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WO2022255232A1 - Élément d'introduction d'ions de batterie biologique et matériau de base de type feuille - Google Patents

Élément d'introduction d'ions de batterie biologique et matériau de base de type feuille Download PDF

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Publication number
WO2022255232A1
WO2022255232A1 PCT/JP2022/021660 JP2022021660W WO2022255232A1 WO 2022255232 A1 WO2022255232 A1 WO 2022255232A1 JP 2022021660 W JP2022021660 W JP 2022021660W WO 2022255232 A1 WO2022255232 A1 WO 2022255232A1
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WIPO (PCT)
Prior art keywords
electrode member
skin
positive electrode
base material
negative electrode
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2022/021660
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English (en)
Japanese (ja)
Inventor
賢司 小蒲
祐介 小蒲
耕平 小蒲
圭亮 小蒲
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Iongear Co Ltd
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Iongear Co Ltd
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Filing date
Publication date
Application filed by Iongear Co Ltd filed Critical Iongear Co Ltd
Priority to JP2023525778A priority Critical patent/JPWO2022255232A1/ja
Publication of WO2022255232A1 publication Critical patent/WO2022255232A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis

Definitions

  • the present invention is used in contact with the skin, and does not provide an external power source, and treats a target site by electro-stimulation caused by an electric current based on a weak DC electromotive force flowing through the subcutaneous tissue of the body.
  • the present invention relates to a battery therapy device, and relates to a bio-battery type iontophoresis member and a sheet-like base material for the bio-battery type iontophoresis member that effectively utilizes the function of a bio-battery that enables the introduction of drug components into the living body.
  • the present inventors have previously proposed a bio-battery therapeutic device that heals muscle and nerve fatigue through electrical stimulation, and patents have been granted for both (see Patent Documents 1 and 2).
  • the bio-battery treatment tool forms a bio-battery when it comes into contact with the skin and supplies a direct current without providing an external power supply, and is an excellent treatment tool having a therapeutic effect as a treatment tool for home use. It has been proven.
  • the above conventional bio-battery therapeutic device treats a living body by introducing an electric current into the living body through the skin.
  • An object of the present invention is to effectively use the function of the bio-cell therapeutic device to further improve the therapeutic effect of the living body.
  • the present inventors focused on the fact that ions pass through the living body when the bioelectrical battery therapeutic device is brought into contact with the living body.
  • the inventors have found that the ionic components of the drug solution also enter the living body when an electric current flows in the living body by means of a bioelectrical battery therapeutic device, and have completed the present invention.
  • the bio-battery type iontophoresis member according to the first invention of the present application is a positive electrode member having flexibility that can be deformed according to the skin; a negative electrode member superimposed on the positive electrode member, having an opening for exposing a part of the positive electrode member, and having flexibility so that it can be deformed according to the skin; a chemical solution-containing layer formed on the negative electrode member in a non-contact state with the positive electrode member and impregnated with a negatively chargeable chemical component; has The positive electrode member forms a positive terminal in a region exposed from the opening of the negative electrode member, When the chemical-containing layer and the positive electrode terminal are in contact with the skin, a circuit is formed in which current flows through the skin into the body, and the chemical component contained in the chemical-containing layer is negatively charged while the current flows. is introduced into the body as negative ions.
  • a protrusion made of the same material as that of the positive electrode member or another material containing a noble metal is provided on the positive electrode member in the opening, and the positive electrode terminal is configured by the protrusion.
  • the chemical containing layer is formed on the negative electrode member in a region 0.5 mm to 5 mm away from the edge of the opening.
  • the bio-battery type iontophoresis member according to the second invention of the present application is a positive electrode member having flexibility that can be deformed according to the skin; a negative electrode member superimposed on the positive electrode member; has The negative electrode member is a mixture of metal powder and a chemical component, so that the negative electrode member has a function as a chemical solution-containing layer in addition to a function as a negative electrode, When the negative electrode member and the positive electrode member are in contact with the skin, a circuit is formed in which an electric current flows through the skin in the body. characterized by being introduced
  • the bio-battery type iontophoresis member according to the third invention of the present application is a positive electrode member having flexibility that can be deformed according to the skin; a negative electrode member superimposed on the positive electrode member, having an opening for exposing a part of the positive electrode member, and having flexibility so that it can be deformed according to the skin; a chemical containing layer formed on the positive electrode member so as to fill the opening and impregnated with a positively chargeable chemical component; has When the chemical-containing layer and the negative electrode member are in contact with the skin, a circuit is formed in which an electric current flows through the skin into the living body, and the chemical component contained in the chemical-containing layer is positively charged while the electric current flows. is introduced into the body as positive ions.
  • the chemical solution containing layer is formed on the negative electrode member so as to extend in a region of 0.5 to 5 mm from the edge of the opening.
  • the edge of the opening in the negative electrode member is formed by the separation band, and the edge of the opening is formed by the opening edge of the separation band.
  • a bio-battery-powered iontophoretic member is The chemical component contained in the chemical-containing layer has a molecular weight of 600 g/mol or less. Further, the chemical components contained in the chemical solution-containing layer are one or more selected from the group consisting of drugs, nutrients, and cell-constituting substances.
  • the chemical liquid component of the chemical liquid containing layer forms a conductive jelly or gel having a viscosity necessary for coating on the surface of the negative electrode member.
  • the chemical-containing layer has a carrier impregnated with the chemical component, and the carrier is made of one or more selected from the group consisting of cloth, nonwoven fabric, and sponge.
  • the positive electrode member is supported on a flexible base material that can be deformed according to the skin. The base material has a region on the edge where the positive electrode member is not arranged, and an adhesive layer having adhesiveness to the skin is formed on the surface of this region on the side of the positive electrode member.
  • the adhesive layer contains the chemical component in addition to the adhesive component.
  • Zn is contained in the conductive base material.
  • the bio-battery type iontophoresis member according to the fourth invention of the present application is a positive electrode member having flexibility that can be deformed according to the skin; a negative electrode member having flexibility that can be deformed according to the skin; a wiring layer that connects the positive electrode member and the negative electrode member; a chemical solution-containing layer provided on the surface of at least one of the negative electrode member or the positive electrode member and impregnated with a negatively or positively charged chemical component; has When the positive electrode member and the chemical solution-containing layer or the negative electrode member and the chemical solution-containing layer are in contact with the skin, a circuit is formed in which an electric current flows in the body through the skin. It is characterized in that the contained chemical components are charged negatively or positively before being introduced into the living body.
  • the sheet-like base material for producing the bio-battery type iontophoresis member according to the present invention is a first sheet base material having flexibility that can be deformed according to the skin and serving as the positive electrode member; a second sheet base material having flexibility that can be deformed according to the skin, and being attached to the first sheet base material to serve as the negative electrode member; has The second sheet base material has an opening that exposes the first sheet base material to the surface side of the second sheet base material.
  • the first sheet base material is a thin film having a thickness of 200 ⁇ m or less, and at least a surface portion thereof is made of noble metal or carbon
  • the second sheet base material has a thin film shape with a thickness of 200 ⁇ m or less, and at least its surface portion is formed of a material that is more ionizable than the material forming the surface portion of the first sheet base material.
  • the first sheet base material is formed by mixing a rubber base material with components constituting a positive electrode
  • the second sheet base material is formed by mixing a rubber base material with components constituting the negative electrode.
  • the first sheet base material and the second sheet base material have a hardness of 80° or less measured by a durometer type A tester based on the International Organization for Standardization.
  • At least one of the first sheet base material and the second sheet base material has an elongation at break of 120% or more.
  • the positive electrode region and the negative electrode region of the bio-battery are brought into contact with, adhered to, or adhered to desired portions of the skin, respectively, and an electric current is passed through the body, whereby the medicinal components of the drug solution are released. It can enter the body as ions and effectively exert the effects of the medicinal ingredients.
  • (a) is a plan view showing a sheet-like base material for a bio-battery iontophoresis member
  • (b) is a plan view showing a bio-battery iontophoresis member having a chemical-impregnated layer impregnated with a chemical on its surface.
  • (a) and (b) are cross-sectional views showing a sheet-like base material for a bio-battery type iontophoresis member.
  • (a) to (d) are cross-sectional views showing a negative iontophoresis type bio-battery type iontophoresis member.
  • FIG. 2(a) is a cross-sectional view showing a bio-battery-type iontophoresis member provided with a separation zone for a negative iontophoresis system and (b) for a positive iontophoresis system.
  • FIG. 4 is a cross-sectional view showing another embodiment of the present invention; (a), (b), and (c) are plan views showing other embodiments of the bio-battery type iontophoresis member according to the present invention.
  • (a) shows a cutting method of the bio-battery type iontophoresis member
  • (b) is a diagram showing a usage method of the bio-battery type iontophoresis member.
  • FIG. 1(a) is a plan view showing a sheet-like base material for a biobattery-type iontophoresis member of an embodiment of the present invention
  • FIG. 1(b) is a biobattery-type iontophoresis member of an embodiment of the present invention.
  • It is a plan view showing. 2(a) and 2(b) are cross-sectional views showing the sheet-like substrate
  • FIGS. 3(a) and 3(b) are cross-sectional views showing the bio-battery type iontophoresis member.
  • the second sheet base material 2 constituting the negative electrode member 12 is superimposed on the first sheet base material 1 constituting the positive electrode member 11 . are spliced together.
  • An opening 2a is formed in the second sheet substrate 2, and the first sheet substrate 1 is exposed through the opening 2a when viewed from the second sheet substrate 2 side. Further, the exposed portion of the first sheet base material 1 in the opening 2a becomes the positive electrode terminal 11a of the positive electrode member 11 (the positive electrode terminal 1a of the first sheet base material 1).
  • FIG. 1A for example, four openings 2a are formed in the second sheet base material 2, and positive terminals 1a are formed in the four openings 2a, respectively.
  • the sheet-like base material shown in FIG. 2B has a sheet-like support material 14 joined to the back surface of the first sheet base material 1 .
  • the first sheet base material 1, the second sheet base material 2, and the support material 14 have such flexibility that they can be deformed according to the skin.
  • the first sheet base material 1 for the positive electrode member is, for example, a sheet mixed with carbon to provide conductivity as a positive electrode
  • the second sheet base material 2 for the negative electrode member is, for example, mixed with zinc. It is a sheet that has conductivity as a negative electrode.
  • the first sheet base material 1 is, for example, a thin film having a thickness of 200 ⁇ m or less, preferably 20 ⁇ m or less, and a noble metal or carbon layer is formed on at least the surface thereof.
  • the second sheet substrate 2 is, for example, a thin film having a thickness of 200 ⁇ m or less, preferably 20 ⁇ m or less, and at least the surface thereof is made of a material that is more ionizable than the first sheet substrate 1 .
  • a conductor with a high ionization tendency is used as the negative electrode member 12, and a conductor with a low ionization tendency is used as the positive electrode member 11.
  • the skin is used as an electrolyte, and the negative electrode member, the skin, the inside of the body, the skin, An electric circuit is formed in the positive electrode member.
  • the first sheet base material 1 and the second sheet base material 2 can each be a sheet in which a material constituting a positive electrode and a negative electrode are mixed in a stretchable rubber base material in order to provide flexibility.
  • the rubber substrate preferably has a hardness of 80° or less, preferably 50° or less, measured with a durometer type A tester based on the International Organization for Standardization.
  • At least one of the first sheet substrate 1 and the second sheet substrate 2 preferably has an elongation at cutting of 120% or more, preferably 300% or more.
  • the material of the first sheet base material 1, which serves as the positive electrode member 11, is flexible enough to adhere to a living body and functions as a positive electrode.
  • Examples include ITO (indium tin oxide, transparent electrode).
  • the material of the second sheet base material 2 to be the negative electrode member 12 similarly has the flexibility to adhere to the living body and functions as a negative electrode, and as described above, there is a zinc-mixed conductive material.
  • This zinc-containing conductive material has anisotropy with respect to electron flow, and the negative electrode member 12 has conductivity in the thickness direction, but has high resistance in the direction parallel to the surface.
  • the support member 14 bonded to the lower surface of the first sheet base material 1 is attached to the laminate of the first sheet 1 (positive electrode member 11) and the second sheet 2 (negative electrode member 12). Since it functions as a reinforcing material, it is possible to make the positive electrode member 11 and the negative electrode member 12 even thinner.
  • the material of the support material 14 is not particularly limited, but examples thereof include a film-like thin film such as a resin, cloth made of fibers, non-woven fabric, and the like.
  • the support material 14 a material larger than the positive electrode member 11 and the negative electrode member 12 is used so that the outer edge portion 14a of the support material 14 protrudes from the end surfaces of the positive electrode member 11 and the negative electrode member 12, and the outer edge portion 14a
  • the support member 14 is arranged so that the is exposed. Then, an adhesive layer having tackiness or adhesiveness capable of adhering to the skin is formed on the skin contact surface of the upper surface of the exposed outer edge portion 14a.
  • a chemical component can be applied to the outer edge portion 14a in addition to the adhesive layer.
  • the liquid medicine component can be introduced into the living body through the skin also from this outer edge portion 14a.
  • a negatively chargeable chemical solution is placed on the second sheet base material 2 of the above-described sheet-like base material.
  • a chemical solution containing layer 15 containing components is formed. That is, the first sheet base material 1 constitutes the positive electrode member 11 , and the second sheet base material 2 constitutes the negative electrode member 12 .
  • An opening 12a is formed in the negative electrode member 12 to expose the positive electrode member 11 under the negative electrode member 12, and the positive electrode terminal 11a is formed in the opening 12a where the positive electrode member 11 is exposed.
  • a chemical solution containing layer 15 is formed in a region separated by a distance d from the edge of the opening 12a on the negative electrode member 12 in which the opening 12a is formed.
  • This distance d is, for example, 0.5 to 5 ⁇ m, and by setting this distance d, contact between the chemical solution containing layer 15 and the positive electrode member 11 can be reliably prevented.
  • convex positive terminals 11b and 11c may be formed in the opening 12a.
  • the surface of the chemical solution-containing layer 15 and the convex surfaces of the convex positive terminals 11b and 11c have substantially the same height, and when the biobattery-type iontophoresis member of this embodiment is brought into contact with the skin surface, Not only the chemical solution-containing layer 15 but also the positive terminals 11b and 11c can be reliably brought into contact with the skin surface.
  • the layer thickness of the negative electrode member 12 (for example, a zinc layer) is as thin as several tens of ⁇ m, even if the convex positive terminals 11b and 11c are not provided, the thickness shown in FIGS.
  • the convex positive terminal 11b shown in FIG. 3(c) is made of the same material as the positive electrode member 11, and the convex positive terminal 11c shown in FIG. 3(d) is made of a noble metal such as gold. ing. If the convex positive electrode terminal 11c is made of noble metal, the electromotive force of the bio-battery can be increased.
  • the chemical solution-containing layer 15 shown in FIG. 3( a ) is formed by directly applying the chemical solution onto the negative electrode member 12 .
  • This chemical solution containing layer 15 is effective for highly viscous jelly-like chemical solutions.
  • the chemical solution contained in the chemical solution containing layer 15 can be made into a highly viscous jelly so as to enhance adhesion to the skin. Accordingly, the chemical solution can be directly applied to the surface of the negative electrode member 12 to form the chemical solution containing layer 15 .
  • the chemical-impregnated layer 15 shown in FIG. 3(b) is formed by impregnating cloth, non-woven fabric, sponge, or the like with a chemical.
  • This chemical solution containing layer 15 is effective for chemical solutions with low viscosity. If a low-viscosity chemical solution is applied directly onto the negative electrode member 12, the chemical solution may flow out from the chemical solution-containing layer 15 toward the positive electrode terminal 11a and come into contact with the positive electrode terminal 11a. Therefore, when the chemical solution is used in a state of low viscosity, it is preferable to impregnate a cloth, non-woven fabric, sponge, or the like with the chemical solution so that the chemical solution does not inadvertently flow out of the chemical solution-containing layer 15 .
  • the distance d between the chemical solution containing layer 15 and the positive electrode terminals 11a, 11b, and 11c is specifically the distance between the end face of the opening 12a provided in the negative electrode member 12 and the edge of the chemical solution containing layer 15. is the distance between By providing the interval d in this way, it is possible to prevent the chemical solution-containing layer 15 from contacting the positive electrode terminals 11a, 11b, and 11c and form a circuit that does not pass through the living body. It can penetrate deeper into the body and effectively enhance its efficacy.
  • the medicinal components contained in the drug-containing layer according to the present invention that is, the medicinal components that can be introduced into the living body by the bio-battery iontophoresis member according to the present invention will be specifically described below.
  • the electromotive voltage of the bio-battery type iontophoresis member normally depends on the material of the members that constitute the positive and negative electrodes, but at the present time, the material easily available to those skilled in the art has a maximum of about 1000 mV. is 300 mV to 700 mV, and due to this electromotive force, a weak current with a maximum current of about several tens of microamperes is generated in the body. However, even with such a voltage and current, it is possible to introduce electrons into the body of a substance with a molecular weight of about 500 g/mol. Further, the bio-battery type iontophoresis member according to the present invention can introduce ions into a living body simply by being attached to the living body.
  • the bio-battery-type iontophoresis member of the present invention can be kept in contact with the skin for a long period of time, and as a result, an effective amount of the medicinal component can be reliably introduced into the body.
  • the drug solutions to be used in the present invention include drugs typified by antiphlogistic and analgesic agents, nutrients typified by vitamins, cell constituents typified by amino acids and collagen, and hair growth and hair growth ingredients. , from medical applications to cosmetic applications.
  • Specific drugs include, for example, indomethacin, felbinac, loxoprofen, diclofenac sodium, and the like.
  • Nutrients include vitamins (vitamin C, vitamin D, vitamin H, vitamin K, thiamine, riboflavin, niacin, vitamin B6, folic acid, biotin, vitamin B12).
  • cell constituents include amino acids, collagen (mainly low-molecular-weight types), placenta, fetic acid, calcium compounds, and so on.
  • Hair growth/restoration ingredients include, for example, minoxidil, t-flavanone, 6-benzylaminopurine, adenosine, finasteride, pantothenyl ethyl ether, pentadecanoic acid glyceride, and adenosine.
  • the bio-battery iontophoresis member shown in FIG. 3 is placed on the living body while the chemical-containing layer 15 and positive terminals 11a, 11b, and 11c of the bio-battery iontophoresis member are in contact with the skin. Then, a circuit is formed between the positive terminals 11a, 11b, and 11c that come into contact with the skin and the negative terminal 12 that comes into contact with the skin through the chemical solution-containing layer 15, with the inside of the body being a current path through the skin. .
  • a circuit is formed in which electrons are generated from the negative electrode member 12, pass through the chemical-containing layer 15, are introduced into the body through the skin, pass through the body, and enter the positive electrode terminal 11a. While the electrons are moving, the chemical solution in the chemical solution-containing layer 15 is negatively charged, and negative ions of the chemical solution are introduced into the living body through the skin.
  • the living body can obtain medicinal effects such as drugs, nutrients, cell antibiotics, and hair growth and restoration.
  • the positive terminal 11a shown in FIGS. 3(a) and 3(b) is configured by the exposed surface of the positive electrode member 11, and the positive terminals 11b and 11c shown in FIGS. Consists of convex electrodes.
  • the positive electrode terminal 11a formed by the exposed surface is sufficiently contactable with the skin. Contact between the terminals and the skin can be reliably obtained.
  • FIG. 4 shows a bio-battery type iontophoresis member that introduces positive ions into the body.
  • the bio-battery type iontophoresis member shown in FIG. 4(a) shows the case where the chemical solution is directly applied in the opening 12a of the negative electrode member 12 to form the chemical solution containing layer 15, and the chemical solution has a jelly-like or gel structure. This is effective when the chemical liquid is made viscous.
  • the bio-battery-type iontophoretic member shown in FIG. 4(b) is a case in which the chemical solution is impregnated into cloth, nonwoven fabric, sponge, or the like, and placed in the opening 12a of the negative electrode member 12.
  • the mode in which the chemical solution-containing layer 15 is formed by impregnating the chemical solution with, etc., is effective when the chemical solution is applied in a fluid state.
  • the bio-battery type iontophoresis member of this embodiment configured in this way, a current is generated that flows through the skin between the positive electrode member 11 and the negative electrode member 12 in the living body.
  • the ions generated from the positive electrode member 11 pass through the chemical solution-containing layer 15 and positively charge the chemical solution, and the positive ions are introduced into the living body through the skin.
  • the positive ions reach the negative electrode member 12 and form a circuit flowing through the positive electrode member 11, the skin, the living body, the skin, and the negative electrode member 12.
  • FIG. the positive ions of the drug solution are introduced into the living body and exert their medicinal effects on the living body.
  • FIG. 5 shows an embodiment in which a ring-shaped insulating separation band 21 is arranged inside the opening 12 a provided in the negative electrode member 12 .
  • the edge of the opening 21a of the separation band 21 constitutes the edge of the negative electrode member 12, and the edge of the opening 12a of the negative electrode member 21 is the separation band 21. It is composed of Therefore, in the negative iontophoretic bio-battery type iontophoretic member shown in FIG. , is formed on the negative electrode member 12 and the separation band 21 .
  • Sufficient insulation between the chemical-containing layer 15 and the positive electrode terminal can be ensured in any type of bio-battery-type iontophoretic member. Also, by providing the separation band 21, it becomes easy to dispose the chemical solution-containing layer 15 at an appropriate position, and difficulty in operation can be reduced.
  • FIG. 6 is a cross-sectional view showing a bio-battery type iontophoresis member according to another embodiment of the present invention.
  • a sheet-like negative electrode member 121 is adhered to the lower surface of the sheet-like positive electrode member 11 .
  • the negative electrode member 121 is formed by hardening metal powder using a binder to form a sheet.
  • the binder contains a medicinal component so that the negative electrode member 121 functions as a drug-containing layer.
  • a jelly-like chemical solution containing layer can be used as the binder in this case. That is, by mixing powder such as Zn as metal particles into the highly viscous jelly-like chemical-containing layer that is not fluidized, the chemical-containing layer can be formed without containing any particular binder component.
  • a negative electrode member 121 that also serves as a negative electrode member 121 can be formed.
  • the chemical component can be applied to a substrate such as a sponge impregnated with the chemical component, and then the metal powder can be carried on the substrate.
  • a negative electrode member 121 can be formed that includes a component and a metal powder.
  • the negative electrode member 121 of the present embodiment can contain a medicinal component in the metal powder by containing the metal powder in the drug layer, and harden with an appropriate binder in that state.
  • a positive electrode terminal 11a is formed at the edge of the positive electrode member 11 not covered with the negative electrode member 121, and the biobattery-type iontophoresis member of the present embodiment is arranged so that the positive electrode terminal 11a contacts the skin. be.
  • the negative electrode member 121 by bringing the negative electrode member 121 and the positive electrode terminal 11a of the positive electrode member 11 into contact with the skin, it functions as a bio-battery type iontophoresis member.
  • the negative electrode member 121 functions not only as a negative electrode that exchanges electrons with the skin, but also as a drug-containing layer containing a medicinal component.
  • FIG. 7(a) to (c) are plan views showing a bio-battery type iontophoresis member according to another embodiment of the present invention.
  • the bio-battery-type iontophoresis member shown in FIG. 7( a ) is obtained by connecting a rectangular negative electrode member 12 and a circular positive electrode member 11 with a thin wiring layer 13 at the center of the negative electrode member 12 and the positive electrode member 11 .
  • Electrode arrangement is T-shaped).
  • a chemical solution containing layer 15 is formed on the rectangular negative electrode member 12 .
  • This bio-battery-type iontophoresis member is placed on a living body so that the chemical solution-containing layer 15 and the positive electrode member 11 are in contact with the skin.
  • the bio-battery-type iontophoresis member shown in FIG. 7(b) is the same as that shown in FIG. The difference is that the connection position of the negative electrode member 12 in the layer 13 is the end of the negative electrode member 12 (the electrode arrangement is L-shaped). 7(c), the negative electrode member 12 as well as the positive electrode member 11 are rectangular (the electrode arrangement is H-shaped). different from Thus, even when the negative electrode member 12 and the positive electrode member 11 are formed at different positions and connected by the wiring layer 13, an excellent effect of introduction of the medicinal effect can be obtained.
  • FIG. 8 is a diagram showing a usage example of the bio-battery type iontophoresis member of this embodiment.
  • the bio-battery type iontophoresis member of the present embodiment (for example, the embodiment shown in FIG. 1) is cut into a T shape including the positive electrode member 11, and the application site of the living body ( For example, elbows, legs, nose, etc.).
  • FIG. 8(b) shows a state in which the T-shaped or H-shaped bio-battery type iontophoresis member shown in FIG.
  • a positive member and a negative member can be arranged in the bio-battery type iontophoresis member in which the positive electrode member 11 and the negative electrode member 12 are connected by the wiring layer 13 in a T-shape or H-shape shown in FIG.
  • This arrangement allows current to pass through the elbow, leg, nose, etc., resulting in the introduction of ions of the drug applied to the bio-powered iontophoresis member into the body.
  • the bioelectrical battery therapeutic device by effectively utilizing the function of the bioelectrical battery therapeutic device, it is possible to ionize the chemical component and introduce it into the living body through the skin, thereby achieving a remarkable effect of efficiently enhancing the efficacy of the drug. Therefore, the range of application of this type of therapeutic device can be expanded.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Veterinary Medicine (AREA)
  • Electrotherapy Devices (AREA)

Abstract

La présente invention concerne une batterie biologique pouvant atteindre un effet thérapeutique en portant une borne d'électrode positive et un élément d'électrode négative en contact avec la peau afin de faire circuler un courant électrique dans un corps vivant à travers la peau. De plus, cette batterie biologique est pourvue d'une couche contenant un liquide chimique stratifiée sur l'élément d'électrode négative pour introduire des électrons depuis l'élément d'électrode négative à travers la couche contenant un liquide chimique au niveau de la peau et du corps vivant. En conséquence, lorsque le courant électrique s'écoule dans le corps vivant à travers la peau, le constituant liquide chimique contenu dans la couche contenant un liquide chimique devient des ions négatifs et est introduit dans le corps vivant. Ainsi, la présente invention peut atteindre un effet thérapeutique de constituants médicinaux sur le corps vivant.
PCT/JP2022/021660 2021-05-29 2022-05-26 Élément d'introduction d'ions de batterie biologique et matériau de base de type feuille Ceased WO2022255232A1 (fr)

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JP2021-090716 2021-05-29

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003000727A (ja) * 2001-04-18 2003-01-07 Vanguard:Kk 皮接治療具
JP2004105515A (ja) * 2002-09-19 2004-04-08 Hayashibara Biochem Lab Inc イオン導入具
WO2018194079A1 (fr) * 2017-04-21 2018-10-25 日本電信電話株式会社 Timbre transdermique pour tissu biologique

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003000727A (ja) * 2001-04-18 2003-01-07 Vanguard:Kk 皮接治療具
JP2004105515A (ja) * 2002-09-19 2004-04-08 Hayashibara Biochem Lab Inc イオン導入具
WO2018194079A1 (fr) * 2017-04-21 2018-10-25 日本電信電話株式会社 Timbre transdermique pour tissu biologique

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