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WO2022147661A1 - Dispositif d'atomisation, méthode de génération d'aérosol et dispositif d'atomisation médical - Google Patents

Dispositif d'atomisation, méthode de génération d'aérosol et dispositif d'atomisation médical Download PDF

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Publication number
WO2022147661A1
WO2022147661A1 PCT/CN2021/070342 CN2021070342W WO2022147661A1 WO 2022147661 A1 WO2022147661 A1 WO 2022147661A1 CN 2021070342 W CN2021070342 W CN 2021070342W WO 2022147661 A1 WO2022147661 A1 WO 2022147661A1
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WIPO (PCT)
Prior art keywords
liquid aerosol
liquid
aerosol
air
atomization
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Ceased
Application number
PCT/CN2021/070342
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English (en)
Chinese (zh)
Inventor
薛墨
雷桂林
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shenzhen Smoore Technology Ltd
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Shenzhen Smoore Technology Ltd
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Priority to PCT/CN2021/070342 priority Critical patent/WO2022147661A1/fr
Publication of WO2022147661A1 publication Critical patent/WO2022147661A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
    • A24F47/00—Smokers' requisites not otherwise provided for
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators

Definitions

  • the present application relates to the technical field of atomization, and in particular, to an atomization device, an aerosol generation method and a medical atomization device.
  • Atomization inhalation is a direct drug delivery method with respiratory tract and lung as target organs. It has the advantages of fast onset of action and high local drug concentration, and has broad application prospects.
  • the particle size of the aerosols produced by the existing atomization technology is generally in the range of several microns to more than ten microns, and the aerosols in this range are easily trapped by the upper respiratory tract, and the proportion of deposition in the alveoli is small.
  • the present application mainly provides an atomization device, an aerosol generation method and a medical atomization device to solve the problem that the particle size of the aerosol generated by the existing atomization technology is too large, resulting in a small proportion of the aerosol deposited in the alveoli.
  • the atomizing device includes: a main body with an air flow channel, the air flow channel includes an air inlet channel, an air outlet channel and an atomization cavity between the air inlet channel and the air outlet channel; an atomization source is arranged in the The atomizing chamber is used for atomizing the liquid aerosol generation substrate by means of physical crushing to form a liquid aerosol, and the liquid aerosol includes a plurality of liquid aerosol particles, wherein the liquid aerosol generation substrate is A solid soluble medium is dissolved; a heater is arranged on the main body and is used for heating the air in the air intake channel to form hot air, and the hot air enters the atomizing cavity and mixes with the liquid aerosol Thereafter, at least part of the liquid contained in the state aerosol particles is evaporated to reduce the size of the liquid aerosol particles.
  • the particle size of the liquid aerosol particles is 1 ⁇ m to 99 ⁇ m, and the particle size of the aerosol particles formed after the liquid aerosol particles are evaporated is 10 nm to 1 ⁇ m.
  • the temperature of the liquid aerosol generated by the atomization source is lower than 40°C, and the temperature formed by the heater is 40°C to 120°C.
  • a drying part is provided on the air outlet channel, and the drying part is used for absorbing the liquid evaporated by the liquid aerosol.
  • the atomizing device further includes a drying part configured to dry the drying part.
  • a thermal insulation member is provided inside or outside the airflow channel.
  • the diameter of the airway is 1 mm to 30 mm.
  • the atomization device further comprises a liquid storage tank in communication with the atomization source, the liquid storage tank for storing the liquid aerosol-generating substrate;
  • the liquid storage tank is arranged in the main body; or
  • the liquid storage tank is detachably connected to the outside of the main body; or
  • the liquid storage tank is separately arranged and connected with the atomization source through a pipeline.
  • the atomizing device further includes an airflow sensing element, the airflow sensing element is disposed on the main body, and is used for detecting the flow state of the gas entering the air intake passage, and when it is detected that the air enters the air inlet channel
  • the heater is triggered to perform heating and the atomization source is triggered to generate liquid aerosol.
  • the heater includes a heating wire, a heating sheet, and an infrared heating device.
  • the nebulizer sources include compression nebulizers, ultrasonic nebulizers, and mesh nebulizers.
  • the aerosol generation method includes: providing a liquid aerosol generation substrate, wherein a solid soluble medium is dissolved in the liquid aerosol generation substrate; atomizing the liquid aerosol generation substrate by means of physical crushing to form a liquid gas Sol, wherein the liquid aerosol includes a plurality of liquid aerosol particles; heating the air entering the air intake channel to form hot air mixed with the liquid aerosol, thereby evaporating at least part of the liquid contained in the liquid aerosol particles , to reduce the size of the liquid aerosol particles.
  • the medical atomizer includes: a main body with an air flow channel, and the air flow channel includes an air inlet channel, an air outlet channel and an atomization cavity between the air inlet channel and the air outlet channel; an atomization source, provided with In the atomizing chamber, the liquid medicine is atomized by physical crushing to form a liquid aerosol, and the liquid aerosol includes a plurality of liquid aerosol particles, wherein the liquid medicine is dissolved in solid soluble particles.
  • a medium arranged on the main body, for heating the air in the air intake channel to form hot air, the hot air enters the atomizing chamber and mixes with the liquid aerosol to evaporate the liquid
  • the aerosol particles contain at least a portion of the liquid to reduce the size of the liquid aerosol particles.
  • the present application discloses an atomizing device, an aerosol generating method and a medical atomizing device.
  • the liquid aerosol generation matrix is atomized by the atomization source in a physical way to avoid the crystallization of the solid soluble medium dissolved in the liquid aerosol generation matrix, and a liquid aerosol is generated, which is heated by a heater and flows through the intake air The air in the channel is formed to form hot air.
  • the hot air enters the atomizing chamber and is mixed with the liquid aerosol
  • at least part of the liquid contained in the liquid aerosol particles in the liquid aerosol is evaporated, thereby reducing the particle size of the aerosol particles, and further It can also crystallize the solid soluble medium in the liquid aerosol particles, and the active ingredients in the liquid aerosol generation matrix are attached to the surface of the precipitated solid soluble medium, so as to convert the liquid aerosol particles into solid aerosol particles.
  • the liquid aerosol is evaporated and transformed into a solid aerosol with a particle size in the nano-scale, and the nano-scale output of the aerosol particles generated by the atomization device can be realized, which can significantly improve the absorption of the active ingredients in the liquid aerosol generation matrix by the lungs. It is beneficial to improve the effectiveness of the liquid aerosol-generating matrix.
  • FIG. 1 is a schematic structural diagram of an embodiment of an atomizing device provided by the application.
  • Fig. 2 is a schematic diagram of the relationship between the concentration of sodium chloride and the particle size of solid aerosol particles in the liquid aerosol generation matrix;
  • Figure 3 is a schematic diagram of the relationship between the temperature of the hot gas and the relative humidity and evaporation time in the airflow channel;
  • Fig. 4 is a schematic diagram of the relationship between the liquid aerosol particles of different particle sizes evaporated under different pipe diameters of the air outlet channel and the required pipe length;
  • Figure 5 is a schematic diagram of the particle size statistics of solid aerosol particles formed after 1% glucose solution atomization and evaporation;
  • FIG. 6 is a schematic structural diagram of another embodiment of the atomizing device provided by the present application.
  • FIG. 7 is a schematic structural diagram of another embodiment of the atomizing device provided by the present application.
  • FIG. 8 is a schematic structural diagram of another embodiment of the atomizing device provided by the application.
  • FIG. 9 is a schematic flowchart of an embodiment of an aerosol generation method provided by the present application.
  • first”, “second” and “third” in the embodiments of the present application are only used for description purposes, and cannot be understood as indicating or implying relative importance or implicitly indicating the number of indicated technical features. Thus, a feature defined as “first”, “second”, “third” may expressly or implicitly include at least one of that feature.
  • "a plurality of” means at least two, such as two, three, etc., unless otherwise expressly and specifically defined.
  • the terms “comprising” and “having”, and any variations thereof, are intended to cover a non-exclusive inclusion.
  • a process, method, system, product or device comprising a series of steps or units is not limited to the listed steps or units, but optionally also includes unlisted steps or units, or optionally also includes For other steps or units inherent to these processes, methods, products or devices.
  • FIG. 1 is a schematic structural diagram of an embodiment of the atomizing device 100 provided by the present application.
  • the atomization device 100 includes an atomization source 10 and a heater 20.
  • the atomization source 10 is used for atomizing a liquid aerosol-generating matrix by means of physical crushing to form a liquid aerosol, and the liquid aerosol contains a plurality of liquid aerosol particles , wherein a solid soluble medium is dissolved in the liquid aerosol generating matrix;
  • the heater 20 is used for heating to evaporate the liquid contained in the liquid aerosol particles in the liquid aerosol to form aerosol particles with the solid soluble medium as the core.
  • the liquid aerosol generating substrate can be a medicinal solution or a nutrient solution, etc., and contains active ingredients such as curative effect or nutritional value.
  • the liquid aerosol referred to in this application means that the aerosol particles contained in the aerosol are completely liquid aerosol particles
  • the solid aerosol means that the aerosol particles contained in the aerosol are completely solid aerosol particles.
  • the heating of the heater 20 can make the liquid contained in the liquid aerosol particles at least partially evaporate, thereby reducing the particle size of the liquid aerosol particles, and further causing the solid soluble medium in the liquid aerosol particles to crystallize and precipitate, forming a solid soluble medium.
  • the liquid in the liquid aerosol particles is further evaporated completely, and the active ingredients in the liquid aerosol generation matrix are attached to the surface of the precipitated solid soluble medium to form solid aerosol particles, and then form the particle size Stable solid aerosol, which can significantly reduce the particle size of aerosol particles.
  • the physical crushing method includes atomization methods such as airflow impact, ultrasonic vibration or vibration mesh, which can atomize the liquid aerosol-forming substrate in a liquid state to form a liquid aerosol.
  • atomization methods such as airflow impact, ultrasonic vibration or vibration mesh, which can atomize the liquid aerosol-forming substrate in a liquid state to form a liquid aerosol.
  • the particle size of the liquid aerosol particles produced is between a few microns and tens of microns, and the aerosol particle size is large, which is easy to be trapped by the user's upper respiratory tract and is not easy to enter the lungs.
  • the proportion of the aerosol particles deposited in the alveoli is less than 20%, but the aerosol particles in the nanometer range can be deposited in the alveoli.
  • the ratio is significantly increased and can reach 50%.
  • the particle size of the aerosol particles can be controlled, so that the particle size of the aerosol particles can be significantly reduced, and the generation of nano-scale aerosol particles can be realized.
  • Increasing the proportion of active ingredients in the liquid aerosol-generating matrix that can be absorbed by the lungs is beneficial to improve the effectiveness of the liquid aerosol-generating matrix.
  • the particle size of the liquid aerosol particles in the liquid aerosol generated by atomization may be 1 ⁇ m to 99 ⁇ m, for example, 3 ⁇ m to 15 ⁇ m, or 10 ⁇ m to 20 ⁇ m; Diameter size of 10nm to 1 ⁇ m, such as 15nm to 500nm, or 15nm to 100nm, to achieve the output of nanoscale aerosol particles, making the aerosol formed by the liquid aerosol generating matrix easier to enter the user's lungs, allowing the liquid aerosol to be generated
  • the proportion of active ingredients in the matrix that can be absorbed by the lungs increases significantly, which is beneficial to improve the effectiveness of the liquid aerosol-generated matrix.
  • the solid soluble medium is a soluble medium that can be absorbed by the human body and is harmless to the human body, and the solid soluble medium includes sodium chloride, potassium chloride, glucose, fructose, sodium lactate, sodium sulfate, magnesium chloride and phosphate. at least one.
  • the solid soluble medium may also be other types of soluble medium, which is not specifically limited in this application.
  • the liquid aerosol generation matrix is often formed by dissolving active ingredients such as chemical agents or nutrients in water or organic solvents (such as ethanol, etc.) and other solvents.
  • the present application is additionally dissolved in the liquid aerosol generation matrix. So that when the liquid in the liquid aerosol is evaporated, the solid soluble medium can be crystallized out. The particle size of the sol particles.
  • the particle size of the aerosol particles generated after evaporation is regulated by adjusting the concentration of the solid soluble medium dissolved in the liquid aerosol-generating matrix. Specifically, the higher the concentration of the solid soluble medium dissolved in the liquid aerosol generation matrix, the larger the particle size of the aerosol particles generated after evaporation, and the solid soluble medium in the liquid aerosol generation matrix can be adjusted according to actual needs. concentration, so as to achieve the purpose of regulating the particle size of aerosol particles.
  • the concentration of the solid soluble medium dissolved in the liquid aerosol generation matrix increases, the concentration of the solid soluble medium in the liquid aerosol particles formed after initial atomization increases.
  • the particle size is also larger, which also has a larger surface area for attachment of the active ingredient in the liquid aerosol-generating matrix.
  • FIG. 2 is a schematic diagram showing the relationship between the concentration of sodium chloride in the liquid aerosol generating substrate and the particle size of the solid aerosol particles.
  • the initial particle size of the liquid aerosol particles formed after atomization is 6 ⁇ m, and after evaporation, the particle size of the generated aerosol particles is the same as that of sodium chloride.
  • the concentration in the liquid aerosol-generating matrix is positively correlated, that is, with the increase of the concentration of sodium chloride in the liquid aerosol-generating matrix, the particle size of the sol particles increases gradually.
  • a broad-spectrum regulation of the particle size of aerosol particles from 10 nm to 1 ⁇ m can be achieved while keeping the concentration of sodium chloride less than its solubility in the liquid aerosol-generating matrix.
  • the atomization source 10 includes a compression nebulizer, an ultrasonic nebulizer, and a mesh nebulizer.
  • the atomization source 10 is a compression type atomizer, it atomizes the liquid aerosol-generating substrate by means of airflow impingement to form a liquid aerosol.
  • the atomization source 10 is an ultrasonic atomizer, which uses ultrasonic vibration to atomize the liquid aerosol-generating substrate to form a liquid aerosol.
  • the atomization source 10 is a mesh atomizer, which atomizes the liquid aerosol-generating matrix by means of vibrating meshes to form the liquid aerosol.
  • the atomization source 10 may also be other types of atomizers, which are not specifically limited in this application.
  • the heater 20 includes a heating wire, a heating sheet, an infrared heating device, etc., which can heat and evaporate the liquid aerosol to form aerosol particles with a smaller particle size.
  • the type of the heater 20 is not specifically limited in this application. .
  • the temperature of the liquid aerosol formed by the atomization source 10 through physical crushing is lower than 40°C, for example, the temperature of the liquid aerosol is 15°C, 20°C or 25°C, etc.; the temperature formed by the heater 20 is 40°C To 120°C, for example, the temperature formed by heating is 50°C, 60°C, or 70°C.
  • the atomization source 10 atomizes the liquid aerosol generation matrix into a liquid aerosol by means of physical crushing, and basically keeps the temperature of the liquid aerosol formed after atomization and the temperature of the liquid aerosol generation matrix before atomization almost equivalent, and then It will not cause the solid soluble medium to crystallize out during the atomization process to block the atomization source 10 .
  • the heater 20 can heat the air entering from the outside to form a hot gas, and the hot gas is mixed with the liquid aerosol to evaporate the liquid in the liquid aerosol; or the heater 20 can heat the mixture of the air entering from the outside and the liquid aerosol, which can make The liquid aerosol is sufficiently evaporated to form a solid aerosol without destroying the effectiveness of the active ingredient in the liquid aerosol-generating matrix. That is, the heater 20 may directly heat the liquid aerosol or a mixture of the liquid aerosol and air, or may first heat the air, and then heat the liquid aerosol through the heated air. It can be understood that the air can also be replaced with other gases that are harmless to the human body, such as nitrogen, carbon dioxide or inert gases.
  • the atomizing device 100 further includes a main body 30 .
  • the main body 30 is provided with an air flow channel 32 .
  • the aerosol passes into the airflow channel 32 , and the main body 30 is provided with an air intake hole 34 , and the air intake hole 34 communicates with the airflow channel 32 .
  • the airflow channel 32 may be a channel opened in the main body 30 , or constituted by a channel in an air duct provided on the main body 30 , which is not specifically limited in this application.
  • the air intake hole 34 can be arranged on the side wall of the main body 30, so that when the atomizing device 100 is carried on a desktop or table, the user can still use the atomizing device 100 by suction, which can prevent the air intake hole 34 from being blocked .
  • the air inlet hole 34 is arranged on the bottom wall of the main body 30 , and further, the air inlet hole 34 can also be arranged on the extension axis of the air flow channel 32 , so that the gas entering from the air inlet hole 34 can enter the air flow channel 32 more quickly , improve the intake efficiency.
  • the diameter of the air inlet hole 34 is adjustable, so that the flow rate of the gas entering from the air inlet hole 34 can be regulated.
  • the suction flow rate of the atomizing device 100 can be adjusted from 5L/min to 8L/min as required, wherein 5L/min can be matched to juvenile users, and 8L/min can be matched to adult users, so as to be adjusted according to different age groups
  • the hole diameter of the air intake hole 34 is adjustable, so that the flow rate of the gas entering from the air inlet hole 34 can be regulated.
  • the suction flow rate of the atomizing device 100 can be adjusted from 5L/min to 8L/min as required, wherein 5L/min can be matched to juvenile users, and 8L/min can be matched to adult users, so as to be adjusted according to different age groups
  • the hole diameter of the air intake hole 34 is adjustable, so that the flow rate of the gas entering from the air inlet hole 34 can be regulated.
  • adapters with different apertures are configured to be connected to the air intake holes 34 to change the air intake apertures of the air intake holes 34 .
  • an aperture adjustment device is connected to the air intake hole 34, and the aperture adjustment device includes a plurality of arcs that enclose and form holes and a power mechanism, and the power mechanism controls the air intake hole 34 by driving the extension of the plurality of arcs. air intake aperture.
  • the power mechanism can also be omitted and manual adjustment can be performed.
  • the aperture adjustment method of the air intake hole 34 may also adopt other forms, which are not specifically limited in this application.
  • the air passage 32 includes an air inlet passage 320 , an air outlet passage 322 , and an atomizing cavity 324 located between the air inlet passage 320 and the air outlet passage 322 .
  • the air inlet channel 320 communicates with the air inlet hole 34 , and the atomization source 10 is located in the atomization chamber 324 and generates liquid aerosol in the atomization chamber 324 .
  • the heater 20 is fixed inside the main body 30 to heat the air flow entering from the air inlet 34;
  • the hot gas is injected into the air inlet 34 and enters the air flow passage 32 through the air inlet 34 .
  • the heater 20 is fixed inside the main body 30 .
  • the heater 20 is disposed on the path of the air inlet channel 320 to heat up the gas flowing through the air flow channel 32 to form a hot gas for mixing with the liquid aerosol.
  • the heater 20 is disposed on the path of the intake passage 320, and the intake passage 320 passes through the heater 20, so that the heater 20 can heat the gas flowing through the airflow passage 32 to form a hot gas.
  • the hot gas and the liquid gas The aerosol is stirred and mixed to accelerate the evaporation of the liquid in the liquid aerosol, so that the active ingredients contained in the liquid aerosol generation matrix are attached to the surface of the precipitated solid soluble medium to form solid aerosol particles, which can significantly reduce the amount of gas.
  • the particle size of the aerosol particles contained in the sol is disposed on the path of the intake passage 320, and the intake passage 320 passes through the heater 20, so that the heater 20 can heat the gas flowing through the airflow passage 32 to form a hot gas.
  • the hot gas and the liquid gas The aerosol is stirred and mixed to accelerate the evaporation of the liquid in the liquid aerosol, so that the active ingredients contained in the liquid aerosol generation matrix are attached to the surface of the precipitated solid soluble medium to form solid aerosol particles, which can
  • the best effect of the embodiment of the present application is to evaporate the liquid aerosol particles generated after atomization to form solid aerosol particles.
  • the key point is whether the liquid in the liquid aerosol can be quickly evaporated, which has been experimentally verified.
  • the initial particle size of the liquid aerosol particles in the liquid aerosol formed by the atomization source 10 is approximately 6 ⁇ m, and the relative humidity of the outside air before entering the heater 20 is 90%.
  • FIG 3 is a schematic diagram of the relationship between the temperature of the hot gas and the relative humidity and evaporation time in the airflow channel.
  • the atomizing device 100 atomizes the liquid aerosol-generating matrix by the atomization source 10 in a physically broken manner, so as to avoid the crystallization of the solid soluble medium dissolved in the liquid aerosol-generating matrix, and generate a liquid
  • the aerosol is heated by the heater 20 into the air entering the air intake channel 320 to form hot air, and the hot air enters the atomization chamber 324 to mix with the liquid aerosol, so that the liquid aerosol can be evaporated and transformed into particle size efficiently and quickly.
  • a solid aerosol with a nanoscale size can significantly increase the proportion of active ingredients in the liquid aerosol generation matrix that can be absorbed by the lungs, which is beneficial to improve the effectiveness of the liquid aerosol generation matrix.
  • the air outlet channel 322 should have a certain diameter and length, so that the evaporation process of the liquid aerosol is completed within the process of passing through the air outlet channel 322 .
  • the diameter of the air outlet channel 322 is 1 mm to 30 mm. Within this range, an appropriate tube length is configured to facilitate the complete evaporation of the liquid in the liquid aerosol in the atomization chamber 324 and the airflow channel 32 .
  • the suction flow is set to 5L/min as the normal suction flow, and the diameters of the air outlet channels 322 are 8mm and 12mm respectively. Two sets of parameters served as controls.
  • FIG. 4 is a schematic diagram showing the relationship between the vaporized liquid aerosol particles of different particle sizes and the required pipe length under different pipe diameters of the gas outlet channel.
  • liquid aerosol particles with a size of 12 ⁇ m can also be completely evaporated in the gas outlet channel 322 .
  • the air outlet channel 322 is a straight air channel arranged along a straight line.
  • the air outlet channel 322 can also be a curved air channel extending in a spiral shape, so that the tube length of the air outlet channel 322 can be greatly increased without affecting the overall height of the atomizing device 100 .
  • FIG. 5 is a schematic diagram of particle size statistics of solid aerosol particles formed after atomization and evaporation of 1% glucose solution. Taking the atomization process of 1% glucose solution as an example, it has been verified by experiments that after atomization and evaporation, the peak size of the solid aerosol particles in the obtained solid aerosol is about 160 nm, and the mass of the solid aerosol particles is about 160 nm. The peak value of the particle size of the distribution is about 600 nm, which effectively realizes the output of the nano-scale aerosol of the liquid aerosol-generating matrix, and is beneficial to improve the curative effect of the liquid aerosol-generating matrix.
  • FIG. 6 is a schematic structural diagram of another embodiment of the atomizing device provided by the present application.
  • the heater 20 is arranged on the air outlet channel 322 to heat up the liquid aerosol in the air outlet channel 322 and the gas entering the air flow channel 32 through the air inlet 34 at the same time, and can also efficiently and quickly evaporate the liquid aerosol into particles. Solid aerosols with nanoscale diameters.
  • the outlet passage 322 passes through the heater 20 , that is, the heater 20 is arranged around the outlet passage 322 .
  • the gas outlet channel 322 is composed of a metal tube with good thermal conductivity
  • the heater 20 is penetrated or surrounded by the outer periphery of the metal tube, and the mixture of gas and liquid aerosol is heated by the heat conduction through the metal tube to evaporate the liquid gas
  • the liquid contained in the sol forms a solid aerosol.
  • the heating part of the heater 20 is arranged in the air outlet channel 322, for example, the heating part is a heating piece, which is arranged on the inner wall of the air outlet channel 322 to heat the mixture of gas and liquid aerosol in a more direct and efficient manner, Helps to reduce evaporation time.
  • the heater 20 is disposed on the air inlet passage 320 and the air outlet passage 322 at the same time.
  • the heater 20 includes a first sub-heater and a second sub-heater, wherein the first sub-heater is disposed on the path of the intake passage 320 to heat the gas to form a hot gas mixed with a liquid aerosol, and the second sub-heater
  • the heater is arranged on the path of the gas outlet channel 322 to reheat the mixture of the hot gas and the liquid aerosol, or to maintain the temperature of the hot gas for heat preservation, thereby accelerating the evaporation of the liquid aerosol into a particle size in the nanometer range. level of solid aerosol speed, further shortening the evaporation time.
  • the heater 20 is disposed outside the main body 30 .
  • FIG. 7 is a schematic structural diagram of another embodiment of the atomizing device provided by the present application.
  • the heater 20 is connected to the air inlet 34 in a detachable or non-detachable manner, so that the heated gas is injected into the air inlet 34 and enters the air passage 32 through the air inlet 34 .
  • the heater 20 is connected to the air inlet 34 in a detachable manner such as screw connection or snap connection.
  • the heater 20 is fixedly connected to the air inlet hole 34 by welding or bonding.
  • the heater 20 is separately disposed relative to the main body 30 and is connected to the air inlet 34 through a heat preservation conduit.
  • the heater 20 may also be disposed inside and outside the main body 30 at the same time.
  • the heater 20 includes a main heater and an auxiliary heater, wherein the main heater is disposed inside the main body 30 , the main heater may be disposed on the path of the air intake passage 320 and/or the path of the air outlet passage 322 , and the auxiliary heater It is arranged on the outer side of the main body 30 and connected to the air intake hole 34 .
  • the auxiliary heater can be used to preheat the gas entering the air inlet 34 and reduce the gas in advance In order to more quickly and efficiently evaporate the liquid aerosol into a solid aerosol with a particle size in the nanometer scale.
  • FIG. 8 is a schematic structural diagram of another embodiment of the atomizing device provided by the present application.
  • the air outlet channel 322 may also be provided with a drying part 36, and the drying part 36 is used for absorbing the liquid evaporated from the liquid aerosol, so as to speed up the conversion rate of the liquid aerosol into a solid aerosol.
  • the drying part 36 may be a dry silica gel layer or a calcium chloride layer or the like disposed on the air outlet channel 322 .
  • the inner side of the air outlet channel 322 is provided with a filling groove for filling the drying part 36, and the drying part 36 is arranged in the filling groove to absorb the evaporated liquid.
  • the drying part 36 is cylindrical and is embedded in the air outlet channel 322 .
  • the drying part 36 is disposed on the outer periphery of the air conduit constituting the air outlet channel 322, and communicates with the air outlet channel 322 through micropores arranged on the air conduit to absorb the evaporated liquid.
  • the atomizing device 100 further includes a drying part 38, which is configured to dry the drying part 36, so that the drying part 36 can maintain a relatively high efficiency to absorb the evaporated liquid.
  • the drying part 38 can be a heating device such as a heating wire or a heating sheet.
  • the drying part 38 dries the moisture absorbed by the drying part 36 by heating, so that the drying part 36 returns to its original state. .
  • heating devices such as heating wires or heating sheets can be embedded in the drying part 36 .
  • the atomizing device 100 may not be provided with the drying part 36, and the hot gas part formed by heating the gas heated by the heater 20 is introduced into the drying part to dry the drying part.
  • the thermal insulation member 39 may be thermal insulation foam or thermal insulation coating, which covers or coats the inner wall or outer side of the airflow channel 32 .
  • the heat preservation member 39 can maintain the high temperature environment inside the airflow channel 32 to accelerate the evaporation of the liquid contained in the liquid aerosol.
  • the heat preservation member 39 is disposed in the atomizing chamber 324 and the air outlet channel 322 to maintain the high temperature environment inside when the liquid aerosol and hot air are mixed and evaporated, which is beneficial to increase the evaporation rate, and can effectively shorten the process of evaporating the liquid aerosol to form a solid gas. Sol time.
  • the atomization device 100 further includes a liquid storage tank 40 communicated with the atomization source 10 .
  • the liquid storage tank 40 is used for storing the liquid aerosol generation
  • the atomization source 10 is used for atomizing the liquid aerosol generating substrate stored in the liquid storage tank 40 , and forming the liquid aerosol in the atomizing chamber 324 .
  • the liquid storage tank 40 is provided in the main body 30 .
  • the liquid storage tank 40 is a liquid storage space formed in the main body 30 , or the liquid storage tank 40 is an independent component and is installed in the main body 30 .
  • the liquid storage tank 40 is detachably connected to the outside of the main body 30 .
  • the liquid storage tank 40 is an independent part, which is connected to the outer surface of the main body 30 by screwing or clipping, etc., and communicates with the atomization source 10 to supply liquid to the atomization source 10, which can facilitate the replacement of the liquid storage.
  • the liquid storage tank 40 is provided separately and connected with the atomization source 10 through a pipeline.
  • the atomizing device 100 further includes a battery (not shown) and a control circuit 50, the battery is used to power the atomization source 10 and the heater 20, and the control circuit 50 is used to control the atomization source 10, the drying part 38 and/or the heating device 20 and so on.
  • the atomizing device 100 also includes an airflow sensing element (not shown), and the gas sensor is connected to the control circuit 50.
  • the control circuit 50 controls the operation of the atomization source 10 and the heater 20.
  • the airflow sensing element is disposed on the main body 30 to detect the flow state of the gas entering the intake passage 320 through the intake hole 34 , for example, to monitor the change of the flow rate or the change of the air pressure.
  • the airflow sensing element sends out a trigger signal to regulate the operation of the atomization source 10 and the heater 20 and the like.
  • the airflow sensing element when the airflow sensing element detects that the flow rate of the gas is greater than the preset threshold, it can determine that the user is using the atomizing device 100 for suction, and the gas is flowing through the intake passage 320, and the airflow sensing element triggers the heater 20 to perform heating and cooling. Trigger the atomization source 10 to generate liquid aerosol to output nano-scale solid aerosol.
  • the airflow sensing element detects that the flow rate of the gas is lower than the preset threshold, it can be determined that the user stops using the atomizer, and the airflow sensing element triggers the heater 20 to stop heating and the atomization source 10 to stop generating liquid aerosol.
  • the airflow sensing element can also detect changes in air pressure of the air in the intake passage 320 to confirm whether the user is using the atomizing device 100 for suction, and then regulate the atomizing source 10 and the heater 20 , which will not be repeated.
  • FIG. 9 is a schematic flowchart of an embodiment of the method for generating an aerosol provided by the present application.
  • the aerosol generating method includes:
  • S10 Provide a liquid aerosol generation substrate, wherein a solid soluble medium is dissolved in the liquid aerosol generation substrate.
  • the liquid aerosol generating substrate can be a medicinal solution or a nutrient solution, etc., and contains active ingredients such as curative effect or nutritional value.
  • the solid soluble medium dissolved in the liquid aerosol generating substrate may be at least one of sodium chloride, potassium chloride, glucose, fructose, sodium lactate, sodium sulfate, magnesium chloride and phosphate.
  • the solid soluble medium may also be other types of soluble medium, which is not specifically limited in this application.
  • the solid soluble medium is completely dissolved in the liquid aerosol generating matrix, so that when the liquid in the liquid aerosol is evaporated later, the solid soluble medium can be crystallized out, so that the liquid aerosol generating matrix is attached to the crystallized solid soluble medium to achieve the output of nanoscale aerosol particles.
  • the particle size of the aerosol particles formed after evaporation is regulated by adjusting the concentration of the solid soluble medium dissolved in the liquid aerosol-generating matrix. Specifically, the higher the concentration of the solid soluble medium dissolved in the liquid aerosol generation matrix, the larger the particle size of the aerosol particles generated after evaporation, so the solid soluble medium in the liquid aerosol generation matrix can be adjusted according to actual needs. In order to achieve the purpose of regulating the particle size of aerosol particles.
  • the atomization source 10 atomizes the liquid aerosol-generating substrate through physical crushing to form a liquid aerosol, wherein the liquid aerosol includes a plurality of liquid aerosol particles.
  • the physical crushing methods include atomization methods such as airflow impact, ultrasonic vibration or vibrating mesh, and the particle size of the generated liquid aerosol particles is between 1 ⁇ m and 99 ⁇ m, and this method can make the liquid aerosol formed after atomization.
  • the temperature is almost the same as the temperature of the liquid aerosol generation matrix before atomization, so that the solubility of the solid soluble medium can be avoided due to the excessive temperature rise during the atomization process, resulting in the occurrence of crystallization.
  • the temperature of the liquid aerosol generated by the atomization source 10 is lower than 40°C, for example, the temperature of the liquid aerosol is 15°C, 20°C, or 25°C.
  • the heater 20 is heated to evaporate the liquid contained in the liquid aerosol particles in the liquid aerosol, wherein the size of the aerosol particles formed by the evaporation of the liquid aerosol particles is 10 nm to 1 ⁇ m, so as to realize the nanoscale output of the aerosol particles .
  • the particle size distribution of the finally formed aerosol particles may be in the range of 60 nm to 500 nm, or in the range of 100 nm to 700 nm.
  • the heating temperature of the heater 20 is 40°C to 120°C, for example, the heating temperature may be 50°C, 60°C, or 70°C.
  • the heater 20 heats the gas entering from the outside to form a hot gas, and the hot gas is mixed with the liquid aerosol to evaporate the liquid in the liquid aerosol, so that the liquid aerosol can be fully evaporated to form a dimensionally stable solid aerosol, so that the aerosol is
  • the particle size of the particles is changed from micron to nanoscale, which makes it easier to be absorbed by the user's lungs.
  • the heater 20 heats the air flowing through the air intake passage 320 to form hot air for mixing with the liquid aerosol, that is, the air has been preheated before being mixed with the liquid aerosol, thereby improving the resistance to the liquid aerosol evaporation efficiency.
  • the hot air formed by heating is mixed with the liquid aerosol generated by the atomization source 10 to evaporate the liquid contained in the liquid aerosol, the solid soluble medium is crystallized and precipitated, and the active ingredients in the liquid aerosol generation matrix are attached to the solid soluble medium.
  • the liquid aerosol particles will form solid aerosol particles, and then the liquid aerosol can be transformed into a solid aerosol, which can significantly reduce the particle size of the aerosol particles and realize the generation of nano-scale aerosol particles.
  • in order to increase the proportion of active ingredients in the liquid aerosol generation matrix that can be absorbed by the lungs which is beneficial to improve the effectiveness of the liquid aerosol generation matrix.
  • the present application also provides a medical atomization device (not shown), which is used for atomizing liquid medicine.
  • the medical nebulizing device may be a nebulizing device as described above.
  • the temperature of the air heated by the heater in the medical atomization device is 40°C to 60°C, such as 45°C, 50°C or 55°C, and the atomization source in the medical atomization device is ultrasonic atomization. device, not repeated here.
  • the present application discloses an atomization device, an aerosol generation method and a medical atomization device.
  • the liquid aerosol generation matrix is atomized by the atomization source in a physical way to avoid the crystallization of the solid soluble medium dissolved in the liquid aerosol generation matrix, and a liquid aerosol is generated, which is heated by a heater and flows through the intake air The air in the channel is formed to form hot air.
  • the hot air enters the atomizing chamber and is mixed with the liquid aerosol
  • at least part of the liquid contained in the liquid aerosol particles in the liquid aerosol is evaporated, thereby reducing the particle size of the aerosol particles, and further It can also crystallize the solid soluble medium in the liquid aerosol particles, and the active ingredients in the liquid aerosol generation matrix are attached to the surface of the precipitated solid soluble medium, so as to convert the liquid aerosol particles into solid aerosol particles.
  • the liquid aerosol is evaporated and transformed into a solid aerosol with a particle size in the nano-scale, and the nano-scale output of the aerosol particles generated by the atomization device can be realized, which can significantly improve the absorption of the active ingredients in the liquid aerosol generation matrix by the lungs. It is beneficial to improve the effectiveness of the liquid aerosol-generating matrix.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention concerne un dispositif d'atomisation (100), une méthode de génération d'aérosol et un dispositif d'atomisation médical. Le dispositif d'atomisation (100) comprend : un corps principal (30) pourvu d'un canal d'écoulement d'air (32). Le canal d'écoulement d'air (32) comprend un canal d'entrée d'air (320), un canal de sortie d'air (322), et une chambre d'atomisation (324) située entre le canal d'entrée d'air (320) et le canal de sortie d'air (322). Une source d'atomisation (10) est disposée au niveau de la chambre d'atomisation (324) et est utilisée pour atomiser un substrat générant un aérosol liquide au moyen d'un broyage physique, de façon à former un aérosol liquide. L'aérosol liquide comprend une pluralité de particules d'aérosol liquide. Un milieu solide soluble est dissous dans le substrat générant un aérosol liquide. Un élément chauffant (2) est disposé sur le corps principal (30) et est utilisé pour chauffer l'air dans le canal d'entrée d'air (320) pour former de l'air chaud. L'air chaud entre dans la chambre d'atomisation (324) et est mélangé à l'aérosol liquide, de telle sorte qu'au moins une partie du liquide contenu dans les particules d'aérosol liquide est évaporée, de façon à réduire la taille des particules d'aérosol liquide. En mélangeant de l'air chaud avec l'aérosol liquide, au moins une partie du liquide contenu dans les particules d'aérosol est évaporée, et ainsi, le dispositif d'atomisation (100) peut obtenir une sortie à l'échelle nanométrique de particules d'aérosol.
PCT/CN2021/070342 2021-01-05 2021-01-05 Dispositif d'atomisation, méthode de génération d'aérosol et dispositif d'atomisation médical Ceased WO2022147661A1 (fr)

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CN117619254A (zh) * 2024-01-25 2024-03-01 东北大学 一种纳米颗粒生成装置及生成方法
WO2024234882A1 (fr) * 2023-05-12 2024-11-21 思摩尔国际控股有限公司 Ensemble support d'atomisation et dispositif de génération d'aérosol
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