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WO2022232307A1 - Systèmes et procédés de retardement de la progression de la myopie - Google Patents

Systèmes et procédés de retardement de la progression de la myopie Download PDF

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Publication number
WO2022232307A1
WO2022232307A1 PCT/US2022/026586 US2022026586W WO2022232307A1 WO 2022232307 A1 WO2022232307 A1 WO 2022232307A1 US 2022026586 W US2022026586 W US 2022026586W WO 2022232307 A1 WO2022232307 A1 WO 2022232307A1
Authority
WO
WIPO (PCT)
Prior art keywords
light source
mpr
illumination
computerized device
luminance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2022/026586
Other languages
English (en)
Inventor
Barry Jonathan LINDER
Yan Zhou
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Reopia Optics Inc
Original Assignee
Reopia Optics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US17/246,058 external-priority patent/US11974374B2/en
Application filed by Reopia Optics Inc filed Critical Reopia Optics Inc
Publication of WO2022232307A1 publication Critical patent/WO2022232307A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • G—PHYSICS
    • G02—OPTICS
    • G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
    • G02C11/00—Non-optical adjuncts; Attachment thereof
    • G02C11/04—Illuminating means
    • G—PHYSICS
    • G02—OPTICS
    • G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
    • G02C11/00—Non-optical adjuncts; Attachment thereof
    • G02C11/10—Electronic devices other than hearing aids
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F3/00—Input arrangements for transferring data to be processed into a form capable of being handled by the computer; Output arrangements for transferring data from processing unit to output unit, e.g. interface arrangements
    • G06F3/01—Input arrangements or combined input and output arrangements for interaction between user and computer
    • G06F3/011—Arrangements for interaction with the human body, e.g. for user immersion in virtual reality
    • G06F3/012—Head tracking input arrangements
    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05B—ELECTRIC HEATING; ELECTRIC LIGHT SOURCES NOT OTHERWISE PROVIDED FOR; CIRCUIT ARRANGEMENTS FOR ELECTRIC LIGHT SOURCES, IN GENERAL
    • H05B47/00—Circuit arrangements for operating light sources in general, i.e. where the type of light source is not relevant
    • H05B47/10—Controlling the light source
    • H05B47/105—Controlling the light source in response to determined parameters
    • H05B47/11—Controlling the light source in response to determined parameters by determining the brightness or colour temperature of ambient light
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0626—Monitoring, verifying, controlling systems and methods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0635—Radiation therapy using light characterised by the body area to be irradiated
    • A61N2005/0642—Irradiating part of the body at a certain distance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0635—Radiation therapy using light characterised by the body area to be irradiated
    • A61N2005/0643—Applicators, probes irradiating specific body areas in close proximity
    • A61N2005/0645—Applicators worn by the patient
    • A61N2005/0647—Applicators worn by the patient the applicator adapted to be worn on the head
    • A61N2005/0648—Applicators worn by the patient the applicator adapted to be worn on the head the light being directed to the eyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
    • A61N2005/0662—Visible light
    • G—PHYSICS
    • G02—OPTICS
    • G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
    • G02C2202/00—Generic optical aspects applicable to one or more of the subgroups of G02C7/00
    • G02C2202/24—Myopia progression prevention

Definitions

  • the present invention relates to systems and methods for retarding the progression of myopia. More specifically, the invention pertains to use of simulated sunlight to illuminate the eyes to prevent myopia progression.
  • Myopia is often referred to as near or short sightedness.
  • the incidence of myopia is increasing around the world, with the highest incidence in Asia.
  • the condition is most often diagnosed in early school age children, and in most cases progresses during the subsequent years of school.
  • systems and methods for retarding myopia progression are provided.
  • a computerized myopia progression retarding (“MPR”) system includes a light source configured to provide illumination and an illumination sensor configured to sense ambient light.
  • the MPR system also includes a processor, operatively coupled to the light source and the illumination sensor, configured to dynamically adjust the illumination in terms of either wavelength bands or luminance provided by the light source to solicit a target wavelength band or luminance for retarding myopia progression of a user.
  • the MPR system includes a computerized device with a display screen, and wherein the light source of the MPR system is an external ambient light source operatively coupled to the computerized device, thereby enabling the external ambient light source and computerized device to cooperatively provide the target wavelength band or luminance for the user.
  • Figures 1A and IB are perspective views of exemplary myopia progression retarders as implemented in eyewear, in accordance with some embodiments of the present invention.
  • Figure 2 is a perspective view of a myopia progression retarder as implemented in a headgear, in accordance with another embodiment of the present invention.
  • Figure 3A is a perspective view of a myopia progression retarder as implemented in a smart device, in accordance with yet another embodiment of the present invention.
  • Figure 3B is a perspective view of another myopia progression retarder as implemented in a smart device, in accordance with yet another embodiment of the present invention.
  • Figure 4 is a flow diagram illustrating the operation of myopia progression retarders, in accordance with some embodiments of the present invention.
  • FIG. 5 is a side view depicting yet another embodiment, wherein the illumination sources include not only those coming directly from a computerized device having a display screen providing visual content to be displayed to a viewer, but also those coming from one or more ambient light bulbs or other lighting sources that provide background room lighting; and
  • Figure 6 a flow diagram illustrating the operation of myopia progression retarders, in accordance with other embodiments of the present invention. DESCRIPTION
  • Figures 1A and IB illustrate exemplary embodiments of myopia progression retarders as implemented in eyewear, in accordance with the present invention.
  • an eyewear 100A includes a frame 110, a video sensor 120a, and a pair of light sources 150, 160.
  • a microprocessor/microcontroller and an optional transceiver can be incorporated into the frame 110 and/or an earpiece 170.
  • a power source (not shown) can also be incorporated into the frame
  • Suitable power sources include rechargeable and/or non- rechargeable batteries. Power can also be generated from head motion via accelerometers. Additional power sources include external wired AC/DC power. Optional supplemental power sources include solar cells. Myopia progression retarders may also be remotely charged via wireless focused-proximity charging and/or inductive charging.
  • Light sources 150, 160 are configured to simulate the intensity and frequency spectrum of outdoor light, especially sunlight, and can be generated by LEDs or any suitable light sources.
  • Light sources 150, 160 may have adjustable parameters defined by the user and/or third part(ies), for example, a variety of light intensity levels including “Sunny”, “direct exposure Sunny” and “in the shade Cloudy”, as well as controllable weighting, bandpass, and filtering of wavelengths.
  • eyeglass frames include integrated light source(s).
  • the integrated light source can be unilateral or bilateral as illustrated by dual light sources 150, 160.
  • the light source(s) can be a continuous Light Emitting Diode (LED), chosen with wavelengths that simulate the spectrum of natural outdoor light.
  • the LED can have a variable luminance, controlled by the controlling microprocessor, with luminance of approaching 10,000 Lux to simulate the exposure expected outdoors on a typical sunny day.
  • Users and/or third part(ies) may also be able to control wavelength of illumination delivered to the user by eyewear 100A, such as illuminating with full spectrum of sunlight, variable wavelength(s), visible vs non-visible Bandwidth of chosen wavelength(s), and/or modulate wavelengths during exposure. Choices can also include displaying simultaneously one or more wavelength(s) and bandwidth(s).
  • the angle of illumination of the light mounted on a set of frames relative to the entrance pupil of the user’s eye can be adjustable. There can be several settings ranging from tangential illumination to nearly perpendicular to the eye’s surface.
  • Video sensor 120a e.g., a camera, can monitor physiologic pupillary response of the user to the light, thereby enabling the eyewear 100A to ensure adequate light exposure to obtain a target pupillary response. Recording use and compliance of the device is confirmed by active pupillary constriction (i.e. a user cannot simply turn on the light, but eyewear 100A is worn on a live person to obtain a pupillary response).
  • Video sensor 120a can be sensitive to visible “white” light and/or to other spectra such as infrared light.
  • the purpose of sensor 120a is to monitor the pupillary reaction and size. Since the pupil response to light exposure is bilateral, only one eye’s pupil need be monitored.
  • Myopia progression retarders can be calibrated to illuminate the eye with a safe level of luminance that causes a pupillary constriction comparable to natural outdoor light levels. The retarders can work in a closed loop manner such that the controller device maintains the safe level of luminance to maintain the constricted pupil size.
  • the light exposure can be delivered in an open loop manner to utilize a pre-set, non-variable level of light exposure. Further variations in illumination can be programmable, and include as examples alternating on-off-on patterns, as well as simulated illumination levels equal to a sunny day, cloudy day, or sunny day in the shade.
  • User usage data can be stored locally in eyewear 100A, in a remote server or a combination of both. Eyewear 100A may also be operatively coupled to an application running on a computer, smart phone and/or tablet, via a Bluetooth or WiFi wireless connection. [0029] Usage data collected can include one or all of the following:
  • usage data can be uploaded to existing cloud database(s), such as adding clinical data to patient record, including refraction obtained from physician visits. Correlation to clinical condition can be performed (manually and/or automatically) and illumination recommendations are adjusted as needed to obtain improved clinical outcomes for specific user(s).
  • Figure IB illustrates a modified embodiment of an eyewear 100B which includes a frame 110, a video sensor 120b, and a pair of light sources 150, 160.
  • the video sensor 120b is located centrally with respect to frame 110
  • myopia progression retarders can be implemented in suitable headgear, e.g., a cap 200, having a video sensor 220 and light sources 250, 260.
  • suitable headgear e.g., a cap 200
  • Other exemplary headgear suitable for incorporating myopia progression retarders include hats, visor, hoods and helmets.
  • the location and number of light source(s) and camera(s) is not limited to the described embodiments.
  • a single camera can be located toward the center of the eyewear and capable of sensing pupil constriction of both eyes.
  • a single light source is located toward the middle of the headgear and provides illumination for both eyes.
  • the light source(s) can be substantially concealed within the eyewear and the illumination (fiber) optically multiplexed, directed and eventually delivered at each eye through miniature lens. Such an arrangement can advantageously provide a more evenly distributed illumination around the frame and also reduces the weight on the nose piece thereby increasing user comfort and compliance.
  • attachments may be added to eyewear or headgear to limit peripheral vision while reading indoors.
  • the attachment can be made from an opaque material to allow ambient lighting to penetrate while blurring out objects otherwise within the user’s peripheral field-of-vision.
  • FIG. 3A depicts yet another embodiment of myopia progression retarder implemented in a computerized device, such as a smart device, a mobile phone, a tablet and a video monitor.
  • smart phone 300 A includes a user-facing camera 320 and a display screen 380 capable of outputting sufficient light intensity and spectrum to simulate sunlight.
  • myopia progression retarders into Virtual Reality (“VR”) or Augmented Reality (“AR”) devices, such as VR goggles and AR glasses, to provide the desired level of illumination to the user’s eyes.
  • VR Virtual Reality
  • AR Augmented Reality
  • a myopia progression retardation system provides illumination simulating outdoor lighting levels and/or spectrum for a user (step 420).
  • the system measures pupillary response of at least one of the user’s eyes (step 440).
  • the system dynamically adjusts the level and/or spectrum of illumination to solicit a desired pupillary response, intended to delay the onset and/or retard the progression of myopia, by maintaining a target pupil constriction consistent with exposure to the outdoor lighting levels and/or spectrum (step 460).
  • Myopia progression retarders may be capable of communicating with each other and/or a central microprocessor controller in accordance with some embodiments of the present invention.
  • the central controller of such a system can either be a dedicated controller device, or a smart portable device (such as an iPhone) with a software application.
  • the controller can be configurable as a stand-alone device or operatively coupled to a central database via, for example, an internet cloud. Duration of light exposure, illumination level, and pupillary response can be recorded.
  • a motion detector capable to measuring head movements for eyeglass frame mounted lighting can wirelessly send data to the central database.
  • Additional optional monitoring sensors can include location, time, integrated metadata including weather, ambient light, and camera to track eye movements, convergent and divergent binocular eye movements, eye targeting movements, and pupillary responses.
  • Real-time automated monitoring of the central data base using artificial intelligence and data mining can also be implemented, and reports routinely generated, or alerts generated if it appears that the lighting system is either not used as recommended, or has been removed from the eyewear or headwear.
  • the light source(s) and camera can be independent components in a kit with universal adaptors to fit each element on any eyeglass frame.
  • Yet another variation of the myopia progression retarder includes the light source without a camera, and the controller works in an open loop manner with pre-set continuous illumination levels.
  • a solar cell measures the ambient light at the user’s location.
  • the myopia progression retarder then computes the amount of supplemental illumination needed to simulate an equivalent outdoor daytime lighting environment.
  • an external light that simulates light level and spectrum of the outdoor light exposure.
  • This configuration allows the camera and light source to be mounted on stands in a convenient location to the user.
  • a camera can still be utilized to measure pupillary response to ensure sufficient light levels to simulate outdoor exposure.
  • a group myopia progression retardation system can include desk-mounted cameras and individualized overhead illumination settings.
  • myopia progression retarding (“MPR”) illumination is directly coming from a computerized device 300 A, a computer display monitor, a laptop, a cell phone, an augmented reality device or a virtual reality device, having a display screen 380 configured to provide visual content to be displayed to a viewer (not shown).
  • the built-in sensor 320 of device 300A can be configured to also sense ambient light.
  • the MPR illumination provided by display screen 380 can use the ambient sensor signal as an input for adjusting its emission spectral band(s) and/or output level to compensate for the missing spectral band(s), therefore maintaining the presence of the needed spectral band(s) for retarding myopia progression of the viewer.
  • a supplemental illumination source 390 can be incorporated into a computerized myopia progression retarding device 300B, e.g., a computer display monitor, a laptop, a cell phone, an augmented reality device or a virtual reality device, having a display screen 380 configured to provide visual content to be displayed to a viewer (not shown).
  • the built-in sensor 320 of myopia progression retarding device 300B can be configured to also sense ambient light.
  • the supplemental illumination source 390 can use the ambient sensor signal as an input for adjusting its emission spectral band(s) and/or output level to compensate for the missing spectral band(s), therefore maintaining the presence of the needed spectral band(s) for retarding myopia progression of the viewer.
  • the illumination sources include not only those coming directly from a computerized device 530, e.g., a computer display monitor, a laptop, a cell phone, an augmented reality device or a virtual reality device, having a display screen 535 configured to provide visual content to be displayed to a viewer 510, but also those coming from one or more ambient light bulbs or other lighting sources that provide background room lighting, such as a table lamp 540 and/or a ceiling light 580.
  • the illumination light source coming directly from the display device 530 and the background room light illumination source(s) can be operatively coupled with each other.
  • the myopia progression retarding device 530 can include and/or can be operatively coupled to one or more illumination sensor(s) configured to sense ambient light.
  • an exemplary illumination sensor can be incorporated into, for example, a wearable 520. If the ambient light is missing or lacking certain outdoor spectral band(s) that is(are) particularly effective in prevention myopia or in retarding myopic progression, such as the violet spectral band from 360nm to 400nm and/or short wavelength blue light around 480 nm, or the indoor lighting luminance level (typically 100-500 lux) is substantially less than that of typical outdoor lighting luminance level ranging from 1000 to over 100 000 lux, the illumination sources, including both that from the display screen 535 and also those that provide background room lighting, can use the ambient sensor signal as an input for adjusting their emission spectral band(s) and/or output luminance level(s) to compensate for the missing spectral band(s) or luminance level, therefore maintaining the presence of the needed spectral band(s) and/or luminance light
  • the ambient light sensor(s) can be configured to also sense day/night or light/dark cycle. Based on the continually changing input from the ambient light sensor(s) during the day/night or light/dark cycle, the myopia progression retarding illumination source(s) can change their respective emission spectral band(s) and/or output level to match the natural circadian rhythm, or circadian cycle or normal diurnal cues (e.g., the light/dark cycle) that is related to the ocular rhythms of eye growth and refractive development.
  • the myopia progression retarding illumination source(s) can change their respective emission spectral band(s) and/or output level to match the natural circadian rhythm, or circadian cycle or normal diurnal cues (e.g., the light/dark cycle) that is related to the ocular rhythms of eye growth and refractive development.
  • the illumination removes its blue spectral component, and/or emit light at specific spectral band and/or dim light output luminance level to discourage screen time. It may also be possible to substantially maintain the desirable myopia progression retarding illumination levels by increasing longer wavelengths while decreasing blue light.
  • FIG. 6 is a flow diagram illustrating the myopia progression retardation methods employed by the various exemplary embodiments of the present invention.
  • one or more illumination source(s) can be configured to provide illumination.
  • Ambient sensor(s) are deployed to sense ambient light (see step 640).
  • a processor of a computerized device is operatively coupled to the illumination source(s) and the sensor(s). The processor can be configured to dynamically adjust the illumination in terms of either wavelength bands and/or luminance provided by the light source to solicit a target wavelength bands and/or luminance for a user, thereby retarding myopia progression of the viewer.

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Abstract

La myopie est un problème cliniquement significatif et croissant dans le monde. Une cause majeure est l'augmentation du temps passé à l'intérieur par les enfants, par exemple, à jouer aux jeux vidéo, étudier et regarder la télévision. Une exposition à des niveaux de lumière globaux suffisants est connue pour être protectrice, et empêche l'apparition et retarde également la progression de la myopie. Des modes de réalisation comprennent un système informatisé de retardement de la progression de la myopie (« MPR ») qui comprend une source de lumière configurée pour fournir un éclairage et un capteur d'éclairage configuré pour détecter la lumière ambiante. Le système MPR comprend également un processeur configuré pour régler dynamiquement l'éclairage en termes de bandes de longueur d'onde ou de luminance fournies par la source de lumière pour solliciter une bande ou une luminance de longueur d'onde cible pour retarder la progression de la myopie d'un utilisateur.
PCT/US2022/026586 2021-04-30 2022-04-27 Systèmes et procédés de retardement de la progression de la myopie Ceased WO2022232307A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17/246,058 2021-04-30
US17/246,058 US11974374B2 (en) 2017-08-02 2021-04-30 Systems and methods for retarding myopia progression

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WO2022232307A1 true WO2022232307A1 (fr) 2022-11-03

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Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100296058A1 (en) * 2007-04-27 2010-11-25 The Institute For Eye Research Limited Determination of optical adjustments for retarding myopia progression
US20150301670A1 (en) * 2014-04-21 2015-10-22 Wistron Corporation Display and brightness adjusting method thereof
US20160158572A1 (en) * 2013-07-23 2016-06-09 Koninklijke Philips N.V. Non-ocular photo-biological stimulation
US20180345034A1 (en) * 2017-06-06 2018-12-06 Peter Butzloff Myopia inhibition apparatus and ocular method
US20190038123A1 (en) * 2017-08-02 2019-02-07 Barry Jonathan Linder Systems and Methods For Retarding Myopia Progression
US20200089025A1 (en) * 2018-09-13 2020-03-19 Wicue, Inc. Dimmable eyewear
US20200409159A1 (en) * 2015-03-16 2020-12-31 Magic Leap, Inc. Methods and systems for diagnosing and treating presbyopia
US20210001145A1 (en) * 2018-02-28 2021-01-07 Sustainable Eye Health Ip Pty Ltd Controlling myopia in humans

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100296058A1 (en) * 2007-04-27 2010-11-25 The Institute For Eye Research Limited Determination of optical adjustments for retarding myopia progression
US20160158572A1 (en) * 2013-07-23 2016-06-09 Koninklijke Philips N.V. Non-ocular photo-biological stimulation
US20150301670A1 (en) * 2014-04-21 2015-10-22 Wistron Corporation Display and brightness adjusting method thereof
US20200409159A1 (en) * 2015-03-16 2020-12-31 Magic Leap, Inc. Methods and systems for diagnosing and treating presbyopia
US20180345034A1 (en) * 2017-06-06 2018-12-06 Peter Butzloff Myopia inhibition apparatus and ocular method
US20190038123A1 (en) * 2017-08-02 2019-02-07 Barry Jonathan Linder Systems and Methods For Retarding Myopia Progression
US20210001145A1 (en) * 2018-02-28 2021-01-07 Sustainable Eye Health Ip Pty Ltd Controlling myopia in humans
US20200089025A1 (en) * 2018-09-13 2020-03-19 Wicue, Inc. Dimmable eyewear

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