WO2022139747A1

WO2022139747A1 - Solution provided with antimicrobial property and skin product manufactured from the product to which said solution is applied

Info

Publication number: WO2022139747A1
Application number: PCT/TR2021/051265
Authority: WO
Inventors: Gulcin Almina FIDANLIK; Mehmet Serhan BODUROGLU
Original assignee: Eczacibasi Tuketim Urunleri Sanayi ve Ticaret AS
Current assignee: Eczacibasi Tuketim Urunleri Sanayi ve Ticaret AS
Priority date: 2020-12-25
Filing date: 2021-11-22
Publication date: 2022-06-30
Anticipated expiration: 2023-06-25
Also published as: TR202021791A2

Abstract

The subject of the invention relates to a solution provided with antimicrobial property, a nonwoven fabric provided with antimicrobial property to which said solution is applied, a skin product manufactured from said fabric and a method for applying said solution to the fabric. The solutions developed within the scope of the invention comprise at least one active ingredient at a ratio of 0.05-0.2% by weight and water at a ratio of 99.8-99.95% by weight, depending on the quantity of active ingredient used.

Description

SOLUTION PROVIDED WITH ANTIMICROBIAL PROPERTY AND SKIN PRODUCT MANUFACTURED FROM THE PRODUCT TO WHICH SAID SOLUTION IS APPLIED

Subject of the Invention

The subject of the invention relates to a solution provided with antimicrobial property, a nonwoven fabric provided with antimicrobial property to which said solution is applied, a skin product manufactured from said fabric and a method for applying said solution to the fabric.

State of the Art

The skin surface is the part of the body that is in continuous contact with the external environment and in interaction with numerous environmental factors and is thus exposed to numerous microbial agents in the environments contacted. Besides, the skin is an important part of the body that protects the internal organs from the external mechanical, chemical and biological effects by separating the same from the external environment, assists with the regulation of the body temperature and water balance and is capable of self-repair by performing the production of collagen and protein.

It is of importance to clean especially our hands with the skin products containing suitable antimicrobial agents, in order to minimize the risk of transmitting the microorganisms our hands are exposed to.

In the ambiences such as travel ambience where to make use of water is not immediately possible or in the ambiences such as public transport where the hygienic conditions are not appropriate, the need to clean our hands or face is today commonly satisfied still by the use of wet wipes. The wet wipes, the use of which has become quite widespread, are required to cleanse the skin without damaging the skin surface where they contact and by protecting the natural skin barrier and to provide the proper conditions of hygiene. Because of their practical use, the wet wipes are today frequently used in the restaurants, schools and even in hospitals, on the surfaces as well as on various body parts such as hands, face, etc. for the purposes of cleaning and hygiene. Because of their practical use, the mothers also make use of the wet wipes for cleansing the skin of their babies.

The wet wipes being used are expected to cleanse the skin surface and achieve the hygienic conditions while at the same time preserving the skin barrier and being free of the products likely to threaten the human health. The ingredients of the wet wipes intended for skin cleansing, the use of which becomes a need and even more widespread especially in the periods of disease and epidemics, has become even more important, since these are the products being exposed to by a greater extent in such periods.

The wet wipes are obtained by way of impregnation of the nonwoven fabrics with a solution having generally high water content. When a nonwoven fabric is subjected to treatment with a solution with high water content, more than one preservative agent (hexamidine diisethionate, methylisothiazolinone, benzisothiazolinone, imidazolidinyl urea, diazolidinyl urea, polyaminopropyl biguanide, DMDMH, etc.) with the possibility of providing action against different microorganisms (bacteria, mould, yeast) are added to the wet wipe solutions usually at high ratios such that no microbiological growth occurs. However, when the products according to the state of the art are used, the skin problems such as skin irritation, etc. occur, and further, the toxic effects emerge as a result of using the strong preservatives, depending on the concentrations and types of the preservatives such products contain.

Nonwoven fabric is a fabric-like material made from short and long (continuous long) fibers, bonded together by chemical, mechanical, heat or solvent treatment. The term is used in the textile manufacturing industry to denote fabrics, such as felt, which are neither woven nor knitted. Various natural and/or synthetic staples called fiber may be used as the raw material in the nonwoven fabrics. Natural fibers may include cotton, viscose and viscose types such as lyocell. There is a broad array of synthetic fibers, and polyester, polyethylene and polypropylene are among the most frequently encountered. These fibers may be used alone (e.g. 100% cotton, 100% polypropylene, etc.) or more than one type of fiber may be combined at various proportions (mixture 20% viscose and 80% polyester) for the manufacture of the nonwoven fabrics. Various methods are available for the manufacture of the nonwoven fabrics, including dry laid processes, wet laid processes and spun laid processes, the latter involving the melting of the polymer. Although it is attempted in all the methods to obtain a sterile product by subjecting the fibers that are to be used and the nonwoven fabrics that are obtained to various treatments, it is not possible to obtain these in a perfectly sterile manner as a result of the processes performed according to the state of the art.

The preservatives used in the solutions applied to the nonwoven fabrics for obtaining the skin products such as wet wipes lead to the odor and color change in the product, in addition to their harmful effects on the skin.

The solutions and the method according to the invention have been developed in order to eliminate the preservatives employed in great numbers and in high concentrations according to the state of the art and in order to obtain a skin product, preferably a wet wipe, provided with antimicrobial property without such preservatives being added to the solution.

Object of the Invention

An object of the invention is to develop a solution that is to be applied to a nonwoven fabric and to provide antimicrobial property to the fabric.

Another object of the invention is to develop a skin product with antimicrobial action wherein no preservative is added to the solution with which the nonwoven fabric is treated when obtaining said skin product. Another object of the invention is to develop a wet wipe with antimicrobial action wherein no preservative is added to the solution with which the nonwoven fabric is treated.

Description of the Tables

Table 1: Inhibitory concentrations (ppm) of some quaternary ammonium compounds as the active ingredient against the bacteria

Table 2: Inhibitory concentrations (ppm) of some quaternary ammonium compounds as the active ingredient against the fungi

Table 3: Inhibitory concentrations (ppm) of some quaternary ammonium compounds as the active ingredient against the algae

Table 4: Results of antimicrobial test for dimethyloctadecyl (3-trimethoxysilylpropyl) ammonium chloride (DTSACI) (7,12%)

Description of the Invention

The solution developed within the scope of the invention comprises at least one active ingredient, which provides the antimicrobial property, and the water.

For the purpose of developing an effective solution within the scope of the invention, the inhibitory concentrations of some raw active ingredients against the bacteria, fungi and algae were examined.

Quaternary ammonium compounds (also commonly known as quats or QACs) are among the known effective antiseptics and disinfectants. When these agents are fixed on a material surface, they cause the death of the bacterial cells through the cationic quaternary group and/or long-chain alkyl group. While the cationic quaternary group kills the cell by causing the attached cell membrane to lose its ionic balance, the long-chain alkyl group realizes the cell death by penetrating the membrane to physically disrupt the cell. In addition to their bactericidal action, the quaternary ammonium compounds are known to exhibit activity against the yeasts, spores and viruses. It was observed in the conducted studies that the antimicrobial action of the quaternary ammonium compounds varied according to the structure of the compounds. The compound poly[trialkyl(vinylbenzyl)ammonium chloride] was observed to have a greater antimicrobial effect against the bacteria and fungi than the monomer form of said compound. In the studies performed with the compound alkyldimethyl benzyl ammonium chloride (ADBAC) having different numbers of carbon atoms, it was observed that increasing the number of carbons up to C12 and C14 has an increasing effect on the activity, but the activity decreases when C14 is exceeded.

The silane coupling agents are used to modify the surface of various materials. The functional organic groups are modified by forming bonds with the molecules of the silane coupling agent and the coupling agent molecules are fixed on the material surface. The surface modified in this way gains the properties originating from the added organic group. Owing to the silane coupling agents modified with the quaternary ammonium compounds, the antibacterial property may be provided to the desired surfaces.

The results of the antimicrobial test for the compound dimethyloctadecyl (3- trimethoxysilylpropyl) ammonium chloride (DTSACI), a silane coupling agent from the quaternary ammonium compounds, which was examined in a study within the scope of the invention, are shown in Table 4 below.

The active ingredients possible to be used within the scope of the invention were identified as a result of the studies performed and the solutions according to the invention were developed by using said active ingredients at appropriate ratios in combination with water.

The solutions developed within the scope of the invention comprise at least one active ingredient at a ratio of 0.05-0.2% by weight and water at a ratio of 99.8-99.95% by weight, depending on the quantity of active ingredient used. Within the scope of the invention, the use of at least one active ingredient selected from dimethyloctadecyl (3-trimethoxysilylpropyl) ammonium chloride and n,n-dimethyl-n-dodecyl- n-(trimethoxysilylpropyl) ammonium chloride is preferred as the active ingredient.

An alternative embodiment of the invention comprises at least one active ingredient at a ratio of 0.1-0.2% by weight. In said embodiment, dimethyloctadecyl (3-trimethoxysilylpropyl) ammonium chloride and/or n,n-dimethyl-n-dodecyl-n-(trimethoxysilylpropyl) ammonium chloride is preferred as the active ingredient.

Another alternative embodiment of the invention comprises at least one active ingredient at a ratio of 0.09-0.15% by weight. In said embodiment, dimethyloctadecyl (3- trimethoxysilylpropyl) ammonium chloride and/or n,n-dimethyl-n-dodecyl-n- (trimethoxysilylpropyl) ammonium chloride is preferred as the active ingredient.

Another alternative embodiment of the invention comprises at least one active ingredient at a ratio of 0.03-0.06% by weight. In said embodiment, dimethyloctadecyl (3- trimethoxysilylpropyl) ammonium chloride and/or n,n-dimethyl-n-dodecyl-n- (trimethoxysilylpropyl) ammonium chloride is preferred as the active ingredient.

After the solutions developed within the scope of the invention are prepared, the nonwoven fabrics are subjected to treatment with the solution according to the invention. The weight of one piece of dry tissue is determined by performing calculations based on a nonwoven fabric with known dimensions (width and length) and weight (g/m2) and the amount of solution to be applied to the fabrics is determined. The determined amount of nonwoven fabric solution is applied to the nonwoven fabrics and then the fabrics are dried. The fabrics are dried preferably in a drying oven.

The application of the solutions developed within the scope of the invention to the nonwoven fabrics may be through any method preferred. For example, treatment of the fibers with the solutions according to the invention may be realized by way of spraying after the manufacture of the fibers or a similar technique involving the spraying on the fibers. As for the nonwoven fabrics, the compositions according to the invention may be applied to the nonwoven fabrics by way of adding the fabric to the active ingredient-containing solutions via the wet laid method or applying the solutions on the fabric surface via said method or a different method, e.g. injection or spraying, followed by the drying process.

The molecular structure of the natural fibers such as viscose and cotton is in the form of cellulose-OH. Unlike the cotton, the viscose does not contain impurities. The viscose is obtained by various chemical processes starting from wood cellulose and cotton linters. The ingredient dimethyloctadecyl (3-trimethoxysilylpropyl) ammonium chloride (DTSACI), one of the active ingredients used within the scope of the invention, adheres onto the surface by forming bonds with hydroxyl terminals present on the surface of viscose. As a result of application of the solutions developed within the scope of the invention to the nonwoven fabrics, the antimicrobial property is provided to the fabric upon the active ingredient adhering to -OH molecules present on the surface, owing to the cellulosic structure of the fabric.

The skin product obtained from the nonwoven fabric, which is provided with antimicrobial property within the scope of the invention, is also included in the scope of the invention.

The skin product developed within the scope of the invention is preferably a wet wipe. In order to obtain the finished skin product, the prepared wet wipe solution is applied to the wet wipes based on the amount of solution to be transferred to 1 piece of dry tissue according to the wetting factor for impregnating the nonwoven fabric with the nonwoven fabric solution according to the invention.

Owing to the application of the solutions developed within the scope of the invention to the nonwoven fabrics and owing to the wet wipes manufactured from said fabrics, there is left no need to add a separate preservative to the solution with which the fabric is impregnated for manufacturing the wet wipe, and as a result, the adverse effects of the preservatives, used in great numbers and in high concentrations, on the human health are eliminated as well as removing the problem of odor and color change encountered when such preservatives are added to the water with which the fabric is treated.

Claims

1. A solution, which is to be applied to a nonwoven fabric during the manufacture of the same for obtaining a skin product provided with antimicrobial property and which is to enable a nonwoven fabric provided with antimicrobial property to be obtained, characterized in that the solution comprises

• at least one active ingredient, which provides antimicrobial property, at a ratio of 0.05- 0.2% by weight and

• water at a ratio of 99.8-99.95% by weight, depending on the quantity of active ingredient used.

2. A solution according to Claim 1 characterized in that said active ingredient is at least one active ingredient selected from dimethyloctadecyl (3-trimethoxysilylpropyl) ammonium chloride and n,n-dimethyl-n-dodecyl-n-(trimethoxysilylpropyl) ammonium chloride.

3. A solution according to Claim 1 characterized in that the solution comprises said active ingredient at a ratio of 0.1-0.2% by weight and said active ingredient is dimethyloctadecyl (3- trimethoxysilylpropyl) ammonium chloride.

4. A solution according to Claim 1 characterized in that the solution comprises said active ingredient at a ratio of 0.1-0.2% by weight and said active ingredient is n,n-dimethyl-n- dodecyl-n-(trimethoxysilylpropyl) ammonium chloride.

5. A solution according to Claim 1 characterized in that the solution comprises said active ingredient at a ratio of 0.09-0.15% by weight and said active ingredient is dimethyloctadecyl (3-trimethoxysilylpropyl) ammonium chloride.

6. A solution according to Claim 1 characterized in that the solution comprises said active ingredient at a ratio of 0.09-0.15% by weight and said active ingredient is n,n-dimethyl-n- dodecyl-n-(trimethoxysilylpropyl) ammonium chloride.

7. A solution according to Claim 1 characterized in that the solution comprises said active ingredient at a ratio of 0.03-0.06% by weight and said active ingredient is dimethyloctadecyl (3-trimethoxysilylpropyl) ammonium chloride.

8. A solution according to Claim 1 characterized in that the solution comprises said active ingredient at a ratio of 0.03-0.06% by weight and said active ingredient is n,n-dimethyl-n- dodecyl-n-(trimethoxysilylpropyl) ammonium chloride.

9. A skin product characterized in that the skin product is manufactured from a nonwoven fabric containing a solution according to any one of the preceding claims.

10. A skin product according to Claim 9 characterized in that the skin product is a wet wipe.

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11. A method for obtaining the skin product characterized in that the method comprises the process steps of

• applying a determined quantity of the nonwoven fabric solution according to the invention to the nonwoven fabric, • drying the nonwoven fabric, and

• treating the nonwoven fabric with the wet wipe solution in a quantity determined according to the wetting factor for impregnation of the nonwoven fabric with the nonwoven fabric solution in the first step and thereby obtaining the wet wipe.

12. A method according to Claim 11 characterized in that the process of application of the nonwoven fabric solution to the nonwoven fabric is realized by way of adding the fabric to the active ingredient-containing solutions via the wet laid method, by way of performing at least one of the spraying or injection methods or by way of performing at least one of the methods of spraying or injection on the fibers from which the nonwoven fabrics are obtained.

13. A method according to Claim 11 characterized in that the nonwoven fabric is dried in a drying oven.

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