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WO2022124027A1 - Composition de préparation externe cutanée - Google Patents

Composition de préparation externe cutanée Download PDF

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Publication number
WO2022124027A1
WO2022124027A1 PCT/JP2021/042258 JP2021042258W WO2022124027A1 WO 2022124027 A1 WO2022124027 A1 WO 2022124027A1 JP 2021042258 W JP2021042258 W JP 2021042258W WO 2022124027 A1 WO2022124027 A1 WO 2022124027A1
Authority
WO
WIPO (PCT)
Prior art keywords
acid
mass
extract
hakushinin
poe
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2021/042258
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English (en)
Japanese (ja)
Inventor
ゆりの 芦澤
薫 森下
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shiseido Co Ltd
Original Assignee
Shiseido Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shiseido Co Ltd filed Critical Shiseido Co Ltd
Priority to CN202180075128.2A priority Critical patent/CN116472029A/zh
Publication of WO2022124027A1 publication Critical patent/WO2022124027A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/13—Coniferophyta (gymnosperms)
    • A61K36/14—Cupressaceae (Cypress family), e.g. juniper or cypress
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/35—Ketones, e.g. benzophenone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9755—Gymnosperms [Coniferophyta]
    • A61K8/9761—Cupressaceae [Cypress family], e.g. juniper or cypress
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations

Definitions

  • the present disclosure relates to a skin external preparation composition containing a hakushinin extract.
  • Hakushinin The extract of the seeds of Oriental Arbor-vitae (Thuja orientalis, Biota orientalis, Platycladus orientalis) of the genus Thuja of the Cupressaceae family is called Hakushinin (Kashiwakojin, Hakushijin) and is used as a crude drug / Chinese medicine. (Hereinafter referred to as "Hakushinin extract” in this document).
  • the hakushinin extract is also used as a vegetable whitening agent, a collagen production promoter, and the like (see, for example, Patent Document 1, Patent Document 2, and Patent Document 3).
  • Hakushinin extract has an unpleasant odor. It is assumed that the external skin preparation to which the hacksinin extract as described in Patent Documents 1 to 3 is applied is particularly applied to the face. When the skin external preparation containing the hakushinin extract is applied to the face, the user will feel the unpleasant odor of the hakushinin extract strongly and for a long time while the hakushinin extract is present on the face.
  • a skin external preparation composition containing a hacksinin extract and a fragrance component.
  • the fragrance components are linalool acetate, cis-jasmon, hexylcinnamic aldehyde, ⁇ -undecalactone, methyl dihydrojasmonate, methyl ⁇ -decalactone, linalool, 1,3,4,6,7,8-hexahydro-4, 6,6,7,8,8-Hexamethylcyclopenta- ⁇ -2-benzopyran, ethyltrimethylcyclopentenylbutenol, ethyllinalool, 16-hydroxy-7-hexadecenoic acid lactone, ethylene brushlate, cyclopentadecenolide , 2,6-dimethyl-7-octen-2-ol, ⁇ -methylbenzene-1-pentanol, isobutylmethyltetrahydropyranol, and at least one selected
  • the discomfort caused by the odor of the hakushinin extract can be reduced.
  • the skin external preparation composition contains 1 ⁇ 10 -4 parts by mass to 30 parts by mass of the fragrance component with respect to 1 part by mass of the hakushinin extract.
  • the content of the oxacinin extract is 0.2% by mass to 0.5% by mass with respect to the mass of the external skin preparation composition.
  • the skin external preparation composition is selected from at least a group consisting of a whitening agent, a collagen production promoter, a hyaluronic acid production promoter, a fibroblast proliferation promoter, and an anti-wrinkle agent. Applies to one.
  • POE is an abbreviation for polyoxyethylene and POP is an abbreviation for polyoxypropylene, and the number in parentheses after POE or POP represents the average number of moles of POE group or POP group added in the compound.
  • the "substantial amount” means an amount in which the action and effect of the addition of the compound can occur.
  • the skin external preparation composition according to the first embodiment of the present disclosure will be described.
  • the skin external preparation composition of the present disclosure can be at least one selected from the group consisting of an aqueous composition, an oily composition, an emulsion, and a non-emulsified composition.
  • the skin external preparation composition according to the first embodiment contains a hakushinin extract.
  • the hakushinin extract can be used, for example, as at least one selected from the group consisting of a whitening component, a collagen production promoting component, a hyaluronic acid production promoting component, a fibroblast growth promoting component, and an anti-wrinkle component.
  • the content of the hacksinin extract is preferably 0.2% by mass or more, more preferably 0.3% by mass or more, based on the mass of the external skin preparation composition. If the content of the hacksinin extract (pure content) is less than 0.2% by mass, the hacksinin extract cannot exert its sufficient action (for example, whitening action, collagen production promoting component, hyaluronic acid production promoting component, etc.). ..
  • the content of the hacksinin extract can be 1% by mass or less, 0.5% by mass or less, or 0.3% by mass or less with respect to the mass of the external skin preparation composition.
  • the skin external preparation composition according to the first embodiment further contains a fragrance component for suppressing or deodorizing the odor of the hakushinin extract.
  • the fragrance component can suppress the odor of the hakushinin extract by, for example, a masking action and / or a harmonizing action.
  • the deodorization referred to in the present disclosure is to prevent or alleviate the odor to be deodorized (hereinafter referred to as "bad odor") by a sensory action.
  • bad odor As the deodorizing action in the present disclosure, a masking action (masking effect) and a harmonizing action (harmonizing effect) can be considered.
  • masking refers to competing a good scent (fragrance, fragrance) superior to a bad odor with respect to a bad odor to relatively deodorize the bad odor (eliminate or alleviate the bad odor).
  • harmonizing is to deodorize a bad odor by mixing a scent that is in harmony with the bad odor with the bad odor and harmonizing the odor as a whole (for example, converting the bad odor into an aroma / aroma). It means to eliminate or alleviate).
  • the fragrance component for example, at least one selected from the group of compounds shown in Table 1 can be mentioned.
  • the fragrance components (1) to (7) have both a masking effect and a harmonizing effect on the odor of hakushinin.
  • the fragrance components (8) to (17) have a masking effect on the odor of hakushinin.
  • the perfume components (1) to (6) have a peach-based and / or jasmine-based scent. Peach-based and / or jasmine-based fragrance components are preferable as deodorant components for the odor of hakushinin extract.
  • the fragrance component is preferably 1 ⁇ 10 -4 parts by mass or more, and more preferably 1 ⁇ 10 -3 parts by mass or more with respect to 1 part by mass of the hakushinin extract (pure content).
  • the fragrance component may be 5 ⁇ 10 -3 parts by mass or more, 1 ⁇ 10 ⁇ 2 parts by mass or more, or 5 ⁇ 10 ⁇ 2 parts by mass or more with respect to 1 part by mass of the hakushinin extract. If the fragrance component is less than 1 ⁇ 10 -4 parts by mass, a sufficient deodorizing effect against the hakushinin odor cannot be obtained.
  • the fragrance component is 30 parts by mass or less, 20 parts by mass or less, 10 parts by mass or less, 5 parts by mass or less, 2 parts by mass or less, 1 part by mass or less, 0. It can be 5 parts by mass or less, or 1 ⁇ 10 -1 parts by mass or less.
  • the content of the fragrance component is 1 ⁇ 10 -4 % by mass or more, 5 ⁇ 10 -4 % by mass or more, 1 ⁇ 10 -3 % by mass or more, and 5 ⁇ 10 -3 with respect to the mass of the external preparation composition for skin. It can be 1 ⁇ 10 ⁇ 2 mass% or more, 5 ⁇ 10 ⁇ 2 mass% or more, 1 ⁇ 10 ⁇ 1 mass% or more, 5 ⁇ 10 ⁇ 1 mass% or more, or 1 mass% or more. ..
  • the content of the fragrance component is 30% by mass or less, 20% by mass or less, 10% by mass or less, 1% by mass or less, 1 ⁇ 10 -1 % by mass or less, and 5 ⁇ 10 with respect to the mass of the external preparation composition for skin. It can be -2 % by mass or less, 1x10-2 % by mass or less, 5x10-3 % by mass or less, or 1x10-3 % by mass or less.
  • the external skin preparation composition of the present disclosure it is possible to suppress the unpleasant odor caused by the hacksinin extract while blending the hacksinin extract. Thereby, even if the skin external preparation composition of the present disclosure is applied to the face, the discomfort felt by the user due to the odor can be reduced.
  • the deodorant according to the second embodiment of the present disclosure will be described.
  • the deodorant of the present disclosure is a deodorant for deodorizing the odor of the hakushinin extract.
  • the deodorant of the present disclosure can be at least one selected from the group consisting of aqueous compositions, oily compositions, emulsions, and non-emulsified ones.
  • the deodorant according to the second embodiment contains a fragrance component having a deodorizing effect on the odor of hakushinin.
  • a fragrance component for example, at least one selected from the group of compounds shown in Table 1 can be mentioned.
  • the content of the fragrance component is preferably 0.01% by mass or more, more preferably 0.05% by mass or more, and further preferably 0.1% by mass or more with respect to the mass of the deodorant. If the content of the fragrance component is less than 0.01% by mass, a sufficient deodorizing effect against the hakushinin odor cannot be obtained.
  • the content of the fragrance component can be 1% by mass or less, 0.5% by mass or less, 0.2% by mass or less, or 0.1% by mass or less with respect to the mass of the deodorant.
  • the odor of the hakushinin extract can be effectively deodorized.
  • the method according to the third embodiment includes a first step of applying the oxacinin extract to the first region.
  • the first step can be a step of applying the hakushinin extract-containing composition to the skin.
  • the method according to the third embodiment includes a second step of applying the deodorant according to the second embodiment to the second region.
  • the deodorant according to the second embodiment can be applied to at least one of the skin and clothes. At least a portion of the second region can overlap with the odor and extent of the hakushinin extract.
  • the second region can be a region closer to the nose than the first region.
  • Either the first step or the second step may come first. From the viewpoint of the deodorizing effect, it is preferable to perform the second step after performing the first step.
  • the deodorant according to the second embodiment can be applied to deodorize the hakushinin odor.
  • the skin external preparation composition according to the first embodiment of the present disclosure and the deodorant according to the second embodiment are other components, for example, water, water-soluble alcohol, oily component, as long as the effects of the present disclosure are not impaired.
  • water used for cosmetics, quasi-drugs, etc. can be used, and for example, purified water, ion-exchanged water, tap water, etc. can be used.
  • water-soluble alcohol examples include lower alcohols, polyhydric alcohols, polyhydric alcohol polymers, divalent alcohol alkyl ethers, dihydric alcohol alkyl ethers, dihydric alcohol ether esters, glycerin monoalkyl ethers, and sugar alcohols. At least one selected from simple sugars, oligo sugars, polysaccharides and derivatives thereof and the like can be mentioned.
  • Examples of the lower alcohol include ethanol, propanol, isopropanol, isobutyl alcohol, t-butyl alcohol and the like.
  • polyhydric alcohol examples include divalent alcohols (eg, ethylene glycol, propylene glycol, trimethylene glycol, 1,2-butylene glycol, 1,3-butylene glycol, tetramethylene glycol, 2,3-butylene glycol, and the like.
  • divalent alcohols eg, ethylene glycol, propylene glycol, trimethylene glycol, 1,2-butylene glycol, 1,3-butylene glycol, tetramethylene glycol, 2,3-butylene glycol, and the like.
  • Divalent alcohol alkyl ethers eg, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, diethylene glycol monobutyl ether, diethylene glycol dimethyl ether, diethylene glycol diethyl ether, diethylene glycol butyl ether, diethylene glycol methyl ethyl ether, triethylene glycol monomethyl ether, triethylene glycol monoethyl).
  • Ether propylene glycol monomethyl ether, propylene glycol monoethyl ether, propylene glycol monobutyl ether, propylene glycol isopropyl ether, dipropylene glycol methyl ether, dipropylene glycol ethyl ether, dipropylene glycol (Cole butyl ether, etc.); Dihydric alcohol ether esters (eg, ethylene glycol monomethyl ether acetate, ethylene glycol monoethyl ether acetate, ethylene glycol monobutyl ether acetate, ethylene glycol monophenyl ether acetate, ethylene glycol diazibate, ethylene glycol dissuccinate).
  • Dihydric alcohol ether esters eg, ethylene glycol monomethyl ether acetate, ethylene glycol monoethyl ether acetate, ethylene glycol monobutyl ether acetate, ethylene glycol monophenyl ether acetate, ethylene glycol dia
  • Sugar alcohols eg, sorbitol, martitol, maltotriose, mannitol,
  • Examples of the monosaccharide include trisaccharides (eg, D-glycerylaldehyde, dihydroxyacetone, etc.), tetrasaccharides (eg, D-erythroth, D-elittlerose, D-threose, erythritol, etc.), and the like.
  • trisaccharides eg, D-glycerylaldehyde, dihydroxyacetone, etc.
  • tetrasaccharides eg, D-erythroth, D-elittlerose, D-threose, erythritol, etc.
  • Five-carbon sugars eg, L-arabinose, D-xylose, L-lyxose, D-arabinose, D-ribose, D-librose, D-xylrose, L- Xylrose, etc.
  • Hexosaccharides eg, D-glucose, D-talose, D-psicos, D-galactose, D-fructouse, L-galactose, L- Mannos, D-tagatos, etc.
  • seven-carbon sugars eg, aldoheptose, heptulose, etc.
  • eight-carbon sugars eg, octulose, etc.
  • deoxy sugars eg, 2-deoxy-D-ribose, etc.
  • amino sugars eg, D-glucosamine, D-galactosamine, si
  • oligosaccharide for example, at least one selected from sucrose, guntianose, umbelliferose, lactose, planteose, isolikunoses, ⁇ , ⁇ -trehalose, raffinose, lycnoses, umbilicin, stachyose, velvascours and the like. Can be mentioned.
  • polysaccharides examples include cellulose, quince seed, chondroitin sulfate, starch, galactan, dermatan sulfate, glycogen, Arabic gum, heparan sulfate, hyaluronic acid, tragant gum, keratan sulfate, chondroitin, xanthan gum, mucoitin sulfate, guagam, dextran, and keratosulfate.
  • Locust bean gum, succinoglucan, caronic acid and the like can be mentioned at least one.
  • the other polyol for example, at least one selected from polyoxyethylene methylglucoside (Glucam E-10), polyoxypropylene methylglucoside (Glucam P-10) and the like can be mentioned.
  • oily component for example, liquid fats and oils, solid fats and oils, waxes, hydrocarbons, higher fatty acids, higher alcohols, synthetic ester oils, silicone oils and the like can be used.
  • Liquid fats and oils include, for example, avocado oil, camellia oil, turtle oil, macadamia nut oil, corn oil, mink oil, olive oil, rapeseed oil, egg yolk oil, sesame oil, persic oil, wheat germ oil, southern ka oil, castor oil, and flaxseed oil. , Saflower oil, cottonseed oil, eno oil, soybean oil, peanut oil, teaseed oil, kaya oil, rice bran oil, cinnamon oil, Japanese millet oil, jojoba oil, germ oil, triglycerin and the like.
  • solid fats and oils include coconut oil, palm oil, horse fat, hardened palm oil, palm oil, beef fat, sheep fat, hardened beef fat, palm kernel oil, pork fat, beef bone fat, mokurou kernel oil, hardened oil, and beef.
  • Examples include leg fat, mokurou, and hydrogenated castor oil.
  • waxes examples include honey wax, candelilla wax, cotton wax, carnauba wax, bayberry wax, ibotarou, whale wax, montan wax, nukarou, lanolin, capoc wax, lanolin acetate, liquid lanolin, sugar cane, lanolin fatty acid isopropyl, hexyl laurate, and reduced lanolin.
  • Jojobaro hard lanolin, cellac wax, POE lanolin alcohol ether, POE lanolin alcohol acetate, POE cholesterol ether, lanolin fatty acid polyethylene glycol, POE hydrogenated lanolin alcohol ether and the like.
  • hydrocarbon oil examples include liquid paraffin, zokerite, squalane, pristane, paraffin, selecin, squalene, petrolatum, microcrystalline wax and the like.
  • higher fatty acids examples include lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, undecylenic acid, tortic acid, isostearic acid, linoleic acid, linoleic acid, eicosapentaenoic acid (EPA), and docosahexaenoic acid ( DHA) and the like.
  • Higher alcohols include, for example, linear alcohols (eg, lauryl alcohols, cetyl alcohols, stearyl alcohols, behenyl alcohols, myristyl alcohols, oleyl alcohols, cetostearyl alcohols, etc.); branched chain alcohols (eg, monostearyl glycerin ethers (batyl alcohols)). ), 2-Deciltetradecinol, lanolin alcohol, cholesterol, phytosterol, hexyldodecanol, isostearyl alcohol, octyldodecanol, etc.) can be used.
  • linear alcohols eg, lauryl alcohols, cetyl alcohols, stearyl alcohols, behenyl alcohols, myristyl alcohols, oleyl alcohols, cetostearyl alcohols, etc.
  • branched chain alcohols eg, monostearyl glycerin ethers (batyl alcohols)
  • Synthetic ester oils include isopropyl myristate, cetyl octanate, octyldodecyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, decyl oleate, hexyldecyl dimethyloctanoate, cetyl lactate, myristyl lactate.
  • Silicone oils include dimethylpolysiloxane, methylhydrogenpolysiloxane, methylphenylpolysiloxane, stearoxymethylpolysiloxane, polyether-modified organopolysiloxane, fluoroalkyl-polyoxyalkylene co-modified organopolysiloxane, and alkyl-modified organopolysiloxane.
  • End-modified organopolysiloxane End-modified organopolysiloxane, fluorine-modified organopolysiloxane, amino-modified organopolysiloxane, silicone gel, acrylic silicone, trimethylsiloxysilicate, silicone RTV rubber, silicone compounds such as cyclopentasiloxane, and the like.
  • the powder is not particularly limited as long as it can be generally used for cosmetic purposes.
  • examples of the powder include inorganic powders (eg, talc, kaolin, mica, silk mica (serisite), white mica, gold mica, synthetic mica, red mica, black mica, lithia mica, fired mica, fired talc, vermiculite, etc.
  • Natural pigments eg, chlorophyll, ⁇ -carotene, etc.
  • Wax powder eg, carnauba wax powder, etc.
  • Starch powder eg, corn starch powder, rice starch powder, etc.
  • anionic surfactant examples include fatty acid sken (eg, sodium laurate, sodium palmitate, etc.); higher alkyl sulfate ester salts (eg, sodium lauryl sulfate, potassium lauryl sulfate, etc.); alkyl ether sulfate (eg, sodium lauryl sulfate, etc.).
  • Triethanolamine sulfonate linear sodium dodecylbenzene sulfonic acid, etc.
  • Higher fatty acid ester sulfate ester salt eg, cured coconut oil fatty acid sodium glycyl sulfate, etc.
  • N-acylglutamate eg, N-sodium lauroyl glutamate, N- Disodium stearoyl glutamate, monosodium N-myristyl-L-glutamate, etc.
  • Sulfated oil eg, funnel oil, etc.
  • cationic surfactant examples include alkyltrimethylammonium salts (eg, stearyltrimethylammonium chloride, lauryltrimethylammonium chloride, etc.); alkylpyridinium salts (eg, cetylpyridinium chloride, etc.); dialkyldimethylammonium salts (eg, disstearyl chloride, etc.).
  • alkyltrimethylammonium salts eg, stearyltrimethylammonium chloride, lauryltrimethylammonium chloride, etc.
  • alkylpyridinium salts eg, cetylpyridinium chloride, etc.
  • dialkyldimethylammonium salts eg, disstearyl chloride, etc.
  • amphoteric surfactant examples include imidazoline-based amphoteric surfactants (eg, 2-undecyl-N, N, N- (hydroxyethylcarboxymethyl) -2-imidazolin sodium, 2-cocoyl-2-imidazolinium hydroki. Side-1-carboxyethyroxy 2-sodium salt, etc.); Betaine-based surfactants (eg, 2-heptadecyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, lauryldimethylaminoacetic acid betaine, alkylbetaine, amide betaine) , Sulfobetaine, etc.) and the like.
  • imidazoline-based amphoteric surfactants eg, 2-undecyl-N, N, N- (hydroxyethylcarboxymethyl) -2-imidazolin sodium, 2-cocoyl-2-imidazolinium hydroki. Side-1-carboxye
  • hydrophilic non-ionic surfactant examples include POE-sorbitan fatty acid esters (eg, POE-sorbitan monooleate, POE-sorbitan monostearate, POE-sorbitan monooleate, POE-sorbitan tetraoleate, etc.); POE-Solbit fatty acid ester (eg, POE-Sorbit monolaurate, POE-Sorbit monooleate, POE-Sorbit pentaoleate, POE-Sorbit monostearate, etc.); POE-glycerin fatty acid ester (eg, POE-glycerin mono) POE-monooleates such as stearate, POE-glycerin monoisostearate, POE-glycerin triisostearate, etc.); POE-fatty acid esters (eg, POE-distearate, POE-monodiolate, ethylene glycol distearate, etc.); POE-
  • lipophilic non-ionic surfactant examples include sorbitan fatty acid esters (eg, sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate, sorbitan.
  • sorbitan fatty acid esters eg, sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate, sorbitan.
  • Trioleate penta-2-ethylhexylate diglycerol sorbitan, tetra-2-ethylhexylate diglycerol sorbitan, etc.; , ⁇ , ⁇ '-Glycerin pyroglutamate oleate, Glycerin monostearate, malic acid, etc.); Propropylene glycol fatty acid ester (for example, propylene glycol monostearate, etc.); Hardened castor oil derivative; Glycerin alkyl ether and the like.
  • thickener examples include Arabic gum, carrageenan, carrageenan, tragacanto gum, carob gum, quince seed (malmero), casein, dextrin, gelatin, sodium pectinate, sodium alginate, methyl cellulose, ethyl cellulose, carboxymethyl cellulose (CMC), hydroxyethyl cellulose.
  • Hydroxypropyl Cellulose Polyvinyl Alcohol (PVA), Polyvinyl Methyl Ether (PVM), PVP (Polyvinylpyrrolidone), Sodium Polyacrylate, Carrageenan Polymer, Locust Bean Gum, Gua Gum, Tamarinto Gum, Dialkyldimethylammonium Sulfate Cellulose, Xanthan Gum, Kay Examples thereof include aluminum magnesium acid acid, bentonite, hectrite, aluminum magnesium silicate (beagum), laponite, silicic anhydride, taurate-based synthetic polymer, acrylate-based synthetic polymer and the like.
  • Natural water-soluble polymers include, for example, plant-based polymers (eg, Arabic gum, tragacanto gum, galactan, guar gum, carob gum, karaya gum, carrageenan, pectin, canten, quinsseed (malmero), algae colloid (cassow extract), starch. (Rice, corn, potato, wheat), glycyrrhizinic acid); Micromolecular macromolecules (eg, xanthan gum, dextran, succinoglucan, purulan, etc.); Animal macromolecules (eg, collagen, casein, albumin, gelatin, etc.), etc. Can be mentioned.
  • plant-based polymers eg, Arabic gum, tragacanto gum, galactan, guar gum, carob gum, karaya gum, carrageenan, pectin, canten, quinsseed (malmero), algae colloid (cassow extract), starch. (Rice, corn, potato, wheat), g
  • Examples of the semi-synthetic water-soluble polymer include starch-based polymers (for example, carboxymethyl starch, methyl hydroxypropyl starch, etc.); cellulose-based polymers (methyl cellulose, ethyl cellulose, methyl hydroxypropyl cellulose, hydroxyethyl cellulose, cellulose sulfate, etc.). , Hydroxypropyl cellulose, carboxymethyl cellulose, sodium carboxymethyl cellulose, crystalline cellulose, cellulose powder, etc.); Examples thereof include alginic acid-based polymers (for example, sodium alginate, propylene glycol alginate, etc.).
  • Examples of the synthetic water-soluble polymer include vinyl-based polymers (for example, polyvinyl alcohol, polyvinyl methyl ether, polyvinylpyrrolidone, carboxyvinyl polymer, etc.); polyoxyethylene-based polymers (for example, polyethylene glycol 20,000, 40). 000, 60,000 polyoxyethylene polyoxypropylene copolymers, etc.); Acrylic polymers (eg, sodium polyacrylate, polyethyl acrylate, polyacrylamide, etc.); Polyethyleneimine; Cationic polymers and the like.
  • vinyl-based polymers for example, polyvinyl alcohol, polyvinyl methyl ether, polyvinylpyrrolidone, carboxyvinyl polymer, etc.
  • polyoxyethylene-based polymers for example, polyethylene glycol 20,000, 40). 000, 60,000 polyoxyethylene polyoxypropylene copolymers, etc.
  • Acrylic polymers eg, sodium polyacrylate, polyethyl acrylate, polyacrylamide, etc.
  • moisturizing agent examples include polyethylene glycol, propylene glycol, glycerin, 1,3-butylene glycol, xylitol, sorbitol, martitol, chondroitin sulfate, hyaluronic acid, mucoitin sulfate, caronic acid, atelocollagen, and cholesteryl-12-hydroxystearate. , Sodium lactate, bile acid salt, dl-pyrrolidone carboxylate, alkylene oxide derivative, short chain soluble collagen, diglycerin (EO) PO adduct, Izayoi rose extract, sardine extract, melilot extract and the like.
  • EO diglycerin
  • the film agent examples include an anionic film agent (for example, (meth) acrylic acid / (meth) acrylic acid ester copolymer, methyl vinyl ether / anhydrous maleic acid high polymer, etc.), and a cationic film agent (for example, cation).
  • an anionic film agent for example, (meth) acrylic acid / (meth) acrylic acid ester copolymer, methyl vinyl ether / anhydrous maleic acid high polymer, etc.
  • a cationic film agent for example, cation.
  • nonionic film agent for example, polyvinyl alcohol, polyvinylpyrrolidone, polyvinylacetate, polyacrylic acid ester copolymer, (meth) Acrylamide, polymer silicone, silicone resin, trimethylsiloxysilic acid, etc.
  • oil-soluble ultraviolet absorber examples include a benzoic acid-based ultraviolet absorber (for example, paraaminobenzoic acid (hereinafter abbreviated as PABA), PABA monoglycerin ester, N, N-dipropoxy PABA ethyl ester, N, N-diethoxyPABA).
  • PABA paraaminobenzoic acid
  • Ethyl ester N, N-dimethyl PABA ethyl ester, N, N-dimethyl PABA butyl ester, N, N-dimethyl PABA ethyl ester, diethylaminohydroxybenzoyl benzoate hexyl, etc.); Anthranyl acid-based ultraviolet absorbers (eg, homomentyl- N-Acetylanthranilate, etc.); Salicylic acid-based ultraviolet absorbers (eg, ethylhexyl salicylate, amylsalicylate, menthylsalicylate, homomentylsalicylate, octylsalicylate, phenylsalicylate, benzylsalicylate, p-isopropanolphenylsalicylate, homosalate, etc.); Acid-based UV absorbers (eg, octylmethoxysinamate, ethyl-4-isopropyls
  • water-soluble ultraviolet absorber examples include a benzophenone-based ultraviolet absorber (for example, 2-hydroxy-4-methoxybenzophenone-5-sulfonate, etc.) and a benzilidenshonou-based ultraviolet absorber (benzilidenshonou sulfonic acid, terephthalili). Denjisho-no-sulphonic acid, etc.), phenylbenzoimidazole-based ultraviolet absorbers (phenylbenzimidazole sulfonic acid, etc.) and the like can be mentioned.
  • metal ion sequestering agent examples include 1-hydroxyethane-1,1-diphosphonic acid, 1-hydroxyethane-1,1-diphosphonic acid tetrasodium salt, disodium edetate, trisodium edetate, and tetrasodium edetate.
  • Sodium citrate sodium polyphosphate, sodium metaphosphate, gluconic acid, phosphoric acid, citric acid, ascorbic acid, succinic acid, edetic acid, ethylenediamine hydroxyethyl triacetate trisodium and the like.
  • amino acids examples include neutral amino acids (eg, threonine, cysteine, etc.); basic amino acids (eg, hydroxylysine, etc.) and the like.
  • amino acid derivative examples include acyl sarcosine sodium (lauroyl sarcosine sodium), acyl glutamate, acyl ⁇ -alanine sodium, glutathione, pyrrolidone carboxylic acid and the like.
  • organic amine examples include monoethanolamine, diethanolamine, triethanolamine, morpholine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, 2-amino-2-methyl-1-propanol and the like. Can be mentioned.
  • polymer emulsion examples include an acrylic resin emulsion, an ethylpolyacrylic acid emulsion, an acrylic resin liquid, a polyacrylic alkyl ester emulsion, a polyvinyl acetate resin emulsion, and a natural rubber latex.
  • vitamins examples include vitamins A, B1, B2, B6, C, E and their derivatives, pantothenic acid and its derivatives, biotin and the like.
  • antioxidants examples include tocopherols, dibutylhydroxytoluene, butylhydroxyanisole, gallic acid esters and the like.
  • antioxidant aid examples include phosphoric acid, citric acid, ascorbic acid, maleic acid, malonic acid, succinic acid, fumaric acid, kephalin, hexametaphosphate, phytic acid, ethylenediamine tetraacetic acid and the like.
  • compoundable components include, for example, preservatives (ethylparaben, butylparaben, chlorphenesin, phenoxyethanol, etc.); anti-inflammatory agents (eg, glycylic acid derivative, glycyrrhetinic acid derivative, salicylic acid derivative, hinokithiol, zinc oxide, allantin, etc.) ); Whitening agents (eg, placenta extract, yukinoshita extract, albutin, etc.); Various extracts (eg, Oubaku, Ouren, Shikon, Shakuyaku, Senburi, Birch, Sage, Biwa, Carrot, Aloe, Zeniaoi, Iris, Grape , Yokuinin, Hechima, Yuri, Saffron, Senkyu, Shokyo, Otogirisou, Ononis, Garlic, Togarashi, Chimpi, Touki, Seaweed, etc.), Activators (eg, Royal Jelly, Photosen
  • compositions of the present disclosure include caffeine, tannin, verapamil, tranexamic acid and its derivatives, various crude drug extracts such as licorice, carin, and ichiyakusou, tocopherol acetate, glycyrrhizic acid, glycyrrhizinic acid and its derivatives or salts thereof. It can also appropriately contain a drug, a whitening agent such as vitamin C, magnesium ascorbic acid phosphate, ascorbic acid glucoside, arbutin, and kodiic acid, amino acids such as arginine and lysine, and derivatives thereof.
  • a whitening agent such as vitamin C, magnesium ascorbic acid phosphate, ascorbic acid glucoside, arbutin, and kodiic acid
  • amino acids such as arginine and lysine, and derivatives thereof.
  • the method for producing the external skin composition and the deodorant of the present disclosure will be described.
  • the skin external preparation composition and deodorant of the present disclosure are not limited to a specific method, and can be produced by a generally known method.
  • a skin external preparation composition and a deodorant can be prepared by mixing each of the above components.
  • the hakushinin extract can be obtained, for example, by the method described in any one of Patent Document 1, Patent Document 2 and Patent Document 3.
  • the matters described in Patent Document 1, Patent Document 2 and Patent Document 3 are renormalized and described in the present specification by reference.
  • the skin external preparation composition and deodorant of the present disclosure may be difficult to be directly specified by the composition or the like, or may not be practical. In such a case, the external skin composition and deodorant of the present disclosure should be allowed to be specified by the manufacturing method thereof.
  • a cosmetic containing 0.3% by mass of hakushinin extract was prepared.
  • Table 2 shows the composition of the cosmetics. The unit of the content rate shown in Table 2 is mass%.
  • Each of the cosmetics according to each test example contains one fragrance component shown in Table 3. The concentration of each fragrance component is adjusted so that the scent of the cosmetics according to each test example has the same intensity, and this fragrance is scented with each fragrance component.
  • the masking effect and harmonizing effect of each fragrance component were sensory-evaluated. The points were decided after consensus. The evaluation criteria for the masking effect and the harmonizing effect are shown below.
  • Table 3 shows the evaluation results of the fragrance components shown in Table 1.
  • the amount of the fragrance component added shown in Table 3 is a mass ratio with respect to 1 part by mass of the hakucinin extract.
  • As the hakushinin extract an extract produced by the method described in Patent Document 3 was used.
  • the fragrance components (1) to (6) have a masking effect on the odor of hakushinin.
  • the fragrance components (1) and (2) had a high masking effect.
  • the fragrance components (1) to (6) had both a masking effect and a harmonizing effect, and it is considered that the fragrance component (1) to (6) had a deodorizing effect against the hakushinin odor.
  • the fragrance components (1) to (6) have a peach-based and / or jasmine-based scent. Therefore, components having a peach-based and / or jasmine-based scent are considered to have a deodorizing effect on the scent of hakushinin.
  • the fragrance components (7) to (17) have a masking effect on the odor of hakushinin.
  • the fragrance components (7) to (9) had a high masking effect.
  • the fragrance components (7) to (17) also have a deodorizing effect on the odor of hakushinin.
  • the deodorizing method for a skin external preparation composition, a deodorant and a hakushinin odor of the present invention has been described based on the above-mentioned embodiments and examples, but is not limited to the above-mentioned embodiments and examples, and is not limited to the above-mentioned embodiments and examples.
  • various modifications, modifications and improvements may be included for each disclosed element (including the elements described in the claims, the specification and the drawings). Further, within the scope of the claims of the present invention, various combinations, substitutions or selections of each disclosed element are possible.
  • the fragrance component having at least one of the peach-based and jasmine-based scents is selected from the group consisting of linaryl acetate, cis-jasmon, hexylcinnamic aldehyde, ⁇ -undecalactone, methyl dihydrojasmonate, and methyl ⁇ -decalactone.
  • the skin external preparation composition according to the appendix, which is at least one.
  • Appendix 3 Hakushinin extract and Skin comprising linalyl acetate, cis-jasmonate, hexylcinnamic aldehyde, ⁇ -undecalactone, methyl dihydrojasmonate, methyl ⁇ -decalactone, and a fragrance component comprising at least one selected from the group consisting of linalool.
  • External preparation composition [Appendix 4] It is a deodorant for deodorizing the odor of hakushinin extract. A deodorant containing a fragrance component having at least one scent of peach or jasmine.
  • the fragrance component having at least one of the peach-based and jasmine-based scents is selected from the group consisting of linalyl acetate, cis-jasmon, hexylcinnamic aldehyde, ⁇ -undecalactone, methyl dihydrojasmonate, and methyl ⁇ -decalactone.
  • the deodorant according to the appendix which is at least one.
  • a deodorant comprising linalyl acetate, cis-jasmonate, hexylcinnamic aldehyde, ⁇ -undecalactone, methyl dihydrojasmonate, methyl ⁇ -decalactone, and a fragrance component comprising at least one selected from the group consisting of linalool. .. [Appendix 7] It is a deodorant for deodorizing the odor of hakushinin extract.
  • fragrance ingredients include linalool acetate, cis-jasmon, hexylcinnamic aldehyde, ⁇ -undecalactone, methyl dihydrojasmonate, methyl ⁇ -decalactone, linalool, 1,3,4,6,7,8-hexahydro-4.
  • the skin external preparation composition of the present disclosure is used as at least one selected from the group consisting of a whitening agent, a collagen production promoter, a hyaluronic acid production promoter, a fibroblast growth promoter, and an anti-wrinkle agent. How to use the external preparation composition.
  • the skin external preparation composition, deodorant, and deodorizing method of hakushinin odor of the present disclosure can be applied to, for example, cosmetics, cleansing agents, etc. applied to the skin.
  • the external skin composition of the present disclosure includes a deodorant, an antiperspirant, a deodorant, a sunscreen cosmetic, a skin care agent, a make-up cosmetic, a hair conditioner, a hair restorer, a hair growth agent, a scalp care agent, and a cleaning agent. It can be applied to charges, therapeutic agents, etc.

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Abstract

Composition de préparation externe cutanée contenant un extrait de Thujae orientalis, et des ingrédients de parfum. Les ingrédients de parfum comprennent au moins un élément choisi dans le groupe constitué par l'acétate de linalyle, la cis-jasmone, l'hexylcinnamaldéhyde, la γ-undécalactone, le méthyl dihydrojasmonate, la méthyl-γ-décalactone, le linalol, le 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexaméthylcyclopenta-γ-2-benzopyrane, l'éthyltriméthylcyclopenténylbutanol, l'éthyllinalol, la lactone de l'acide 16-hydroxy-7-hexadécénoïque, le brassylate d'éthylène, le cyclopentadécénolide, le 2,6-diméthyl-7-octén-2-ol, le γ-méthylbenzène-1-pentanol, l'isobutylméthyltétrahydropyranol et la cétone de framboise.
PCT/JP2021/042258 2020-12-07 2021-11-17 Composition de préparation externe cutanée Ceased WO2022124027A1 (fr)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025093184A1 (fr) * 2023-11-03 2025-05-08 Beiersdorf Ag Combinaisons de principes actifs constituées d'alkylamidothiazoles et de gamma undécalactone

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Publication number Priority date Publication date Assignee Title
JP2005179226A (ja) * 2003-12-18 2005-07-07 Shiseido Co Ltd 柏子仁から美白成分を抽出する方法
JP2010132629A (ja) * 2008-12-03 2010-06-17 Triple Act:Kk 皮膚外用組成物
WO2012057123A1 (fr) * 2010-10-27 2012-05-03 株式会社 資生堂 Agent favorisant la production de collagène, agent favorisant la production d'hyaluronane, agent favorisant la prolifération de fibroblastes et agent antirides
JP2012236792A (ja) * 2011-05-11 2012-12-06 Takasago Internatl Corp 細胞賦活剤、抗酸化剤、香料組成物及び皮膚外用剤
JP2014114291A (ja) * 2013-12-13 2014-06-26 Showa Denko Kk 化粧料または皮膚外用剤

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005179226A (ja) * 2003-12-18 2005-07-07 Shiseido Co Ltd 柏子仁から美白成分を抽出する方法
JP2010132629A (ja) * 2008-12-03 2010-06-17 Triple Act:Kk 皮膚外用組成物
WO2012057123A1 (fr) * 2010-10-27 2012-05-03 株式会社 資生堂 Agent favorisant la production de collagène, agent favorisant la production d'hyaluronane, agent favorisant la prolifération de fibroblastes et agent antirides
JP2012236792A (ja) * 2011-05-11 2012-12-06 Takasago Internatl Corp 細胞賦活剤、抗酸化剤、香料組成物及び皮膚外用剤
JP2014114291A (ja) * 2013-12-13 2014-06-26 Showa Denko Kk 化粧料または皮膚外用剤

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025093184A1 (fr) * 2023-11-03 2025-05-08 Beiersdorf Ag Combinaisons de principes actifs constituées d'alkylamidothiazoles et de gamma undécalactone

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