WO2022166686A1 - Bioelectrical signal processing method and device in implantable closed-loop system - Google Patents

Abstract

A bioelectrical signal processing method and device in an implantable closed-loop system. The device at least comprises: a sampling electrode (101), a stimulation electrode (102), an electrical balance circuit (103), an amplification module (104), an analog switch (105), and a microcontroller unit (106); at the beginning of sampling, the analog switch (105) is switchingly connected to the sampling electrode (101) and to the amplification module (104), and a bioelectrical signal acquired by the sampling electrode (101) is subjected to amplification filtering processing of an amplification circuit (1041) and a second-order filter (1042) in the amplification module (104) and sent to the microcontroller unit for analysis; after determining a stimulation signal, the analog switch (105) is triggered to be switchingly connected to the stimulation electrode (102) and to the electrical balance circuit (103), and the stimulation signal is fed back to the stimulation electrode (102) for the treatment of a detected organism; and after the treatment is finished, the electrical balance circuit (103) releases additional charge accumulated and left by applying the stimulation signal by the stimulation electrode (102). Therefore, the accumulated charge generated by means of closed-loop stimulation can be rapidly released, the interference damage to an implant is reduced or avoided, and the acquisition sensitivity of bioelectric signals is improved.

Description

Method and device for processing bioelectrical signals in an implantable closed-loop system technical field

This document relates to the technical field of medical devices, in particular to a bioelectric signal processing device and method in an implantable closed-loop system.

Background technique

At present, an implantable medical device (Implantable Medical Device, IMD) usually has the function of detecting bioelectrical signals (such as ECG signals or EEG signals, etc.). The IMD can analyze the collected bioelectrical signals to improve or enhance the performance of the treatment.

However, the acquisition sensitivity of the existing bioelectric signals is not high, and when the IMD stimulates and treats the implanted object and other organisms, the accumulated charges are often generated, which is easy to interfere and damage the organism.

SUMMARY OF THE INVENTION

The purpose of one or more embodiments of this specification is to provide a method and device for processing bioelectrical signals in an implantable closed-loop system, so as to improve the acquisition sensitivity of bioelectrical signals, and at the same time, it can quickly release the accumulated charges generated by closed-loop stimulation, reduce or Avoid interfering damage to the implant.

To solve the above technical problems, one or more embodiments of the present specification are implemented as follows:

In a first aspect, a bioelectrical signal processing device in an implantable closed-loop system is proposed, which at least includes: sampling electrodes and stimulation electrodes, an electrical balance circuit, an amplification module, an analog switch and a micro-control unit; wherein the analog switch is respectively connected with the the sampling electrode, the stimulation electrode, the electric balance circuit and the amplifying module are connected;

The sampling electrode and the stimulation electrode are implanted in the organism to be detected, and are respectively used to collect bioelectric signals of the organism to be detected in the sampling phase, and to transmit stimulation signals to the organism to be detected in the treatment phase;

The electric balance circuit is used to release the residual extra charge accumulated by the stimulation signal after the treatment period is over;

The amplifying module at least includes: an amplifying circuit and a second-order filter with a built-in high resistance, for amplifying the bioelectrical signal collected in the sampling stage;

At the beginning of sampling, the analog switch is switched to be connected to the sampling electrode, and at the same time, it is switched to be connected to the amplification module. The bioelectrical signal collected by the sampling electrode is processed by the amplification circuit in the amplification module and the amplification and filtering of the second-order filter, and then sent to the microcomputer. The control unit analyzes; after the stimulation signal is determined, the analog switch is triggered to connect to the stimulation electrode, and at the same time, it is switched to the electrical balance circuit, and the stimulation signal is fed back to the stimulation electrode to treat the detected organism; after the treatment, all The electric balance circuit releases the residual extra charge accumulated by the stimulation signal applied to the stimulation electrode.

In the second aspect, a bioelectric signal processing device in an implantable closed-loop system is proposed, including: sampling electrodes, stimulation electrodes, electrical balance circuit, amplifier circuit, second-order filter with built-in high resistance, analog switch, micro-control unit, an analog-to-digital converter, a low-dropout linear voltage regulator, a DC converter, a constant-current stimulation circuit and a battery; wherein the analog switch is respectively connected with the sampling electrode, the stimulation electrode, the electrical balance circuit and the amplifying circuit;

The sampling electrode and the stimulation electrode are implanted in the organism to be detected, and are respectively used to collect bioelectric signals of the organism to be detected in the sampling phase, and to emit stimulation signals to the organism to be detected in the treatment phase; the The electric balance circuit is used for releasing the extra charge accumulated by the stimulation signal after the treatment stage is over; the amplifying circuit is used for amplifying the bioelectrical signal collected in the sampling stage;

At the beginning of sampling, the analog switch is switched to be connected to the sampling electrode, and at the same time, it is switched to be connected to the amplification circuit. The bioelectrical signal collected by the sampling electrode is amplified by the amplification circuit, filtered by the second-order filter, and then passed through the analog and digital signals. The converter is sent to the micro-control unit for analysis; at the same time, the battery provides a stable voltage for the closed loop through a low-dropout linear regulator, and the stimulated signal obtained through the analysis is stabilized by a constant current through a DC converter and a constant current stimulation circuit. After the stimulation signal is determined, the analog switch is triggered to connect to the stimulation electrode, and at the same time, it is switched to the electrical balance circuit, and the stimulation signal is fed back to the stimulation electrode to treat the detected organism; after the treatment, the electrical The balance circuit releases the residual extra charge accumulated by the stimulation signal applied to the stimulation electrode.

In the third aspect, a bioelectric signal processing method in an implantable closed-loop system is proposed, including:

At the beginning of sampling, the analog switch is switched to be connected to the sampling electrode, and at the same time, it is switched to be connected to the amplification module. The bioelectrical signal collected by the sampling electrode is processed by the amplification circuit in the amplification module and the amplification and filtering of the second-order filter, and then sent to the microcomputer. control unit for analysis;

After the stimulation signal is determined, the analog switch is triggered to connect to the stimulation electrode, and at the same time, it is connected to the electric balance circuit, and the stimulation signal is fed back to the stimulation electrode to treat the detected organism; after the treatment, the electric balance circuit The stimulation electrode releases the residual extra charge accumulated by applying the stimulation signal.

It can be seen from the technical solutions provided by one or more of the above embodiments of this specification that setting an electrical balance circuit in the sampling circuit can reduce or even avoid damage interference caused by extra charges remaining in stimulation therapy. and a second-order filter to improve the signal sampling accuracy and sensitivity in the sampling circuit.

Description of drawings

In order to more clearly illustrate one or more embodiments of the present specification or the technical solutions in the prior art, the following briefly introduces the accompanying drawings required for the description of one or more embodiments or the prior art. It is obvious that , the drawings in the following description are only some embodiments described in this specification, and for those of ordinary skill in the art, other drawings can also be obtained from these drawings without creative effort.

FIG. 1 is a schematic structural diagram of a bioelectric signal processing apparatus 100 in an implantable closed-loop system provided by an embodiment of the present specification.

FIG. 2 is a schematic structural diagram of a bioelectric signal processing apparatus 200 in an implantable closed-loop system provided by an embodiment of the present specification.

FIG. 3 is a schematic diagram of steps of a bioelectric signal processing method in an implantable closed-loop system provided by an embodiment of the present specification.

Detailed ways

In order to make those skilled in the art better understand the technical solutions in this specification, the technical solutions in one or more embodiments of this specification will be clearly and completely described below with reference to the accompanying drawings in one or more embodiments of this specification. It is apparent that the described embodiment or embodiments are only some, but not all, embodiments of this specification. Based on one or more embodiments in this specification, all other embodiments obtained by persons of ordinary skill in the art without creative efforts shall fall within the protection scope of this document.

Example 1

1 is a schematic structural diagram of a bioelectrical signal processing apparatus 100 in an implantable closed-loop system provided by an embodiment of the present specification. It should be understood that this specification is mainly intended to solve some problems in collecting bioelectrical signals. For the functional modules or circuit elements related to the processing of the acquisition operation, other functional modules not shown can be understood as being implemented according to the existing solution, and will not be described here. The implantable closed-loop system may specifically be an implantable closed-loop self-response neurostimulation system, and the solutions involved in this specification are all implemented based on the implantable closed-loop self-response neurostimulation system.

1 , the device 100 may at least include: sampling electrodes 101 and stimulation electrodes 102, an electrical balance circuit 103, an amplification module 104, an analog switch 105, and a micro-control unit 106; wherein the analog switch 105 is respectively associated with the The sampling electrode 101, the stimulation electrode 102, the electrical balance circuit 103 and the amplifying module 104 are connected; in fact, the signal input end of the analog switch 105 is connected to the sampling electrode 101 and the stimulation electrode 102, and in different processing stages through the built-in The control module switches the analog switch to be connected to the sampling electrode 101, or to the stimulation electrode 102; the signal output end of the analog switch 105 is connected to the electrical balance circuit 103 and the amplifying module 104, and is switched to the sampling electrode 101 at the analog switch 105 At the same time, the analog switch 105 is switched to be connected to the amplifying module 104 , and at the same time that the analog switch 105 is switched to the stimulation electrode 102 , the analog switch 105 is switched to be connected to the electrical balance circuit 103 .

The sampling electrode 101 and the stimulation electrode 102 are implanted in the organism to be detected, and are respectively used to collect the bioelectrical signal of the organism to be detected in the sampling phase, and to transmit stimulation signals to the organism to be detected in the treatment phase; In fact, the sampling electrode 101 and the stimulation electrode 102 here can be different electrodes or the same electrode; that is to say, in the detected organism, it can generally be the brain, specifically the cerebral cortex or the inner side of the brain. , implanted at the target site for use as EEG signal acquisition or stimulation.

The electrical balance circuit 103 is used to release the residual extra charge accumulated by the stimulation signal after the treatment period ends. Considering that when the stimulation treatment is performed on the brain through the stimulation electrode 102, the circuit in which it is located is a closed circuit, and when the stimulation signal is applied, residual extra charges will accumulate, thereby causing damage and interference to the brain. In order to reduce or even avoid the occurrence of such interference, the solution has a built-in electrical balance circuit. After each stimulation treatment, before the next sampling starts, the analog switch is switched to the electrical balance circuit to discharge the residual extra The charge is released. Thereby, the extra charge is reduced or completely released as much as possible, and the damage interference to the brain is reduced or even avoided. The electrical balance circuit may specifically be a differential amplifier.

The amplifying module 104 at least includes: an amplifying circuit 1041 and a second-order filter 1042 with a built-in high resistance, for amplifying the bioelectrical signals collected in the sampling stage; in fact, the amplifying module also includes: and the micro-controller The low-dropout linear regulator 1043 connected to the unit is used to supply power to the AD reference of the amplifying module and the MCU through a fixed output voltage. In the embodiment of this specification, the voltage range provided by the low dropout linear regulator is greater than or equal to 1.8V and less than or equal to 3V.

When sampling starts, the analog switch 105 is switched and connected to the sampling electrode 101, and at the same time, it is switched to the amplification module 104, and the bioelectric signal collected by the sampling electrode 101 is amplified by the amplification circuit 1041 and the second-order filter 1042 in the amplification module. The filtering process is sent to the micro-control unit 106 for analysis; after the algorithm analysis determines that the abnormal brain wave needs to be given a stimulation signal, the analog switch 105 is switched and connected to the stimulation electrode 102, and at the same time, it is switched to the electrical balance circuit 103, and the constant current stimulation The circuit turns on the stimulation signal and applies the stimulation signal to the stimulation electrode 102 to treat the detected organism; after the treatment, the electrical balance circuit 103 releases the residual extra charge accumulated on the cells after the stimulation signal is applied to the stimulation electrode 102 .

In the embodiment of this specification, after the sampled bioelectrical signal is amplified and filtered, the relative resolution of the bioelectrical signal is: V/2 ^x /N, where V is a low-dropout linear regulator The supplied voltage, the X is the number of bits when AD sampling, and the N is the amplification factor of the amplifying circuit. It can be seen that, through the amplification and filtering processing of the amplification module 104 in this specification, the relative resolution of the collected bioelectrical signals is appropriately improved before being analyzed by the micro-control unit 106, thereby ensuring the accuracy or accuracy of the collected bioelectrical signals. sensitivity.

Embodiment 2

FIG. 2 is a schematic structural diagram of a bioelectric signal processing apparatus 200 in an implantable closed-loop system according to an embodiment of the present specification. The apparatus 200 may be based on the specific implementation of the apparatus 100 in FIG. 1 , and the apparatus 200 may include: sampling electrodes 201, stimulation electrode 202, electrical balance circuit 203, amplifier circuit 204, second-order filter with built-in high resistance 205, analog switch 206, micro-control unit 207, analog-to-digital converter 208, low-dropout linear regulator 209, DC conversion device 210, constant current stimulation circuit 211 and battery 212; wherein, the analog switch 206 is respectively connected with the sampling electrode 201, the stimulation electrode 202, the electrical balance circuit 203 and the amplifying circuit 204; in fact, the analog switch The signal input end of 206 is connected to the sampling electrode 201 and the stimulation electrode 202, and the analog switch 206 is switched to be connected to the sampling electrode 201 through the built-in control module at different processing stages, or is switched to be connected to the stimulation electrode 202; the signal of the analog switch 206 The output terminal is connected to the electrical balance circuit 203 and the amplifier circuit 204, and when the analog switch 206 is switched to the sampling electrode 201, the analog switch 206 is switched to the amplifier circuit 204, and at the same time that the analog switch 206 is switched to the stimulation electrode 202, the analog switch 206 is switched to the electrical balance circuit 203.

The sampling electrode 201 and the stimulation electrode 202 are implanted in the body to be detected, and are respectively used to collect the bioelectrical signals of the detected organism in the sampling phase, and to transmit stimulation signals to the detected organism in the treatment phase; In fact, the sampling electrode 201 and the stimulation electrode 202 here can be different electrodes respectively, that is to say, in the body to be detected, it can generally be the brain, specifically the cerebral cortex or the inner side of the brain. The sampling electrode 201 and the stimulation electrode 202 is implanted at the target site for use as EEG signal acquisition or stimulation.

The electrical balance circuit 203 is used to release the residual electric charge accumulated by the stimulation signal after the treatment phase ends; the amplification circuit 204 is used to amplify the bioelectrical signal collected in the sampling phase. Considering that when the stimulation treatment is performed on the brain through the stimulation electrode 202, the circuit in which it is located is a closed circuit, and when the stimulation signal is applied, residual extra charges will accumulate, thereby causing damage and interference to the brain. In order to reduce or even avoid the occurrence of such interference, the solution has a built-in electrical balance circuit. After each stimulation treatment, before the next sampling starts, the analog switch is switched to the electrical balance circuit to discharge the residual extra The charge is released. Thereby, the extra charge is reduced or completely released as much as possible, and the damage interference to the brain is reduced or even avoided. At the same time, an amplifying circuit 204 is also arranged in the acquisition circuit, so as to cooperate with the second-order filter 205 to amplify and filter the acquired bioelectrical signal, thereby improving the signal sampling accuracy or sensitivity.

In the embodiment of this specification, the voltage range provided by the low dropout linear regulator is greater than or equal to 1.8V and less than or equal to 3V.

In the embodiment of this specification, after the sampled bioelectrical signal is amplified and filtered, the relative resolution of the bioelectrical signal is: V/2 ^x /N, where V is a low-dropout linear regulator The supplied voltage, the X is the number of bits when AD sampling, and the N is the amplification factor of the amplifying circuit. It can be seen that through the amplification and filtering processing of the amplification circuit and the second-order filter in this specification, the relative resolution of the collected bioelectrical signals is appropriately improved before being analyzed by the micro-control unit, thereby ensuring the collection of bioelectrical signals. accuracy or sensitivity.

Referring to the signal flow in the device 200 shown in FIG. 2, it can be seen that at the beginning of sampling, the analog switch 206 is switched and connected to the sampling electrode 201, and at the same time, is switched to the amplifying circuit 204, and the bioelectric signal collected by the sampling electrode 201 is amplified. The circuit 204 is amplified and processed by the second-order filter 205, and then sent to the micro-control unit 207 for analysis through the analog-to-digital converter 208; at the same time, the battery 212 provides stability for the closed loop through the low-dropout linear regulator 209. The voltage of the DC converter 210 and the constant current stimulation circuit 211 are used for constant current voltage stabilization processing on the analyzed stimulation signal; after the stimulation signal is determined, the analog switch 206 is triggered to switch to connect to the stimulation electrode 202, and at the same time, switch to connect to the The electric balance circuit 203 feeds back the stimulation signal to the stimulation electrode 202 to treat the detected organism; after the treatment, the electric balance circuit 203 releases the residual extra charge accumulated by the stimulation signal applied to the stimulation electrode 202 .

Therefore, through the technical solution implemented above, an electrical balance circuit is provided in the sampling circuit, which can reduce or even avoid the damage interference caused by the extra charge remaining in the stimulation therapy. Improve the signal sampling accuracy and sensitivity in the sampling circuit.

Embodiment 3

Referring to FIG. 3, which is a schematic diagram of steps of a bioelectric signal processing method in an implantable closed-loop system provided by an embodiment of the present specification, the method may include the following steps:

Step 301, when the sampling starts, the analog switch is switched to be connected to the sampling electrode, and at the same time, it is switched to be connected to the amplification module, and the bioelectric signal collected by the sampling electrode is processed by the amplification circuit in the amplification module and the amplification and filtering of the second-order filter, sent to the micro-control unit for analysis;

Step 302, after determining the stimulation signal, trigger the analog switch to switch and connect to the stimulation electrode, and at the same time, switch to connect to the electric balance circuit, and feed the stimulation signal back to the stimulation electrode to treat the detected organism;

Step 303 , after the treatment ends, the electrical balance circuit releases the residual extra charge accumulated by the stimulation signal applied to the stimulation electrode.

Optionally, in the sampling phase and the stimulation phase, a low-dropout linear regulator connected to the micro-control unit supplies power to the AD reference of the amplifying module and the MCU through a fixed output voltage.

Optionally, the voltage range provided by the low dropout linear regulator is: [1.8, 3]V.

Optionally, after the sampled bioelectrical signal is amplified and filtered, the relative resolution of the bioelectrical signal is: V/2 ^x /N, where V is the voltage provided by the low dropout linear regulator , the X is the number of bits in AD sampling, and the N is the magnification of the amplifying circuit.

Therefore, through the technical solution implemented above, an electrical balance circuit is provided in the sampling circuit, which can reduce or even avoid the damage interference caused by the extra charge remaining in the stimulation therapy. Improve the signal sampling accuracy and sensitivity in the sampling circuit.

It should be understood that the bioelectrical signals involved in the embodiments of this specification may at least include: EEG signals, or deep brain electrophysiological signals, or cerebral cortex bioelectrical signals, or central nervous system signals, and the like.

In a word, the above descriptions are only preferred embodiments of the present specification, and are not intended to limit the protection scope of the present specification. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of this specification shall be included within the protection scope of this specification.

The systems, devices, modules or units described in one or more of the above embodiments may be specifically implemented by computer chips or entities, or by products with certain functions. A typical implementation device is a computer. Specifically, the computer may be, for example, a personal computer, a laptop computer, a cellular phone, a camera phone, a smart phone, a personal digital assistant, a media player, a navigation device, an email device, a game console, a tablet computer, a wearable device, or A combination of any of these devices.

Computer-readable media includes both persistent and non-permanent, removable and non-removable media, and storage of information may be implemented by any method or technology. Information may be computer readable instructions, data structures, modules of programs, or other data. Examples of computer storage media include, but are not limited to, phase-change memory (PRAM), static random access memory (SRAM), dynamic random access memory (DRAM), other types of random access memory (RAM), read only memory (ROM), Electrically Erasable Programmable Read Only Memory (EEPROM), Flash Memory or other memory technology, Compact Disc Read Only Memory (CD-ROM), Digital Versatile Disc (DVD) or other optical storage, Magnetic tape cassettes, magnetic tape magnetic disk storage or other magnetic storage devices or any other non-transmission medium that can be used to store information that can be accessed by a computing device. As defined herein, computer-readable media does not include transitory computer-readable media, such as modulated data signals and carrier waves.

It should also be noted that the terms "comprising", "comprising" or any other variation thereof are intended to encompass a non-exclusive inclusion such that a process, method, article or device comprising a series of elements includes not only those elements, but also Other elements not expressly listed, or which are inherent to such a process, method, article of manufacture, or apparatus are also included. Without further limitation, an element qualified by the phrase "comprising a..." does not preclude the presence of additional identical elements in the process, method, article of manufacture, or device that includes the element.

Each embodiment in this specification is described in a progressive manner, and the same and similar parts between the various embodiments may be referred to each other, and each embodiment focuses on the differences from other embodiments. In particular, as for the system embodiments, since they are basically similar to the method embodiments, the description is relatively simple, and for related parts, please refer to the partial descriptions of the method embodiments.

The foregoing describes specific embodiments of the present specification. Other embodiments are within the scope of the appended claims. In some cases, the actions or steps recited in the claims can be performed in an order different from that in the embodiments and still achieve desirable results. Additionally, the processes depicted in the figures do not necessarily require the particular order shown, or sequential order, to achieve desirable results. In some embodiments, multitasking and parallel processing are also possible or may be advantageous.

Claims (10)

A bioelectrical signal processing device in an implantable closed-loop system, characterized in that it at least comprises: sampling electrodes and stimulation electrodes, an electrical balance circuit, an amplification module, an analog switch and a micro-control unit; wherein the analog switch is respectively connected with the The sampling electrode, the stimulation electrode, the electric balance circuit and the amplification module are connected; The sampling electrode and the stimulation electrode are implanted in the organism to be detected, and are respectively used to collect bioelectric signals of the organism to be detected in the sampling phase, and to transmit stimulation signals to the organism to be detected in the treatment phase; The electric balance circuit is used to release the residual extra charge accumulated by the stimulation signal after the treatment period is over; The amplifying module at least includes: an amplifying circuit and a second-order filter with a built-in high resistance, for amplifying the bioelectrical signal collected in the sampling stage; At the beginning of sampling, the analog switch is switched to be connected to the sampling electrode, and at the same time, it is switched to be connected to the amplification module. The bioelectrical signal collected by the sampling electrode is processed by the amplification circuit in the amplification module and the amplification and filtering of the second-order filter, and then sent to the microcomputer. The control unit analyzes; after the stimulation signal is determined, the analog switch is triggered to connect to the stimulation electrode, and at the same time, it is switched to the electrical balance circuit, and the stimulation signal is fed back to the stimulation electrode to treat the detected organism; after the treatment, all The electric balance circuit releases the residual extra charge accumulated by the stimulation signal applied to the stimulation electrode. The bioelectric signal processing device in an implantable closed-loop system according to claim 1, wherein the amplifying module further comprises: a low-dropout linear voltage regulator connected to the micro-control unit; The low-dropout linear regulator is used for supplying power to the amplifying module through a fixed output voltage. The bioelectric signal processing device in an implantable closed-loop system according to claim 2, wherein the voltage range provided by the low-dropout linear regulator is: [1.8, 3]V. The biological electrical signal processing device in an implantable closed-loop system according to claim 1, wherein the electrical balance circuit is specifically a differential amplifier. The bioelectrical signal processing device in an implantable closed-loop system according to any one of claims 2 to 4, wherein after the sampled bioelectrical signal is amplified and filtered, the relative resolution of the bioelectrical signal is is: V/2 ^x /N, where V is the voltage provided by the low-dropout linear regulator, X is the number of bits in AD sampling, and N is the amplification factor of the amplifying circuit. A bioelectrical signal processing device in an implantable closed-loop system, characterized in that it comprises: sampling electrodes, stimulation electrodes, electrical balance circuit, amplifier circuit, second-order filter with built-in high resistance, analog switch, micro-control unit, analog-digital a converter, a low-dropout linear regulator, a DC converter, a constant current stimulation circuit and a battery; wherein the analog switch is respectively connected with the sampling electrode, the stimulation electrode, the electrical balance circuit and the amplifying circuit; The sampling electrode and the stimulation electrode are implanted in the organism to be detected, and are respectively used to collect bioelectric signals of the organism to be detected in the sampling phase, and to emit stimulation signals to the organism to be detected in the treatment phase; the The electric balance circuit is used for releasing the extra charge accumulated by the stimulation signal after the treatment stage is over; the amplifying circuit is used for amplifying the bioelectrical signal collected in the sampling stage; At the beginning of sampling, the analog switch is switched to be connected to the sampling electrode, and at the same time, it is switched to be connected to the amplification circuit. The bioelectrical signal collected by the sampling electrode is amplified by the amplification circuit, filtered by the second-order filter, and then passed through the analog and digital signals. The converter is sent to the micro-control unit for analysis; at the same time, the battery provides a stable voltage for the closed loop through a low-dropout linear regulator, and the stimulated signal obtained through the analysis is stabilized by a constant current through a DC converter and a constant current stimulation circuit. After the stimulation signal is determined, the analog switch is triggered to connect to the stimulation electrode, and at the same time, it is switched to the electrical balance circuit, and the stimulation signal is fed back to the stimulation electrode to treat the detected organism; after the treatment, the electrical The balance circuit releases the residual extra charge accumulated by the stimulation signal applied to the stimulation electrode. A bioelectrical signal processing method in an implantable closed-loop system, characterized in that it includes: At the beginning of sampling, the analog switch is switched to be connected to the sampling electrode, and at the same time, it is switched to be connected to the amplification module. The bioelectrical signal collected by the sampling electrode is processed by the amplification circuit in the amplification module and the amplification and filtering of the second-order filter, and then sent to the microcomputer. control unit for analysis; After the stimulation signal is determined, the analog switch is triggered to connect to the stimulation electrode, and at the same time, it is connected to the electric balance circuit, and the stimulation signal is fed back to the stimulation electrode to treat the detected organism; after the treatment, the electric balance circuit The stimulation electrode releases the residual extra charge accumulated by applying the stimulation signal. The method for processing bioelectrical signals in an implantable closed-loop system according to claim 7, wherein in the sampling stage and the stimulation stage, the low-dropout linear voltage regulator connected with the micro-control unit can set the output voltage to be the desired value through a fixed output voltage. power supply to the amplifying module. The method for processing bioelectrical signals in an implantable closed-loop system according to claim 8, wherein the voltage range provided by the low-dropout linear regulator is: [1.8, 3]V. The method for processing bioelectrical signals in an implantable closed-loop system according to any one of claims 8 or 9, wherein after the sampled bioelectrical signals are amplified and filtered, the relative resolution of the bioelectrical signals is: V/2 ^x /N, where V is the voltage provided by the low-dropout linear regulator, X is the number of bits in AD sampling, and N is the amplification factor of the amplifying circuit.

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