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WO2022211660A1 - Procédé de détermination non invasive du contenu en glucose du sang d'une personne - Google Patents

Procédé de détermination non invasive du contenu en glucose du sang d'une personne Download PDF

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Publication number
WO2022211660A1
WO2022211660A1 PCT/RU2021/000140 RU2021000140W WO2022211660A1 WO 2022211660 A1 WO2022211660 A1 WO 2022211660A1 RU 2021000140 W RU2021000140 W RU 2021000140W WO 2022211660 A1 WO2022211660 A1 WO 2022211660A1
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WO
WIPO (PCT)
Prior art keywords
blood
patient
glucose
glucose levels
medicine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/RU2021/000140
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English (en)
Russian (ru)
Inventor
Олег Олегович ТИХОНЕНКО
Андрей Юрьевич ЩЕРБАКОВ
Злата Олеговна ТИХОНЕНКО
Даниил Олегович ТИХОНЕНКО
Юрий Алексеевич КИРИЧЕК
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Efimcev Artem Nikolaevich
Original Assignee
Efimcev Artem Nikolaevich
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Efimcev Artem Nikolaevich filed Critical Efimcev Artem Nikolaevich
Priority to PCT/RU2021/000140 priority Critical patent/WO2022211660A1/fr
Publication of WO2022211660A1 publication Critical patent/WO2022211660A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/026—Measuring blood flow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters

Definitions

  • the invention relates to medicine and technology, and more specifically to a method for non-invasive determination of glucose in human blood.
  • the present invention can be used to create diagnostic systems in medicine, as well as to create socially oriented systems for the early diagnosis of diabetes and related diseases.
  • the urgent task in medicine is the rapid diagnosis and control of diabetes, which do not require complex and expensive medical equipment, relying on technical means available to the patient and allowing the use of telemedicine methods.
  • the present invention is based on the task of creating a method for non-invasive determination of glucose in human blood, which would allow solving the above problems.
  • Combo Glucometer (https://cnogacare.coA. which is a non-invasive glucometer with an optical sensor from the Israeli company CNOGA Medical.
  • the measurement method used in the Combo Glucometer (CoG) is based on the photoplethysmography method which evaluates changes in the state of the vessels inside the user's finger when illuminated with light of different wavelengths.
  • the principle of operation of the device is as follows.Several LEDs shine in the wavelength range from visual to infrared through the fingertip.When light passes through it, part of the radiation is absorbed and the reflected light signal changes A sensor built into the device's camera detects changes in the light signal in real time. correlation between signal and biological parameters to get blood glucose level.
  • Such calibration must be carried out periodically in order to constantly maintain the accuracy of measurements at a high level.
  • the meter is equipped with wireless communication technologies that allow you to transfer information to a companion application, and has a large internal memory - it stores up to 2000 test results. At the same time, it can give results in mg / dl and mmol / l. Measurement time - about 40 sec.
  • the device is combined, requiring a long, repeated adjustment by the usual invasive method.
  • the device does not allow continuous monitoring of glucose concentration, its increase or decrease.
  • Another close to the claimed invention is RU2515410C2, which describes a method for non-invasive measurement of blood glucose concentration, which consists in irradiating the zone of maximum accumulation of blood vessels with a laser beam, receiving and instrumental transformation by highlighting the orientation of the polarization vector and the intensity of backscattered radiation and calculating the glucose concentration from them in the blood, characterized in that the intensity and polarization of the backscattered light field is recorded by two channels located symmetrically relative to the laser beam, the analyzers of the receiving channels are preliminarily adjusted at angles of ⁇ 45° relative to the plane of the polarizer transmission, at the same time the dynamics of blood microcirculation in the studied area of the skin is recorded measurements are carried out directly from the surface of the skin.
  • the device requires the use of a laser and thus has a high energy consumption.
  • Registration requires two channels located symmetrically with respect to the laser beam, pre-tuned receiver channel analyzers at angles of ⁇ 45° relative to the polarizer transmission plane, which greatly complicates the design and use.
  • the objectives of the invention are solved and the disadvantages of the prototypes are eliminated in a method for non-invasive determination of glucose in human blood, in which human blood vessels are irradiated using an optical radiation source and a signal reflected from the blood vessel is received, characterized in that the reflected signal is received using one optical receiver and parameters of the reflected signal at the receiver, including but not limited to amplitude, frequency and phase determine the speed of blood in the blood vessel and thus determine the increase or decrease in blood glucose associated with the increase or decrease in the speed of blood in the blood vessel.
  • a bracelet device for measuring heart rate (HR - heart rate) is taken as the basis.
  • This device is equipped with an LED that emits monochromatic coherent light in a narrow frequency range.
  • the measurement of the pulse is based on the reception by the photodiode of the radiation reflected from the subcutaneous capillaries, which changes synchronously with the pulse.
  • the capillary When the capillary is full, it absorbs light strongly; when it is not filled, it absorbs light weakly.
  • Diabetes mellitus is characterized by the fact that glucose changes shape, accumulates in the cell. In this case, the amount of water in the capillary increases, which makes the blood lighter and more fluid. In this case, the relative increase in blood flow velocity is proportional to the square root of the relative increase in glucose concentration.
  • the speed function changes the form
  • V V B + c ⁇ , where V is the speed
  • the Doppler effect consists in the fact that an object in motion changes the frequency of the signal reflected from it or emitted by it. When a blood cell moves towards the emitter, the reflected frequency is higher; away from the emitter, the reflected frequency is lower.
  • the light wave falls on the velocity vector at an angle a.
  • AF defines the projection of the velocity vector onto the light beam (V-cosa):
  • C is the speed of light in body tissues.
  • V AF C/2Ffl cosa.
  • the design of the glucometer is mounted on the basis of Google Android devices and bracelets based on it, or Apple Watch and is completely non-invasive. In this case, it is necessary to modify (or supplement) the software of the device in such a way that, using the existing controlled light source, simultaneously with the process of measuring the pulse, in which the human blood vessels are irradiated with the help of an optical radiation source and the signal reflected from the blood vessel is received.
  • the reflected signal is received using a single optical receiver and the parameters of the reflected signal in the receiver, including but not limited to its amplitude, frequency and phase, determine the speed of blood movement in the blood vessel and thus determine the increase or decrease in blood glucose associated with an increase or by reducing the speed of blood movement in a blood vessel using the Doppler method described above, or by isolating frequencies characteristic of the movement of blood cells. Let's describe this method.
  • the received signal will contain frequency harmonics of the order of 100 Hz, while as the speed increases, the frequency will increase in proportion to the speed of blood movement, since the erythrocytes will move in front of source of optical radiation faster.
  • an increase or decrease in blood glucose level is determined, since an increase in glucose level is associated with an increase in blood velocity, as described above.
  • this method allows you to very quickly assess the patient's condition and perform diagnosis and control of blood glucose levels, as well as give recommendations for eliminating identified problems in real time. At the same time, it is done quite operational, reasonable and documented conclusion about the patient's condition, which may be important for insurance medicine.
  • the frequency measurement method reduces external interference and measurement errors, no additional complex devices are required to assess the glucose level, it does not require piercing the patient's skin and attaching sensors to the body, it is convenient for the patient, it allows you to evaluate the glucose level several times a minute, quickly signal a sharp increase or drop in glucose levels.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Medical Informatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physiology (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Optics & Photonics (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

L'invention se rapporte au domaine de la médecine et des techniques connexes, et concerne plus précisément un procédé de détermination non invasive du contenu en glucose du sang d'une personne. La présente invention peut être utilisée dans la création de systèmes diagnostiques en médecine et dans les techniques connexes, ainsi que pour créer des systèmes à orientation sociale de diagnostic précoce du diabète et de maladies l'accompagnant. En comparaison à d'autres procédés d'estimation non invasive du niveau de glucose connus des auteurs, ce procédé permet d'évaluer de manière très fonctionnelle l'état d'un patient et d'effectuer le diagnostic et le contrôle du niveau de glucose dans le sang, et d'émettre des recommandations pour éliminer les problèmes découverts en temps réel. Il est ainsi possible de tirer une conclusion fonctionnelle, fondée et documentée sur l'état du patient qui peut avoir un rôle concernant les assurances médicales. Ce procédé de mesure de fréquence permet de réduire les interférences externes et les erreurs de mesure, ne nécessite pas de dispositifs complexes supplémentaires afin d'estimer le niveau de glucose, ne nécessite pas de perforation de la peau du patient ni de fixation de capteurs au corps, est commode pour le patient, et permet d'estimer le niveau de glucose plusieurs fois par minute, et d'avertir fonctionnellement d'une hausse ou d'une chute brutale du niveau de glucose.
PCT/RU2021/000140 2021-04-01 2021-04-01 Procédé de détermination non invasive du contenu en glucose du sang d'une personne Ceased WO2022211660A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/RU2021/000140 WO2022211660A1 (fr) 2021-04-01 2021-04-01 Procédé de détermination non invasive du contenu en glucose du sang d'une personne

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/RU2021/000140 WO2022211660A1 (fr) 2021-04-01 2021-04-01 Procédé de détermination non invasive du contenu en glucose du sang d'une personne

Publications (1)

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WO2022211660A1 true WO2022211660A1 (fr) 2022-10-06

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PCT/RU2021/000140 Ceased WO2022211660A1 (fr) 2021-04-01 2021-04-01 Procédé de détermination non invasive du contenu en glucose du sang d'une personne

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101390751A (zh) * 2008-11-07 2009-03-25 中南大学 无创血糖检测传感器集成器
US20110124987A1 (en) * 2008-04-21 2011-05-26 Drexel University Methods for Measuring Changes in Optical Properties of Wound Tissue and Correlating Near Infrared Absorption (FNIR) and Diffuse Reflectance Spectroscopy Scattering (DRS) With Tissue Neovascularization and Collagen Concentration to Determine Whether Wound is Healing
US20150133794A1 (en) * 2012-11-21 2015-05-14 Folim G. Halaka Cancer cell detection using dielectrophoretic dynamic light scattering (ddls) spectroscopy
CN107320112A (zh) * 2017-07-07 2017-11-07 广州医软智能科技有限公司 微循环的多参数成像检测方法及装置

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110124987A1 (en) * 2008-04-21 2011-05-26 Drexel University Methods for Measuring Changes in Optical Properties of Wound Tissue and Correlating Near Infrared Absorption (FNIR) and Diffuse Reflectance Spectroscopy Scattering (DRS) With Tissue Neovascularization and Collagen Concentration to Determine Whether Wound is Healing
CN101390751A (zh) * 2008-11-07 2009-03-25 中南大学 无创血糖检测传感器集成器
US20150133794A1 (en) * 2012-11-21 2015-05-14 Folim G. Halaka Cancer cell detection using dielectrophoretic dynamic light scattering (ddls) spectroscopy
CN107320112A (zh) * 2017-07-07 2017-11-07 广州医软智能科技有限公司 微循环的多参数成像检测方法及装置

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