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WO2022128275A1 - Lentille intraoculaire ayant une cavité ayant une section transversale en forme de fente - Google Patents

Lentille intraoculaire ayant une cavité ayant une section transversale en forme de fente Download PDF

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Publication number
WO2022128275A1
WO2022128275A1 PCT/EP2021/081531 EP2021081531W WO2022128275A1 WO 2022128275 A1 WO2022128275 A1 WO 2022128275A1 EP 2021081531 W EP2021081531 W EP 2021081531W WO 2022128275 A1 WO2022128275 A1 WO 2022128275A1
Authority
WO
WIPO (PCT)
Prior art keywords
cavity
intraocular lens
access line
fluid
outer edge
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2021/081531
Other languages
German (de)
English (en)
Inventor
Johannes Kindt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Carl Zeiss Meditec AG
Original Assignee
Carl Zeiss Meditec AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Carl Zeiss Meditec AG filed Critical Carl Zeiss Meditec AG
Publication of WO2022128275A1 publication Critical patent/WO2022128275A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses or corneal implants; Artificial eyes
    • A61F2/16—Intraocular lenses
    • A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
    • A61F2/1624—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus having adjustable focus; power activated variable focus means, e.g. mechanically or electrically by the ciliary muscle or from the outside
    • A61F2/1627—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus having adjustable focus; power activated variable focus means, e.g. mechanically or electrically by the ciliary muscle or from the outside for changing index of refraction, e.g. by external means or by tilting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses or corneal implants; Artificial eyes
    • A61F2/16—Intraocular lenses
    • A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
    • A61F2/1624—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus having adjustable focus; power activated variable focus means, e.g. mechanically or electrically by the ciliary muscle or from the outside
    • A61F2/1635—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus having adjustable focus; power activated variable focus means, e.g. mechanically or electrically by the ciliary muscle or from the outside for changing shape
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0003—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having an inflatable pocket filled with fluid, e.g. liquid or gas

Definitions

  • Intraocular lens with a slit-shaped cavity in cross-section Intraocular lens with a slit-shaped cavity in cross-section
  • the invention relates to an intraocular lens with a cavity within the optical body that is slot-shaped in cross section.
  • An intraocular lens is intended as a replacement for a natural eye lens if the natural eye lens no longer enables good vision due to clouding or hardening.
  • a preoperative eye measurement and an established surgical technique for removing the natural lens of the eye e.g. using phacoemulsification
  • a monofocal lens this means that the patient does not need additional glasses for at least one focal length.
  • the preoperative eye measurement usually works well, but is not error-free. Tolerances can add up unfavorably, so that the measurement result deviates undetected from the desired result and the patient has an intraocular lens implanted, which results in blurred vision.
  • the healing process may not proceed as expected, resulting in the patient not achieving clear vision.
  • Such a visual defect can result in the patient requiring more than 1 diopter vision correction. This can be achieved with glasses, but there is a desire to enable correction without additional visual aids.
  • a solution for this can be a laser surgical treatment of the cornea.
  • vision correction on the cornea, such a procedure is not free from side effects.
  • some patients report dry eyes after such an operation, which is considered to be very disadvantageous.
  • Other intraocular lenses are described, for example, in US Pat.
  • the intraocular lens according to the invention has a one-piece, concave or convex optic body and a haptic body adjoining the optic body.
  • the intraocular lens has:
  • first cavity access line connecting the first cavity as a single access line for the first cavity to an outer edge of the haptic body of the intraocular lens.
  • the intraocular lens thus has an optic body and a haptic body adjoining it, the optic body being provided with a first slot-shaped cavity in a first plane.
  • This first cavity is provided within the optic body and does not reach an outer edge of the optic body.
  • the first cavity is therefore completely surrounded by the material of the optic body.
  • the first cavity according to the invention is connected to an outer edge of the haptic body by means of a first cavity access line.
  • the cavity access line is set up to conduct an externally supplied fluid from the outer edge of the haptic body to the cavity so that the fluid can reach the first cavity and preferably fill the cavity.
  • the cavity can be made, for example, by an optical cutting technique using a femtosecond laser.
  • a laser beam can be focused on the first plane, so that the material of the optic body is removed in this plane.
  • Another manufacturing option is that two halves of the optical body are connected to one another, for example by ultrasonic welding or by gluing, with a recess being provided in one half or in both halves. After joining, the first cavity is then formed.
  • the first cavity access line is connected to the outer edge of the haptic body, so that an opening is formed which preferably runs flush with the outer edge. There is therefore no filling tube or the like protruding from the outer edge of the haptic body, which could interfere with folding the intraocular lens and transporting it through an injector.
  • Fluid can be delivered into the first lumen access line through the opening, for example by means of a syringe. If fluid is supplied through the opening and the first lumen access line into the first lumen, this can be done by a surgeon until the first lumen is completely filled with fluid.
  • the fluid preferably has a different refractive index than the material from which the optic body is formed. Through the combination of the two refractive indices, a different refractive index can be achieved overall for the intraocular lens and thus a vision correction can take place.
  • the volume of fluid supplied can also be larger than the volume of the first cavity. Since the material of the intraocular lens has high elasticity, the first cavity can widen and expand in this case and thus change the contour of the outer edge of the optic body, for example reducing the radius of the curvature of the optic body on an outside. As a result, a higher refractive power of the intraocular lens can be achieved and thus vision correction can be carried out.
  • the opening at the outer edge of the haptic body is particularly advantageous since the side of the haptic body opposite the opening can serve as an abutment for the compressive force exerted by the syringe during filling of the fluid, without this resulting in damage to the optic body.
  • the abutment can be formed by an additional instrument, which an operator provides during the supply of the fluid into the first cavity access line.
  • the haptic body can additionally or alternatively be designed to be mechanically stable in the area of the opening, for example particularly thick, so that an additional instrument is not required is. In such an embodiment, too, the optic body is not touched by the syringe, so that there is no risk of damage to the optic body.
  • the first cavity access line ensures that a defined access of fluid to the first cavity is possible. A surgeon therefore does not have to pierce an optic body with a syringe, so that the surface of the optic body is not damaged for this reason either.
  • the first cavity is preferably not arranged concentrically around the optical axis of the optical body. It is thus possible, by supplying fluid into the first cavity, to achieve a curvature on the outside of the optical body which is greater in a first axis of symmetry than in a second axis of symmetry arranged perpendicular thereto, both of which run perpendicular to the optical axis. As a result, vision correction can also be achieved with astigmatism. In general, a cylinder refractive power change can be achieved in this way.
  • a second slot-shaped cavity can be arranged within the optical body in the first plane, with the first cavity and the second cavity being designed separately from one another. If a fluid is filled in each of the first cavity and the second cavity, a radius of curvature of at least a part of the outside of the optical body can be increased, so that the refractive power of the intraocular lens is reduced as a whole.
  • the intraocular lens prefferably has a third cavity within the optic body in a second plane displaced parallel thereto to the first plane, the third cavity having a third cavity access line which encloses the third cavity as the only access line for the third cavity with an outer edge connecting the intraocular lens.
  • Fluid can also be introduced into the intraocular lens in the third cavity, so that an even more specific and possibly greater curvature of a first outer side of the optic body can be achieved, while a smaller curvature of a second outer side of the optic body, which is opposite the first outer side, can be achieved.
  • the intraocular lens has a fluid in the first or the second cavity.
  • the fluid to be supplied or the fluid already contained in the intraocular lens can be a highly viscous fluid, for example hyaluronic acid or a silicone oil. It may alternatively be a granular fluid, the granular particles being sized to be forced under pressure through a needle of a syringe. It is also possible that the fluid has a granulate mixture which has a refractive index adapted to the needs of the patient.
  • the fluid can also be a suspension whose ability to flow within the first cavity or the second cavity decreases, so that the fluid no longer forces back out of the cavity.
  • the fluid can be a swellable suspension, for example, of finely dispersed hydrophilic material, which can be cross-linked hyaluronic acid, which draws additional water into a cavity, thereby swelling until the cavity is closed.
  • a fluid is used which will cross-link after delivery into a cavity, for example a structural protein solution such as collagen, crystalline, hyaluronic acid/chondroitin.
  • FIG. 1 shows a schematic illustration of a cross-sectional view of an intraocular lens according to a first embodiment of the invention
  • FIG. 2 shows a schematic illustration of a plan view of the intraocular lens according to the first embodiment
  • FIG. 3 shows a schematic representation of a cross-sectional view of the intraocular lens according to the first embodiment with a fluid in a first cavity
  • FIG. 4 shows a schematic illustration of a cross-sectional view of an intraocular lens according to a second embodiment
  • FIG. 5 is a schematic representation of a top view of the intraocular lens according to the second embodiment
  • FIG. 6 shows a schematic representation of a cross-sectional view of the intraocular lens of the second embodiment with a fluid in a first cavity and a second cavity
  • 7 is a schematic representation of a cross-sectional view of an intraocular lens according to a third embodiment
  • FIG 8 is a schematic representation of a top view of the intraocular lens according to the third embodiment.
  • FIG. 1 shows a schematic representation of a cross-sectional view of an intraocular lens 1 according to a first embodiment
  • FIG. 2 shows a schematic representation of a plan view of such an intraocular lens 1 3 on.
  • the haptic body 3 consists of a first haptic part 31 and a second haptic part 32.
  • the optic body 2 is penetrated by an optical axis A, which in this embodiment runs through the geometric center of the optic body 2, see FIG
  • the haptic part 31 and the second haptic part 32 are arranged point-symmetrically to the optical axis A in this embodiment.
  • the intraocular lens 1 has a first cavity 14 which is designed in the form of a slit and is arranged in a first plane 15 .
  • the first plane 15 preferably runs perpendicularly to the optical axis A of the optical body 2.
  • the first cavity 14 has a uniform height H1 in its longitudinal extension.
  • the intraocular lens 1 additionally has a first cavity access line 18 which connects the first cavity 14 as the only access line for the first cavity 14 to an outer edge 17 of the haptic body 3 .
  • a first end 181 of the cavity access line 18 is connected to the first cavity 14, and a second end 182 of the cavity access line 18 opens out at the outer edge 17 of the haptic body 3.
  • the second end 182 forms an opening 19 for a cannula 40 of a syringe, 2 and 3 3, an abutment 41 can be attached preferably opposite the opening 19, see FIG.
  • the volume of fluid may be sized to precisely fill first lumen access line 18 and first lumen 14 .
  • the refractive power of the intraocular lens 1 can be changed overall. If that supplied fluid volume is greater than the volume of the first cavity 14 in the unfilled state, the first cavity 14 can be widened and enlarged due to the great elasticity of the intraocular lens 1, so that it reaches a maximum height H2, which is greater than H1. This leads to a change in the curvature of the outer surface of the optic body 2. It can be seen from FIG. 3 that the outer radius of the optic body 2 is smaller than in the case of the intraocular lens 1 shown in FIG.
  • Such a reduced outer radius means a greater refractive power of the intraocular lens 1 compared to the intraocular lens shown in FIG.
  • Such a higher refractive power condition remains stable when the fluid remains in the first lumen 14 and does not flow back out of the first lumen access line 18 . This can be achieved in that the fluid 50 has a sufficiently high viscosity or is sufficiently strongly crosslinked in the injected state, so that backflow is prevented.
  • FIGS. 4 and 5 show a schematic representation of a cross-sectional view and a top view, respectively, of an intraocular lens 1 according to a second embodiment.
  • a second cavity 24 is arranged in addition to the first cavity 14 in the first plane 15 .
  • the first cavity 14 and the second cavity 24 are designed separately from one another and do not touch.
  • the first cavity 14 and the second cavity 24 may be arc-shaped or crescent-shaped in plan view.
  • the first cavity 14 is connected to the outer edge 17 of the haptic body 3 by means of the first cavity access line 18
  • the second cavity 24 is connected to the outer edge 17 of the haptic body 3 by means of a second cavity access line 28 .
  • the second lumen access conduit 28 has a first end 281 connected to the second lumen 24 .
  • the second cavity access line 28 has a second end 282 which opens out at the outer edge 17 of the haptic body 3 . If a fluid 50 is fed into the first cavity 14 and the second cavity 24, the respective cavity 14, 24 can be widened in such a way that the surface of the optic body 2 is deformed, see FIG of the outer edge 16 of the optical body 2 is reached and thus its refractive power can be changed in a targeted manner.
  • a third cavity 34 is also provided in FIG. 4 in a second plane 35, which lies parallel to the first plane 15, this third cavity 34 not being shown in the top view of FIG.
  • no fluid 50 is contained in the third cavity 34 .
  • FIG. 7 shows a schematic representation of a third embodiment of the intraocular lens according to the invention in a cross-sectional view
  • FIG. 8 shows the associated plan view.
  • the first cavity 14 is not arranged concentrically around the optical axis A of the optical body 2 and has a distorted oval or elliptical shape when viewed from above. If such a first cavity 14 is filled with a fluid 50, this leads to an asymmetrical curvature of the outer edge 16 of the optic body 2 in relation to the optical axis A.
  • the curvature of the outer edge 16 of the optic body 2 along a first axis of symmetry S1 differs from that Curvature of the outer edge 16 of the optic body 2 along a second axis of symmetry S2, which is perpendicular to the first axis of symmetry S1, wherein the symmetry axes S1, S2 are arranged perpendicular to the optical axis A.

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  • Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Prostheses (AREA)

Abstract

L'invention concerne une lentille intraoculaire avec un corps optique monobloc, qui a une conception concave ou convexe, et un corps haptique adjacent au corps optique, ladite lentille intraoculaire ayant : - une première cavité, qui présente une section transversale en forme de fente, à l'intérieur du corps optique sur un premier plan, la première cavité n'atteignant pas un bord extérieur du corps optique, et la cavité ayant une hauteur constante en section transversale sur l'étendue longitudinale de la cavité, et - un premier tube d'accès à la cavité qui relie la première cavité à un bord extérieur du corps haptique de la lentille intraoculaire en tant que seul tube d'accès pour la première cavité.
PCT/EP2021/081531 2020-12-18 2021-11-12 Lentille intraoculaire ayant une cavité ayant une section transversale en forme de fente Ceased WO2022128275A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102020007788.9A DE102020007788A1 (de) 2020-12-18 2020-12-18 Intraokularlinse mit im Querschnitt schlitzförmigem Hohlraum
DE102020007788.9 2020-12-18

Publications (1)

Publication Number Publication Date
WO2022128275A1 true WO2022128275A1 (fr) 2022-06-23

Family

ID=78725471

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2021/081531 Ceased WO2022128275A1 (fr) 2020-12-18 2021-11-12 Lentille intraoculaire ayant une cavité ayant une section transversale en forme de fente

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Country Link
DE (1) DE102020007788A1 (fr)
WO (1) WO2022128275A1 (fr)

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4731078A (en) 1985-08-21 1988-03-15 Kingston Technologies Limited Partnership Intraocular lens
WO1989006520A1 (fr) * 1988-01-14 1989-07-27 Gerald Horn Ensembles de lentilles intraoculaires
EP0356050A1 (fr) 1988-08-15 1990-02-28 Storz Instrument Company Lentille intra-oculaire accomodable
US5152788A (en) 1989-12-27 1992-10-06 Minnesota Mining And Manufacturing Company Multifocal diffractive ophthalmic lens and method of manufacture
US5443506A (en) 1992-11-18 1995-08-22 Garabet; Antoine L. Lens with variable optical properties
US5776192A (en) 1994-04-19 1998-07-07 Surgical Concepts, Inc Artificial lens insertible between the iris and natural lens of the eye
US6730123B1 (en) 2000-06-22 2004-05-04 Proteus Vision, Llc Adjustable intraocular lens
WO2004052242A1 (fr) * 2002-12-12 2004-06-24 Powervision Systeme de lentille permettant un reglage de puissance au moyen de micropompes
US20050149183A1 (en) 2001-08-31 2005-07-07 Shadduck John H. Intraocular lens system and method for power adjustment
US20150173890A1 (en) 2012-10-08 2015-06-25 Valdemar Portney Multi-mode operating optic for presbyopia correction
US10368979B2 (en) 2006-12-19 2019-08-06 Powervision, Inc. Accommodating intraocular lenses

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4731078A (en) 1985-08-21 1988-03-15 Kingston Technologies Limited Partnership Intraocular lens
WO1989006520A1 (fr) * 1988-01-14 1989-07-27 Gerald Horn Ensembles de lentilles intraoculaires
EP0356050A1 (fr) 1988-08-15 1990-02-28 Storz Instrument Company Lentille intra-oculaire accomodable
US5152788A (en) 1989-12-27 1992-10-06 Minnesota Mining And Manufacturing Company Multifocal diffractive ophthalmic lens and method of manufacture
US5443506A (en) 1992-11-18 1995-08-22 Garabet; Antoine L. Lens with variable optical properties
US5776192A (en) 1994-04-19 1998-07-07 Surgical Concepts, Inc Artificial lens insertible between the iris and natural lens of the eye
US6730123B1 (en) 2000-06-22 2004-05-04 Proteus Vision, Llc Adjustable intraocular lens
US20050149183A1 (en) 2001-08-31 2005-07-07 Shadduck John H. Intraocular lens system and method for power adjustment
WO2004052242A1 (fr) * 2002-12-12 2004-06-24 Powervision Systeme de lentille permettant un reglage de puissance au moyen de micropompes
US10368979B2 (en) 2006-12-19 2019-08-06 Powervision, Inc. Accommodating intraocular lenses
US20150173890A1 (en) 2012-10-08 2015-06-25 Valdemar Portney Multi-mode operating optic for presbyopia correction

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