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WO2022109301A1 - Cathéter radial amélioré et systèmes d'administration de médicament pour atténuation de vasospasme - Google Patents

Cathéter radial amélioré et systèmes d'administration de médicament pour atténuation de vasospasme Download PDF

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Publication number
WO2022109301A1
WO2022109301A1 PCT/US2021/060142 US2021060142W WO2022109301A1 WO 2022109301 A1 WO2022109301 A1 WO 2022109301A1 US 2021060142 W US2021060142 W US 2021060142W WO 2022109301 A1 WO2022109301 A1 WO 2022109301A1
Authority
WO
WIPO (PCT)
Prior art keywords
catheter
lumen
catheter system
drug
vasospasm
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2021/060142
Other languages
English (en)
Inventor
Russel CORVESE
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Infinity Neuro LLC
Original Assignee
Infinity Neuro LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Infinity Neuro LLC filed Critical Infinity Neuro LLC
Publication of WO2022109301A1 publication Critical patent/WO2022109301A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0021—Catheters; Hollow probes characterised by the form of the tubing
    • A61M25/0023—Catheters; Hollow probes characterised by the form of the tubing by the form of the lumen, e.g. cross-section, variable diameter
    • A61M25/0026—Multi-lumen catheters with stationary elements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/04—Macromolecular materials
    • A61L29/041—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A61L29/146—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0021—Catheters; Hollow probes characterised by the form of the tubing
    • A61M25/0023—Catheters; Hollow probes characterised by the form of the tubing by the form of the lumen, e.g. cross-section, variable diameter
    • A61M25/0026—Multi-lumen catheters with stationary elements
    • A61M2025/0035—Multi-lumen catheters with stationary elements characterized by a variable lumen cross-section by means of a resilient flexible septum or outer wall
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0021—Catheters; Hollow probes characterised by the form of the tubing
    • A61M25/0023—Catheters; Hollow probes characterised by the form of the tubing by the form of the lumen, e.g. cross-section, variable diameter
    • A61M25/0026—Multi-lumen catheters with stationary elements
    • A61M2025/0039—Multi-lumen catheters with stationary elements characterized by lumina being arranged coaxially

Definitions

  • the present disclosures relate to the fields of vasospasm mitigation and neurovascular therapy access and delivery paradigms.
  • FIG. 1 schematically cartoons an exemplary' dual lumen catheter of the present invention.
  • catheters for radial use comprising two lumens, in combination, one lumen for delivery of anti -vasospasm drug, being a layer between a porous membrane and a principal catheter sheath; and, the working or primary lumen disposed centrally therein coaxially with the secondary lumen, and effective for delivery of therapies.
  • the improvements comprise, in combination, at least one of ePTFE and PTFE; whereby porosity control is modulated, for example to elute between about 3.3 and 5.4 PSI, of said agent, inter alia and related desiderata, such as contrast and the like endoluminal support devices.
  • an improved dual-lumen radial catheter system which comprises, in combination, at least a working lumen and infusion lumen, the working lumen defined between a principal catheter shaft, and, the infusion, or secondary, lumen being comprised of an injection port for a porous membrane which terminates at a bond to the principal catheter shaft and provides a layer between membrane and principal catheter shaft to be loaded with drug.
  • porous membrane 101 has at least one vasospasm mitigating drug 111 (heparized saline or tpA) emplaced via injection port for membrane 201.
  • Working lumen 99 is defined by principal catheter shaft 97.
  • Porous membrane 101 is bonded to principal catheter shaft 97, defining its terminal point 301.
  • a computer system or machines of the invention include one or more processors (e.g., a central processing unit (CPU) a graphics processing unit (GPU) or both), a main memory and a static memory, which communicate with each other via a bus.
  • a processor may be provided by one or more processors including, for example, one or more of a single core or multi-core processor (e.g., AMD Phenom II X2, Intel Core Duo, AMD Phenom II X4, Intel Core i5, Intel Core I & Extreme Edition 980X, or Intel Xeon E7-2820).
  • a single core or multi-core processor e.g., AMD Phenom II X2, Intel Core Duo, AMD Phenom II X4, Intel Core i5, Intel Core I & Extreme Edition 980X, or Intel Xeon E7-2820.
  • An VO mechanism may include a video display unit (e.g., a liquid crystal display (LCD) or a cathode ray tube (CRT)), an alphanumeric input device (e.g., a keyboard), a cursor control device (e.g., a mouse), a disk drive unit, a signal generation device (e.g., a speaker), an accelerometer, a microphone, a cellular radio frequency antenna, and a network interface device (e.g., a network interface card (NIC), Wi-Fi card, cellular modem, data jack, Ethernet port, modem jack, HDMI port, mini-HDMI port, USB port), touchscreen (e.g., CRT, LCD, LED, AMOLED, Super AMOLED), pointing device, trackpad, light (e.g., LED), light/image projection device, or a combination thereof.
  • a video display unit e.g., a liquid crystal display (LCD) or a cathode ray tube (CRT)
  • Memory refers to a non-transitory memory which is provided by one or more tangible devices which preferably include one or more machine-readable medium on which is stored one or more sets of instructions (e.g., software) embodying any one or more of the methodologies or functions described herein.
  • the software may also reside, completely or at least partially, within the main memory, processor, or both during execution thereof by a computer within system, the main memory and the processor also constituting machine-readable media.
  • the software may further be transmitted or received over a network via the network interface device.
  • machine-readable medium can in an exemplary embodiment be a single medium
  • the term “machine-readable medium” should be taken to include a single medium or multiple media (e.g., a centralized or distributed database, and/or associated caches and servers) that store the one or more sets of instructions.
  • the term “machine-readable medium” shall also be taken to include any medium that is capable of storing, encoding or carrying a set of instructions for execution by the machine and that cause the machine to perform any one or more of the methodologies of the present invention.
  • Memory may be, for example, one or more of a hard disk drive, solid state drive (SSD), an optical disc, flash memory, zip disk, tape drive, “cloud” storage location, or a combination thereof.
  • a device of the invention includes a tangible, non-transitory computer readable medium for memory.
  • Exemplary devices for use as memory include semiconductor memory devices, (e.g., EPROM, EEPROM, solid state drive (SSD), and flash memory devices e.g., SD, micro SD, SDXC, SDIO, SDHC cards); magnetic disks, (e.g., internal hard disks or removable disks); and optical disks (e.g., CD and DVD disks).

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Pulmonology (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

L'invention concerne des cathéters multi-lumières et leur procédé de fabrication, à savoir des cathéters nouveaux améliorés qui sont conçus pour délivrer des médicaments, en particulier pour les systèmes d'accès radial confrontés à un vasospasme, etc. La porosité de la membrane est fabriquée, par exemple, dans un système à double lumière de type plug and play à charger avec des médicaments à délivrer.
PCT/US2021/060142 2020-11-20 2021-11-19 Cathéter radial amélioré et systèmes d'administration de médicament pour atténuation de vasospasme Ceased WO2022109301A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063116249P 2020-11-20 2020-11-20
US63/116,249 2020-11-20

Publications (1)

Publication Number Publication Date
WO2022109301A1 true WO2022109301A1 (fr) 2022-05-27

Family

ID=81709716

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2021/060142 Ceased WO2022109301A1 (fr) 2020-11-20 2021-11-19 Cathéter radial amélioré et systèmes d'administration de médicament pour atténuation de vasospasme

Country Status (1)

Country Link
WO (1) WO2022109301A1 (fr)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5458568A (en) * 1991-05-24 1995-10-17 Cortrak Medical, Inc. Porous balloon for selective dilatation and drug delivery
US20090287166A1 (en) * 2008-05-19 2009-11-19 Cna Tek Inc. Integrated device for ischemic treatment
US20150359549A1 (en) * 2008-12-23 2015-12-17 Covidien Lp Systems and methods for removing obstructive matter from body lumens and treating vascular defects
KR20170133422A (ko) * 2015-03-31 2017-12-05 아클라런트, 인코포레이션 통기 경로를 갖는 유스타키오관 확장 벌룬
US20180050180A1 (en) * 2011-10-06 2018-02-22 W. L. Gore & Associates, Inc. Controlled porosity devices for tissue treatments, methods of use, and methods of manufacture

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5458568A (en) * 1991-05-24 1995-10-17 Cortrak Medical, Inc. Porous balloon for selective dilatation and drug delivery
US20090287166A1 (en) * 2008-05-19 2009-11-19 Cna Tek Inc. Integrated device for ischemic treatment
US20150359549A1 (en) * 2008-12-23 2015-12-17 Covidien Lp Systems and methods for removing obstructive matter from body lumens and treating vascular defects
US20180050180A1 (en) * 2011-10-06 2018-02-22 W. L. Gore & Associates, Inc. Controlled porosity devices for tissue treatments, methods of use, and methods of manufacture
KR20170133422A (ko) * 2015-03-31 2017-12-05 아클라런트, 인코포레이션 통기 경로를 갖는 유스타키오관 확장 벌룬

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