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WO2022155792A1 - Hydrogel à base d'alginate de sodium chargé de lutéine, son procédé de préparation et son utilisation - Google Patents

Hydrogel à base d'alginate de sodium chargé de lutéine, son procédé de préparation et son utilisation Download PDF

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Publication number
WO2022155792A1
WO2022155792A1 PCT/CN2021/072739 CN2021072739W WO2022155792A1 WO 2022155792 A1 WO2022155792 A1 WO 2022155792A1 CN 2021072739 W CN2021072739 W CN 2021072739W WO 2022155792 A1 WO2022155792 A1 WO 2022155792A1
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WO
WIPO (PCT)
Prior art keywords
lutein
sodium alginate
protein isolate
solution
chickpea protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CN2021/072739
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English (en)
Chinese (zh)
Inventor
宋江峰
戴竹青
徐鹏翔
李大婧
刘春泉
冯蕾
张钟元
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jiangsu Yanjiang Agricultural Science Research Institute
Original Assignee
Jiangsu Yanjiang Agricultural Science Research Institute
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Filing date
Publication date
Application filed by Jiangsu Yanjiang Agricultural Science Research Institute filed Critical Jiangsu Yanjiang Agricultural Science Research Institute
Priority to PCT/CN2021/072739 priority Critical patent/WO2022155792A1/fr
Publication of WO2022155792A1 publication Critical patent/WO2022155792A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals

Definitions

  • Figure 9 shows the comparison diagram of the content of inflammatory factor interleukin-6 (IL-6) in the serum of mice with different treatments in the present invention
  • Figure 11 shows a graph showing the comparison of the expression levels of the gene TNF- ⁇ in the colon tissue of mice by different treatments in the present invention
  • Figure 26 shows the family-level distribution characteristics of the intestinal flora of mice with different treatments of the present invention.
  • the absorption peak at 1025cm-1 represents the stretching vibration of C-O, and this characteristic peak is the absorption peak shared by polysaccharides, which is closely related to galacturonic acid and paleo in AH Llucuronic acid related.
  • the broad absorption peak at 3246 cm-1 represents the asymmetric stretching vibration of -OH in the polysaccharide.
  • the absorption peaks at 1593 cm-1 and 1404 cm-1 represent the symmetric and asymmetric stretching vibrations of AH's characteristic COO-, respectively.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention concerne un hydrogel à base d'alginate de sodium chargé de lutéine, son procédé de préparation et son utilisation. L'hydrogel à base d'alginate de sodium chargé en lutéine comprend les ingrédients suivants en parties en poids : 3,12 à 10,53 parties en poids de lutéine, 46,8 à 47,7 parties en poids d'un isolat de protéines de pois chiches, 120 à 125 parties en poids d'alginate de sodium, 8,4 à 42 parties en poids de Ca2+-EGTA, et 7,12 à 35,6 parties en poids de D-gluconolactone. L'invention concerne en outre un procédé de préparation de l'hydrogel à base d'alginate de sodium chargé de lutéine. L'hydrogel à base d'alginate de sodium obtenu chargé de lutéine a une capacité de charge de lutéine de 760 μg/g et une efficacité d'encapsulation de 96 % ou plus, et présente une bonne performance de chargement de médicament et une bonne performance de libération prolongée. L'invention concerne en outre son utilisation dans la préparation d'un médicament pour la prévention ou le traitement de maladies provoquées par des taux de facteurs inflammatoires et des structures microbiennes intestinales.
PCT/CN2021/072739 2021-01-19 2021-01-19 Hydrogel à base d'alginate de sodium chargé de lutéine, son procédé de préparation et son utilisation Ceased WO2022155792A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/CN2021/072739 WO2022155792A1 (fr) 2021-01-19 2021-01-19 Hydrogel à base d'alginate de sodium chargé de lutéine, son procédé de préparation et son utilisation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2021/072739 WO2022155792A1 (fr) 2021-01-19 2021-01-19 Hydrogel à base d'alginate de sodium chargé de lutéine, son procédé de préparation et son utilisation

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WO2022155792A1 true WO2022155792A1 (fr) 2022-07-28

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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115381770A (zh) * 2022-08-26 2022-11-25 华南理工大学 同时递送两亲活性物质的海藻酸钙微凝胶及其制备方法与应用
CN116210897A (zh) * 2023-01-18 2023-06-06 中国海洋大学 一种ros响应型虾青素抗炎水凝胶及其制备方法与应用
CN116785234A (zh) * 2023-07-19 2023-09-22 南方医科大学 一种载药纳米复合水凝胶及其制备方法和应用
CN118725340A (zh) * 2024-07-12 2024-10-01 烟台百脉山生物科技有限公司 一种海藻酸钠-蛋清凝胶珠及其制备方法
CN118987158A (zh) * 2024-08-20 2024-11-22 南昌大学第一附属医院 一种用于预防骨质疏松症的药物组合物及其制备工艺
CN118994698A (zh) * 2024-10-23 2024-11-22 宁波大学 一种蚕豆蛋白与淀粉发泡水凝胶的制备方法及其制备减振包装的应用
CN119385149A (zh) * 2024-12-31 2025-02-07 四川清和科技有限公司 上浮型载铜海藻酸钠水凝胶球及其制备方法和应用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030064133A1 (en) * 2001-08-23 2003-04-03 Bio-Dar Ltd Stable coated microcapsules
CN107184566A (zh) * 2017-05-19 2017-09-22 澳门大学 含有叶黄素的药物组合物及其制备方法和制剂
CN109452648A (zh) * 2018-12-14 2019-03-12 杨鹏熙 叶绿素-海藻酸钠微球的制备方法
US20190254302A1 (en) * 2018-01-23 2019-08-22 Cornell University Systems and methods for controlling the release from enzyme-responsive microcapsules with a smart natural shell
CN111938157A (zh) * 2020-08-17 2020-11-17 江苏省农业科学院 一种叶黄素纳米乳液的制备方法

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030064133A1 (en) * 2001-08-23 2003-04-03 Bio-Dar Ltd Stable coated microcapsules
CN107184566A (zh) * 2017-05-19 2017-09-22 澳门大学 含有叶黄素的药物组合物及其制备方法和制剂
US20190254302A1 (en) * 2018-01-23 2019-08-22 Cornell University Systems and methods for controlling the release from enzyme-responsive microcapsules with a smart natural shell
CN109452648A (zh) * 2018-12-14 2019-03-12 杨鹏熙 叶绿素-海藻酸钠微球的制备方法
CN111938157A (zh) * 2020-08-17 2020-11-17 江苏省农业科学院 一种叶黄素纳米乳液的制备方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HUANG JIN, FEIFEI BAI, YANCHEN WU, QINGZHUO YE, DONG LIANG, CAIHONG SHIC, XIANGRONG ZHANG: "Development and evaluation of lutein-loaded alginate microspheres with improved stability and antioxidant", JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, vol. 99, 29 April 2019 (2019-04-29), XP055953586, DOI: 10.1002/jsfa.9766 *

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115381770A (zh) * 2022-08-26 2022-11-25 华南理工大学 同时递送两亲活性物质的海藻酸钙微凝胶及其制备方法与应用
CN116210897A (zh) * 2023-01-18 2023-06-06 中国海洋大学 一种ros响应型虾青素抗炎水凝胶及其制备方法与应用
CN116210897B (zh) * 2023-01-18 2024-09-13 中国海洋大学 一种ros响应型虾青素抗炎水凝胶及其制备方法与应用
CN116785234A (zh) * 2023-07-19 2023-09-22 南方医科大学 一种载药纳米复合水凝胶及其制备方法和应用
CN118725340A (zh) * 2024-07-12 2024-10-01 烟台百脉山生物科技有限公司 一种海藻酸钠-蛋清凝胶珠及其制备方法
CN118987158A (zh) * 2024-08-20 2024-11-22 南昌大学第一附属医院 一种用于预防骨质疏松症的药物组合物及其制备工艺
CN118994698A (zh) * 2024-10-23 2024-11-22 宁波大学 一种蚕豆蛋白与淀粉发泡水凝胶的制备方法及其制备减振包装的应用
CN119385149A (zh) * 2024-12-31 2025-02-07 四川清和科技有限公司 上浮型载铜海藻酸钠水凝胶球及其制备方法和应用

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