Navarro Modular radiation bean analyzer
WO2017158634A1 (fr) * 2016-03-18 2017-09-21 Ospedale Pediatrico Bambino Gesu' Système et procédé de détermination expérimentale de quantités dosimétriques avec des scanners ct

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ANONYMOUS: "DYNAMIC THORAX PHANTOM MODEL 008A", SUN NUCLEAR, A MIRION MEDICAL COMPANY, 3 September 2021 (2021-09-03), XP093065359, Retrieved from the Internet <URL:https://www.cirsinc.com/products/radiation-therapy/dynamic-thorax-motion-phantom/> [retrieved on 20230719] *
ANONYMOUS: "V-Slot Belt & Pinion Linear Drive System", OPENBUILDS, XP009546327, Retrieved from the Internet <URL:https://web.archive.org/web/2021043142957/https://openbuilds.com/builds/v-slot%E2%84%A2-belt-pinion-example-build.97> [retrieved on 20221216] *

Also Published As

Publication number Publication date
ES2940533A1 (es) 2023-05-08

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