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WO2022240007A1 - Système de détection de tomographie optoacoustique de type stylo à balayage libre pour la mesure de la mélanine dans la peau - Google Patents

Système de détection de tomographie optoacoustique de type stylo à balayage libre pour la mesure de la mélanine dans la peau Download PDF

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Publication number
WO2022240007A1
WO2022240007A1 PCT/KR2022/005870 KR2022005870W WO2022240007A1 WO 2022240007 A1 WO2022240007 A1 WO 2022240007A1 KR 2022005870 W KR2022005870 W KR 2022005870W WO 2022240007 A1 WO2022240007 A1 WO 2022240007A1
Authority
WO
WIPO (PCT)
Prior art keywords
optoacoustic
pen
lens
sensing system
signal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2022/005870
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English (en)
Korean (ko)
Inventor
전만식
성대운
이재율
김지현
한상엽
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Industry Academic Cooperation Foundation of KNU
Original Assignee
Industry Academic Cooperation Foundation of KNU
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Filing date
Publication date
Application filed by Industry Academic Cooperation Foundation of KNU filed Critical Industry Academic Cooperation Foundation of KNU
Publication of WO2022240007A1 publication Critical patent/WO2022240007A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0093—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy
    • A61B5/0095—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy by applying light and detecting acoustic waves, i.e. photoacoustic measurements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/44—Detecting, measuring or recording for evaluating the integumentary system, e.g. skin, hair or nails
    • A61B5/441—Skin evaluation, e.g. for skin disorder diagnosis
    • A61B5/443—Evaluating skin constituents, e.g. elastin, melanin, water
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/74—Details of notification to user or communication with user or patient; User input means
    • A61B5/742—Details of notification to user or communication with user or patient; User input means using visual displays
    • A61B5/7445—Display arrangements, e.g. multiple display units

Definitions

  • the present invention relates to a free scanning pen-type optoacoustic tomographic sensing system for measuring intradermal melanin, and more particularly, to a free scanning pen-type optoacoustic tomographic sensing system for non-invasively measuring intradermal melanin.
  • the most representative method is a non-invasive method, which is measured using scattering-based imaging equipment.
  • scattering-based imaging equipment has a problem in that it is difficult to accurately measure because the measurable depth is shallow and the depth direction of the melanocyte nevus is unknown.
  • Patent Document 1 Republic of Korea Patent Publication No. 10-2014-0001453
  • Another object of the present invention is to provide a pen-type photoacoustic tomographic sensing system capable of measuring the depth-direction formation of melanoma or efficiently distinguishing borderline, complex, and intradermal nevus according to the location of melanocyte nevus in skin tissue. is to provide
  • Another object of the present invention is to improve the precision and efficiency of evaluation by being used for diagnosis and postoperative evaluation of skin diseases such as malignant melanoma or for diagnosis and evaluation before and after point removal surgery. It is to provide a pen-type photoacoustic tomographic sensing system.
  • the pen-type probe includes a collimator that converts the laser into parallel light; An axicon lens that generates a Bessel beam by receiving parallel light; and an acoustic lens, and may include an ultrasonic transducer positioned at a rear end of the axicon lens to obtain an optoacoustic signal.
  • the pen-type probe may further include a donut lens that allows the Bessel beam to pass through and be focused on a specific region or point, and to match an axis of the focused Bessel beam with an axis of a direction in which the optoacoustic signal is obtained. .
  • a hole having a predetermined size may be formed in the center of the donut lens, and the ultrasonic transducer may be inserted into the hole and positioned around the ultrasonic transducer.
  • one surface of the donut lens may be formed as a flat surface and the other surface may be formed to have a parabolic surface by a predetermined curvature, and the parabolic surface may be provided to face the axicon lens.
  • the signal acquisition unit may include an amplification module that amplifies the acquired optoacoustic signal; a digitizer acquiring data corresponding to the amplified photoacoustic signal; and a display outputting the acquired data.
  • a pen-type optoacoustic tomography sensing system capable of penetrating a laser deeper than a measurable depth with conventional scattering-based imaging equipment, it is possible to obtain depth direction navigation information of a cell nevus. It can be used for diagnosis and postoperative evaluation of skin diseases such as malignant melanoma, or for diagnosis and evaluation before and after mole removal surgery to improve the precision and efficiency of evaluation.
  • FIG. 1 is a diagram for explaining the configuration of a pen-type optoacoustic tomography sensing system according to an embodiment of the present invention
  • FIG. 3 is a diagram for explaining how a laser is transmitted and an optoacoustic signal is acquired in a pen-type probe according to an embodiment of the present invention.
  • FIG. 1 is a view for explaining the configuration of a pen-type optoacoustic tomography sensing system according to an embodiment of the present invention
  • FIG. 2 is a combination of an ultrasonic transducer 230 and a donut lens 250 according to an embodiment of the present invention
  • FIG. 3 is a diagram for explaining how a laser is transmitted and an optoacoustic signal is obtained in the pen-type probe 200 according to an embodiment of the present invention.
  • the light source unit 100 is for transmitting the laser generated through optical coupling with the pen-type probe 200 to generate laser, and includes a laser source 110 and a collimator 120.
  • the light source unit 100 generates a wavelength of 700 nm band when measuring the melanin component in order to take advantage of the fact that different biological tissues have various absorbances according to the wavelength of light, and blood vessels
  • it may include a laser source 110 capable of generating a wavelength in the 500 nm band.
  • the collimator 120 included in the light source unit 100 is provided for optical coupling with the pen-type probe 200, and the collimator 120 of the light source unit 100 is connected to the collimator 210 of the pen-type probe 200. do. Through this, the laser generated from the laser source 110 is transmitted to the collimator 210 of the pen type probe 200 .
  • the light source unit 100 is connected to the pen-type probe 200 through the collimator 120 forming a parallel beam of light through an optical fiber.
  • the pen-type probe 200 receives the laser generated from the light source unit 100 through light coupling with the light source unit 100, irradiates it to a target to be photographed, and acquires an optoacoustic signal output from the target to be photographed. And the acquired optoacoustic signal may be transmitted to the signal acquisition unit 300 .
  • the pen-type probe 200 is configured and arranged according to an optical design that converts laser from an optical fiber into small-diameter collimated light and then generates a Bessel beam to perform line focusing or area focusing on a target area.
  • the pen-type probe 200 in the present invention includes a collimator 210, an axicon lens 220, an ultrasonic transducer 230, an acoustic lens 240, and a donut lens 250. arranged to do
  • the collimator 210 converts the laser into small-aperture collimated light and irradiates it toward the axicon lens 220 .
  • the donut lens 250 is provided to increase the Sigmal to noise ratio (SNR) while enabling the optoacoustic tomography sensing system according to the present embodiment to have a deeper imaging depth.
  • SNR Sigmal to noise ratio
  • the Bessel beam generated from the axicon lens 220 is passed through and focused on a specific area or point passing through, and when the Bessel beam is irradiated toward a photographing target, the axis of the focused Bessel beam and the acoustic lens 240 The axis of the acquisition path of the photoacoustic signal obtained from the photographed object to be collected may be matched.
  • the donut lens 250 has a hole having a predetermined size in the center, and the ultrasonic transducer 230 is inserted into the hole so that the ultrasonic transducer 230 is positioned around the ultrasonic transducer 230 .
  • one surface of the donut lens 250 is formed as a flat surface, and the other surface is formed as a plano-convex lens having a predetermined curvature.
  • the donut lens 250 has a diameter of 25.4 cm and a center thickness of 25.4 cm. may be selected within 12 cm to 18 cm, and the diameter of the hole may be provided as 12 cm. Of course, this may be changed in consideration of the external diameter and focal length of the inserted ultrasonic transducer 230 as an example for convenience of description.
  • the Bessel beam passing through the donut lens 250 is converged at a certain point, and as shown in FIG. 3, the axis of the Bessel area and the axis of the path for obtaining the photoacoustic signal coincide
  • the pen-type probe 200 according to the example enables deep sensing as well as increasing a signal-to-noise ratio.
  • the optoacoustic tomographic sensing system viewed through the donut lens 250 according to the present embodiment is 3 to 5 mm from the skin surface compared to the imaging depth ( ⁇ 1 mm) of conventional scattering-based image imaging equipment. Since it has an imaging depth of up to, it is possible to measure areas deep below the skin surface.
  • the central axes of the collimator 210, the axicon lens 220, the ultrasonic transducer 230, the acoustic lens 240, and the donut lens 250 are all on the same line. , it can be provided in the form of a probe for a handle of a fiber-based pen type, thereby providing a user-friendly and easily usable optoacoustic tomography sensing system through free scanning.
  • the signal acquisition unit 300 is provided to amplify the photoacoustic signal obtained from the pen-type probe 200 and acquire data, and includes the amplification module 310, the digitizer 320, and the display 330. can include
  • the amplification module 310 receives and amplifies the optoacoustic signal obtained from the ultrasonic transducer 230 .
  • the digitizer 320 acquires data corresponding to the amplified optoacoustic signal.
  • the display 330 outputs the data acquired by the digitizer 320 as an image.
  • collimator 220 axicon lens
  • ultrasonic transducer 240 acoustic lens
  • amplification module 320 digitizer

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Acoustics & Sound (AREA)
  • Dermatology (AREA)
  • Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)

Abstract

L'invention concerne un système de détection de tomographie optoacoustique comprenant : une unité de source de lumière qui génère un laser ; une sonde de type stylo qui est optiquement accouplée à l'unité de source de lumière pour irradier le laser et obtenir un signal optoacoustique ; et une unité d'obtention de signal qui amplifie le signal optoacoustique obtenu et obtient des données. Par l'utilisation d'un système de détection de tomographie optoacoustique de type stylo en mesure de transmettre un laser plus profondément que la profondeur qui peut être mesurée à l'aide d'un équipement d'imagerie basé sur la diffusion de l'état de la technique associé, des informations de navigation dans la direction de profondeur d'un naevus cellulaire peuvent être obtenues et l'utilisation de la sonde de type stylo peut permettre un balayage libre indépendamment de l'emplacement d'un objet à mesurer.
PCT/KR2022/005870 2021-05-11 2022-04-25 Système de détection de tomographie optoacoustique de type stylo à balayage libre pour la mesure de la mélanine dans la peau Ceased WO2022240007A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020210060957A KR102542585B1 (ko) 2021-05-11 2021-05-11 피부 내 멜라닌 측정용 자유 스캐닝 펜타입 광음향 단층 센싱 시스템
KR10-2021-0060957 2021-05-11

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WO2022240007A1 true WO2022240007A1 (fr) 2022-11-17

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU222926U1 (ru) * 2023-11-22 2024-01-23 Федеральное государственное бюджетное научное учреждение "Федеральный исследовательский центр Институт прикладной физики им. А.В. Гапонова-Грехова Российской академии наук" (ИПФ РАН) Оптоакустический зонд на основе линзы аксикона для оптоакустической микроскопии оптического разрешения

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116593398A (zh) * 2023-05-19 2023-08-15 上海科技大学 一种双角度光声传感系统

Citations (5)

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US20060184042A1 (en) * 2005-01-22 2006-08-17 The Texas A&M University System Method, system and apparatus for dark-field reflection-mode photoacoustic tomography
KR20160081004A (ko) * 2014-12-30 2016-07-08 포항공과대학교 산학협력단 멜라노이딘 및/또는 멜라노이딘의 금속 킬레이팅 복합체를 포함하는 광흡수제, 이의 제조방법, 및 용도
KR20170086276A (ko) * 2016-01-18 2017-07-26 포항공과대학교 산학협력단 Mems 스캐너를 이용한 광음향/초음파 손잡이형 펜타입 프로브, 및 이를 이용한 광음향 영상 획득 시스템 및 방법
KR20180061920A (ko) * 2016-11-30 2018-06-08 부경대학교 산학협력단 광음향 단층촬영을 위한 프로브 및 실시간 광음향 단층촬영 장치
KR20190116805A (ko) * 2018-04-05 2019-10-15 경북대학교 산학협력단 광음향 내시경 프로브 및 상기 광음향 내시경 시스템

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101420003B1 (ko) 2012-06-27 2014-08-14 한양대학교 산학협력단 통합 단층 촬영 시스템

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060184042A1 (en) * 2005-01-22 2006-08-17 The Texas A&M University System Method, system and apparatus for dark-field reflection-mode photoacoustic tomography
KR20160081004A (ko) * 2014-12-30 2016-07-08 포항공과대학교 산학협력단 멜라노이딘 및/또는 멜라노이딘의 금속 킬레이팅 복합체를 포함하는 광흡수제, 이의 제조방법, 및 용도
KR20170086276A (ko) * 2016-01-18 2017-07-26 포항공과대학교 산학협력단 Mems 스캐너를 이용한 광음향/초음파 손잡이형 펜타입 프로브, 및 이를 이용한 광음향 영상 획득 시스템 및 방법
KR20180061920A (ko) * 2016-11-30 2018-06-08 부경대학교 산학협력단 광음향 단층촬영을 위한 프로브 및 실시간 광음향 단층촬영 장치
KR20190116805A (ko) * 2018-04-05 2019-10-15 경북대학교 산학협력단 광음향 내시경 프로브 및 상기 광음향 내시경 시스템

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU222926U1 (ru) * 2023-11-22 2024-01-23 Федеральное государственное бюджетное научное учреждение "Федеральный исследовательский центр Институт прикладной физики им. А.В. Гапонова-Грехова Российской академии наук" (ИПФ РАН) Оптоакустический зонд на основе линзы аксикона для оптоакустической микроскопии оптического разрешения

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KR20220153408A (ko) 2022-11-18
KR102542585B9 (ko) 2023-12-08
KR102542585B1 (ko) 2023-06-12

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