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WO2022260632A2 - Herbal cream containing hypericum perforatum oil and propolis - Google Patents

Herbal cream containing hypericum perforatum oil and propolis Download PDF

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Publication number
WO2022260632A2
WO2022260632A2 PCT/TR2022/050536 TR2022050536W WO2022260632A2 WO 2022260632 A2 WO2022260632 A2 WO 2022260632A2 TR 2022050536 W TR2022050536 W TR 2022050536W WO 2022260632 A2 WO2022260632 A2 WO 2022260632A2
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WO
WIPO (PCT)
Prior art keywords
topical composition
composition according
weight
hypericum perforatum
propolis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/TR2022/050536
Other languages
French (fr)
Other versions
WO2022260632A3 (en
Inventor
Haydar GOKSU
Gulsah AYDIN
Meral KEKECOGLU
Neslihan SIRIN
Nisa SIPAHI
Tugba TURKEN AKCAY
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Duzce Universitesi Rektorlugu
Original Assignee
Duzce Universitesi Rektorlugu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from TR2021/009490 external-priority patent/TR2021009490A2/en
Application filed by Duzce Universitesi Rektorlugu filed Critical Duzce Universitesi Rektorlugu
Publication of WO2022260632A2 publication Critical patent/WO2022260632A2/en
Publication of WO2022260632A3 publication Critical patent/WO2022260632A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A61K35/64—Insects, e.g. bees, wasps or fleas
    • A61K35/644—Beeswax; Propolis; Royal jelly; Honey
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/38—Clusiaceae, Hypericaceae or Guttiferae (Hypericum or Mangosteen family), e.g. common St. Johnswort
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/927—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of insects, e.g. shellac
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/52—Stabilizers
    • A61K2800/524—Preservatives

Definitions

  • the present invention relates to a topical composition
  • a topical composition comprising hypericum perforatum oil, propolis extract and at least one auxiliary substance.
  • the subject matter topical composition is particularly used in cosmetic treatment.
  • Hypericum perforatum is known by names like Hypericum Calycinum, Prunella Vulgaris, Verbena Officinalis, Tipton’s weed, Hypericum Androsaemum. Since ancient times, the wound healing, ache preventing and diuretic effects of hypericum perforatum have been utilized, and various preparations prepared from hypericum perforatum have been used by people against sciatica and poisonous bites. Since ancient Greek and Roman, hypericum perforatum is an herb used by people as antimicrobial and in wound and burn healing, in the treatment of children who suffer from urinary incontinence, in chronic diseases of lung, stomach, intestine, kidney and urinary tract. Hypericum perforatum oil (Oleum Hyperici) prepared from this herb is used today as external antiseptic and for wound healing, primarily particularly for burn wounds.
  • Propolis is a product known as bee gum among beekeepers and is used by bees for providing sterilization of honey combs which exists in a hive, for protecting a hive against insects, fungi and bacteria, for repairing and reinforcing honey combs.
  • propolis extracts There are present studies comprising usage of propolis extracts in cosmetic sector because of their antioxidant, antibacterial and anti-inflammatory activities.
  • Propolis is used in sun protectors because of its effect of protecting from the sun, and the protecting and wound healing and anti-aging effects thereof are utilized in other cosmetic products because of its antibacterial and antioxidant effects.
  • the main object of the present invention is to provide a topical composition used in cosmetic treatment and which has physical, chemical and antimicrobial stability and which comprises hypericum perforatum oil and natural preserving substances.
  • the main object of the present invention relates to a topical composition
  • a topical composition comprising hypericum perforatum oil, propolis extract and at least one auxiliary substance.
  • the proportion of amount of said propolis extract to the total composition is between 0.1% and 1 % by weight and particularly between 0.125% and 0.625% by weight.
  • the propolis extract provided in said composition is ethanolic extract of propolis.
  • the amount of hypericum perforatum oil, which exists in the invention is between 5% and 10% by weight and particularly between 5% and 7.5% by weight with respect to the total composition.
  • the proportion of amount of hypericum perforatum oil to amount of propolis extract is between 8 and 60 and preferably between 12 and 40.
  • the subject matter composition comprises polyethylene glycol.
  • the molecular weight of said polyethylene glycol (PEG400) is 400 daltons.
  • the amount of polyethylene glycol, provided in this embodiment of the present invention, is between 10% and 20% by weight and particularly between 11.25% and 15.5% by weight with respect to the total composition.
  • the subject matter topical composition comprises coco caprylate. Said coco caprylate amount is between 5% and 7.5% by weight with respect to the total composition.
  • the subject matter topical composition moreover comprises at least one auxiliary substance selected from skin care agents, emollients, solvents, emulsifiers, preserving substances, surfactants, dehumidifiers, chelating agents, viscosity agents, buffers, antioxidants, perfumes and antimicrobial preservers.
  • auxiliary substance selected from skin care agents, emollients, solvents, emulsifiers, preserving substances, surfactants, dehumidifiers, chelating agents, viscosity agents, buffers, antioxidants, perfumes and antimicrobial preservers.
  • said topical composition is in ointment, pomade, soap, gel, emulsion, spray, shampoo, foam, balm, lotion or cream form.
  • the subject matter topical composition is particularly in cream form.
  • the topical composition of the embodiment of the present invention comprises the following substances;
  • the subject matter composition is used in cosmetic treatment.
  • the main embodiment of the present invention relates to a topical composition comprising hypericum perforatum oil, propolis extract and at least one auxiliary substance.
  • the propolis extract is used as antimicrobial and preserving agent.
  • the proportion of amount of said propolis extract to the total composition is between 0.1% and 1% by weight and particularly between 0.125% and 0.625% by weight.
  • the propolis extract comprises the following ingredients (Table 1).
  • propolis extract which exists in said composition is the ethanolic extract of propolis.
  • the biological activity value of the ethanolic extract of propolis is greater when compared with the other extracts of propolis. Thus, it provides the desired preserving activity at the maximum level in the subject matter composition.
  • the inventors have subjected the obtained composition to a series of tests.
  • the subject matter composition prepared by said propolis extract shows preserving activity as expected (Table 2a, 2b).
  • the maximum temperature in the realized antimicrobial activity test is 25 e C, and the maximum humidity is 75.
  • the amount of hypericum perforatum oil, which exists in the invention is between 5% and 10% by weight and particularly between 5% and 7.5% by weight with respect to the total composition.
  • the proportion of amount of hypericum perforatum oil to amount of propolis extract is between 8 and 60 and preferably between 12 and 40.
  • the subject matter composition comprises polyethylene glycol.
  • Polyethylene glycol (PEG) provides homogenous distribution of propolis ethanolic extract in the subject matter water-based topical formulation.
  • PEG400 polyethylene glycol
  • the average molecular weight of 0 said polyethylene glycol (PEG400) is 400 daltons.
  • the user In topical compositions, the user must apply said composition to the desired region comfortably.
  • the desired consistence and viscosity have been reached in the subject matter composition thanks to the consistence provider and viscosity balancer characteristic of PEG400.
  • the amount of polyethylene glycol is between 10% and 20% by weight and 5 particularly between 11.25% and 15.5% by weight with respect to the total composition.
  • the subject matter topical composition comprises coco caprylate.
  • Said coco caprylate amount is between 5% and 7.5% by weight with respect to the total composition.
  • the subject matter topical composition moreover comprises at least one auxiliary substance selected from skin care agents, emollients, solvents, emulsifiers, preserving substances, surfactants, dehumidifiers, chelating agents, viscosity agents, buffers, antioxidants, perfumes and antimicrobial preservers.
  • auxiliary substance selected from skin care agents, emollients, solvents, emulsifiers, preserving substances, surfactants, dehumidifiers, chelating agents, viscosity agents, buffers, antioxidants, perfumes and antimicrobial preservers.
  • the subject matter topical composition is in ointment, pomade, soap, gel, emulsion, spray, shampoo, foam, balm, lotion or cream form.
  • the subject matter topical composition is particularly in cream form.
  • the topical composition of the embodiment of the present invention comprises the below mentioned substances;
  • the subject matter composition is used in cosmetic treatment.
  • the antimicrobial effects of hypericum perforatum oil increase by means of usage of propolis extract in the subject matter composition.
  • the preserving effect of hypericum perforatum oil supports the preserving effect of propolis.
  • the product which has physical, chemical and microbiological stability is a topical composition used in the applicable cosmetic treatment.
  • a method is provided which comprises the below mentioned steps for the production of the subject matter composition:
  • Hypericum perforatum oil, propolis extract (solution), PEG-400, sodium polyacrylate, dicaprylyl carbonate, polyglyceril-3-caprate, coco caprylate, sodium stearyl glutamate, odor agent and water have been mixed, and composition in cream form has been obtained.
  • the protection scope of the present invention is set forth in the annexed claims and cannot be restricted to the illustrative disclosures given above, under the detailed description. It is because a person skilled in the relevant art can obviously produce similar embodiments under the light of the foregoing disclosures, without departing from the main principles of the present invention.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Insects & Arthropods (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Birds (AREA)
  • Zoology (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Animal Husbandry (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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Abstract

The present invention relates to a topical composition comprising hypericum perforatum oil, propolis extract and at least one auxiliary substance. The subject matter topical composition is particularly used in cosmetic treatment.

Description

HERBAL CREAM CONTAINING HYPERICUM PERFORATUM OIL AND PROPOLIS
TECHNICAL FIELD
The present invention relates to a topical composition comprising hypericum perforatum oil, propolis extract and at least one auxiliary substance. The subject matter topical composition is particularly used in cosmetic treatment.
PRIOR ART
Hypericum perforatum is known by names like Hypericum Calycinum, Prunella Vulgaris, Verbena Officinalis, Tipton’s weed, Hypericum Androsaemum. Since ancient times, the wound healing, ache preventing and diuretic effects of hypericum perforatum have been utilized, and various preparations prepared from hypericum perforatum have been used by people against sciatica and poisonous bites. Since ancient Greek and Roman, hypericum perforatum is an herb used by people as antimicrobial and in wound and burn healing, in the treatment of children who suffer from urinary incontinence, in chronic diseases of lung, stomach, intestine, kidney and urinary tract. Hypericum perforatum oil (Oleum Hyperici) prepared from this herb is used today as external antiseptic and for wound healing, primarily particularly for burn wounds.
Propolis is a product known as bee gum among beekeepers and is used by bees for providing sterilization of honey combs which exists in a hive, for protecting a hive against insects, fungi and bacteria, for repairing and reinforcing honey combs. There are present studies comprising usage of propolis extracts in cosmetic sector because of their antioxidant, antibacterial and anti-inflammatory activities. Propolis is used in sun protectors because of its effect of protecting from the sun, and the protecting and wound healing and anti-aging effects thereof are utilized in other cosmetic products because of its antibacterial and antioxidant effects.
In the known state of the art, various synthetic and natural compositions are developed for use in cosmetic treatment. Since the harms of synthetic compositions to nature and to humans are known, natural compositions are more preferred by patients. In order for said natural oils to be comfortably applied to skin by the patient, said natural oils must be turned in a topical dosage form. However, it is not always easy to obtain an effective and reliable topical form because of the physical, chemical and antimicrobial stability problem of the compositions comprising natural oil known in the art. Natural oils deteriorate when subjected to atmosphere during production or before usage by a patient, or phase stability and homogeneity problems occur since oils do not easily dissolve in water. In terms of usage by a patient, in order for the topical composition to be easily applied to the region which is to be treated, the composition must have a suitable viscosity, phase stability and homogeneity.
In the known state of the art, topical compositions are still needed which overcome the above mentioned problems and which are formed by natural and herbal substances used in cosmetic treatment. The main object of the present invention is to provide a topical composition used in cosmetic treatment and which has physical, chemical and antimicrobial stability and which comprises hypericum perforatum oil and natural preserving substances.
BRIEF DESCRIPTION OF THE INVENTION
The main object of the present invention relates to a topical composition comprising hypericum perforatum oil, propolis extract and at least one auxiliary substance. The proportion of amount of said propolis extract to the total composition is between 0.1% and 1 % by weight and particularly between 0.125% and 0.625% by weight.
In an embodiment of the invention, the propolis extract provided in said composition is ethanolic extract of propolis.
In an embodiment of the present invention, the amount of hypericum perforatum oil, which exists in the invention, is between 5% and 10% by weight and particularly between 5% and 7.5% by weight with respect to the total composition.
In an embodiment of the present invention, the proportion of amount of hypericum perforatum oil to amount of propolis extract is between 8 and 60 and preferably between 12 and 40.
In an embodiment of the present invention, the subject matter composition comprises polyethylene glycol. The molecular weight of said polyethylene glycol (PEG400) is 400 daltons. The amount of polyethylene glycol, provided in this embodiment of the present invention, is between 10% and 20% by weight and particularly between 11.25% and 15.5% by weight with respect to the total composition. In an embodiment of the present invention, the subject matter topical composition comprises coco caprylate. Said coco caprylate amount is between 5% and 7.5% by weight with respect to the total composition.
In another embodiment of the present invention, the subject matter topical composition moreover comprises at least one auxiliary substance selected from skin care agents, emollients, solvents, emulsifiers, preserving substances, surfactants, dehumidifiers, chelating agents, viscosity agents, buffers, antioxidants, perfumes and antimicrobial preservers.
In an embodiment of the present invention, said topical composition is in ointment, pomade, soap, gel, emulsion, spray, shampoo, foam, balm, lotion or cream form. The subject matter topical composition is particularly in cream form.
The topical composition of the embodiment of the present invention comprises the following substances;
Figure imgf000004_0001
In an embodiment of the present invention, the subject matter composition is used in cosmetic treatment.
In an embodiment of the present invention, a method comprising the below mentioned steps for the production of the subject matter topical composition:
Mixing of hypericum perforatum oil, propolis extract (solution), PEG-400, sodium polyacrylate, dicaprylyl carbonate, polyglyceril-3-caprate, coco caprylate, sodium stearyl glutamate, odor agent and water, and obtaining the composition in cream form. DETAILED DESCRIPTION OF THE INVENTION
The main embodiment of the present invention relates to a topical composition comprising hypericum perforatum oil, propolis extract and at least one auxiliary substance. In the present invention, the propolis extract is used as antimicrobial and preserving agent. The proportion of amount of said propolis extract to the total composition is between 0.1% and 1% by weight and particularly between 0.125% and 0.625% by weight. By means of the propolis extract used at these amounts, the preserving effect of the hypericum perforatum oil is supported by the preserving effect of propolis, and the desired antimicrobial and preserving efficiency is also reached. Thanks to this, no other synthetic preserving substance is needed.
In accordance with the results of the ingredient analysis tests of the propolis extract provided in the present invention, the propolis extract comprises the following ingredients (Table 1).
Figure imgf000005_0001
Table 1 - ingredient of the subject matter propolis extract
In an embodiment of the present invention, propolis extract which exists in said composition is the ethanolic extract of propolis. The biological activity value of the ethanolic extract of propolis is greater when compared with the other extracts of propolis. Thus, it provides the desired preserving activity at the maximum level in the subject matter composition.
The inventors have subjected the obtained composition to a series of tests. Thus, it has been provided that the subject matter composition prepared by said propolis extract shows preserving activity as expected (Table 2a, 2b). The maximum temperature in the realized antimicrobial activity test is 25eC, and the maximum humidity is 75.
Figure imgf000006_0001
Table 2a - Analysis report for antimicrobia activity test
Figure imgf000006_0002
Table 2b - Analysis report for antimicrobial activity test
In an embodiment of the present invention, the amount of hypericum perforatum oil, which exists in the invention, is between 5% and 10% by weight and particularly between 5% and 7.5% by weight with respect to the total composition. By means of these optimum ranges where the hypericum perforatum oil is used, the desired antimicrobial effect is reached. Thus, said composition is used in cosmetic treatment.
In an embodiment of the present invention, the proportion of amount of hypericum perforatum oil to amount of propolis extract is between 8 and 60 and preferably between 12 and 40. By means of this optimum proportion presented by the inventor, chemical, physical and microbiological stability have been reached in the subject matter topical composition. An undesired condition is not faced in the stability tests realized for tracing the findings related to the changes in the composition. Acceptable changes occur in odor and color. The product has preserved its first appearance also at high temperatures and has remained stable during the test durations (Table 3a).
5
In an embodiment of the present invention, the subject matter composition comprises polyethylene glycol. Polyethylene glycol (PEG) provides homogenous distribution of propolis ethanolic extract in the subject matter water-based topical formulation. As a result of the tests made, no remarkable phase separation is faced (Table 3a). The average molecular weight of 0 said polyethylene glycol (PEG400) is 400 daltons. In topical compositions, the user must apply said composition to the desired region comfortably. The desired consistence and viscosity have been reached in the subject matter composition thanks to the consistence provider and viscosity balancer characteristic of PEG400. In this embodiment of the invention, the amount of polyethylene glycol is between 10% and 20% by weight and 5 particularly between 11.25% and 15.5% by weight with respect to the total composition. By means of these proportions, after the person who uses the product comfortably applies the subject matter composition to the region, the desired high absorption is reached in a topical composition.
Figure imgf000007_0001
Figure imgf000007_0002
Table 3b - Stability analysis report
In accordance with an embodiment of the present invention, the subject matter topical composition comprises coco caprylate. Said coco caprylate amount is between 5% and 7.5% by weight with respect to the total composition.
In another embodiment of the present invention, the subject matter topical composition moreover comprises at least one auxiliary substance selected from skin care agents, emollients, solvents, emulsifiers, preserving substances, surfactants, dehumidifiers, chelating agents, viscosity agents, buffers, antioxidants, perfumes and antimicrobial preservers.
In an embodiment of the present invention, the subject matter topical composition is in ointment, pomade, soap, gel, emulsion, spray, shampoo, foam, balm, lotion or cream form. The subject matter topical composition is particularly in cream form.
The topical composition of the embodiment of the present invention comprises the below mentioned substances;
Figure imgf000008_0001
In an embodiment of the present invention, the subject matter composition is used in cosmetic treatment. The antimicrobial effects of hypericum perforatum oil increase by means of usage of propolis extract in the subject matter composition. The preserving effect of hypericum perforatum oil supports the preserving effect of propolis. Thus, the product which has physical, chemical and microbiological stability is a topical composition used in the applicable cosmetic treatment. In accordance with an embodiment of the present invention, a method is provided which comprises the below mentioned steps for the production of the subject matter composition:
Mixing of hypericum perforatum oil, propolis extract (solution), PEG-400, sodium polyacrylate, dicaprylyl carbonate, polyglyceril-3-caprate, coco caprylate, sodium stearyl glutamate, odor agent and water, and obtaining the composition in cream form.
Example
Figure imgf000009_0001
Hypericum perforatum oil, propolis extract (solution), PEG-400, sodium polyacrylate, dicaprylyl carbonate, polyglyceril-3-caprate, coco caprylate, sodium stearyl glutamate, odor agent and water have been mixed, and composition in cream form has been obtained. The protection scope of the present invention is set forth in the annexed claims and cannot be restricted to the illustrative disclosures given above, under the detailed description. It is because a person skilled in the relevant art can obviously produce similar embodiments under the light of the foregoing disclosures, without departing from the main principles of the present invention.

Claims

1. A topical composition comprising hypericum perforatum oil, propolis extract and at least one auxiliary substance, wherein the proportion of amount of said propolis extract to the total composition is between 0.1% and 1% by weight and particularly between 0.125% and 0.625% by weight.
2. The topical composition according to claim 1 , wherein the amount of hypericum perforatum oil, which exists in the invention, is between 5% and 10% by weight and particularly between 5% and 7.5% by weight with respect to the total composition.
3. The topical composition according to claim 1 , wherein the proportion of amount of hypericum perforatum oil to amount of propolis extract is between 8 and 60 and preferably between 12 and 40.
4. The topical composition according to claim 1 , wherein said propolis extract is ethanolic extract of propolis.
5. The topical composition according to claim 1 , wherein said auxiliary substance is polyethylene glycol.
6. The topical composition according to claim 5, wherein the molecular weight of said polyethylene glycol is 400 daltons.
7. The topical composition according to claim 5 or 6, wherein the amount of polyethylene glycol is between 10% and 20% by weight and particularly between 11.25% and 15.5% by weight with respect to the total composition.
8. The topical composition according to claim 1 , wherein the subject matter topical composition moreover comprises coco caprylate.
9. The topical composition according to claim 8, wherein said coco caprylate amount is between 5% and 7.5% by weight with respect to the total composition.
10. The topical composition according to any one of the preceding claims, wherein the subject matter topical composition moreover comprises at least one auxiliary substance selected from skin care agents, emollients, solvents, emulsifiers, preserving substances, surfactants, dehumidifiers, chelating agents, viscosity agents,
Figure imgf000011_0001
11. The topical composition according to any one of the preceding claims, wherein said composition is in ointment, pomade, soap, gel, emulsion, spray, shampoo, foam, balm, lotion or cream form.
12. The topical composition according to any one of the preceding claims, wherein said composition is in cream form.
13. The topical composition according to any one of the preceding claims, wherein the subject matter topical composition comprises the below mentioned substances:
Figure imgf000011_0002
14. A method comprising the below mentioned steps for the production of a topical composition according to claim 1 :
Mixing of hypericum perforatum oil, propolis extract (solution), PEG-400, sodium polyacrylate, dicaprylyl carbonate, polyglyceril-3-caprate, coco caprylate, sodium stearyl glutamate, odor agent and water, and obtaining the composition in cream form.
15. A topical composition according to any one of the preceding claims for use in cosmetic treatment.
PCT/TR2022/050536 2021-06-09 2022-06-06 Herbal cream containing hypericum perforatum oil and propolis Ceased WO2022260632A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
TR2021/009490 TR2021009490A2 (en) 2021-06-09 HERBAL CREAM CONTAINING St. John's Wort Oil and Propolis
TR2021009490 2021-06-09

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WO2022260632A2 true WO2022260632A2 (en) 2022-12-15
WO2022260632A3 WO2022260632A3 (en) 2023-01-05

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6197305B1 (en) * 1998-01-05 2001-03-06 Farmo-Nat Ltd. Anti-fungal compositions with prolonged activity
US7666451B2 (en) * 2003-03-21 2010-02-23 Elizabeth Anne Mazzio Method of treating dyshidrosis(pompholyx) and related dry skin disorders
RS20070382A (en) * 2007-09-26 2009-07-15 Anka Štangl Procedure for preparation of skin care cream
WO2014103475A1 (en) * 2012-12-27 2014-07-03 株式会社林原 Skin-exterior anti-ageing composition and production method therefor

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