[go: up one dir, main page]

WO2022211183A1 - Position-adjustable drug administration device - Google Patents

Position-adjustable drug administration device Download PDF

Info

Publication number
WO2022211183A1
WO2022211183A1 PCT/KR2021/006829 KR2021006829W WO2022211183A1 WO 2022211183 A1 WO2022211183 A1 WO 2022211183A1 KR 2021006829 W KR2021006829 W KR 2021006829W WO 2022211183 A1 WO2022211183 A1 WO 2022211183A1
Authority
WO
WIPO (PCT)
Prior art keywords
unit
nozzle
administration device
drug administration
drug
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2021/006829
Other languages
French (fr)
Korean (ko)
Inventor
김희승
이정찬
이은지
박수진
문재희
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SEOUL TECHNO HOLDINGS Inc
Original Assignee
SEOUL TECHNO HOLDINGS Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SEOUL TECHNO HOLDINGS Inc filed Critical SEOUL TECHNO HOLDINGS Inc
Publication of WO2022211183A1 publication Critical patent/WO2022211183A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/006—Sprayers or atomisers specially adapted for therapeutic purposes operated by applying mechanical pressure to the liquid to be sprayed or atomised
    • A61M11/007—Syringe-type or piston-type sprayers or atomisers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/06—Sprayers or atomisers specially adapted for therapeutic purposes of the injector type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M2025/0008—Catheters; Hollow probes having visible markings on its surface, i.e. visible to the naked eye, for any purpose, e.g. insertion depth markers, rotational markers or identification of type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/10—Trunk
    • A61M2210/1021—Abdominal cavity

Definitions

  • the present invention relates to a drug administration device capable of administering a drug into the body.
  • a drug administration device capable of efficiently administering a drug into the body by changing the position of the nozzle.
  • Cancer remains a difficult problem to solve.
  • the typical treatment method is to administer an anticancer agent, a drug that acts on various metabolic pathways of cancer cells and exhibits cytotoxic and growth inhibitory effects on cancer cells. is in progress
  • the method of administering anticancer drugs was difficult to exert due to weak absorption in the body.
  • a method of directly administering intraperitoneal anticancer drugs was developed.
  • the method of administering an intraperitoneal anticancer agent is to utilize a trocar, a laparoscopic observation device, and an injector.
  • trocars of different diameters (about 5mm, 12mm) are prepared.
  • the method of administration of anticancer drugs is as follows.
  • a trocar is inserted into the abdominal cavity and installed so that the inside and outside of the abdominal cavity communicate.
  • the plurality of trocars are preferably spaced apart.
  • the intra-abdominal pressure is increased using a laparoscope.
  • intra-abdominal pressure is maintained after increasing to 12 mmHg.
  • the laparoscopic observation device is injected into the trocar having a diameter of 5 mm so that the situation in the abdominal cavity can be checked on an external monitor.
  • the operator observes the intra-abdominal condition through the monitor and places the injector into the abdominal cavity using a 12mm trocar.
  • the operator places the injector at the target position and then injects the drug onto the target using the injector.
  • the drug absorption efficiency is increased compared to the prior art, but there is a problem in that the drug is concentrated and distributed in a specific location. That is, the administration efficiency of the drug was partially increased, but this was not a satisfactory level.
  • the drug is administered to a position adjacent to the drug discharge portion of the injector, but the drug is not administered to a distant position, so there are still problems to be solved in terms of drug delivery.
  • the present invention has been made to solve the above problems, and an object of the present invention is to provide a drug administration device capable of uniformly injecting a drug into the abdominal cavity.
  • the drug administration device for administering intraperitoneal drugs has a fixed frame part, one side abutting on the fixed frame part, a hollow hole is formed, and a nozzle part and the nozzle for moving and supplying the drug supplied to one side to the other side through the hollow hole It is located on the periphery of the unit includes a control unit capable of adjusting the position of the nozzle unit.
  • the nozzle part is characterized in that it is connected to the fixed frame part with the adjusting part interposed therebetween.
  • the nozzle part is rotatably connected to the fixed frame part.
  • the adjustment part is inclined at a set angle and is connected to the fixed frame part, and the nozzle part is inclined at an angle corresponding to the inclined angle of the adjustment part.
  • the adjusting unit is characterized in that it can move the nozzle unit in one direction or the other by a set length.
  • the distance the control unit moves the nozzle unit is characterized in that 1cm to 10cm.
  • the adjusting unit includes a pressing unit disposed at a symmetrical position to press the nozzle unit at a symmetrical position, and the nozzle unit may be moved in one direction or the other direction by releasing the pressing force due to a change in the pressing force of the pressing unit. do.
  • the pressing part is a roller, and it is characterized in that the nozzle part can be moved by rotation of the roller in one direction or the other direction.
  • the pressing part is a slider that can slide in one direction or the other, so that the nozzle part can be moved by sliding.
  • the drug dispensing device of the present invention is a cylinder part for supplying a drug to a supply hole located on one side according to the action of the piston applied in one direction, the drug is located therein, the fixed frame part positioned spaced apart from the cylinder, the fixed One side is fixed in contact with the frame part, and one side includes a nozzle part for supplying the drug supplied by the supply hole and the cylinder part to the other side, and a control part installed in the nozzle part to change the position of the nozzle part do.
  • the adjusting part is installed in the nozzle part in a form that surrounds the nozzle part, and one surface of the adjusting part is connected to and in contact with the fixed frame part.
  • the nozzle part is characterized in that it is connected to be rotatably based on an axis set in the fixed frame part.
  • the adjusting unit includes a pressing unit disposed at a symmetrical position to press the nozzle unit at a symmetrical position, and the nozzle unit may be moved in one direction or the other direction by releasing the pressing force due to a change in the pressing force of the pressing unit. do.
  • the nozzle part can be rotated at an angle set based on the fixed frame part, and the depth positioned in the abdominal cavity can be changed.
  • 1 is a drug administration device of the present invention according to a first embodiment.
  • Figure 2a is a cross-sectional view of the nozzle portion of the present invention drug dispensing device according to one embodiment
  • Figure 2b is a cross-sectional view of the nozzle portion of the present invention drug dispensing device according to another embodiment.
  • 3 is a drug administration device of the present invention according to the second embodiment.
  • Figure 4a is a control unit of the present invention drug dispensing device according to an embodiment
  • Figure 4b shows the addition of a stop portion to the control unit of the present invention drug dispensing device according to an embodiment.
  • Figure 5a is a control unit of the present invention drug administration device according to another embodiment
  • Figure 5b shows the addition of a stop portion to the control unit of the present invention drug administration device according to another embodiment.
  • FIG. 6A is a design diagram of the experimental box viewed from the front
  • FIG. 6B is a design diagram of the experimental box viewed directly from the top.
  • FIG. 7 is a view showing a comparison of the depth of penetration of the injected solution into the peritoneum of the pig when the nozzle unit has a distance of 2 cm, 4 cm, and 8 cm from the floor according to an embodiment.
  • Figure 8 is an experiment of drug penetration depth results after varying the distance from the floor to the nozzle unit at each point of the experiment box, and DCD (depth of concentrated diffusion) and DMD (depth of maximal diffusion) for each point and distance it is measured
  • FIG. 9A is a graph showing the experimental results of FIG. 8
  • FIG. 9B is a table of the experimental results of FIG. 8 .
  • 1 is a drug administration device of the present invention according to a first embodiment.
  • the drug administration device of the present invention includes a fixed frame unit 100 , a nozzle unit 200 , and an adjustment unit 300 .
  • the drug administration device according to the present invention may further include a cylinder unit 400 and a control unit 500 .
  • it may further include a trocar, an endoscope, and a display for the implementation of the drug administration device of the present invention.
  • the nozzle unit 200 may be moved along the circumference of the fixed frame unit 100 , and the nozzle unit 200 may be rotated based on a portion in contact with the fixed frame unit 100 , Due to the control unit 300, the nozzle unit 200 can be moved to one side or the other side, so that the drug can be evenly delivered into the abdominal cavity.
  • the fixed frame part 100 includes a body part 110 and a perimeter part 120 .
  • the body portion 110 and the perimeter portion 120 may be formed in a circular shape that is easy to rotate, for example. More precisely, the body portion 110 may be formed to be observed in a cylindrical shape, and the peripheral portion 120 may be formed to be observed in a plate shape.
  • the fixed frame unit 100 is connected to the control unit 500 and may rotate in the longitudinal direction when receiving a signal from the control unit 500 .
  • the body part 110 and the peripheral part 120 are integrally connected, and when a control signal is applied, the body part 110 and the peripheral part 120 may be integrally rotated about the aforementioned axis.
  • the peripheral part 120 is operated independently of the body part 110 , so that only the peripheral part 120 may be rotated about the body part 110 as an axis.
  • the peripheral part 120 is rotatably connected to the body part 110 and the gears, bearings, shafts, etc., so that when a control signal from the control unit 500 is applied, the peripheral part 120 is moved in one direction or the other. direction can be rotated.
  • Figure 2a is a cross-sectional view of the nozzle unit 200 of the present invention drug dispensing device according to an embodiment
  • Figure 2b is a cross-sectional view of the nozzle unit 200 of the present invention drug dispensing device according to another embodiment.
  • the end side of the nozzle unit 200 will be described with reference to FIGS. 2A and 2B .
  • the nozzle unit 200 has a set length and includes a hollow hole. Therefore, the nozzle unit 200 may receive the drug through one side and move it to the other side to be administered into the abdominal cavity. A flow path may be formed on the other side of the nozzle unit 200 to spray the drug.
  • the other end side of the nozzle unit 200 may be provided with a swirl chamber, and the tip portion may be formed in an inclined shape.
  • the vortex part 210 is located inside the nozzle part 200 and is arranged to close the hollow hole.
  • a circumferential flow path may be formed around the vortex portion 210 . The drug is moved along the circumferential flow path when entering the vortex chamber, and when sprayed from the tip of the nozzle unit 200, it may be sprayed in the form of a spray due to the vortex.
  • the nozzle part 200 may include a spring 230 and a closing part 220 .
  • the spring 230 may support the nozzle unit 200 .
  • the closing part 220 has a flow path formed along the periphery like the vortex part 210 . Therefore, the drug passes through the flow path of the closure part 220 like the vortex part 210 described above and moves between the closure part 220 and the tip of the nozzle part 200 .
  • a hollow hole is also formed at the tip of the nozzle unit 200 , but the size thereof is very small compared to the hollow holes formed in the nozzle unit 200 .
  • the drug is pressed between the tip and the closure part 220 according to the operation of the spring 230 and passes through the tip, and may be sprayed in the form of a spray.
  • the nozzle unit 200 is connected to the fixed frame unit 100 in contact with one side. More precisely, the nozzle part 200 is fixed in contact with one surface of the peripheral part 120 of the fixed frame part 100 .
  • the nozzle unit 200 is disposed at a set angle with the fixed frame unit 100 .
  • the nozzle part 200 is connected to the fixed frame part 100 so that the other end (tip part) of the nozzle part 200 faces the center of the fixed frame part 100 .
  • the nozzle unit 200 and the fixed frame unit 100 are connected through the rotating unit 240 .
  • the nozzle unit 200 may be connected to the fixed frame unit 100 and the rotating unit 240 .
  • the rotating unit 240 permits movement of the nozzle unit 200 to be rotatable with respect to the fixed frame unit 100 . In this case, the set angle formed by the nozzle unit 200 in relation to the fixed frame unit 100 is maintained.
  • the adjusting unit 300 is disposed to surround the nozzle unit 200 .
  • the adjusting unit 300 moves the nozzle unit 200 in one direction or the other direction. Accordingly, the depth of the nozzle unit 200 in the abdominal cavity may be adjusted.
  • the above-described rotating unit 240 may allow the nozzle unit 200 to move along the longitudinal direction of the nozzle unit 200 .
  • the rotating unit 240 may include a fixed housing unit and a pressure bar.
  • the fixed housing portion is formed with a hole having a shape corresponding to the circumference of the nozzle unit 200, and a hole through which the pressure bar can be drawn in and out is formed on one side.
  • the fixed housing unit is rotatably connected to the fixed frame unit 100 .
  • the nozzle unit 200 may be disposed in the fixed housing unit, and the pressure bar may be inserted into a hole formed in a side surface of the fixed housing unit to fix the nozzle unit 200 .
  • the pressure bar may be moved in a direction drawn out from the hole of the fixed housing unit to allow the longitudinal movement of the nozzle unit 200 .
  • the pressure bar may be connected to the fixed housing through a spring.
  • the pressure bar may be drawn in or drawn out according to the application of the control signal of the controller 500 .
  • the cylinder part 400 may be fixedly positioned on one side.
  • the cylinder part 400 may include a body part 410 and a plunger part 420 .
  • the body portion 410 has a supply hole formed on one side and a space is formed therein, so that the drug can be located.
  • the plunger part 420 may be moved along the longitudinal direction of the body part 110 inside the body part 410 .
  • the plunger part 420 applies a pressing force so that the drug located in the body part 410 is ejected through the supply hole.
  • a pipe part may be connected to one side of the nozzle part 200 and to each of the supply holes of the body part 410 of the cylinder part 400 . Therefore, the drug located in the cylinder unit 400 may be sprayed into the abdominal cavity through the nozzle unit 200 .
  • the drug administration device according to the first embodiment may be operated as follows.
  • the operator places two or more trocars in the abdominal cavity on the patient.
  • the operator places the endoscope in the patient's abdominal cavity through a trocar.
  • the operator checks the screen output to the display through the endoscope to check the condition of the patient's abdominal cavity.
  • the nozzle unit 200 of the drug administration device of the present invention is positioned on another trocar.
  • the depth of the nozzle unit 200 may be adjusted through the adjustment unit 300 .
  • the rotation angle of the nozzle unit 200 may be changed through the rotation unit 240 .
  • the angle of the nozzle unit 200 may be changed according to the rotation of the fixed frame unit 100 .
  • the position of the nozzle unit 200 may be variously changed.
  • the cylinder unit 400 is operated to inject the drug, and the intraperitoneal drug may be administered in the form of a spray through the nozzle unit 200 .
  • the nozzle unit 200 is rotated along the circumference of the fixed frame unit 100 and can administer a drug. That is, the nozzle unit 200 may move in a cone shape to administer the drug.
  • 3 is a drug administration device of the present invention according to the second embodiment.
  • the drug administration device may be provided with one rotating unit 240 and one adjusting unit 300 . That is, the nozzle unit 200 does not come into contact with the fixed frame unit 100 , but the adjustment unit 300 connected to the nozzle unit 200 in a form surrounding the nozzle unit 200 abuts the fixed frame unit 100 . All.
  • the adjusting unit 300 may adjust the set angle of the cylinder and at the same time change the position in the longitudinal direction of the cylinder.
  • the adjusting unit 300 is installed while maintaining a set angle with the fixed frame unit 100
  • the nozzle unit 200 is installed in the adjusting unit 300
  • the nozzle unit 200 is also based on the fixed frame unit 100 .
  • the adjusting unit 300 may be rotated while maintaining an angle set with respect to the fixed frame unit 100 in the same manner as the above-described rotating unit 240 .
  • the nozzle unit 200 may be rotated together with the adjusting unit 300 to change the position of the other end.
  • the control unit 300 moves the nozzle unit 200 in one direction or the other direction so that the nozzle unit 200 can be located deeply or shallowly in the abdominal cavity.
  • Figure 4a is a control unit of the present invention drug dispensing device according to an embodiment
  • Figure 4b shows the addition of a stop portion to the control unit of the present invention drug dispensing device according to an embodiment.
  • the adjusting unit 300 may be configured to include a pressing unit 320 .
  • the control unit 300 is spaced apart in the fixed housing unit 310 so that the pressing unit 320 is disposed, and the nozzle unit 200 is positioned between the pressing units 320 by applying and releasing the pressing force of the pressing unit 320 . It is possible to enable movement of the nozzle unit 200 in one direction or in the other direction.
  • the pressing unit 320 may be a roller.
  • rollers are arranged spaced apart, and the nozzle unit 200 is disposed in contact with the rollers between the rollers, so that the nozzle unit 200 is moved according to the rotation of the roller in one direction or the other direction, and accordingly, the position of the nozzle unit 200 is can be changed.
  • Four rollers may be arranged at the corners of a rectangle in the fixed housing unit 310 for safe fixing of the nozzle unit 200 . However, it is sufficient if one or more rollers are provided.
  • the roller may include a wheel part 321 and a flange part 322 .
  • the wheel part 321 may be formed in a circular shape, and the circumference may be formed in a smooth shape.
  • the flange portion 322 may be formed to protrude from the wheel portion 321 in a radial direction.
  • the flange part 322 may be formed on one side and the other side of the wheel part 321 . Therefore, a groove is formed between the flange parts 322 , and when the nozzle part 200 is positioned at this position, the nozzle part 200 is guided in the wheel part 321 and can be moved in one direction or the other direction.
  • the present invention of the embodiment shown in FIG. 4B has a configuration similar to that of the embodiment shown in FIG. 4A, but the control unit 300 and the nozzle unit 200 may include additional stops 250 and 330, respectively. have.
  • the stop part 250 may be, for example, an electromagnet. That is, the stop part 250 may be disposed on some surface of the nozzle part 200 , and the stop part 330 may also be disposed on the adjustment part 300 .
  • the controller 500 applies a control signal to operate the stop part of the nozzle part 200 and the stop parts 250 and 330 built in the wheel part 321 to prevent the nozzle part 200 from moving. ) can be fixed. After that, when it is necessary to move the nozzle unit 200 , the control unit 500 does not apply the control signal. In this case, the stop part 250 of the nozzle part 200 and the stop part 330 of the wheel part 321 stop operating, and the nozzle part 200 may move in one direction or the other direction.
  • Figure 5a is a control unit of the present invention drug administration device according to another embodiment
  • Figure 5b shows the addition of a stop portion to the control unit of the present invention drug administration device according to another embodiment.
  • the adjusting unit 300 of the present invention may be a slider 340 .
  • a groove may be formed in the fixed housing portion 310 of the adjustment unit 300 along the length of the fixed housing portion 310 , and a slider 340 movable along the groove may be positioned.
  • the slider 340 may be connected to the nozzle unit 200 . Accordingly, the nozzle unit 200 may be moved according to the movement of the slider 340 in one direction or the other direction. Therefore, the position of the nozzle unit 200 in the abdominal cavity may be changed.
  • the present invention according to the embodiment shown in Fig. 5B is similar to the configuration of the invention according to the embodiment shown in Fig. 5A.
  • the stop portion 330 may be additionally included.
  • the stop part 330 may be located in the fixed housing part 310 and the slider 340 . Therefore, when the control signal of the control unit 500 is not applied, the slider 340 moves along the groove of the fixed housing unit 310 to change the position of the nozzle unit 200, and when the control signal is applied, the slider 340 ) may be fixed in position in the fixed housing unit 310 .
  • FIG. 6A is a design diagram of the experimental box viewed from the front
  • FIG. 6B is a design diagram of the experimental box viewed directly from the top.
  • test box is 21X16X15cm (3.5L volume) and is made of plastic.
  • Pig peritoneal tissue was placed in the experimental box.
  • the peritoneal tissue of the pig was positioned at a point corresponding to 1:1:1 or 2:1 based on the length of the box in FIGS. 6A and 6B in consideration of the asymmetry of the human body.
  • the volume of the peritoneal tissue of the pig was set to 3X3X0.5 cm.
  • the point at which the nozzle part is located in the test box was set to point A to point F.
  • Thermometers were inserted at positions that did not overlap with points A to F.
  • the test box was fixed in a bathtub filled with hot water at 36 degrees.
  • the injection pressure of the nozzle part was set to 7 bar, and a 30 ⁇ m-sized aerosol was injected at a speed of 5 km/h and 30 ml/min.
  • 50 ml of 1% methylene blue was used as the sprayed liquid, and to measure the penetration depth of the drug, 3 mg of doxorubicin mixed with 50 ml of 0.9% NaCl was used. That is, the spray range and penetration depth were measured using two liquids.
  • the pressure in the test box was maintained at 12 mmHg for 30 minutes, and then the nozzle unit 200 was removed using an air-waste system equipped with a glass microfilter.
  • the nozzle part was positioned 2cm, 4cm, and 8cm apart from the floor at points A to H, and experiments were performed, respectively.
  • FIG. 7 is a view showing a comparison of the depth of penetration of the injected solution into the peritoneum of the pig when the nozzle unit has a distance of 2 cm, 4 cm, and 8 cm from the floor according to an embodiment.
  • doxorubicin After spraying doxorubicin to test the penetration depth using the nozzle, 1.5 ⁇ g/ml of 4',6-diamidino-2-phenylindole (DAPI) staining was performed on the pig peritoneal tissue, and the penetration depth was measured by confocal laser scanning microscopy. I checked using it.
  • DAPI 4',6-diamidino-2-phenylindole
  • the depth of drug penetration is defined as the depth of concentrated diffusion (DCD) where most of the drug is distributed and the depth of maximal diffusion (DMD), which is the maximum penetration depth of the drug. 4cm and 8cm were different.
  • Figure 8 is an experiment of drug penetration depth results after varying the distance from the floor to the nozzle unit at each point of the experiment box, and DCD (depth of concentrated diffusion) and DMD (depth of maximal diffusion) for each point and distance it is measured
  • FIG. 9A is a graph showing the experimental results of FIG. 8
  • FIG. 9B is a table of the experimental results of FIG. 8 .

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Mechanical Engineering (AREA)
  • Biophysics (AREA)
  • Pulmonology (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

Disclosed is a drug administration device comprising: a fixed frame part; a nozzle part having one side in contact with the fixed frame part, and comprising a hollow hole so that a drug provided to the one side is moved and supplied to the other side through the hollow hole; and a control part positioned at the perimeter of the nozzle part so as to be capable of adjusting the position of the nozzle part.

Description

위치 조절이 가능한 약물투여장치Position-adjustable drug administration device

본 발명은 체내에 약물을 투여할 수 있는 약물투여장치에 관한 것이다.The present invention relates to a drug administration device capable of administering a drug into the body.

보다 정확하게는 노즐의 위치가 변경 가능하여 효율적으로 채내에 약물을 투여할 수 있는 약물투여장치에 관한 것이다.More precisely, it relates to a drug administration device capable of efficiently administering a drug into the body by changing the position of the nozzle.

암은 풀기 어려운 숙제로 남아있다. 항암 치료의 방식은 그 종류가 다양하나, 암세포의 각종 대사경로에 작용하여 암세포에 세포독성, 성장억제효과를 나타내는 약물인 항암제를 투여하는 것이 대표적인 치료의 방식이며, 암을 극복하기 위하여 이에 연구가 진행되고 있다.Cancer remains a difficult problem to solve. Although there are various types of anticancer treatment, the typical treatment method is to administer an anticancer agent, a drug that acts on various metabolic pathways of cancer cells and exhibits cytotoxic and growth inhibitory effects on cancer cells. is in progress

항암제 투여 방식은 체내 흡수가 약하여 약효가 발휘되는데 어려움이 있었다. 이를 해결하기 위한 방식으로 복강 내 항암제를 직접 투여하는 방식의 개발되었다.The method of administering anticancer drugs was difficult to exert due to weak absorption in the body. In order to solve this problem, a method of directly administering intraperitoneal anticancer drugs was developed.

일반적으로 복강 내 항암제를 투여하는 방식은 투관침, 복강경 관찰기구, 인젝터를 활용하는 것이 이용된다. 일반적으로 투관침은 직경이 다른(약 5mm, 12mm) 것이 준비된다.In general, the method of administering an intraperitoneal anticancer agent is to utilize a trocar, a laparoscopic observation device, and an injector. In general, trocars of different diameters (about 5mm, 12mm) are prepared.

함암제(약물) 투여방식은 다음과 같다. The method of administration of anticancer drugs (drugs) is as follows.

우선 복강 내외가 연통되도록 투관침을 복강에 삽입하여 설치한다. 복수의 투관침은 당연하게도 이격되어 위치됨이 바람직하다. 이후 복강경을 이용하여 복강 내 압력을 상승시킨다. 일례로 복강압은 12 mmHg까지 상승 후 유지한다.First, a trocar is inserted into the abdominal cavity and installed so that the inside and outside of the abdominal cavity communicate. Of course, the plurality of trocars are preferably spaced apart. Thereafter, the intra-abdominal pressure is increased using a laparoscope. For example, intra-abdominal pressure is maintained after increasing to 12 mmHg.

이후 복강경 관찰기구를 5mm의 직경을 가지는 투관침 내로 주입하여 복강 내 상황을 외부의 모니터에서 확인할 수 있도록 한다. 시술자는 모니터를 통하여 복강 내 상태를 관찰하며, 12mm 투관침을 이용하여 인젝터를 복강 내에 위치시킨다. 시술자는 목표하고자 하는 위치에 인젝터를 위치시킨 후 인젝터를 이용하여 표적에 약물을 분사한다.Thereafter, the laparoscopic observation device is injected into the trocar having a diameter of 5 mm so that the situation in the abdominal cavity can be checked on an external monitor. The operator observes the intra-abdominal condition through the monitor and places the injector into the abdominal cavity using a 12mm trocar. The operator places the injector at the target position and then injects the drug onto the target using the injector.

이와 같은 방식으로 인하여 약물의 흡수 효율은 종래 대비 약물 흡수 효율은 증가하였으나, 약물이 특정한 위치에 집중 분포된다는 문제점을 겪고 있다. 즉, 약물의 투여 효율이 일부 증가하였으나, 이는 만족할만한 수준이 아니었다. Due to this method, the drug absorption efficiency is increased compared to the prior art, but there is a problem in that the drug is concentrated and distributed in a specific location. That is, the administration efficiency of the drug was partially increased, but this was not a satisfactory level.

즉, 위와 같은 약물 투여방식은 인젝터의 약물 배출 부분과 인접한 위치에는 약물 투여되나 먼 위치에는 약물이 투여되지 않아, 약물의 전달이라는 측면에서는 아직도 해결되어야 할 문제점들이 남아있다.That is, in the above drug administration method, the drug is administered to a position adjacent to the drug discharge portion of the injector, but the drug is not administered to a distant position, so there are still problems to be solved in terms of drug delivery.

본 발명은 전술한 문제점을 해결하고자 한 것으로, 복강 내에 약물을 균등하게 분사할 수 있는 약물투여장치를 제공하는데 목적이 있다.The present invention has been made to solve the above problems, and an object of the present invention is to provide a drug administration device capable of uniformly injecting a drug into the abdominal cavity.

복강 내 약물을 투여하는 약물투여장치는 고정프레임부, 상기 고정프레임부와 일측이 맞닿고, 중공홀이 형성되어 일측으로 공급받은 약물을 상기 중공홀을 통하여 타측으로 이동 공급하는 노즐부 및 상기 노즐부의 둘레에 위치되어 상기 노즐부의 위치를 조절할 수 있는 조절부를 포함한다.The drug administration device for administering intraperitoneal drugs has a fixed frame part, one side abutting on the fixed frame part, a hollow hole is formed, and a nozzle part and the nozzle for moving and supplying the drug supplied to one side to the other side through the hollow hole It is located on the periphery of the unit includes a control unit capable of adjusting the position of the nozzle unit.

상기 노즐부는 상기 조절부를 사이에 두고 상기 고정프레임부와 연결되는 것을 특징으로 한다.The nozzle part is characterized in that it is connected to the fixed frame part with the adjusting part interposed therebetween.

상기 노즐부는 상기 고정프레임부와 회동 가능하게 연결되는 것을 특징으로 한다.The nozzle part is rotatably connected to the fixed frame part.

상기 조절부는 설정된 각도로 경사져서 상기 고정프레임부와 연결되고, 상기 노즐부는 상기 조절부의 경사진 각도와 대응되는 각도로 경사진 것을 특징으로 한다.The adjustment part is inclined at a set angle and is connected to the fixed frame part, and the nozzle part is inclined at an angle corresponding to the inclined angle of the adjustment part.

상기 조절부는 상기 노즐부를 설정된 길이만큼 일방향 또는 타방향으로 이동시킬 수 있는 것을 특징으로 한다.The adjusting unit is characterized in that it can move the nozzle unit in one direction or the other by a set length.

상기 조절부가 상기 노즐부를 움직이는 거리는 1cm 내지 10cm인 것을 특징으로 한다.The distance the control unit moves the nozzle unit is characterized in that 1cm to 10cm.

상기 조절부는 대칭되는 위치에 배치되어 상기 노즐부를 대칭되는 위치에서 가압하는 가압부를 포함하며 상기 가압부의 가압력의 변화로 인하여 상기 노즐부는 상기 가압력이 해제되어 일방향 또는 타방향으로 이동될 수 있는 것을 특징으로 한다.The adjusting unit includes a pressing unit disposed at a symmetrical position to press the nozzle unit at a symmetrical position, and the nozzle unit may be moved in one direction or the other direction by releasing the pressing force due to a change in the pressing force of the pressing unit. do.

상기 가압부는 롤러이며, 상기 롤러의 일방향 또는 타방향 회전으로 상기 노즐부를 이동시킬 수 있는 것을 특징으로 한다.The pressing part is a roller, and it is characterized in that the nozzle part can be moved by rotation of the roller in one direction or the other direction.

상기 가압부는 일방향 또는 타방향으로 슬라이드 이동할 수 있는 슬라이더여서 슬라이드 이동에 의하여 상기 노즐부를 이동시킬 수 있는 것을 특징으로 한다.The pressing part is a slider that can slide in one direction or the other, so that the nozzle part can be moved by sliding.

또한, 본 발명인 약물투여장치는 내부에 약물이 위치되고, 일방향으로 가해지는 피스톤의 동작에 따라 일측에 위치된 공급홀로 약물을 공급하는 실린더부, 상기 실린더와 이격되어 위치되는 고정프레임부, 상기 고정프레임부에 일면이 맞닿아 고정되며, 일측이 상기 공급홀과 상기 실린더부에 의하여 공급되는 상기 약물을 타측으로 공급하는 노즐부 및 상기 노즐부에 설치되어 상기 노즐부의 위치를 변경할 수 있는 조절부를 포함한다.In addition, the drug dispensing device of the present invention is a cylinder part for supplying a drug to a supply hole located on one side according to the action of the piston applied in one direction, the drug is located therein, the fixed frame part positioned spaced apart from the cylinder, the fixed One side is fixed in contact with the frame part, and one side includes a nozzle part for supplying the drug supplied by the supply hole and the cylinder part to the other side, and a control part installed in the nozzle part to change the position of the nozzle part do.

상기 조절부는 상기 노즐부를 감싸는 형태로 상기 노즐부에 설치되고, 상기 조절부의 일면은 상기 고정프레임부와 맞닿으며 연결되는 것을 특징으로 한다.The adjusting part is installed in the nozzle part in a form that surrounds the nozzle part, and one surface of the adjusting part is connected to and in contact with the fixed frame part.

상기 노즐부는 상기 고정프레임부에서 설정된 축을 기준으로 회동 가능하게 연결되는 것을 특징으로 한다.The nozzle part is characterized in that it is connected to be rotatably based on an axis set in the fixed frame part.

상기 조절부는 대칭되는 위치에 배치되어 상기 노즐부를 대칭되는 위치에서 가압하는 가압부를 포함하며 상기 가압부의 가압력의 변화로 인하여 상기 노즐부는 상기 가압력이 해제되어 일방향 또는 타방향으로 이동될 수 있는 것을 특징으로 한다.The adjusting unit includes a pressing unit disposed at a symmetrical position to press the nozzle unit at a symmetrical position, and the nozzle unit may be moved in one direction or the other direction by releasing the pressing force due to a change in the pressing force of the pressing unit. do.

본 발명은 노즐부가 고정프레임부를 기준으로 설정된 각도로 회동될 수 있으며, 복강 내에 위치되는 깊이가 변경될 수 있으므로, 복강 내 넓은 면적에 약물을 분산하여 투여할 수 있어 약물의 효율적 투여가 가능하다. In the present invention, the nozzle part can be rotated at an angle set based on the fixed frame part, and the depth positioned in the abdominal cavity can be changed.

도 1은 제1실시예에 의한 본 발명인 약물투여장치이다.1 is a drug administration device of the present invention according to a first embodiment.

도 2a는 일 실시예에 의한 본 발명인 약물투여장치의 노즐부의 단면도이고, 도 2b는 다른 실시예에 의한 본 발명인 약물투유장치의 노즐부의 단면도이다.Figure 2a is a cross-sectional view of the nozzle portion of the present invention drug dispensing device according to one embodiment, Figure 2b is a cross-sectional view of the nozzle portion of the present invention drug dispensing device according to another embodiment.

도 3은 제2실시예에 의한 본 발명인 약물투여장치이다.3 is a drug administration device of the present invention according to the second embodiment.

도 4a는 일 실시예에 의한 본 발명인 약물투여장치의 조절부이고, 도 4b는 일 실시예에 의한 본 발명인 약물투여장치의 조절부에 스톱부가 추가된 것을 도시한 것이다.Figure 4a is a control unit of the present invention drug dispensing device according to an embodiment, Figure 4b shows the addition of a stop portion to the control unit of the present invention drug dispensing device according to an embodiment.

도 5a는 다른 실시예에 의한 본 발명인 약물투여장치의 조절부이고, 도 5b는 다른 실시예에 의한 본 발명인 약물투여장치의 조절부에 스톱부가 추가된 것을 도시한 것이다.Figure 5a is a control unit of the present invention drug administration device according to another embodiment, Figure 5b shows the addition of a stop portion to the control unit of the present invention drug administration device according to another embodiment.

도 6a는 실험 박스를 정면에서 바라본 형태의 설계도이고, 도 6b는 실험 박스를 상면에서 바로본 형태의 설계도이다.6A is a design diagram of the experimental box viewed from the front, and FIG. 6B is a design diagram of the experimental box viewed directly from the top.

도 7은 일 실시예에 의하여 노즐부가 바닥과의 거리가 2cm, 4cm, 8cm 일 때 분사된 용액이 돼지 복막에 침투한 깊이 정도를 비교하여 도시한 것이다.7 is a view showing a comparison of the depth of penetration of the injected solution into the peritoneum of the pig when the nozzle unit has a distance of 2 cm, 4 cm, and 8 cm from the floor according to an embodiment.

도 8은 노즐부를 실험박스의 각각의 포인트에 바닥과의 거리를 다르게 한 후 약물 침투 깊이 결과를 실험한 것으로 각각의 포인트 및 거리별로 DCD(depth of concentrated diffusion) 및 DMD(depth of maximal diffusion)를 측정한 것이다.Figure 8 is an experiment of drug penetration depth results after varying the distance from the floor to the nozzle unit at each point of the experiment box, and DCD (depth of concentrated diffusion) and DMD (depth of maximal diffusion) for each point and distance it is measured

도 9a는 도 8의 실험결과를 그래프로 도시한 것이며, 도 9b는 도 8의 실험결과를 테이블로 정리한 것이다.FIG. 9A is a graph showing the experimental results of FIG. 8 , and FIG. 9B is a table of the experimental results of FIG. 8 .

이하, 본 발명의 일실시예를 예시적인 도면을 통해 상세하게 설명한다. 그러나 이는 본 발명의 범위를 한정하려고 의도된 것은 아니다.Hereinafter, an embodiment of the present invention will be described in detail with reference to exemplary drawings. However, this is not intended to limit the scope of the present invention.

각 도면의 구성요소들에 참조부호를 부가함에 있어서, 동일한 구성요소들에 대해서는 비록 다른 도면상에 표시되더라도 가능한 한 동일한 부호를 가지도록 하고 있음에 유의해야 한다. 또한, 본 발명을 설명함에 있어, 관련된 공지 구성 또는 기능에 대한 구체적인 설명이 본 발명의 요지를 흐릴 수 있다고 판단되는 경우에는 그 상세한 설명은 생략한다.In adding reference numerals to the components of each drawing, it should be noted that the same components are given the same reference numerals as much as possible even though they are indicated on different drawings. In addition, in describing the present invention, if it is determined that a detailed description of a related known configuration or function may obscure the gist of the present invention, the detailed description thereof will be omitted.

또한, 도면에 도시된 구성요소의 크기나 형상 등은 설명의 명료성과 편의상 과장되게 도시될 수 있다. 또한, 본 발명의 구성 및 작용을 고려하여 특별히 정의된 용어들은 본 발명의 실시예를 설명하기 위한 것일 뿐이고, 본 발명의 범위를 한정하는 것이 아니다.In addition, the size or shape of the components shown in the drawings may be exaggerated for clarity and convenience of explanation. In addition, terms specifically defined in consideration of the structure and operation of the present invention are only for describing the embodiments of the present invention, and do not limit the scope of the present invention.

도 1은 제1실시예에 의한 본 발명인 약물투여장치이다.1 is a drug administration device of the present invention according to a first embodiment.

본 발명인 약물투여장치는 고정프레임부(100), 노즐부(200), 조절부(300)를 포함한다. 또한, 본 발명인 약물투여장치는 실린더부(400), 제어부(500)를 더 포함할 수 있다. 또한, 본 발명인 약물투여장치의 실시를 위하여 추가로 투관침, 내시경 및 디스플레이를 포함할 수 있다.The drug administration device of the present invention includes a fixed frame unit 100 , a nozzle unit 200 , and an adjustment unit 300 . In addition, the drug administration device according to the present invention may further include a cylinder unit 400 and a control unit 500 . In addition, it may further include a trocar, an endoscope, and a display for the implementation of the drug administration device of the present invention.

본 발명인 약물투여장치는 노즐부(200)가 고정프레임부(100)의 둘레를 따라서 이동될 수 있으며, 노즐부(200)가 고정프레임부(100)와 맞닿은 부분을 기준으로 회동될 수 있으며, 조절부(300)로 인하여 노즐부(200)가 일측 또는 타측으로 이동될 수 있으므로 복강 내로 약물이 골고루 전달될 수 있다.In the drug administration device of the present invention, the nozzle unit 200 may be moved along the circumference of the fixed frame unit 100 , and the nozzle unit 200 may be rotated based on a portion in contact with the fixed frame unit 100 , Due to the control unit 300, the nozzle unit 200 can be moved to one side or the other side, so that the drug can be evenly delivered into the abdominal cavity.

고정프레임부(100)는 바디부(110)와 둘레부(120)를 포함한다. 바디부(110)와 둘레부(120)는 일례로 회전이 용이한 원형의 형상으로 형성될 수 있다. 보다 정확하게 바디부(110)는 원통형의 형상으로 관찰되도록 형성될 수 있으며, 둘레부(120)는 플레이트 형상으로 관찰되도록 형성될 수 있다. The fixed frame part 100 includes a body part 110 and a perimeter part 120 . The body portion 110 and the perimeter portion 120 may be formed in a circular shape that is easy to rotate, for example. More precisely, the body portion 110 may be formed to be observed in a cylindrical shape, and the peripheral portion 120 may be formed to be observed in a plate shape.

고정프레임부(100)는 제어부(500)와 연결되어 제어부(500)의 신호를 받으면 길이방향을 축으로 회전할 수 있다. 일례로 바디부(110)와 둘레부(120)는 일체로 연결되어, 제어신호가 인가되면 바디부(110)와 둘레부(120)가 일체로 전술한 축을 중심으로 하여 회전될 수 있다. The fixed frame unit 100 is connected to the control unit 500 and may rotate in the longitudinal direction when receiving a signal from the control unit 500 . For example, the body part 110 and the peripheral part 120 are integrally connected, and when a control signal is applied, the body part 110 and the peripheral part 120 may be integrally rotated about the aforementioned axis.

다른 실시예로는 둘레부(120)는 바디부(110)와 독립적으로 동작되어, 둘레부(120)만 바디부(110)를 축으로 회전될 수 있다. 미도시되어 있으나 둘레부(120)는 바디부(110)와 기어, 베어링, 샤프트 등이 결합되어 회전 가능하게 연결되어 있어서 제어부(500)의 제어신호가 인가되면 둘레부(120)는 일방향 또는 타방향으로 회전될 수 있다.In another embodiment, the peripheral part 120 is operated independently of the body part 110 , so that only the peripheral part 120 may be rotated about the body part 110 as an axis. Although not shown, the peripheral part 120 is rotatably connected to the body part 110 and the gears, bearings, shafts, etc., so that when a control signal from the control unit 500 is applied, the peripheral part 120 is moved in one direction or the other. direction can be rotated.

도 2a는 일 실시예에 의한 본 발명인 약물투여장치의 노즐부(200)의 단면도이고, 도 2b는 다른 실시예에 의한 본 발명인 약물투유장치의 노즐부(200)의 단면도이다.Figure 2a is a cross-sectional view of the nozzle unit 200 of the present invention drug dispensing device according to an embodiment, Figure 2b is a cross-sectional view of the nozzle unit 200 of the present invention drug dispensing device according to another embodiment.

도 2a, 2b를 통하여 노즐부(200)의 단부 측을 설명하도록 하겠다. 노즐부(200)는 설정된 길이를 가지고, 중공홀을 포함한다. 따라서 노즐부(200)는 일측을 통하여 약물을 받아 타측으로 이동시켜 복강 내로 투여할 수 있다. 노즐부(200)의 타측에는 약물을 분무할 수 있도록 유로가 형성될 수 있다. The end side of the nozzle unit 200 will be described with reference to FIGS. 2A and 2B . The nozzle unit 200 has a set length and includes a hollow hole. Therefore, the nozzle unit 200 may receive the drug through one side and move it to the other side to be administered into the abdominal cavity. A flow path may be formed on the other side of the nozzle unit 200 to spray the drug.

일례로 노즐부(200)의 타측의 단부측은 와류실이 구비되고, 팁부분은 경사진 형태로 형성될 수 있다. 와류부(210)는 노즐부(200)의 내부에 위치되며 중공홀을 폐쇄하도록 배치된다. 다만, 와류부(210)의 둘레에는 원주형의 유로가 형성될 수 있다. 약물은 와류실로 진입 시 원주형 유로를 따라서 이동되고, 노즐부(200)의 팁에서 분사되는 경우 와류로 인하여 분무 형태로 분사될 수 있다.For example, the other end side of the nozzle unit 200 may be provided with a swirl chamber, and the tip portion may be formed in an inclined shape. The vortex part 210 is located inside the nozzle part 200 and is arranged to close the hollow hole. However, a circumferential flow path may be formed around the vortex portion 210 . The drug is moved along the circumferential flow path when entering the vortex chamber, and when sprayed from the tip of the nozzle unit 200, it may be sprayed in the form of a spray due to the vortex.

또 다른 실시예로 노즐부(200)는 스프링(230), 폐쇄부(220)를 포함할 수 있다. 스프링(230)은 노즐부(200)를 지지할 수 있다. 폐쇄부(220)는 와류부(210)와 마찬가지로 둘레를 따라 유로가 형성되어 있다. 따라서 약물은 전술한 와류부(210)와 마찬가지로 폐쇄부(220)의 유로를 통과하며 폐쇄부(220)와 노즐부(200)의 팁 사이로 이동한다. 노즐부(200)의 팁에도 중공홀이 형성되어 있으나, 그 크기는 노즐부(200)에 형성된 중공홀들과 대비 시 매우 작다. 약물은 팁과 폐쇄부(220) 사이에서 스프링(230)의 동작에 따라 가압되며 팁을 통과하여, 분무형태로 분사될 수 있다. In another embodiment, the nozzle part 200 may include a spring 230 and a closing part 220 . The spring 230 may support the nozzle unit 200 . The closing part 220 has a flow path formed along the periphery like the vortex part 210 . Therefore, the drug passes through the flow path of the closure part 220 like the vortex part 210 described above and moves between the closure part 220 and the tip of the nozzle part 200 . A hollow hole is also formed at the tip of the nozzle unit 200 , but the size thereof is very small compared to the hollow holes formed in the nozzle unit 200 . The drug is pressed between the tip and the closure part 220 according to the operation of the spring 230 and passes through the tip, and may be sprayed in the form of a spray.

다시 도 1로 돌아와서 본 발명의 나머지 구성을 설명하자면, 노즐부(200)는 고정프레임부(100)에 일측이 맞닿아 연결된다. 보다 정확하게 노즐부(200)는 고정프레임부(100)의 둘레부(120)의 일면과 맞닿아 고정된다. 여기서 노즐부(200)는 고정프레임부(100)와 설정된 각도를 가지고 배치된다. 노즐부(200)의 타측 단부(팁 부분)이 고정프레임부(100)의 중심을 향하도록 노즐부(200)는 고정프레임부(100)와 연결된다. 노즐부(200)와 고정프레임부(100)는 회동부(240)를 통하여 연결된다.Returning to FIG. 1 again to explain the rest of the configuration of the present invention, the nozzle unit 200 is connected to the fixed frame unit 100 in contact with one side. More precisely, the nozzle part 200 is fixed in contact with one surface of the peripheral part 120 of the fixed frame part 100 . Here, the nozzle unit 200 is disposed at a set angle with the fixed frame unit 100 . The nozzle part 200 is connected to the fixed frame part 100 so that the other end (tip part) of the nozzle part 200 faces the center of the fixed frame part 100 . The nozzle unit 200 and the fixed frame unit 100 are connected through the rotating unit 240 .

노즐부(200)는 고정프레임부(100)와 회동부(240)를 통하여 연결될 수 있다. 회동부(240)는 노즐부(200)가 고정프레임부(100)를 기준으로 회동 가능하도록 움직임을 허여한다. 이 경우 노즐부(200)가 고정프레임부(100)와의 관계에서 형성된 설정된 각도는 유지된다.The nozzle unit 200 may be connected to the fixed frame unit 100 and the rotating unit 240 . The rotating unit 240 permits movement of the nozzle unit 200 to be rotatable with respect to the fixed frame unit 100 . In this case, the set angle formed by the nozzle unit 200 in relation to the fixed frame unit 100 is maintained.

조절부(300)는 노즐부(200)를 감싸는 형태로 배치된다. 조절부(300)는 노즐부(200)를 일방향 또는 타방향으로 이동시킨다. 따라서 노즐부(200)는 복강 내 깊이가 조절될 수 있다. 전술한 회동부(240)는 노즐부(200)가 노즐부(200)의 길이방향을 따라 이동될 수 있도록 허여할 수 있다.The adjusting unit 300 is disposed to surround the nozzle unit 200 . The adjusting unit 300 moves the nozzle unit 200 in one direction or the other direction. Accordingly, the depth of the nozzle unit 200 in the abdominal cavity may be adjusted. The above-described rotating unit 240 may allow the nozzle unit 200 to move along the longitudinal direction of the nozzle unit 200 .

일례로 회동부(240)는 고정하우징부와 압력바를 포함할 수 있다. 고정하우징부는 노즐부(200)의 둘레와 대응되는 형태의 홀이 형성되어 있으며, 일측에 압력바가 인입, 인출될 수 있는 홀이 형성된다. 한편 고정하우징부는 고정프레임부(100)에 회전 가능하게 연결된다. 고정하우징부 내에는 노즐부(200)가 배치되고, 압력바는 고정하우징부의 측면에 형성된 홀에 삽입되어 노즐부(200)를 고정할 수 있다. For example, the rotating unit 240 may include a fixed housing unit and a pressure bar. The fixed housing portion is formed with a hole having a shape corresponding to the circumference of the nozzle unit 200, and a hole through which the pressure bar can be drawn in and out is formed on one side. Meanwhile, the fixed housing unit is rotatably connected to the fixed frame unit 100 . The nozzle unit 200 may be disposed in the fixed housing unit, and the pressure bar may be inserted into a hole formed in a side surface of the fixed housing unit to fix the nozzle unit 200 .

노즐부(200)의 움직임을 허여하는 경우, 압력바는 고정하우징부의 홀에서 인출되는 방향으로 이동되어 노즐부(200)의 길이방향 움직임을 허여할 수 있다. 또한, 추가로 압력바의 이동거리가 제약되기 위하여 압력바는 고정하우징부와 스프링을 통하여 연결될 수 있다. In the case of allowing the movement of the nozzle unit 200 , the pressure bar may be moved in a direction drawn out from the hole of the fixed housing unit to allow the longitudinal movement of the nozzle unit 200 . In addition, in order to further restrict the movement distance of the pressure bar, the pressure bar may be connected to the fixed housing through a spring.

한편, 압력바는 제어부(500)의 제어신호의 인가에 따라 인입, 인출될 수 있다.Meanwhile, the pressure bar may be drawn in or drawn out according to the application of the control signal of the controller 500 .

실린더부(400)는 일측에 고정 위치될 수 있다. 실린더부(400)는 몸체부(410)와 플런저부(420)를 포함할 수 있다. 몸체부(410)는 일측에 공급홀이 형성되고 내부에 공간이 형성되어 약물이 위치될 수 있다. 플런저부(420)는 몸체부(410)의 내부에서 바디부(110)의 길이방향을 따라 이동될 수 있다. 플런저부(420)는 가압력을 인가하여 몸체부(410) 내에 위치된 약물이 공급홀을 통과하여 분출되도록 한다.The cylinder part 400 may be fixedly positioned on one side. The cylinder part 400 may include a body part 410 and a plunger part 420 . The body portion 410 has a supply hole formed on one side and a space is formed therein, so that the drug can be located. The plunger part 420 may be moved along the longitudinal direction of the body part 110 inside the body part 410 . The plunger part 420 applies a pressing force so that the drug located in the body part 410 is ejected through the supply hole.

노즐부(200)의 일측과 실린더부(400)의 몸체부(410)의 공급홀 각각에 관부가 연결될 수 있다. 따라서 실린더부(400)에 위치된 약물은 노즐부(200)를 통하여 복강 내로 분무될 수 있다.A pipe part may be connected to one side of the nozzle part 200 and to each of the supply holes of the body part 410 of the cylinder part 400 . Therefore, the drug located in the cylinder unit 400 may be sprayed into the abdominal cavity through the nozzle unit 200 .

제1실시예에 의한 약물투여장치는 다음과 같이 동작될 수 있다.The drug administration device according to the first embodiment may be operated as follows.

시술자는 환자에게 투관침을 복강에 두 개 이상 설치한다. 시술자는 투관침을 통하여 내시경을 환자의 복강 내에 위치시킨다. 그리고 시술자는 내시경을 통하여 디스플레이에 출력되는 화면을 확인하여 환자의 복강 내 상태를 확인한다. The operator places two or more trocars in the abdominal cavity on the patient. The operator places the endoscope in the patient's abdominal cavity through a trocar. And the operator checks the screen output to the display through the endoscope to check the condition of the patient's abdominal cavity.

다른 투관침에는 본 발명인 약물투여장치의 노즐부(200)를 위치시킨다. 노즐부(200)는 조절부(300)를 통하여 깊이가 조절될 수 있다. 또는 노즐부(200)는 회동부(240)를 통하여 회동 각도가 변경될 수 있다. 또는 노즐부(200)는 고정프레임부(100)의 회동에 따라 각도가 변화될 수 있다. 이와 같이 노즐부(200)의 위치는 다양하게 변경될 수 있다. 이후 실린더부(400)를 동작하여 약물을 주입하고, 노즐부(200)를 통하여 분무 형식으로 복강 내 약물을 투여할 수 있다. 아울러 노즐부(200)는 고정프레임부(100)의 둘레를 따라서 회전되며 약물을 투여할 수 있다. 즉, 노즐부(200)는 원추형을 그리며 움직여, 약물을 투여할 수도 있다.The nozzle unit 200 of the drug administration device of the present invention is positioned on another trocar. The depth of the nozzle unit 200 may be adjusted through the adjustment unit 300 . Alternatively, the rotation angle of the nozzle unit 200 may be changed through the rotation unit 240 . Alternatively, the angle of the nozzle unit 200 may be changed according to the rotation of the fixed frame unit 100 . As such, the position of the nozzle unit 200 may be variously changed. Thereafter, the cylinder unit 400 is operated to inject the drug, and the intraperitoneal drug may be administered in the form of a spray through the nozzle unit 200 . In addition, the nozzle unit 200 is rotated along the circumference of the fixed frame unit 100 and can administer a drug. That is, the nozzle unit 200 may move in a cone shape to administer the drug.

도 3은 제2실시예에 의한 본 발명인 약물투여장치이다.3 is a drug administration device of the present invention according to the second embodiment.

제2실시예에 의한 약물투여장치는 회동부(240)와 조절부(300)가 하나로 구비될 수 있다. 즉, 노즐부(200)는 고정프레임부(100)와 맞닿지 않고, 노즐부(200)를 둘러싸는 형태로 노즐부(200)와 연결된 조절부(300)가 고정프레임부(100)와 맞닿는다.The drug administration device according to the second embodiment may be provided with one rotating unit 240 and one adjusting unit 300 . That is, the nozzle unit 200 does not come into contact with the fixed frame unit 100 , but the adjustment unit 300 connected to the nozzle unit 200 in a form surrounding the nozzle unit 200 abuts the fixed frame unit 100 . All.

따라서 조절부(300)는 실린더의 설정된 각도를 조절함과 동시에 실린더의 길이방향 위치를 변경할 수 있다. 조절부(300)는 고정프레임부(100)와 설정된 각도를 유지하며 설치되고, 조절부(300) 내에 노즐부(200)가 설치되어, 노즐부(200)도 고정프레임부(100)를 기준으로 설정된 각도를 유지할 수 있다. 또한, 조절부(300)는 전술한 회동부(240)와 동일하게 고정프레임부(100)를 기준으로 설정된 각도를 유지한 채 회동될 수 있다. 노즐부(200)는 조절부(300)와 함께 회동되어 타측 단부의 위치가 변경될 수 있다. 또한, 조절부(300)는 노즐부(200)를 일방향 또는 타방향으로 이동시켜 노즐부(200)가 복강 내에 깊이 또는 얕게 위치될 수 있도록 한다. Accordingly, the adjusting unit 300 may adjust the set angle of the cylinder and at the same time change the position in the longitudinal direction of the cylinder. The adjusting unit 300 is installed while maintaining a set angle with the fixed frame unit 100 , and the nozzle unit 200 is installed in the adjusting unit 300 , and the nozzle unit 200 is also based on the fixed frame unit 100 . You can keep the angle set to . Also, the adjusting unit 300 may be rotated while maintaining an angle set with respect to the fixed frame unit 100 in the same manner as the above-described rotating unit 240 . The nozzle unit 200 may be rotated together with the adjusting unit 300 to change the position of the other end. In addition, the control unit 300 moves the nozzle unit 200 in one direction or the other direction so that the nozzle unit 200 can be located deeply or shallowly in the abdominal cavity.

도 4a는 일 실시예에 의한 본 발명인 약물투여장치의 조절부이고, 도 4b는 일 실시예에 의한 본 발명인 약물투여장치의 조절부에 스톱부가 추가된 것을 도시한 것이다.Figure 4a is a control unit of the present invention drug dispensing device according to an embodiment, Figure 4b shows the addition of a stop portion to the control unit of the present invention drug dispensing device according to an embodiment.

본 발명인 조절부(300)는 가압부(320)를 포함하여 구성될 수 있다.The adjusting unit 300 according to the present invention may be configured to include a pressing unit 320 .

조절부(300)는 고정하우징부(310) 내에 이격되어 가압부(320)가 배치되고, 가압부(320) 사이로 노즐부(200)가 위치되어 가압부(320)의 가압력 인가, 해제에 의하여 노즐부(200)의 일방향 또는 타방향 이동이 가능하도록 할 수 있다. 일례로 가압부(320)는 롤러일 수 있다. The control unit 300 is spaced apart in the fixed housing unit 310 so that the pressing unit 320 is disposed, and the nozzle unit 200 is positioned between the pressing units 320 by applying and releasing the pressing force of the pressing unit 320 . It is possible to enable movement of the nozzle unit 200 in one direction or in the other direction. For example, the pressing unit 320 may be a roller.

롤러는 이격되어 배치되고, 롤러 사이에 노즐부(200)가 롤러와 맞닿으며 배치되어 롤러의 일방향 또는 타방향 회전에 따라 노즐부(200)는 이동되며, 그에 따라 노즐부(200)의 위치가 변경될 수 있다. 롤러는 노즐부(200)의 안전한 고정을 위하여 고정하우징부(310)에 4개가 사각형의 모서리에 배치된 형태일 수 있다. 그러나 롤러는 하나 이상으로 구비되면 충분하다.The rollers are arranged spaced apart, and the nozzle unit 200 is disposed in contact with the rollers between the rollers, so that the nozzle unit 200 is moved according to the rotation of the roller in one direction or the other direction, and accordingly, the position of the nozzle unit 200 is can be changed. Four rollers may be arranged at the corners of a rectangle in the fixed housing unit 310 for safe fixing of the nozzle unit 200 . However, it is sufficient if one or more rollers are provided.

롤러는 휠부(321)와 플랜지부(322)로 구성될 수 있다. 휠부(321)는 원형의 형상으로 형성되며 둘레는 매끈한 형태로 형성될 수 있다. 플랜지부(322)는 휠부(321)에서 방사방향으로 돌출되는 형태로 형성될 수 있다. 플랜지부(322)는 휠부(321)의 일측과 타측에 형성될 수 있다. 그러므로 플랜지부(322) 사이에는 홈이 형성되고, 이 위치에 노즐부(200)가 위치되면 노즐부(200)는 휠부(321) 내에서 가이드되며 일방향 또는 타방향으로 이동될 수 있다.The roller may include a wheel part 321 and a flange part 322 . The wheel part 321 may be formed in a circular shape, and the circumference may be formed in a smooth shape. The flange portion 322 may be formed to protrude from the wheel portion 321 in a radial direction. The flange part 322 may be formed on one side and the other side of the wheel part 321 . Therefore, a groove is formed between the flange parts 322 , and when the nozzle part 200 is positioned at this position, the nozzle part 200 is guided in the wheel part 321 and can be moved in one direction or the other direction.

도 4b에 도시된 실시예의 본 발명은 도 4a에 도시된 실시예와 발명의 구성이 유사하지만, 조절부(300)와 노즐부(200)는 각각 스톱부(250, 330)가 추가로 포함될 수 있다. 스톱부(250)는 일례로 전자석일 수 있다. 즉, 노즐부(200)의 일부면에는 스톱부(250)가 배치되고, 조절부(300)에도 스톱부(330)가 배치될 수 있다. 제어부(500)는 제어신호를 인가하여 노즐부(200)의 스톱부와 휠부(321) 내 내장된 스톱부(250, 330)를 동작시켜, 노즐부(200)가 이동되지 못하도록 노즐부(200)의 위치를 고정할 수 있다. 그 후 노즐부(200)를 이동할 필요가 있는 경우 제어부(500)는 제어신호를 인가하지 않는다. 이 경우 노즐부(200)의 스톱부(250)와 휠부(321)의 스톱부(330)는 동작이 중지되고 노즐부(200)는 일방향 또는 타방향으로 이동될 수 있다.The present invention of the embodiment shown in FIG. 4B has a configuration similar to that of the embodiment shown in FIG. 4A, but the control unit 300 and the nozzle unit 200 may include additional stops 250 and 330, respectively. have. The stop part 250 may be, for example, an electromagnet. That is, the stop part 250 may be disposed on some surface of the nozzle part 200 , and the stop part 330 may also be disposed on the adjustment part 300 . The controller 500 applies a control signal to operate the stop part of the nozzle part 200 and the stop parts 250 and 330 built in the wheel part 321 to prevent the nozzle part 200 from moving. ) can be fixed. After that, when it is necessary to move the nozzle unit 200 , the control unit 500 does not apply the control signal. In this case, the stop part 250 of the nozzle part 200 and the stop part 330 of the wheel part 321 stop operating, and the nozzle part 200 may move in one direction or the other direction.

도 5a는 다른 실시예에 의한 본 발명인 약물투여장치의 조절부이고, 도 5b는 다른 실시예에 의한 본 발명인 약물투여장치의 조절부에 스톱부가 추가된 것을 도시한 것이다.Figure 5a is a control unit of the present invention drug administration device according to another embodiment, Figure 5b shows the addition of a stop portion to the control unit of the present invention drug administration device according to another embodiment.

도 5a에 도시된 실시예에 의한 본 발명의 조절부(300)는 슬라이더(340)일 수 있다. 조절부(300)의 고정하우징부(310)에는 고정하우징부(310)의 길이를 따라 홈이 형성될 수 있으며, 이 홈을 따라 이동될 수 있는 슬라이더(340)가 위치될 수 있다. 슬라이더(340)는 노즐부(200)와 연결될 수 있다. 따라서 노즐부(200)는 슬라이더(340)의 일방향 또는 타방향 이동에 따라 이동될 수 있다. 그러므로 노즐부(200)는 복강 내 위치가 변경될 수 있다.The adjusting unit 300 of the present invention according to the embodiment shown in FIG. 5A may be a slider 340 . A groove may be formed in the fixed housing portion 310 of the adjustment unit 300 along the length of the fixed housing portion 310 , and a slider 340 movable along the groove may be positioned. The slider 340 may be connected to the nozzle unit 200 . Accordingly, the nozzle unit 200 may be moved according to the movement of the slider 340 in one direction or the other direction. Therefore, the position of the nozzle unit 200 in the abdominal cavity may be changed.

도 5b에 도시된 실시예에 의한 본 발명은 도 5a에 도시된 실시예에 의한 발명의 구성과 유사하다. 다만 전술하여 설명한 바와 마찬가지로 스톱부(330)를 추가로 포함할 수 있다. 다만, 제6실시예에 의하는 경우 스톱부(330)는 고정하우징부(310)와 슬라이더(340)에 위치될 수 있다. 그러므로 제어부(500)의 제어신호가 인가되지 않는 경우 슬라이더(340)는 고정하우징부(310)의 홈을 따라 이동되어 노즐부(200)의 위치를 변경하고, 제어신호가 인가된 경우 슬라이더(340)는 고정하우징부(310)에서 위치가 고정될 수 있다.The present invention according to the embodiment shown in Fig. 5B is similar to the configuration of the invention according to the embodiment shown in Fig. 5A. However, as described above, the stop portion 330 may be additionally included. However, according to the sixth embodiment, the stop part 330 may be located in the fixed housing part 310 and the slider 340 . Therefore, when the control signal of the control unit 500 is not applied, the slider 340 moves along the groove of the fixed housing unit 310 to change the position of the nozzle unit 200, and when the control signal is applied, the slider 340 ) may be fixed in position in the fixed housing unit 310 .

도 6a는 실험 박스를 정면에서 바라본 형태의 설계도이고, 도 6b는 실험 박스를 상면에서 바로본 형태의 설계도이다.6A is a design diagram of the experimental box viewed from the front, and FIG. 6B is a design diagram of the experimental box viewed directly from the top.

본 발명인 약물투여장치의 효율성을 확인하기 위하여 ex vivo 실험을 수행하였다. 실험 박스는 21X16X15cm(3.5L 부피)이며 플라스틱 재질이다. 실험 박스에는 돼지의 복막조직을 배치하였다. 돼지의 복막 조직은 인체의 비대칭을 고려하여 도 6a, 6b의 박스의 길이를 기준으로 1:1:1 또는 2:1에 해당하는 지점에 위치시켰다. (벽 내에 위치) 돼지의 복막조직의 부피는 3X3X0.5cm로 설정하였다.In order to confirm the effectiveness of the drug administration device of the present invention, an ex vivo experiment was performed. The test box is 21X16X15cm (3.5L volume) and is made of plastic. Pig peritoneal tissue was placed in the experimental box. The peritoneal tissue of the pig was positioned at a point corresponding to 1:1:1 or 2:1 based on the length of the box in FIGS. 6A and 6B in consideration of the asymmetry of the human body. The volume of the peritoneal tissue of the pig (located within the wall) was set to 3X3X0.5 cm.

이후 노즐부가 실험 박스 내에 위치되는 지점을 A포인트 내지 F포인트로 설정하였다. A포인트 내지 F포인트와 중첩되지 않는 위치에는 온도계를 삽입하였다. 그리고 실험 박스는 36도의 온수가 담긴 욕조에 고정하였다.Thereafter, the point at which the nozzle part is located in the test box was set to point A to point F. Thermometers were inserted at positions that did not overlap with points A to F. And the test box was fixed in a bathtub filled with hot water at 36 degrees.

노즐부의 분사 압력은 7bar로 설정하였으며, 30 μm크기의 에어로졸을 5 km/h의 속도와 30 ml/min의 속도로 분사되도록 하였다. 노즐부의 분사 범위를 측정하기 위하여 분사되는 액체는 1% methylene blue 50 ml를 사용하였고, 약물의 침투 깊이를 측정하기 위하여는 3 mg의 doxorubicin을 50 ml의 0.9%의 NaCl에 섞은 용액을 사용하였다. 즉, 두 개의 액체를 이용하여 분사 범위와 침투 깊이를 측정하였다.The injection pressure of the nozzle part was set to 7 bar, and a 30 μm-sized aerosol was injected at a speed of 5 km/h and 30 ml/min. To measure the spray range of the nozzle part, 50 ml of 1% methylene blue was used as the sprayed liquid, and to measure the penetration depth of the drug, 3 mg of doxorubicin mixed with 50 ml of 0.9% NaCl was used. That is, the spray range and penetration depth were measured using two liquids.

용액을 분사한 후 30분동안 실험 박스 내의 압력을 12 mmHg로 유지한 후 glass microfilter가 장착된 air-waste system을 이용하여 노즐부(200)를 제거하였다. 노즐부는 A포인트 내지 H포인트에서 바닥과 2cm, 4cm, 8cm 이격하여 위치시켜서 각각 실험을 수행하였다. After spraying the solution, the pressure in the test box was maintained at 12 mmHg for 30 minutes, and then the nozzle unit 200 was removed using an air-waste system equipped with a glass microfilter. The nozzle part was positioned 2cm, 4cm, and 8cm apart from the floor at points A to H, and experiments were performed, respectively.

일단 노즐부와 바닥 사이의 거리에 따른 용액 분사 범위를 확인하여 보면 노즐부와 실험 박스의 바닥 사이의 거리가 2 cm 인 경우 실험 박스의 바닥에 약물이 주로 분포되었고, 노즐부와 실험 박스의 바닥 사이의 거리가 4 cm, 8cm으로 멀어지는 경우, 실험 박스의 바닥뿐만 아니라, 측면, 그리고 천정에까지 분사 용액인 methylene blue가 전달되는 것을 확인할 수 있었다. Once the solution injection range according to the distance between the nozzle part and the floor was checked, when the distance between the nozzle part and the bottom of the experiment box was 2 cm, the drug was mainly distributed at the bottom of the experiment box, and the nozzle part and the bottom of the experiment box When the distance between them increased to 4 cm and 8 cm, it was confirmed that the spray solution, methylene blue, was delivered not only to the bottom of the experiment box, but also to the side and ceiling.

도 7은 일 실시예에 의하여 노즐부가 바닥과의 거리가 2cm, 4cm, 8cm 일 때 분사된 용액이 돼지 복막에 침투한 깊이 정도를 비교하여 도시한 것이다.7 is a view showing a comparison of the depth of penetration of the injected solution into the peritoneum of the pig when the nozzle unit has a distance of 2 cm, 4 cm, and 8 cm from the floor according to an embodiment.

위와 같은 실험을 정리한 결과는 다음과 같다.The results of the above experiments are summarized as follows.

노즐부를 이용하여 침투 깊이를 실험하고자 하는 doxorubicin을 분사한 후 돼지 복막조직에 1.5 μg/ml of 4', 6-diamidino-2-phenylindole (DAPI) 염색을 시행하고, 침투 깊이를 confocal laser scanning microscopy를 이용하여 확인해 보았다. After spraying doxorubicin to test the penetration depth using the nozzle, 1.5 μg/ml of 4',6-diamidino-2-phenylindole (DAPI) staining was performed on the pig peritoneal tissue, and the penetration depth was measured by confocal laser scanning microscopy. I checked using it.

약물 침투의 깊이는 약물의 대부분이 분포하는 depth of concentrated diffusion (DCD)와 약물이 최대 침투 깊이인 depth of maximal diffusion (DMD)로 정의하여 전술한 A포인트 내지 H포인트에서 바닥과의 깊이를 2cm, 4cm, 8cm 다르게 하였다.The depth of drug penetration is defined as the depth of concentrated diffusion (DCD) where most of the drug is distributed and the depth of maximal diffusion (DMD), which is the maximum penetration depth of the drug. 4cm and 8cm were different.

도 8은 노즐부를 실험박스의 각각의 포인트에 바닥과의 거리를 다르게 한 후 약물 침투 깊이 결과를 실험한 것으로 각각의 포인트 및 거리별로 DCD(depth of concentrated diffusion) 및 DMD(depth of maximal diffusion)를 측정한 것이다.Figure 8 is an experiment of drug penetration depth results after varying the distance from the floor to the nozzle unit at each point of the experiment box, and DCD (depth of concentrated diffusion) and DMD (depth of maximal diffusion) for each point and distance it is measured

도 9a는 도 8의 실험결과를 그래프로 도시한 것이며, 도 9b는 도 8의 실험결과를 테이블로 정리한 것이다.FIG. 9A is a graph showing the experimental results of FIG. 8 , and FIG. 9B is a table of the experimental results of FIG. 8 .

그 결과 도 8, 9a, 9b에서 확인할 수 있듯이 DCD의 경우 4 cm의 깊이에서 전체 8구역 중 5구역 (62.5%)에서의 가장 침투력이 높았으며, DMD의 경우 4 cm과 8 cm의 깊이에서 각각 5 구역 (62.5%)에서 가장 침투력이 높았음을 확인할 수 있었다. As a result, as can be seen in FIGS. 8, 9a, and 9b, in the case of DCD, at a depth of 4 cm, the penetration power was the highest in area 5 (62.5%) of all 8 areas, and in the case of DMD, at a depth of 4 cm and 8 cm, respectively. It was confirmed that the penetration power was the highest in zone 5 (62.5%).

그렇다면 이러한 실험 결과에서 도출할 수 있는 것은 복강 내 노즐부(200)의 위치를 고려하여 노즐부(200)와 대상이 되는 위치 사이의 거리를 다르게 한다면 약물의 분포 및 침투력에 큰 영향을 미칠 수 있으므로 노즐부(200)의 위치에 자율성을 부여할 필요가 있음을 알 수 있다. 본 발명의 경우 노즐부(200)의 위치가 변화될 수 있는 약물투여장치는 약물의 효과적인 투여에서 큰 기여를 할 수 있다.If so, what can be derived from these experimental results is that if the distance between the nozzle unit 200 and the target position is changed in consideration of the position of the nozzle unit 200 in the abdominal cavity, it can have a large effect on the distribution and penetration of the drug. It can be seen that it is necessary to impart autonomy to the position of the nozzle unit 200 . In the case of the present invention, the drug administration device in which the position of the nozzle unit 200 can be changed can make a great contribution to the effective administration of the drug.

본 발명은 특정한 실시 예에 관련하여 도시하고 설명하였지만, 이하의 특허청구범위에 의해 제공되는 본 발명의 기술적 사상을 벗어나지 않는 한도 내에서, 본 발명이 다양하게 개량 및 변화될 수 있다는 것은 당 업계에서 통상의 지식을 가진 자에게 있어서 자명할 것이다.Although the present invention has been shown and described in relation to specific embodiments, it is within the art that the present invention can be variously improved and changed without departing from the spirit of the present invention provided by the following claims. It will be obvious to those of ordinary skill in the art.

Claims (13)

복강 내 약물을 투여하는 약물투여장치에 있어서,In the drug administration device for administering intraperitoneal drugs, 고정프레임부;fixed frame unit; 상기 고정프레임부와 일측이 맞닿고, 중공홀이 형성되어 일측으로 공급받은 약물을 상기 중공홀을 통하여 타측으로 이동 공급하는 노즐부; 및a nozzle part having one side in contact with the fixed frame part and having a hollow hole formed so as to move and supply the drug supplied to one side to the other side through the hollow hole; and 상기 노즐부의 둘레에 위치되어 상기 노즐부의 위치를 조절할 수 있는 조절부An adjusting unit positioned around the nozzle unit to adjust the position of the nozzle unit 를 포함하는 약물투여장치.A drug administration device comprising a. 제1항에 있어서,According to claim 1, 상기 노즐부는the nozzle part 상기 조절부를 사이에 두고 상기 고정프레임부와 연결되는 것Connecting to the fixed frame portion with the adjustment portion therebetween 을 특징으로 하는 약물투여장치.A drug administration device, characterized in that. 제1항에 있어서,According to claim 1, 상기 노즐부는 상기 고정프레임부와 회동 가능하게 연결되는 것The nozzle part is rotatably connected to the fixed frame part 을 특징으로 하는 약물투여장치.A drug administration device, characterized in that. 제1항에 있어서,According to claim 1, 상기 조절부는 설정된 각도로 경사져서 상기 고정프레임부와 연결되고,The adjustment part is inclined at a set angle and is connected to the fixed frame part, 상기 노즐부는 상기 조절부의 경사진 각도와 대응되는 각도로 경사진 것The nozzle part is inclined at an angle corresponding to the inclined angle of the adjustment part 을 특징으로 하는 약물투여장치.A drug administration device, characterized in that. 제1항에 있어서,According to claim 1, 상기 조절부는the control unit 상기 노즐부를 설정된 길이만큼 일방향 또는 타방향으로 이동시킬 수 있는 것What can move the nozzle unit in one direction or the other by a set length 을 특징으로 하는 약물투여장치.A drug administration device, characterized in that. 제5항에 있어서,6. The method of claim 5, 상기 조절부가 상기 노즐부를 움직이는 거리는 1cm 내지 10cm인 것The distance the control unit moves the nozzle unit is 1cm to 10cm 을 특징으로 하는 약물투여장치.A drug administration device, characterized in that. 제5항에 있어서,6. The method of claim 5, 상기 조절부는the control unit 대칭되는 위치에 배치되어 상기 노즐부를 대칭되는 위치에서 가압하는 가압부를 포함하며It is disposed at a symmetrical position and includes a pressing unit for pressing the nozzle unit at a symmetrical position, 상기 가압부의 가압력의 변화로 인하여 상기 노즐부는 상기 가압력이 해제되어 일방향 또는 타방향으로 이동될 수 있는 것Due to the change in the pressing force of the pressing part, the nozzle part may be moved in one direction or the other direction by releasing the pressing force 을 특징으로 하는 약물투여장치.A drug administration device, characterized in that. 제7항에 있어서,8. The method of claim 7, 상기 가압부는 롤러이며,The pressing part is a roller, 상기 롤러의 일방향 또는 타방향 회전으로 상기 노즐부를 이동시킬 수 있는 것What can move the nozzle unit by rotation of the roller in one direction or the other direction 을 특징으로 하는 약물투여장치. A drug administration device, characterized in that. 제7항에 있어서,8. The method of claim 7, 상기 가압부는 일방향 또는 타방향으로 슬라이드 이동할 수 있는 슬라이더여서 슬라이드 이동에 의하여 상기 노즐부를 이동시킬 수 있는 것The pressing part is a slider that can slide in one direction or the other, so that the nozzle part can be moved by sliding movement. 을 특징으로 하는 약물투여장치.A drug administration device, characterized in that. 내부에 약물이 위치되고, 일방향으로 가해지는 피스톤의 동작에 따라 일측에 위치된 공급홀로 약물을 공급하는 실린더부;A cylinder part in which the drug is located, and supplies the drug to the supply hole located on one side according to the operation of the piston applied in one direction; 상기 실린더와 이격되어 위치되는 고정프레임부;a fixed frame portion spaced apart from the cylinder; 상기 고정프레임부에 일면이 맞닿아 고정되며, 일측이 상기 공급홀과 상기 실린더부에 의하여 공급되는 상기 약물을 타측으로 공급하는 노즐부; 및a nozzle unit having one side fixed in contact with the fixed frame unit, and one side supplying the drug supplied by the supply hole and the cylinder unit to the other side; and 상기 노즐부에 설치되어 상기 노즐부의 위치를 변경할 수 있는 조절부A control unit installed in the nozzle unit to change the position of the nozzle unit 를 포함하는 약물투여장치.A drug administration device comprising a. 제10항에 있어서,11. The method of claim 10, 상기 조절부는 상기 노즐부를 감싸는 형태로 상기 노즐부에 설치되고,The adjustment part is installed in the nozzle part in a form surrounding the nozzle part, 상기 조절부의 일면은 상기 고정프레임부와 맞닿으며 연결되는 것One surface of the adjusting part is connected to and in contact with the fixed frame part 을 특징으로 하는 약물투여장치.A drug administration device, characterized in that. 제10항에 있어서,11. The method of claim 10, 상기 노즐부는 상기 고정프레임부에서 설정된 축을 기준으로 회동 가능하게 연결되는 것The nozzle part is rotatably connected based on the axis set in the fixed frame part 을 특징으로 하는 약물투여장치.A drug administration device, characterized in that. 제10항에 있어서,11. The method of claim 10, 상기 조절부는the control unit 대칭되는 위치에 배치되어 상기 노즐부를 대칭되는 위치에서 가압하는 가압부를 포함하며It is disposed at a symmetrical position and includes a pressing unit for pressing the nozzle unit at a symmetrical position, 상기 가압부의 가압력의 변화로 인하여 상기 노즐부는 상기 가압력이 해제되어 일방향 또는 타방향으로 이동될 수 있는 것Due to the change in the pressing force of the pressing part, the nozzle part may be moved in one direction or the other direction by releasing the pressing force 을 특징으로 하는 약물투여장치.A drug administration device, characterized in that.
PCT/KR2021/006829 2021-04-01 2021-06-01 Position-adjustable drug administration device Ceased WO2022211183A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2021-0042898 2021-04-01
KR1020210042898A KR102573392B1 (en) 2021-04-01 2021-04-01 Position adjustable injector for drug delivery

Publications (1)

Publication Number Publication Date
WO2022211183A1 true WO2022211183A1 (en) 2022-10-06

Family

ID=83456391

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2021/006829 Ceased WO2022211183A1 (en) 2021-04-01 2021-06-01 Position-adjustable drug administration device

Country Status (2)

Country Link
KR (1) KR102573392B1 (en)
WO (1) WO2022211183A1 (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0319387Y2 (en) * 1985-08-20 1991-04-24
US6723082B1 (en) * 1995-05-10 2004-04-20 Sam G. Payne Delivery catheter system for heart chamber
KR20110022770A (en) * 2009-08-28 2011-03-08 국립암센터 Trocar assembly and surgical device for thermal chemotherapy comprising the same
KR20120015939A (en) * 2010-08-13 2012-02-22 (주)세원메디텍 Catheter device for intravenous drug injection
US20150045769A1 (en) * 2013-08-08 2015-02-12 Jose Gustavo Cabrera Aquino Injection device for minimally invasive procedures and uses thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101781485B1 (en) 2016-07-01 2017-09-26 주식회사 두배시스템 Drug delivery device

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0319387Y2 (en) * 1985-08-20 1991-04-24
US6723082B1 (en) * 1995-05-10 2004-04-20 Sam G. Payne Delivery catheter system for heart chamber
KR20110022770A (en) * 2009-08-28 2011-03-08 국립암센터 Trocar assembly and surgical device for thermal chemotherapy comprising the same
KR20120015939A (en) * 2010-08-13 2012-02-22 (주)세원메디텍 Catheter device for intravenous drug injection
US20150045769A1 (en) * 2013-08-08 2015-02-12 Jose Gustavo Cabrera Aquino Injection device for minimally invasive procedures and uses thereof

Also Published As

Publication number Publication date
KR20220137218A (en) 2022-10-12
KR102573392B1 (en) 2023-08-31
KR102573392B9 (en) 2024-02-16

Similar Documents

Publication Publication Date Title
JP4928266B2 (en) System and method for delivering a substance to a body cavity
WO2015142013A1 (en) Medicinal fluid injection device
CN107049947B (en) Transnasal anticonvulsive pharmaceutical composition comprising poorly soluble anticonvulsant
CN101605529A (en) Stable formulations and methods for their preparation and use
US20130211320A1 (en) System and method for delivering an anti-adhesive substance to a body cavity
WO2013064478A1 (en) Aid device for intraocular injection
WO2014189161A1 (en) Multi-needle assembly having stopper
WO2022211183A1 (en) Position-adjustable drug administration device
WO2014051300A1 (en) Liquid sprayer
WO2021153932A1 (en) Rotational high-pressure injection system for intraperitoneal chemotherapy
KR20220165679A (en) System for intraperitoneal gas provision comprising twin-fluid nozzle
WO2018093177A1 (en) Liquid supply roller device
CN217489463U (en) Atomizing catheter for administration of medicine through bronchus
WO2013141446A1 (en) Drug delivery system using implant
KR101781485B1 (en) Drug delivery device
CN109674495B (en) Method and apparatus for administering a drug
WO2018021705A1 (en) Nerve blocking material injector set for controlling pain
EP2408501B1 (en) Catheter mount
WO2011122751A1 (en) Liquid medicine administering device for endoscopic surgery, medical controller for liquid medicine, and liquid medicine administering device for endoscopic surgery comprising same
CN108245770A (en) A kind of portable gynemetrics's drug delivery device
EP4616878A1 (en) Cannula for rectal administration of an enema and compositions for use therewith
CN117547692B (en) Fine powder spraying device
CN113262157A (en) Multi-cavity integrated foot bath device for preventing and treating diabetic foot
CN116510138B (en) Powder spraying device
WO2017160135A1 (en) Needle catheter for supplying drug

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 21935297

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

32PN Ep: public notification in the ep bulletin as address of the adressee cannot be established

Free format text: NOTING OF LOSS OF RIGHTS PURSUANT TO RULE 112(1) EPC (EPO FORM 1205A DATED 23/11/2023)

122 Ep: pct application non-entry in european phase

Ref document number: 21935297

Country of ref document: EP

Kind code of ref document: A1