[go: up one dir, main page]

WO2022139460A1 - Composition comprenant un extrait d'euphrasia pectinata pour la réduction de la chute des cheveux ou des poils et la stimulation de la repousse des cheveux ou des poils - Google Patents

Composition comprenant un extrait d'euphrasia pectinata pour la réduction de la chute des cheveux ou des poils et la stimulation de la repousse des cheveux ou des poils Download PDF

Info

Publication number
WO2022139460A1
WO2022139460A1 PCT/KR2021/019610 KR2021019610W WO2022139460A1 WO 2022139460 A1 WO2022139460 A1 WO 2022139460A1 KR 2021019610 W KR2021019610 W KR 2021019610W WO 2022139460 A1 WO2022139460 A1 WO 2022139460A1
Authority
WO
WIPO (PCT)
Prior art keywords
hair
extract
composition
hair loss
somicho
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2021/019610
Other languages
English (en)
Korean (ko)
Inventor
김호철
김영식
이지현
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kyung Hee University
Original Assignee
Kyung Hee University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyung Hee University filed Critical Kyung Hee University
Publication of WO2022139460A1 publication Critical patent/WO2022139460A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/64—Orobanchaceae (Broom-rape family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2200/00—Function of food ingredients
    • A23V2200/30—Foods, ingredients or supplements having a functional effect on health
    • A23V2200/318—Foods, ingredients or supplements having a functional effect on health having an effect on skin health and hair or coat
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2250/00—Food ingredients
    • A23V2250/20—Natural extracts
    • A23V2250/21—Plant extracts

Definitions

  • the present invention relates to a food composition for improving hair loss or promoting hair growth, comprising a Somicho extract, a cosmetic composition, a feed composition, and a pharmaceutical composition for preventing or treating hair loss disease, including a Somicho extract;
  • a method for preventing or treating hair loss disease comprising administering to an individual a composition comprising a Somicho extract as an active ingredient;
  • it relates to a food composition, a cosmetic composition, a feed composition comprising a Somicho extract, to improve hair loss or to promote hair growth, and to a preventive or therapeutic use for a hair loss disease of a pharmaceutical composition comprising the Somicho extract.
  • Hair loss refers to a state in which there is no hair in the area where hair should normally exist, and it means the hair loss of the scalp.
  • hair loss symptoms 29% of adult males and 15% of females answered that they are currently experiencing hair loss symptoms, and 49% of males and 27% of females in their 60s or older responded that they were experiencing hair loss symptoms. .
  • 47% of those who currently experienced hair loss symptoms felt that hair loss was serious, indicating that the need for hair loss treatment was great (Gallup Korea, Research on Hair Loss - 2013/2019 comparison). So far, minoxidil, Propecia (Finasteride), and Dutasteride (Dutasteride) have been approved as hair loss treatments at home and abroad, and are being used to treat hair loss patients.
  • Somicho ( ⁇ , Euphrasia pectinata ) is a plant belonging to the genus Milletae, and it has been reported on the effect of inhibiting cancer cell proliferation, etc. (Phytochemistry Letters 12, 2015, 252-256). has not been studied at all.
  • the present inventors have completed the present invention by confirming that the Somicho extract has remarkable effects on improving hair loss and promoting hair growth.
  • It is an object of the present invention to provide a food composition for improving hair loss or promoting hair growth comprising a Somicho extract as an active ingredient.
  • Another object of the present invention is to provide a cosmetic composition for improving hair loss or promoting hair growth, comprising a Somicho extract as an active ingredient.
  • Another object of the present invention is to provide a feed composition for improving hair loss or promoting hair growth comprising a Somicho extract as an active ingredient.
  • Another object of the present invention is to provide a pharmaceutical composition for preventing or treating hair loss disease comprising a Somicho extract as an active ingredient.
  • Another object of the present invention is to provide a method for preventing or treating hair loss disease comprising administering to an individual a composition comprising a Somicho extract as an active ingredient.
  • Another object of the present invention is to provide a use for improving hair loss or promoting hair growth of a food composition comprising a Somicho extract as an active ingredient.
  • Another object of the present invention is to provide a use for improving hair loss or promoting hair growth of a cosmetic composition comprising a Somicho extract as an active ingredient.
  • Another object of the present invention is to provide a use for improving hair loss or promoting hair growth of a feed composition comprising a Somicho extract as an active ingredient.
  • Another object of the present invention is to provide a use for preventing or treating hair loss disease of a pharmaceutical composition comprising a Somicho extract as an active ingredient.
  • the Somicho extract of the present invention increases the growth rate of human-derived dermal papilla cells and has an excellent hair loss improvement and hair growth promoting effect, so it can be used as a drug, food, health functional food, cosmetic, etc. effective for preventing and treating hair loss.
  • 1 is a diagram showing the results of comparison of the effect of increasing human dermal papilla cell proliferation by a somicho extract or minoxidil (MX) treatment.
  • One aspect of the present invention for achieving the above object provides a food composition for improving hair loss or promoting hair growth comprising a Somicho extract as an active ingredient.
  • Another aspect of the present invention provides a cosmetic composition for improving hair loss or promoting hair growth comprising a Somicho extract as an active ingredient
  • Another aspect of the present invention provides a feed composition for improving hair loss or promoting hair growth comprising a Somicho extract as an active ingredient.
  • Somi-cho ( ⁇ ) of the present invention is a plant belonging to the genus Euphrasia of the family Orobanchaceae, specifically, Euphrasia pectinata , Euphrasia officinalis , Or Euphrasia regelii ( Euphrasia regelii ) It may be, but is not limited thereto.
  • Somi vinegar of the present invention may be harvested from nature or purchased commercially, but is not limited thereto.
  • the effect of promoting the proliferation of dermal papilla cells was confirmed, and the effect was confirmed to be similar to or superior to minoxidil marketed as a hair loss treatment agent (Example 2), somicho It was identified for the first time that the extract can be used for improving hair loss or promoting hair growth.
  • the Somicho extract of the present invention refers to the form of the extract obtained by extraction with one or more solvents, and the solvent used for the preparation of the extract includes water, carbon number 1 (C 1 ) to carbon number 6 (C 6 ) alcohol, Preferably, ethanol, methanol or butanol, an organic solvent, or a mixed solvent thereof may be used, but is not limited thereto.
  • the extraction method methods such as solvent extraction, hot water extraction, cold extraction, reflux cooling extraction, ultrasonic extraction, or steam extraction may be used, but are not limited thereto.
  • the Somicho extract of the present invention may be extracted with ethanol, for example, may be extracted with 60 to 80% ethanol.
  • reflux extraction was performed using 70% ethanol, but the present invention is not limited thereto.
  • “Improving hair loss” of the present invention refers to a process of treating, alleviating, alleviating a hair loss condition, or its effect, and the like, and may mean any action that inhibits the progress of hair loss.
  • “Promoting hair growth” of the present invention means any action that increases hair growth from the hair follicle, and may mean any action that increases the total amount of hair.
  • the hair loss improvement or hair growth promotion may be achieved by promoting the activity of dermal papilla cells, promoting proliferation, or inhibiting apoptosis.
  • Hair follicle a physiological organ in the body that produces hair, is the anagen phase, in which the hair is generated and generated, actively growing, the catagen phase, in which the hair is degenerated, and the resting phase (hair follicle) maintained until shedding It is involved in hair growth, maintenance, and loss while repeating the hair cycle, divided into the telogen phase) and the exogen phase in which hair loss occurs.
  • the activity of this hair follicle is caused by the hair papilla cells, and in particular, the proliferation and differentiation of the hair papilla cells is primarily involved in the progression of the hair growth cycle and hair formation.
  • hair growth and hair loss are closely related to the proliferation and death of hair papilla cells. Therefore, prolonging the growth phase or inhibiting apoptosis by inducing the proliferation of dermal papilla cells and shortening the catagen phase, resting phase, and hair loss phase improves hair loss and It could be a treatment option.
  • cell division and migration in the vicinity of nipples are closely related to hair growth. Cells are activated by various cytokines and hormones, so cells move to nipples and affect hair growth. Therefore, proliferation of dermal papilla cells is a very important factor in suppressing hair loss and hair growth.
  • composition comprising the Somicho extract of the present invention significantly increases the proliferative power of dermal papilla cells (Example 2), it can be used to improve hair loss or promote hair growth.
  • the composition of the present invention may be a food composition, a cosmetic composition, or a feed composition.
  • the composition may further include a pharmaceutically acceptable carrier, and may be formulated with a carrier and provided as food, cosmetics and feed.
  • the “food” of the present invention includes meat, sausage, bread, chocolate, candy, snacks, confectionery, pizza, ramen, other noodles, gum, and dairy products including ice cream, various soups, beverages, tea, drinks, alcoholic beverages, vitamins It includes all foods in the usual sense, such as complexes and health functional foods, and is not limited thereto as long as it can contain the Somicho extract of the present invention.
  • it can be prepared by adding the Somicho extract of the present invention to juice, tea, jelly and juice, etc.
  • the food composition of the present invention can be prepared in the form of powder, granule, tablet, capsule, pill, or liquid, but this not limited
  • the food composition when the food composition is prepared, it can be prepared by adding raw materials and components commonly added in the art, and the type is not particularly limited. For example, it may include, as an additional ingredient, various herbal extracts, food-logically acceptable food supplements or natural carbohydrates, such as conventional food, but is not limited thereto.
  • health functional food means a food manufactured and processed using raw materials or ingredients useful for the human body according to the Health Functional Food Act No. 6727, , 'functionality' refers to obtaining useful effects for health purposes such as regulating nutrients or physiological effects on the structure and function of the human body.
  • health food means food that has an active health maintenance or promotion effect compared to general food
  • health supplement means food for the purpose of health supplementation.
  • the terms health functional food, health food and health supplement food can be mixed.
  • the food composition of the present invention may be added as it is or used together with other foods or food ingredients, and may be appropriately used according to a conventional method.
  • the health functional food composition of the present invention can be prepared by a method commonly used in the art, and at the time of manufacture, it can be prepared by adding raw materials and components commonly added in the art.
  • the health functional food composition may further include a physiologically acceptable carrier, the type of carrier is not particularly limited and any carrier commonly used in the art may be used.
  • the health functional food composition is a food such as a preservative, a disinfectant, an antioxidant, a colorant, a coloring agent, a bleaching agent, a seasoning, a sweetener, a flavoring, an expanding agent, a strengthening agent, an emulsifier, a thickener, a film agent, a gum base agent, a foam inhibitor, a solvent, an improving agent, etc. It may contain additives.
  • the additive may be selected according to the type of food and used in an appropriate amount.
  • the formulation of the health functional food may be manufactured without limitation as long as it is a formulation recognized as a food.
  • cosmetic composition refers to solutions, external ointments, creams, foams, nourishing lotions, softening lotions, packs, softening water, emulsions, makeup bases, essences, soaps, liquid detergents, bathing agents, sunscreen creams, sun oils, Suspension, emulsion, paste, gel, lotion, powder, soap, surfactant-containing cleansing, oil, powder foundation, emulsion foundation, wax foundation, patch and spray, specifically As such, it may be prepared in the form of an external preparation for skin, but is not limited thereto.
  • the external preparation for skin includes hair tonic, hair cream, hair lotion, hair shampoo, hair conditioner, hair conditioner, hair spray, hair aerosol, pomade, powder, gel, hair pack, hair treatment, eyebrow hair growth agent, eyelash hair growth agent, and It may be selected from the group consisting of eyelash nutrients, but is not limited thereto.
  • the cosmetic composition of the present invention may further include one or more cosmetically acceptable carriers to be formulated in general skin cosmetics, and conventional ingredients include, for example, oil, water, surfactant, humectant, lower alcohol, A thickener, a chelating agent, a colorant, a preservative, a fragrance, etc. may be appropriately mixed, but is not limited thereto.
  • the cosmetically acceptable carrier included in the cosmetic composition of the present invention varies depending on the formulation.
  • the cosmetic composition of the present invention includes, in addition to the Somicho extract, commonly used auxiliary agents, such as hydrophilic or lipophilic gelling agents, hydrophilic or lipophilic active agents, preservatives, antioxidants, solvents, fragrances, fillers, blocking agents, pigments, odorants, and dyes and the like.
  • auxiliary agents such as hydrophilic or lipophilic gelling agents, hydrophilic or lipophilic active agents, preservatives, antioxidants, solvents, fragrances, fillers, blocking agents, pigments, odorants, and dyes and the like.
  • feed of the present invention refers to any natural or artificial diet, one meal, etc. or a component of the one meal meal suitable for or suitable for eating, ingestion, and digestion by animals, a feed containing the extract of the present invention.
  • a feed containing the extract of the present invention can be prepared in various types of feed known in the art, specifically, it may include a concentrated feed, roughage or special feed.
  • the breeding target may be included without limitation as long as it is an organism capable of ingesting the feed of the present invention.
  • the feed composition of the present invention may further include organic acids such as citric acid, fumaric acid, adipic acid, and lactic acid for administration; phosphates such as potassium phosphate, sodium phosphate, and polymerized phosphate; One or more of natural antioxidants such as polyphenol, catechin, tocopherol, vitamin C, green tea extract, chitosan, and tannic acid can be mixed and used. can do.
  • diluents, dispersants, surfactants, binders or lubricants may be additionally added to form an injectable formulation such as an aqueous solution, suspension, emulsion, etc., capsules, granules or tablets.
  • the feed composition of the present invention includes various auxiliary agents such as amino acids, inorganic salts, vitamins, antioxidants, antifungals, and antibacterial agents as auxiliary components, and plant protein feed such as milled or crushed wheat, barley, and corn, blood meal, meat meal, fish meal, etc.
  • auxiliary agents such as amino acids, inorganic salts, vitamins, antioxidants, antifungals, and antibacterial agents
  • plant protein feed such as milled or crushed wheat, barley, and corn, blood meal, meat meal, fish meal, etc.
  • main ingredients such as animal protein feed, animal fat and vegetable fat, it can be used together with nutritional supplements, growth promoters, digestion and absorption promoters, and disease prevention agents.
  • the feed composition comprising the Somicho extract of the present invention as an active ingredient can be used to improve hair loss or promote hair growth in breeding subjects.
  • Another aspect of the present invention provides a pharmaceutical composition for preventing or treating hair loss disease comprising a Somicho extract as an active ingredient.
  • the hair loss of the present invention means a state in which there is no hair in a part where hair should normally exist, and specifically, it may mean that the hair (thick and dark hair) of the scalp falls out.
  • the cause of hair loss is not limited, but may be caused by various dietary and environmental influences such as genetic causes, hormonal imbalance, mental stress, exposure to air pollution, and intake of processed foods.
  • the hair loss includes hereditary androgenetic alopecia (baldness), circular alopecia, ringworm of the head due to fungal infection, telogen alopecia, hair growth wall, hair growth disorder diseases, etc. It can mean hair loss due to alopecia, solitary folliculitis, lichen planus pilaris, burns and trauma hair loss.
  • the term “treatment” refers to clinical intervention to alter the natural process of an individual or cell to be treated, which may be performed during the course of or to prevent a clinical pathology.
  • the desired therapeutic effect includes preventing the occurrence or recurrence of a disease, alleviating symptoms, reducing any direct or indirect pathological consequences of the disease, preventing metastasis, reducing the rate of disease progression, and alleviating the disease state. or temporary relief, remission or improvement of prognosis.
  • it includes all acts of improving the course of hair loss by administering a composition comprising a Somicho extract as an active ingredient.
  • prevention of the present invention means any action that inhibits or delays the onset of the hair loss disease by administration of a composition comprising the Somicho extract according to the present invention as an active ingredient.
  • the pharmaceutical composition of the present invention may exhibit a preventive or therapeutic effect for hair loss disease by increasing the proliferative power of dermal papilla cells.
  • compositions may further include an appropriate carrier, excipient or diluent commonly used in the preparation of pharmaceutical compositions.
  • the composition comprising a pharmaceutically acceptable carrier may be in various oral or parenteral dosage forms. In the case of formulation, it can be prepared using a diluent or excipient such as a filler, extender, binder, wetting agent, disintegrant, surfactant, etc. commonly used.
  • Solid preparations for oral administration may include tablet pills, powders, granules, capsules, etc., and these solid preparations include at least one excipient in one or more compounds, for example, starch, calcium carbonate, sucrose or lactose. It can be prepared by mixing (lactose), gelatin, etc.
  • Liquid preparations for oral administration include suspensions, internal solutions, emulsions, syrups, etc.
  • simple diluents such as water and liquid paraffin
  • various excipients such as wetting agents, sweeteners, fragrances, and preservatives may be included.
  • Formulations for parenteral administration may include sterile aqueous solutions, non-aqueous solutions, suspensions, emulsions, lyophilized formulations, and suppositories.
  • Non-aqueous solvents and suspensions may include propylene glycol, polyethylene glycol, vegetable oils such as olive oil, and injectable esters such as ethyl oleate.
  • injectable esters such as ethyl oleate.
  • base of the suppository witepsol, macrogol, tween 61, cacao butter, laurin, glycerogelatin, and the like can be used.
  • the pharmaceutical composition of the present invention is not limited thereto, but tablets, pills, powders, granules, capsules, suspensions, internal solutions, emulsions, syrups, sterilized aqueous solutions, non-aqueous solvents, suspensions, emulsions, freeze-dried preparations and It may have any one formulation selected from the group consisting of suppositories.
  • Another aspect of the present invention provides a method for preventing or treating hair loss disease comprising administering to an individual a composition comprising a Somicho extract as an active ingredient.
  • the term "individual” may refer to all animals, including humans, who have or are likely to become bald.
  • the animal may be a mammal, such as a cow, a horse, a sheep, a pig, a goat, a camel, an antelope, a dog, or a cat, in need of treatment for symptoms similar to those of a human as well as humans, but is not limited thereto.
  • the prevention or treatment method of the present invention may include the step of administering the composition in a pharmaceutically effective amount to an individual who has become or is likely to become a hair loss state.
  • the term "administration” means introducing the pharmaceutical composition of the present invention to a patient by any suitable method, and the administration route of the composition of the present invention may be oral or parenteral as long as it can reach the target tissue. It may be administered via a route.
  • Another aspect of the present invention provides a use for improving hair loss or promoting hair growth of a food composition comprising a Somicho extract as an active ingredient.
  • Another aspect of the present invention provides a use for improving hair loss or promoting hair growth of a cosmetic composition comprising a Somicho extract as an active ingredient.
  • Another aspect of the present invention provides a use for improving hair loss or promoting hair growth of a feed composition comprising a Somicho extract as an active ingredient.
  • Another aspect of the present invention provides a use for preventing or treating hair loss disease of a pharmaceutical composition comprising a Somicho extract as an active ingredient.
  • the ethanol extract of Somicho was treated with human dermal papilla cells (HDPC) to measure cell proliferation, and the existing hair loss treatment agent The efficacy was compared with phosphorus minoxidil (MX: Minoxidil).
  • Human dermal papilla cells were treated with 70% somicholic alcohol extract or minoxidil (MX), respectively, and cell proliferation ability was confirmed through WST Assay. Specifically, human dermal papilla cells were seeded in a 96-well plate using DMEM medium containing 10% (v/v) FBS and 1% (v/v) penicillin/streptomycin under 5% CO 2 and 37° C. conditions. After that, 37 °C, 5% CO 2 Incubated in an incubator for 24 hours. Then, the medium was treated with the alcohol extract of Somicho of Example 1 at a concentration of 5, 10, or 50 ⁇ g/mL, and minoxidil was treated with a concentration of 5 and 10 ⁇ M.
  • MX somicholic alcohol extract
  • MX minoxidil
  • CCK D-Plus TM CCK cell viability assay kit

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Botany (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Polymers & Plastics (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Husbandry (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Birds (AREA)
  • Zoology (AREA)
  • Medical Informatics (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

La présente invention concerne : une composition alimentaire, une composition cosmétique et une composition alimentaire pour animaux permettant la réduction de la chute des cheveux ou des poils ou la stimulation de la repousse des cheveux ou des poils, et une composition pharmaceutique pour la prévention ou le traitement d'une maladie provoquant la chute des cheveux ou des poils, chaque composition comprenant un extrait d'Euphrasia pectinata ; une méthode de prévention ou de traitement d'une maladie provoquant la chute des cheveux ou des poils, la méthode comprenant une étape d'administration à un sujet d'une composition comprenant un extrait d'Euphrasia pectinata en tant que principe actif ; et une utilisation d'une composition alimentaire, d'une composition cosmétique et d'une composition alimentaire pour animaux pour réduire la chute des cheveux ou des poils ou stimuler la repousse des cheveux ou des poils, et une utilisation d'une composition pharmaceutique pour prévenir ou traiter une maladie provoquant la chute des cheveux ou des poils, chaque composition comprenant un extrait d'Euphrasia pectinata. L'extrait d'Euphrasia pectinata de la présente invention augmente le taux de croissance de cellules de papilles dermiques issues du corps humain pour présenter d'excellents effets de réduction de la chute des cheveux ou des poils et de stimulation de la repousse des cheveux ou des poils et, en tant que tel, peut être utilisé dans des médicaments, des aliments, des aliments fonctionnels pour la santé, des cosmétiques, etc., qui sont efficaces pour la prévention et le traitement de la chute des cheveux ou des poils.
PCT/KR2021/019610 2020-12-24 2021-12-22 Composition comprenant un extrait d'euphrasia pectinata pour la réduction de la chute des cheveux ou des poils et la stimulation de la repousse des cheveux ou des poils Ceased WO2022139460A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2020-0183033 2020-12-24
KR1020200183033A KR20220091869A (ko) 2020-12-24 2020-12-24 소미초 추출물을 포함하는 탈모 개선 및 발모 촉진용 조성물

Publications (1)

Publication Number Publication Date
WO2022139460A1 true WO2022139460A1 (fr) 2022-06-30

Family

ID=82158468

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2021/019610 Ceased WO2022139460A1 (fr) 2020-12-24 2021-12-22 Composition comprenant un extrait d'euphrasia pectinata pour la réduction de la chute des cheveux ou des poils et la stimulation de la repousse des cheveux ou des poils

Country Status (2)

Country Link
KR (1) KR20220091869A (fr)
WO (1) WO2022139460A1 (fr)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101208736B1 (ko) * 2010-10-15 2012-12-06 애경산업(주) 플라보노이드를 함유하는 발모 및 육모 조성물
CN106726818A (zh) * 2015-11-20 2017-05-31 周丽 一种防脱发洗发水
WO2018207952A1 (fr) * 2017-05-12 2018-11-15 国立大学法人九州大学 Composition pour la pousse des cheveux et/ou la restauration des cheveux

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101208736B1 (ko) * 2010-10-15 2012-12-06 애경산업(주) 플라보노이드를 함유하는 발모 및 육모 조성물
CN106726818A (zh) * 2015-11-20 2017-05-31 周丽 一种防脱发洗发水
WO2018207952A1 (fr) * 2017-05-12 2018-11-15 国立大学法人九州大学 Composition pour la pousse des cheveux et/ou la restauration des cheveux

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ANONYMOUS: "Assessment report on Euphrasia officinalis L. and Euphrasia rostkoviana Hayne, herba", EUROPEAN MEDICINES AGENCY, 16 September 2010 (2010-09-16), XP055945992, Retrieved from the Internet <URL:https://www.ema.europa.eu/en/documents/herbal-report/final-assessment-report-euphrasia-officinalis-l-euphrasia-rostkoviana-hayne-herba_en.pdf> *
MCCULLOCH, M.: "Do Eyebright Drops and Supplements Benefit Health?", HEALTHLINE WEBSITE, pages 1 - 15, XP009537821, Retrieved from the Internet <URL:https://www.healthline.com/nutrition/eyebright> *

Also Published As

Publication number Publication date
KR20220091869A (ko) 2022-07-01

Similar Documents

Publication Publication Date Title
KR102153414B1 (ko) 약콩 발효물을 포함하는 탈모 개선 및 발모 촉진용 조성물
KR101889793B1 (ko) 수산동물 발효물을 포함하는 탈모 방지 및 육모 촉진을 위한 조성물
JP2000086510A (ja) ヒスタミン遊離抑制剤
US20090269424A1 (en) Peripheral blood flow-improving composition
US20240424049A1 (en) Composition for alleviating hair loss and promoting hair growth comprising oat extract
JP3241609B2 (ja) 甜茶抽出物を有効成分とする医薬並びにこれを配合した食品および化粧品
KR101154219B1 (ko) 복령 등의 복합 생약 추출물을 함유하는 탈모 방지 및 발모 촉진효과를 갖는 화장료 조성물
KR101965594B1 (ko) 콩 추출물을 포함하는 탈모 방지 또는 육모 촉진용 조성물
KR101498201B1 (ko) 몽우리청각 추출물을 유효성분으로 포함하는 탈모방지 또는 발모개선용 조성물
KR20210025155A (ko) 수벌번데기 추출물을 포함하는 탈모방지 또는 육모촉진용 조성물
CN106999528A (zh) 用于预防掉发或刺激头发生长的包含高山黄芩萃取物的组合物
WO2022139460A1 (fr) Composition comprenant un extrait d&#39;euphrasia pectinata pour la réduction de la chute des cheveux ou des poils et la stimulation de la repousse des cheveux ou des poils
JP3241610B2 (ja) 甜茶抽出物を有効成分とする医薬並びにこれを配合した食品および化粧品
KR20130033623A (ko) 감잎 등의 복합 생약 추출물의 탈모 방지 및 발모 촉진 효과를 갖는 외용 조성물
CN116249514A (zh) 包含奶蓟花提取物作为有效成分的用于防止脱发或促进生发的组合物
KR101897720B1 (ko) 갈색거저리 탈지 분획물을 함유하는 모발 성장 촉진용 조성물
KR102538135B1 (ko) 천연 복합 추출물을 포함하는 탈모 예방 또는 발모 촉진용 조성물
WO2024014663A1 (fr) Composition pharmaceutique destinée à prévenir ou à traiter l&#39;alopécie comprenant de l&#39;akkermansia
US20250387437A1 (en) Pharmaceutical composition for preventing or treating alopecia including akkermansia
KR101273027B1 (ko) 캄페롤을 유효성분으로 함유하는 피지 분비 억제용 및항비만용 조성물
KR102650115B1 (ko) 좀깨잎나무 추출물을 포함하는 탈모 개선 및 발모 촉진용 조성물
KR102467403B1 (ko) 탈모 방지 및 발모 촉진용 화장료 조성물 및 이의 제조방법
KR101609436B1 (ko) 갈고리가시우무 추출물을 포함하는 탈모 방지 또는 육모 촉진을 위한 조성물
KR20250079900A (ko) 민물김 추출물을 유효성분으로 포함하는 탈모 예방 및 발모 촉진용 조성물
JP6998044B2 (ja) 亜鉛トランスポーター発現促進剤

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 21911527

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 21911527

Country of ref document: EP

Kind code of ref document: A1