WO2022109904A1 - Method for two-dimensional image selection and three-dimensional blood vessel synthesis and storage medium - Google Patents

Abstract

A method for two-dimensional image selection and three-dimensional blood vessel synthesis and a storage medium, the method comprising: loading a plurality of coronary two-dimensional angiographic image sequence groups (S100); selecting one of the coronary two-dimensional angiographic image sequence groups (S200); displaying a series of thumbnail images in each of the coronary two-dimensional angiographic image sequence groups (S300); selecting thumbnail images of interest from within at least two of the coronary two-dimensional angiographic image sequence groups, wherein the thumbnail images will display a magnified view, i.e. coronary two-dimensional angiographic images for three-dimensional blood vessel synthesis are obtained (S400). A method for two-dimensional image selection and three-dimensional blood vessel synthesis and a storage medium are achieved. The foregoing method may effectively reduce the difficulty and error when obtaining blood vessel information, improve the accuracy with which the blood vessel information is obtained, and has good practicability.

Description

Method and storage medium for two-dimensional image selection and three-dimensional blood vessel synthesis technical field

The invention relates to the technical field of coronary medicine, in particular to a method and a storage medium for two-dimensional image selection and three-dimensional blood vessel synthesis.

Background technique

The deposition of lipids and carbohydrates in human blood on the blood vessel wall will form plaques on the blood vessel wall, which will then lead to vascular stenosis; especially the vascular stenosis near the coronary arteries of the heart will lead to insufficient blood supply to the heart muscle and induce coronary heart disease. , angina pectoris and other diseases pose a serious threat to human health. According to statistics, there are about 11 million coronary heart disease patients in my country, and the number of patients treated with cardiovascular interventional surgery is increasing by more than 10% every year.

Although conventional medical detection methods such as coronary angiography (CAG) and computed tomography (CT) can display the severity of coronary artery stenosis, they cannot accurately evaluate coronary ischemia. In order to improve the accuracy of coronary vascular function evaluation, in 1993, Pijls proposed a new index for calculating coronary vascular function through pressure measurement - Fractional Flow Reserve (FFR). After long-term basic and clinical research, FFR It has become the gold standard for functional evaluation of coronary stenosis.

Fractional flow reserve (FFR) usually refers to the fractional myocardial blood flow reserve, which is defined as the ratio of the maximum blood flow that the diseased coronary artery can provide to the myocardium to the maximum blood flow when the coronary artery is completely normal. In the state, the ratio of blood flow can be replaced by the pressure value. That is, the measurement of the FFR value can be calculated by measuring the pressure at the distal stenosis of the coronary artery and the pressure at the proximal end of the coronary stenosis through the pressure sensor under the state of maximum coronary hyperemia.

In the prior art, image processing algorithms are usually applied to the two-dimensional angiography sequence images. First, fully automatic, semi-automatic or manual methods are used to calculate the path of the blood vessel, and then the edge detection method is used to obtain the outline of the blood vessel, so as to further calculate the blood vessel. diameter of. However, the problem with this method is the overlapping and intersection of various organs around the blood vessels, which will cause uncertainties to the algorithm.

SUMMARY OF THE INVENTION

The invention provides a method and storage medium for selecting two-dimensional images and synthesizing three-dimensional blood vessels, so as to avoid the overlapping and crossing of various organs around blood vessels in the two-dimensional imaging sequence images from causing uncertain factors to the algorithm.

In order to achieve the above object, in the first aspect, the present application provides a method for selecting a two-dimensional image of a coronary artery for three-dimensional blood vessel synthesis, including:

Load multiple sets of coronary two-dimensional angiography image sequence groups;

selecting a group of said coronary two-dimensional angiography image sequence groups;

A series of thumbnail images are displayed in each group of the two-dimensional coronary angiography image sequence group;

Said thumbnail images of interest are selected from at least two sets of said series of coronary 2D angiography images, and said thumbnail images are displayed as enlarged images, ie, 2D coronary angiography images for 3D vascular synthesis are obtained.

Optionally, in the above method for selecting a 2D coronary artery image for 3D vascular synthesis, when each group of the 2D coronary angiography image sequence group is displayed on a page, an intermediate frame is selected as a thumbnail for display by default.

In a second aspect, the application provides a method for synthesizing a three-dimensional blood vessel, comprising:

According to the above-mentioned method for selecting a two-dimensional coronary artery image for three-dimensional blood vessel synthesis, image information of at least two two-dimensional coronary angiography images of interest with different shooting angles, including the shooting angle and the shooting distance, are acquired;

Obtaining a three-dimensional blood vessel centerline and a three-dimensional blood vessel radius according to the image information of the two-dimensional coronary angiography image;

A three-dimensional blood vessel is synthesized according to the three-dimensional blood vessel centerline and the three-dimensional blood vessel radius.

Optionally, in the above-mentioned method for synthesizing a three-dimensional blood vessel, the method for obtaining a three-dimensional blood vessel centerline according to the two-dimensional coronary angiography image includes:

extracting a two-dimensional blood vessel centerline from each of the two-dimensional coronary angiography images of interest;

Projecting the radiation source into the three-dimensional space to form a radiation point;

The two-dimensional blood vessel centerline is projected into the three-dimensional space;

All points in the three-dimensional space are connected with the radiation point, which will generate a series of intersections;

The intersection points are connected in sequence to obtain the three-dimensional blood vessel centerline.

Optionally, in the above-mentioned method for synthesizing a three-dimensional blood vessel, the method for obtaining a blood vessel centerline and a three-dimensional blood vessel radius according to the two-dimensional coronary angiography image includes:

Acquiring a two-dimensional blood vessel contour line according to the two-dimensional blood vessel centerline;

Acquiring the two-dimensional blood vessel radius in each of the two-dimensional coronary angiography images of interest according to the two-dimensional blood vessel contour;

The three-dimensional blood vessel radius is obtained according to the two-dimensional blood vessel radius, and the specific formula is:

Wherein, R represents the three-dimensional blood vessel radius, and r ₁ , r ₂ , and rn represent the two-dimensional blood vessel radius of the first, second, and _nth two-dimensional contrast images of interest, respectively.

Optionally, in the above-mentioned method for synthesizing a three-dimensional blood vessel, the method for extracting a two-dimensional blood vessel centerline from each of the two-dimensional coronary angiography images includes:

Read two-dimensional coronary angiography images;

Obtain the vessel segment of interest;

Picking the start point, seed point and end point of the vessel segment of interest;

Segmenting the two-dimensional angiography images between two adjacent points of the starting point, the seed point, and the ending point, respectively, to obtain at least two local blood vessel area maps;

extracting at least one blood vessel local path line from each of said local blood vessel area maps;

connecting the corresponding blood vessel local path lines on each of the local blood vessel area maps to obtain at least one of the blood vessel path lines;

One of the blood vessel path lines is selected as the two-dimensional blood vessel centerline.

Optionally, in the above-mentioned method for synthesizing three-dimensional blood vessels, the method for extracting at least one local blood vessel path line from each of the local blood vessel area maps includes:

Perform image enhancement processing on the local blood vessel area map to obtain a rough blood vessel map with strong contrast;

Meshing the rough blood vessel map, and extracting at least one local path line of the blood vessel along the direction from the start point to the end point.

Optionally, in the above-mentioned method for synthesizing a three-dimensional blood vessel, the method for performing grid division on the rough blood vessel map, and along the direction from the starting point to the ending point, extracting at least one local path line of the blood vessel includes:

meshing the rough blood vessel map;

Along the extension direction of the blood vessel from the starting point to the ending point, search for the shortest time path of the intersection between the starting point and the surrounding n grids as the second point, and search for the second point and the surrounding The shortest time path of the intersections on the n grids is used as the third point, and the third point repeats the above steps until the shortest time path reaches the end point, where n is a positive integer greater than or equal to 1;

According to the search sequence, connect a line in the extending direction of the blood vessel from the starting point to the ending point to obtain at least one local path line of the blood vessel.

Optionally, in the above-mentioned method for synthesizing a three-dimensional blood vessel, the method for selecting one of the blood vessel path lines as the two-dimensional blood vessel centerline includes:

If there are two or more vessel path lines, summing the time taken for each vessel path line from the starting point to the ending point;

The blood vessel path line with the least amount of time is taken as the two-dimensional blood vessel center line.

Optionally, the above-mentioned method for synthesizing a three-dimensional blood vessel, a method for obtaining a two-dimensional blood vessel contour line according to the blood vessel centerline, is characterized in that, comprising:

Extracting the two-dimensional blood vessel centerline according to the coronary two-dimensional angiography image;

obtaining a straightened blood vessel image according to the two-dimensional blood vessel centerline;

On the straightened blood vessel image, set a blood vessel diameter threshold D _threshold ;

According to the D _threshold , a preset contour line of the blood vessel is generated on both sides of the blood vessel center straight line;

moving the preset contour line of the blood vessel to the center of the blood vessel step by step, to obtain the contour line of the blood vessel after straightening;

The contour of the straightened blood vessel is projected back onto the image from which the two-dimensional blood vessel centerline is extracted to obtain a two-dimensional blood vessel contour.

Optionally, in the above-mentioned method for synthesizing a three-dimensional blood vessel, the method for synthesizing a three-dimensional blood vessel according to the three-dimensional blood vessel centerline and the three-dimensional blood vessel radius includes:

Each point on the center line of the three-dimensional blood vessel is drawn in the three-dimensional space along the corresponding three-dimensional blood vessel radius to obtain a plurality of edge points, and the edge points are connected in sequence to obtain an approximate circle polygon;

Points on two adjacent polygons are connected in sequence in the form of right-angled triangles to obtain a three-dimensional blood vessel.

In a third aspect, the present application provides a computer storage medium, when the computer program is executed by a processor, the above-mentioned method for selecting a two-dimensional coronary artery image for three-dimensional blood vessel synthesis is implemented.

The beneficial effects brought by the solutions provided in the embodiments of the present application include at least:

The present application provides a method for synthesizing a three-dimensional blood vessel. In the process of calculating the blood vessel information from a two-dimensional image of a coronary artery, by reducing the influence of other parts on the blood vessel, the blood vessel radius can be obtained more easily, and the vascular radius is improved. accuracy and improve the robustness of the algorithm.

Description of drawings

The accompanying drawings described herein are used to provide further understanding of the present invention and constitute a part of the present invention. The exemplary embodiments of the present invention and their descriptions are used to explain the present invention and do not constitute an improper limitation of the present invention. In the attached image:

Reference numerals are explained below:

FIG. 1 is a flowchart of an embodiment of a method for selecting a two-dimensional image of a coronary artery for three-dimensional vessel synthesis according to the present application;

2 is a flowchart of another embodiment of a method for selecting a two-dimensional coronary artery image for three-dimensional blood vessel synthesis according to the present application;

Fig. 3 is the flow chart of S600 of this application;

4 is a flowchart of S620 of the application;

5 is a flowchart of S630 of the application;

FIG. 6 is a flowchart of S700 of the present application.

Detailed ways

In order to make the objectives, technical solutions and advantages of the present invention clearer, the technical solutions of the present invention will be clearly and completely described below with reference to the specific embodiments of the present invention and the corresponding drawings. Obviously, the described embodiments are only some, but not all, embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present invention.

Various embodiments of the present invention will be disclosed in the drawings below, and for the sake of clarity, many practical details will be described together in the following description. It should be understood, however, that these practical details should not be used to limit the invention. That is, in some embodiments of the invention, these practical details are unnecessary. In addition, for the purpose of simplifying the drawings, some well-known structures and components will be shown in a simple schematic manner in the drawings.

In the prior art, it is often necessary to extract the blood vessel contour when calculating the blood vessel evaluation parameters through the three-dimensional model of the blood vessel. Due to the problems of curling and unclear edges of the blood vessel, it is particularly difficult to extract the blood vessel contour, and the calculation data is huge and cumbersome, so how to quickly extract the blood vessel contour. Vessel contours and the accuracy of extraction have always been issues that technicians need to solve.

Example 1:

As shown in Figure 1, in order to solve the above-mentioned problems, the application provides a method for selecting a two-dimensional coronary artery image for three-dimensional blood vessel synthesis, including:

S100, loading multiple sets of two-dimensional coronary angiography image sequence groups;

S200, selecting a group of the two-dimensional coronary angiography image sequence groups;

S300, displaying a series of thumbnail images in each group of the two-dimensional coronary angiography image sequence group;

S400: Select the thumbnail image of interest from at least two sets of the coronary two-dimensional angiography image sequence groups, and the thumbnail image will display an enlarged image, that is, obtain a two-dimensional coronary angiography image for three-dimensional vascular synthesis .

In an embodiment of the present application, when each group of the two-dimensional coronary angiography image sequence group is displayed on a page, an intermediate frame is selected as a thumbnail for display by default.

Example 2:

As shown in Figure 2, the present application provides a method for synthesizing a three-dimensional blood vessel, comprising:

S500, according to the method of Embodiment 1, obtain image information of at least two two-dimensional coronary angiography images of interest with different shooting angles, including the shooting angle and the shooting distance;

S600, as shown in FIG. 3, obtaining a three-dimensional blood vessel centerline and a three-dimensional blood vessel radius according to the image information of the coronary two-dimensional angiography image, including:

S610, extract a two-dimensional blood vessel centerline from each of the two-dimensional coronary angiography images of interest, including:

S611, read a coronary two-dimensional angiography image;

S612, acquiring the blood vessel segment of interest;

S613, picking up the starting point, the seed point and the ending point of the blood vessel segment of interest;

S614, segment the two-dimensional angiography images between two adjacent points of the starting point, the seed point, and the ending point, respectively, to obtain at least two local blood vessel area maps;

S615, extracting at least one local blood vessel path line from each of the local blood vessel area maps, including:

Perform image enhancement processing on the local blood vessel area map to obtain a rough blood vessel map with strong contrast, including: in each of the local blood vessel area maps, the blood vessel segment of interest is used as the foreground, and other areas are used as the background. The foreground and the background are weakened to obtain the rough blood vessel image with strong contrast.

Meshing the rough blood vessel map, and extracting at least one local blood vessel path line along the direction from the start point to the end point, including:

meshing the rough blood vessel map;

Along the extension direction of the blood vessel from the starting point to the ending point, search for the shortest time path of the intersection between the starting point and the surrounding n grids as the second point, and search for the second point and the surrounding The shortest time path of the intersections on the n grids is used as the third point, and the third point repeats the above steps until the shortest time path reaches the end point, where n is a positive integer greater than or equal to 1;

According to the search sequence, connect a line in the extending direction of the blood vessel from the starting point to the ending point to obtain at least one local path line of the blood vessel.

S616, selecting one of the blood vessel path lines as the two-dimensional blood vessel centerline, including:

If there are two or more vessel path lines, summing the time taken for each vessel path line from the starting point to the ending point;

The blood vessel path line with the least amount of time is taken as the two-dimensional blood vessel center line.

S620, as shown in FIG. 4, according to the shooting angle of each of the two-dimensional coronary angiography images, project each of the two-dimensional blood vessel centerlines into a three-dimensional space, and synthesize the three-dimensional blood vessel centerlines, including:

S621, project the radiation source into the three-dimensional space to form a radiation point;

S622, the two-dimensional blood vessel centerline is projected into a three-dimensional space;

S623, all points in the three-dimensional space are connected with the radiation point, and a series of intersection points will be generated;

S624, connecting the intersection points in sequence to obtain the three-dimensional blood vessel centerline;

S630, as shown in FIG. 5, obtaining a two-dimensional blood vessel contour line according to the two-dimensional blood vessel centerline, including:

S631, extracting a two-dimensional blood vessel centerline according to a two-dimensional coronary angiography image;

S632, obtaining a straightened blood vessel image according to the two-dimensional blood vessel centerline, including:

Straightening the two-dimensional blood vessel center line to obtain a blood vessel center line;

Along the blood vessel extension direction from the starting point to the ending point, the local blood vessel area map is divided into x units, where x is a positive integer;

Correspondingly setting the two-dimensional blood vessel centerline of each of the cells along the blood vessel center line;

The correspondingly set image is the straightened blood vessel image.

S633, on the straightened blood vessel image, set a blood vessel diameter threshold D _threshold ;

S634, according to the D _threshold , generate blood vessel preset contour lines on both sides of the blood vessel center line;

S635, moving the preset contour line of the blood vessel to the center of the blood vessel step by step, to obtain the contour line of the blood vessel after straightening, including:

dividing the blood vessel preset contour line into y units, where y is a positive integer;

Acquire z points on each of the units on the preset contour line of each of the blood vessels;

along a straight line perpendicular to the center of the blood vessel, the z points are respectively moved closer to the center line of the blood vessel in a graded manner to generate z close points, where z is a positive integer;

Set the RGB difference threshold as the ΔRGB _threshold , along the line perpendicular to the center of the blood vessel, compare the RGB value of the close point with the RGB value of the point on the line of the center of the blood vessel for each approach, and the difference is When the value is less than or equal to the ΔRGB _threshold , the approaching point stops straightly approaching the center of the blood vessel;

Obtain the close point as a contour point;

The smooth curve formed by sequentially connecting the contour points is the contour line of the straightened blood vessel.

S636: Project the straightened blood vessel contour line back onto the image from which the two-dimensional blood vessel centerline was extracted to obtain a two-dimensional blood vessel contour line.

S640, acquiring the two-dimensional blood vessel radius in each of the two-dimensional coronary angiography images of interest according to the two-dimensional blood vessel contour;

S650, obtain the three-dimensional blood vessel radius according to the two-dimensional blood vessel radius, and the specific formula is:

Wherein, R represents the three-dimensional blood vessel radius, and r ₁ , r ₂ , and rn represent the two-dimensional blood vessel radius of the first, second, and _nth two-dimensional contrast images of interest, respectively.

S700, as shown in Figure 6, synthesizing a three-dimensional blood vessel according to the three-dimensional blood vessel centerline and the three-dimensional blood vessel radius, including:

S710: Draw a picture in the three-dimensional space along the corresponding three-dimensional blood vessel radius for each point on the center line of the three-dimensional blood vessel to obtain a plurality of edge points, and connect the edge points in sequence to obtain an approximate circle polygon ;

S720: Connect the points on two adjacent polygons in sequence in the form of a right-angled triangle to obtain a three-dimensional blood vessel.

The present application provides a computer storage medium, and when the computer program is executed by a processor, the above-mentioned method for selecting a two-dimensional coronary artery image for three-dimensional blood vessel synthesis is implemented.

As will be appreciated by one skilled in the art, various aspects of the present invention may be embodied as a system, method or computer program product. Accordingly, various aspects of the present invention may be embodied in the form of an entirely hardware implementation, an entirely software implementation (including firmware, resident software, microcode, etc.), or a combination of hardware and software aspects, It may be collectively referred to herein as a "circuit," "module," or "system." Furthermore, in some embodiments, various aspects of the present invention may also be implemented in the form of a computer program product on one or more computer-readable media having computer-readable program code embodied thereon. Implementation of the method and/or system of embodiments of the present invention may involve performing or completing selected tasks manually, automatically, or a combination thereof.

For example, hardware for performing selected tasks according to embodiments of the invention may be implemented as a chip or a circuit. As software, selected tasks according to embodiments of the invention may be implemented as a plurality of software instructions executed by a computer using any suitable operating system. In an exemplary embodiment of the invention, one or more tasks in accordance with exemplary embodiments of methods and/or systems as herein are performed by a data processor, such as a computing platform for executing a plurality of instructions. Optionally, the data processor includes volatile storage for storing instructions and/or data and/or non-volatile storage for storing instructions and/or data, such as a magnetic hard disk and/or a Move media. Optionally, a network connection is also provided. A display and/or user input device, such as a keyboard or mouse, is optionally also provided.

Any combination of one or more computer readable may be utilized. The computer-readable medium may be a computer-readable signal medium or a computer-readable storage medium. The computer-readable storage medium can be, for example, but not limited to, an electrical, magnetic, optical, electromagnetic, infrared, or semiconductor system, apparatus or device, or a combination of any of the above. More specific examples (non-exhaustive list) of computer-readable storage media would include the following:

Electrical connection with one or more wires, portable computer disk, hard disk, random access memory (RAM), read only memory (ROM), erasable programmable read only memory (EPROM or flash memory), optical fiber, portable compact disk Read only memory (CD-ROM), optical storage device, magnetic storage device, or any suitable combination of the above. In this document, a computer-readable storage medium can be any tangible medium that contains or stores a program that can be used by or in conjunction with an instruction execution system, apparatus, or device.

A computer-readable signal medium may include a propagated data signal in baseband or as part of a carrier wave, with computer-readable program code embodied thereon. Such propagated data signals may take a variety of forms, including but not limited to electromagnetic signals, optical signals, or any suitable combination of the foregoing. A computer-readable signal medium can also be any computer-readable medium other than a computer-readable storage medium that can transmit, propagate, or transport the program for use by or in connection with the instruction execution system, apparatus, or device .

Program code embodied on a computer-readable medium may be transmitted using any suitable medium, including but not limited to wireless, wireline, optical fiber cable, RF, etc., or any suitable combination of the foregoing.

For example, computer program code for performing operations for various aspects of the present invention may be written in any combination of one or more programming languages, including object-oriented programming languages such as Java, Smalltalk, C++, and conventional procedural programming languages, such as The "C" programming language or similar programming language. The program code may execute entirely on the user's computer, partly on the user's computer, as a stand-alone software package, partly on the user's computer and partly on a remote computer, or entirely on the remote computer or server. In the case of a remote computer, the remote computer may be connected to the user's computer through any kind of network - including a local area network (LAN) or wide area network (WAN) - or may be connected to an external computer (eg using an Internet service provider via Internet connection).

It will be understood that each block of the flowchart illustrations and/or block diagrams, and combinations of blocks in the flowchart illustrations and/or block diagrams, can be implemented by computer program instructions. These computer program instructions may be provided to the processor of a general purpose computer, special purpose computer or other programmable data processing apparatus to produce a machine that causes the computer program instructions when executed by the processor of the computer or other programmable data processing apparatus , resulting in means for implementing the functions/acts specified in one or more blocks of the flowchart and/or block diagrams.

These computer program instructions can also be stored on a computer readable medium, the instructions cause a computer, other programmable data processing apparatus, or other device to operate in a particular manner, whereby the instructions stored on the computer readable medium produce the An article of manufacture of instructions implementing the functions/acts specified in one or more blocks of the flowcharts and/or block diagrams.

Computer program instructions can also be loaded on a computer (eg, a coronary artery analysis system) or other programmable data processing device to cause a series of operational steps to be performed on the computer, other programmable data processing device or other device to produce a computer-implemented process , such that instructions executing on a computer, other programmable apparatus, or other device provide a process for implementing the functions/acts specified in the flowchart and/or one or more block diagram blocks.

The above specific examples of the present invention further describe the purpose, technical solutions and beneficial effects of the present invention in detail. It should be understood that the above are only specific embodiments of the present invention, and are not intended to limit the present invention. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included within the protection scope of the present invention.

Claims (12)

A method for selecting two-dimensional images of coronary arteries for three-dimensional blood vessel synthesis, comprising: Load multiple sets of coronary two-dimensional angiography image sequence groups; selecting a group of said coronary two-dimensional angiography image sequence groups; A series of thumbnail images are displayed in each group of the two-dimensional coronary angiography image sequence group; Said thumbnail images of interest are selected from at least two sets of said series of coronary 2D angiography images, and said thumbnail images are displayed as enlarged images, ie, 2D coronary angiography images for 3D vascular synthesis are obtained. The method for selecting a 2D coronary artery image for 3D vascular synthesis according to claim 1, wherein when each group of the coronary 2D angiography image sequence group is displayed on a page, an intermediate frame is selected as a thumbnail by default show. A method for synthesizing three-dimensional blood vessels, comprising: The method for selecting a 2D coronary artery image for 3D vascular synthesis according to claim 1 or 2, acquiring image information of at least two 2D coronary angiography images of interest with different shooting angles, including the shooting angle and the shooting angle. distance; Obtaining a three-dimensional blood vessel centerline and a three-dimensional blood vessel radius according to the image information of the two-dimensional coronary angiography image; A three-dimensional blood vessel is synthesized according to the three-dimensional blood vessel centerline and the three-dimensional blood vessel radius. The method for synthesizing a three-dimensional blood vessel according to claim 3, wherein the method for obtaining a three-dimensional blood vessel centerline according to the two-dimensional coronary angiography image comprises: extracting a two-dimensional blood vessel centerline from each of the two-dimensional coronary angiography images of interest; Projecting the radiation source into the three-dimensional space to form a radiation point; The two-dimensional blood vessel centerline is projected into the three-dimensional space; All points in the three-dimensional space are connected with the radiation point, which will generate a series of intersections; The intersection points are connected in sequence to obtain the three-dimensional blood vessel centerline. The method for synthesizing a three-dimensional blood vessel according to claim 3, wherein the method for obtaining a blood vessel centerline and a three-dimensional blood vessel radius according to the two-dimensional coronary angiography image comprises: Acquiring a two-dimensional blood vessel contour line according to the two-dimensional blood vessel centerline; Obtaining the two-dimensional blood vessel radius in each of the two-dimensional coronary angiography images of interest according to the two-dimensional blood vessel contour; The three-dimensional blood vessel radius is obtained according to the two-dimensional blood vessel radius, and the specific formula is:

Wherein, R represents the three-dimensional blood vessel radius, and r ₁ , r ₂ , and rn represent the two-dimensional blood vessel radius of the first, second, and _nth two-dimensional contrast images of interest, respectively. The method for synthesizing three-dimensional blood vessels according to claim 4, wherein the method for respectively extracting a two-dimensional blood vessel centerline from each of the two-dimensional coronary angiography images comprises: Read two-dimensional coronary angiography images; Obtain the vessel segment of interest; Picking the start point, seed point and end point of the vessel segment of interest; Segmenting the two-dimensional angiography images between two adjacent points of the starting point, the seed point, and the ending point, respectively, to obtain at least two local blood vessel area maps; extracting at least one blood vessel local path line from each of said local blood vessel area maps; connecting the corresponding blood vessel local path lines on each of the local blood vessel area maps to obtain at least one of the blood vessel path lines; One of the blood vessel path lines is selected as the two-dimensional blood vessel centerline. The method for synthesizing three-dimensional blood vessels according to claim 6, wherein the method for extracting at least one local blood vessel path line from each of the local blood vessel area maps comprises: Perform image enhancement processing on the local blood vessel area map to obtain a rough blood vessel map with strong contrast; Meshing the rough blood vessel map, and extracting at least one local path line of the blood vessel along the direction from the start point to the end point. The method for synthesizing a three-dimensional blood vessel according to claim 7, wherein the rough blood vessel map is divided into grids, and at least one local path line of the blood vessel is extracted along the direction from the starting point to the ending point. methods include: meshing the rough blood vessel map; Along the extension direction of the blood vessel from the starting point to the ending point, search for the shortest time path of the intersection between the starting point and the surrounding n grids as the second point, and search for the second point and the surrounding The shortest time path of the intersections on the n grids is used as the third point, and the third point repeats the above steps until the shortest time path reaches the end point, where n is a positive integer greater than or equal to 1; According to the search sequence, connect a line in the extending direction of the blood vessel from the starting point to the ending point to obtain at least one local path line of the blood vessel. The method for synthesizing a three-dimensional blood vessel according to claim 8, wherein the method for selecting one of the blood vessel path lines as the two-dimensional blood vessel centerline comprises: If there are two or more vessel path lines, summing the time taken for each vessel path line from the starting point to the ending point; The blood vessel path line with the least amount of time is taken as the two-dimensional blood vessel center line. The method for synthesizing a three-dimensional blood vessel according to claim 9, wherein the method for obtaining a two-dimensional blood vessel contour line according to the blood vessel centerline is characterized in that, comprising: Extracting the two-dimensional blood vessel centerline according to the coronary two-dimensional angiography image; obtaining a straightened blood vessel image according to the two-dimensional blood vessel centerline; On the straightened blood vessel image, set a blood vessel diameter threshold D _threshold ; According to the D _threshold , a preset contour line of the blood vessel is generated on both sides of the blood vessel center straight line; moving the preset contour line of the blood vessel to the center of the blood vessel step by step, to obtain the contour line of the blood vessel after straightening; The contour of the straightened blood vessel is projected back onto the image from which the two-dimensional blood vessel centerline is extracted to obtain a two-dimensional blood vessel contour. The method for synthesizing a three-dimensional blood vessel according to claim 10, wherein the method for synthesizing a three-dimensional blood vessel according to the three-dimensional blood vessel centerline and the three-dimensional blood vessel radius comprises: Each point on the center line of the three-dimensional blood vessel is drawn in the three-dimensional space along the corresponding three-dimensional blood vessel radius to obtain a plurality of edge points, and the edge points are connected in sequence to obtain an approximate circle polygon; Points on two adjacent polygons are connected in sequence in the form of right-angled triangles to obtain a three-dimensional blood vessel. A computer storage medium, characterized in that, when the computer program is executed by a processor, the method for selecting a two-dimensional coronary artery image for three-dimensional blood vessel synthesis according to claim 1 or 2 is implemented.

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