WO2022038630A1

WO2022038630A1 - Surface cleaning composition and use thereof

Info

Publication number: WO2022038630A1
Application number: PCT/IN2021/050761
Authority: WO
Inventors: Debojit Chakrabarty; Reji N JOY; Srushti SANGHVI; Vaishali NEVREKAR
Original assignee: Jyothy Labs Ltd
Current assignee: Jyothy Labs Ltd
Priority date: 2020-08-20
Filing date: 2021-08-09
Publication date: 2022-02-24
Anticipated expiration: 2023-02-20

Abstract

The present disclosure discloses a composition comprising: (a) one or more quaternary ammonium compound; (b) an antimicrobial agent; (c) a surfactant; (d) a polymer; and (e) a chelating agent, wherein the one or more quaternary ammonium compound and the antimicrobial agent is in the weight ratio range of 1:100 to 100:1. The present disclosure also discloses a process for preparing the composition. The composition of the present disclosure exhibits cleaning and antimicrobial effect on hard nonporous surfaces.

Description

SURFACE CLEANING COMPOSITION AND USE THEREOF

FIELD OF INVENTION

[0001] The present disclosure relates to the field of chemical compositions, and in particular relates to antimicrobial surface cleaning composition. The present disclosure further relates to a process for preparing said composition and its uses thereof.

BACKGROUND OF THE INVENTION

[0002] With the rapid spread of infectious diseases globally, maintaining surface hygiene is important in controlling the spread of diseases mediated via surface microbes. Disinfectants used for sanitizing surfaces are expected to reduce the risk of exposure and spread of multiple germs that we come across in our day to day lives.

[0003] Contact with surfaces contaminated with disease causing pathogenic microorganisms, such as viruses, bacteria, and fungi has led to widespread occurrence of serious diseases like influenza, lung infections, food poisoning, and various respiratory ailments. These diseases are associated with high morbidity and mortality rates and have posed major risks to human health and survival. Commonly contacted surfaces, such as furniture, slabs, windows, and floor act as major hubs for spread of pathogenic microorganisms from one person to another. Hence, many surface cleaning compositions also useful for killing microorganisms present on the surfaces have been formulated.

[0004] ES2607055T3 discloses an antimicrobial composition for disinfecting both porous and non-porous surfaces. The said composition is based on a combination of alcohol, alkanediol, and foaming surfactant.

[0005] AU2014211458B2 discloses an antimicrobial composition comprising a lactam and a hydrotrope. The antimicrobial composition is aimed to serve as a hard surface cleaner, such as a toilet cleaner. [0006] US9701931B2 relates to a hard surface disinfectant composition based on a combination of hydrogen peroxide generator, a peracetic acid catalyst, a slow hydrolyzing acid, and optionally a carboxylic acid.

[0007] Although considerable research has been done in this field, most of the existing germ-killing compositions still fail to demonstrate appreciable antimicrobial activity and lack rapid and long-lasting germ-killing effects. Hence, there arises a need in the present state of the art to develop a surface cleaning composition that can exhibit quick and effective antimicrobial action against a wide range of microbes yet displays bioactivity for prolonged periods of time.

SUMMARY OF THE INVENTION

[0008] In a first aspect of the present disclosure, there is provided a surface cleaning composition comprising: (a) one or more quaternary ammonium compound; (b) an antimicrobial agent; (c) a surfactant; (d) a polymer; and (e) a chelating agent, wherein the one or more quaternary ammonium compound and the antimicrobial agent is in the weight ratio range of 1 : 100 to 100: 1.

[0009] In a second aspect of the present disclosure, there is provided a surface cleaning composition comprising: (a) one or more quaternary ammonium compound is a combination of alkyl dimethyl benzyl ammonium chloride, octyl decyl dimethyl ammonium chloride, di decyl dimethyl ammonium chloride, di octyl dimethyl ammonium chloride in the range of 0.04 % - 40.0 % (w/w); (b) an antimicrobial agent is hydroxy dichlorodiphenyl ether in the range of 0.01 % - 10.0 % (w/w); (c) a surfactant is a combination of lauryl amine oxide and alcohol ethoxylate in the range of 0.02 % - 20.0 % (w/w); (d) a polymer is acrylic acid copolymer in the range of 0.01 % - 10.0 % (w/w); (e) a chelating agent is EDTA disodium powder in the range of 0.01 % - 5.0 % (w/w); wherein the one or more quaternary ammonium compound and the antimicrobial agent is in the weight ratio range of 1:100 to 100:1. [0010] In a third aspect of the present disclosure, there is provided a process of preparing the surface cleaning composition comprising: (1) one or more quaternary ammonium compound; (2) an antimicrobial agent; (3) a surfactant; (4) a polymer; and (5) a chelating agent wherein the one or more quaternary ammonium compound and the antimicrobial agent is in the weight ratio range of 1: 100 to 100:1, the process comprising: (a) mixing the one or more quaternary ammonium compound, the surfactant, the polymer, the chelating agent, and water to obtain a reaction mixture; (b) dissolving the antimicrobial agent in the high boiling point solvent to obtain a blend; and (c) contacting the reaction mixture, the blend, the pH stabilizer, the antioxidant, the corrosion inhibitor, the perfume, and optionally the active of essential oil to obtain the composition.

[0011] In a fourth aspect of the present disclosure, there is provided a surface cleaning composition comprising: (1) one or more quaternary ammonium compound; (2) an antimicrobial agent; (3) a surfactant; (4) a polymer; and (5) a chelating agent, wherein the one or more quaternary ammonium compound and the antimicrobial agent is in the weight ratio range of 1: 100 to 100: 1 for use as surface cleaner wherein, the surface is a hard and non-porous surface selected from glass, plastics, ceramics, or metals.

[0012] These and other features, aspects, and advantages of the present subject matter will be better understood with reference to the following description. This summary is provided to introduce a selection of concepts in a simplified form. This summary is not intended to identify key features or essential features of the claimed subject matter.

BRIEF DESCRIPTION OF THE DRAWINGS

[0013] Figure 1 depicts the surface of the original tile and the grease coated tiles (a) before application, and (b) after application of the surface cleaning composition, in accordance with an implementation of the present disclosure. DETAILED DESCRIPTION OF THE INVENTION

[0014] Those skilled in the art will be aware that the present disclosure is subject to variations and modifications other than those specifically described. It is to be understood that the present disclosure includes all such variations and modifications. The disclosure also includes all such steps, features, compositions, and compounds referred to or indicated in this specification, individually or collectively, and any or all combinations of any or more of such steps or features.

Definitions

[0015] For convenience, before further description of the present disclosure, certain terms employed in the specification, and examples are delineated here. These definitions should be read in the light of the remainder of the disclosure and understood as by a person of skill in the art. The terms used herein have the meanings recognized and known to those of skill in the art, however, for convenience and completeness, particular terms and their meanings are set forth below.

[0016] The articles “a”, “an” and “the” are used to refer to one or to more than one (i.e., to at least one) of the grammatical object of the article.

[0017] The terms “comprise” and “comprising” are used in the inclusive, open sense, meaning that additional elements may be included. It is not intended to be construed as “consists of only”.

[0018] Throughout this specification, unless the context requires otherwise the word “comprise”, and variations, such as “comprises” and “comprising”, will be understood to imply the inclusion of a stated element or step or group of element or steps but not the exclusion of any other element or step or group of element or steps.

[0019] The term “including” is used to mean “including but not limited to”. “Including” and “including but not limited to” are used interchangeably.

[0020] Ratios, concentrations, amounts, and other numerical data may be presented herein in a range format. It is to be understood that such range format is used merely for convenience and brevity and should be interpreted flexibly to include not only the numerical values explicitly recited as the limits of the range, but also to include all the individual numerical values or sub-ranges encompassed within that range as if each numerical value and sub-range is explicitly recited. For example, a concentration range of about 0.01-10 % should be interpreted to include not only the explicitly recited limits of about 0.01% to about 10% but also to include sub-ranges, such as 1-9%, 1.5-9.5% and so forth, as well as individual amounts, including fractional amounts, within the specified ranges, such as 1.25%, and 5.55% for example.

[0021] The term “microorganism”, as used herein refers to various viral or bacterial or fungal or yeast strains that are found generally on the surface of any object, preferably, hard non-porous surfaces, such as glass, plastics, ceramics, or metals and possibly can harm human health on either coming into direct contact or on consumption.

[0022] The term “quaternary ammonium compound” used herein refers to compounds of nitrogen coordinate to four substituents to form a positively charged polyatomic ions with the structure NR4⁺. In the present disclosure, the quaternary ammonium compound is capable of exhibiting antimicrobial activity, which includes killing or inhibiting the growth of microorganisms.

[0023] The term “antimicrobial agent” used herein refers to a chemical substance that is capable of exhibiting germ-killing properties, which includes killing or inhibiting the growth of microorganisms.

[0024] The term “surfactant” used herein refers to wetting agents or surface acting agents that can form amphipathic micelles which lower the liquid-liquid or liquid- solid surface tension.

[0025] The term “polymer” used herein refers to a wide class of materials consisting of large molecules derived from many small repeating subunits called monomers. Deriving the benefits of its long-chained structure, the present disclosure employs polymers in enhancing the surfactant properties of the present composition.

[0026] The term “essential oil” used herein refers to a concentrated hydrophobic liquid containing volatile chemical compounds or actives obtained by distillation and having the characteristic odor of the plant or other source from which it is extracted. The active of essential oil, as used herein may also possess anti-microbial effect, specifically, anti-viral effect. For example, thymol and other actives of essential oil of thyme, cinnamon, bay, clove, almond (bitter), lovage, pimento, marjoram, angelica, and nutmeg possess antimicrobial, specifically, virucidal benefits. The actives of essential oils comprise of terpenes, aromatic and aliphatic compounds (especially alcohols, esters, ethers, aldehydes, ketones, lactones, phenols and phenol ethers) as their most common ingredients.

[0027] The term “chelating agent” used herein refers to chemical compounds that bind with the metal ions to form a complex.

[0028] The term “pH stabilizer” used herein refers to a chemical ingredient from the category of buffering agents, added to the present composition to maintain the pH of the composition at a desired pH level.

[0029] The term “corrosion inhibitor” used herein refers to a chemical substance which is used to reduce or completely prevent the corrosion or wear of the material of interest.

[0030] The term “diluent” used herein refers to a chemical substance that facilitates complete dissolution of other polar and non-polar ingredients. Examples include but are not limited to water and alcohol.

[0031] The term “high boiling point solvent” used herein refers to a chemical substance that has high boiling point and facilitates complete dissolution of other polar and non-polar ingredients. Such a chemical substance prevents the components of the solution from evaporating quickly. [0032] The term antioxidant used herein refers to substances that are used to protect the material of interest from the possible attack of oxygen and prevent its further degradation.

[0033] The term “perfume” used herein refers to a fragrance imparting agent, that is used for the purpose of providing an overall fragrance to the present composition, that is similar to the source of said perfume. For the purpose of the present disclosure, perfume may be selected from the group, but not limited to, alcohols, ethyl alcohol, essential oils, esters, ethers, aldehyde, ketones, natural aromatic substances, synthetic aromatic substances, and natural extracts.

[0034] The term “germ” and “microbe” have been used interchangeably in the entire specification and both refer to disease causing microorganisms, such as bacteria, virus, yeast and fungi.

[0035] The term “surface” used herein refers to hard and non-porous exterior area of an object. For the purpose of the present disclosure, surface may be selected from, but not limited to, glass, plastics, ceramics, and metals.

[0036] The term “cleaning” used herein refers to disinfecting, sterilizing, and removal of soil, grease, and grime from the surface of any object, preferably, hard non-porous surfaces, such as glass, plastics, ceramics, or metals.

[0037] Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this disclosure belongs. Although any methods and materials similar or equivalent to those described herein can be used in the practice or testing of the disclosure, the preferred methods, and materials are now described. All publications mentioned herein are incorporated herein by reference.

[0038] The present disclosure is not to be limited in scope by the specific embodiments described herein, which are intended for the purposes of exemplification only. Functionally equivalent products, compositions, and methods are clearly within the scope of the disclosure, as described herein. [0039] Thus, to meet the high market demands and to keep the product cost effective, majority of the available surface germ killing compositions use very less effective antimicrobial components. Such components are unable to impart the essential antimicrobial efficacy on the contaminated surface. Moreover, the existing compositions fail to provide quick and long-lasting action as they either evaporate very quickly or are not able to spread properly or uniformly on the subjected surface. As a result, they need to be applied in larger amounts which leads not only to higher consumer cost, but also to excess amount of product usage, which could potentially harm the environment along with possible development of resistant microorganisms. Such products are intended to blind the customers with untrue promises and safety claims by keeping them unaware of the actual efficacy of the chemicals added. This is one of the major reasons that we still see rapidly increasing infectious diseases despite of the wide range of germ kill products readily available in the market. In addition to above, most of these products include harmful chemical ingredients that in the long run, could cause serious health and environmental risks on regular exposure.

[0040] The present disclosure addresses the above-mentioned shortcomings of the existing antimicrobial compositions by disclosing a composition that is highly user friendly and very reliable in terms of quick, effective, and long-lasting germ-killing activity.

[0041] In view of the above, the present disclosure relates to a surface cleaning composition comprising a combination of quaternary ammonium compounds and an antimicrobial agent in conjunction with a combination of surfactants, a film forming polymer and a chelating agent. The specific combination of quaternary ammonium compounds which include alkyl dimethyl benzyl ammonium chloride, octyl decyl dimethyl ammonium chloride, di decyl dimethyl ammonium chloride, and di octyl dimethyl ammonium chloride with the antimicrobial agent hydroxy dichlorodiphenyl ether imparts to the composition its exclusive synergistic antimicrobial efficacy against a wide range of commonly encountered disease-causing microbes, such as Staphylococcus aureus and Candiaa albicans. The combination of the antimicrobial quaternary ammonium compounds and the antimicrobial agent with the combination of surfactants comprising lauryl amine oxide and alcohol ethoxylate, the film forming poly (acrylic acid) based polymer and the chelating agent ensures an all-surface compatibility in addition to providing wide surface coverage on hard non-porous surfaces. Thus, the enhanced surfactant properties in conjunction with antimicrobial agent present in composition provide instantaneous germ-killing action and, additionally assures germ protection benefits extended up to 24-hours from the time of application of the product based on the results obtained from standard microbiological assays. The chelating agent enhances the antimicrobial capabilities of quaternary ammonium compounds. Further, a dominant role is played by the combination of antimicrobial quaternary ammonium compounds and antimicrobial agent used in the composition of the present disclosure, due to the strongly positively charged quaternary ammonium compounds in conjunction with antimicrobial agent, which results in imparting good substantive property on hard non-porous surfaces by virtue of charge interactions. Thus, the components of the surface cleaning composition work synergistically with each other resulting in a superior germ protection activity. The resulting composition, optionally comprising an active of essential oil thymol as an antiviral agent, successfully demonstrates >99.9% microbe kill rate and is found to be effective in killing viruses, which include viruses belonging to the family of Coronavirus, which is an enveloped virus. Few examples include the severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) viruses which have led to severe epidemics in the past. The disclosed composition further comprises other additives, such as pH stabilizer, corrosion inhibitor, high boiling point solvent, antioxidant, and perfume which contributes to the overall user-safety, storage stability and marketability of the final product. Further to this, the present composition also offers effective cleaning and removal of soil, grease, and grime, whilst, providing anti-bacterial and anti-viral benefits as stated above. It is expected that there could be logical extensions of this composition for other applications like toilet and bathroom cleaning as well, where the nature of the hard surfaces might not be perfectly flat though being nonporous, but might possess curved surface features, as well as some porosity. Providing extended germ-kill benefits in categories mentioned above, will certainly be a gamechanger in the industry and shall provide a huge reassurance to the consumers by guaranteeing extended germ protection benefits on hard non-porous surfaces.

[0042] In an embodiment of the present disclosure, there is provided a surface cleaning composition comprising: (a) one or more quaternary ammonium compound; (b) an antimicrobial agent; (c) a surfactant; (d) a polymer; and (e) a chelating agent, wherein the one or more quaternary ammonium compound and the antimicrobial agent is in the weight ratio range of 1 : 100 to 100: 1.

[0043] In an embodiment of the present disclosure, there is provided a surface cleaning composition as described herein, wherein the one or more quaternary ammonium compound and the antimicrobial agent is in the weight ratio range of 1:10 to 10: 1. In another embodiment of the present disclosure, the one or more quaternary ammonium compound and the antimicrobial agent is in the weight ratio range of 1:5 to 5: 1. In yet another embodiment of the present disclosure, the one or more quaternary ammonium compound and the antimicrobial agent is in the weight ratio range of 1:4 to 5:1.

[0044] In an embodiment of the present disclosure, there is provided a surface cleaning composition comprising: (a) one or more quaternary ammonium compound selected from alkyl dimethyl benzyl ammonium chloride, octyl decyl dimethyl ammonium chloride, di decyl dimethyl ammonium chloride, di octyl dimethyl ammonium chloride, alkyl dimethyl ethyl benzyl ammonium chloride, or combinations thereof; (b) an antimicrobial agent selected from hydroxy dichlorodiphenyl ether, trichlorocarbanilide, chloro xylenol, bromo nitro propanediol, chloro cresols, polychloro hydroxy phenolic compounds, or combinations thereof; (c) a surfactant selected from lauryl amine oxide, alcohol ethoxylate, lauryl myristyl amine oxide, cocoamidopropyl amine oxide, cocoamidopropyl betaine, coco betaine, hydroxysultaines, alcohol ethoxylate propoxylates, nonyl phenol ethoxylates, or combinations thereof; (d) a polymer selected from acrylic acid homopolymers or copolymers, methacrylic acid derivatives, polyvinyl pyrrolidone, polyvinyl alcohol, hydroxyethyl cellulose, hydroxypropyl methyl cellulose, or combinations thereof; and (e) a chelating agent selected from ethylenediaminetetraacetic acid (EDTA) disodium, EDTA tetrasodium, l-hydroxyethylidene-l,l-diphosphonic acid (HEDP), diethylenetriamine penta(methylene phosphonic acid) (DTPMP), ethylenediamine tetra(methylene phosphonic acid) (EDTMP), diethylenetriaminepentaacetic acid (DTPA), sodium gluconate, methylglycinediacetic acid sodium salt, or combinations thereof, wherein the one or more quaternary ammonium compound and the antimicrobial agent is in the weight ratio range of 1: 100 to 100: 1.

[0045] In another embodiment of the present disclosure, there is provided a surface cleaning composition comprising: (a) one or more quaternary ammonium compound selected from alkyl dimethyl benzyl ammonium chloride, octyl decyl dimethyl ammonium chloride, di decyl dimethyl ammonium chloride, di octyl dimethyl ammonium chloride or combinations thereof; (b) an antimicrobial agent is hydroxy dichlorodiphenyl ether; (c) a surfactant selected from lauryl amine oxide, alcohol ethoxylate, or combinations thereof; (d) a polymer is acrylic acid homopolymers or copolymers; and (e) a chelating agent is EDTA disodium, wherein the one or more quaternary ammonium compound and the antimicrobial agent is in the weight ratio range of 1 : 100 to 100: 1.

[0046] In an embodiment of the present disclosure, there is provided a surface cleaning composition as described herein, wherein (a) one or more quaternary ammonium compound selected from alkyl dimethyl benzyl ammonium chloride, octyl decyl dimethyl ammonium chloride, di decyl dimethyl ammonium chloride, di octyl dimethyl ammonium chloride, alkyl dimethyl ethyl benzyl ammonium chloride, or combinations thereof; (b) an antimicrobial agent is hydroxy dichlorodiphenyl ether; (c) a surfactant selected from lauryl amine oxide, alcohol ethoxylate, or combinations thereof; (d) a polymer is acrylic acid homopolymers or copolymers; and (e) a chelating agent is EDTA disodium, wherein the one or more quaternary ammonium compound and the antimicrobial agent is in the weight ratio range of 1:10 to 10: 1. In another embodiment of the present disclosure, wherein the one or more quaternary ammonium compound and the antimicrobial agent is in the weight ratio range of 1:5 to 5: 1. In yet another embodiment of the present disclosure, wherein the one or more quaternary ammonium compound and the antimicrobial agent weight ratio is 5: 1.

[0047] In an embodiment of the present disclosure, there is provided a surface cleaning composition as described herein, wherein the composition further comprises a pH stabilizer, a corrosion inhibitor, a high boiling point solvent, an antioxidant, a perfume, and optionally an active of essential oil.

[0048] In an embodiment of the present disclosure, there is provided a surface cleaning composition as described herein, wherein the pH stabilizer is selected from triethanolamine, monoethanolamine, diethanolamine, sodium bicarbonate, sodium carbonate, potassium carbonate, sodium hydroxide, or combinations thereof; the corrosion inhibitor is selected from sodium metasilicate pentahydrate, sodium silicate, sodium metasilicate nonahydrate, or combination thereof; the high boiling point solvent is selected from glycol ethers, methyl alcohol, ethyl alcohol, isopropyl alcohol, benzyl alcohol, or combination thereof; the antioxidant is selected from butylated hydroxy toluene, butylated hydroxy anisole, benzophenone-3, benzophenone-4, or combination thereof; and the active of essential oil selected from thymol, eugenol, menthol, geraniol, verbenone, eucalyptol, pinocarvone, cedrol, anethol, carvacrol, hinokitiol, berberine, ferulic acid, cinnamic acid, methyl salicylic acid, methyl salicylate, terpineol, or combinations thereof. [0049] In an embodiment of the present disclosure, there is provided a surface cleaning composition as described herein, wherein the composition further comprises triethanolamine as a pH stabilizer, sodium metasilicate pentahydrate as a corrosion inhibitor, glycol ether as a high boiling point solvent, butylated hydroxy toluene as an antioxidant, perfume, and optionally thymol as an active of essential oil.

[0050] In an embodiment of the present disclosure, there is provided a surface cleaning composition as described herein, wherein (a) one or more quaternary ammonium compound selected from alkyl dimethyl benzyl ammonium chloride, octyl decyl dimethyl ammonium chloride, di decyl dimethyl ammonium chloride, di octyl dimethyl ammonium chloride, or combinations thereof; (b) an antimicrobial agent is hydroxy dichlorodiphenyl ether; (c) a surfactant selected from lauryl amine oxide, alcohol ethoxylate, or combinations thereof; (d) a polymer is acrylic acid homopolymers or copolymers; (e) a chelating agent is EDTA disodium powder; (f) optionally, an active of essential oil is thymol; (g) a pH stabilizer is triethanolamine; (h) a corrosion inhibitor is sodium metasilicate pentahydrate; (i) a high boiling point solvent is glycol ethers; (j) an antioxidant is butylated hydroxy toluene; (k) a perfume; and (1) water (q.s), wherein the one or more quaternary ammonium compound and the antimicrobial agent is in the weight ratio range of 1: 10 to 10:1.

[0051] In an embodiment of the present disclosure, there is provided a surface cleaning composition comprising: (a) one or more quaternary ammonium compound is a combination of alkyl dimethyl benzyl ammonium chloride, octyl decyl dimethyl ammonium chloride, di decyl dimethyl ammonium chloride, di octyl dimethyl ammonium chloride in the range of 0.04 % - 40.0 % (w/w); (b) an antimicrobial agent is hydroxy dichlorodiphenyl ether in the range of 0.01 % - 10.0 % (w/w); (c) a surfactant is a combination of lauryl amine oxide and alcohol ethoxylate in the range of 0.02 % - 20.0 % (w/w); (d) a polymer is acrylic acid copolymer in the range of 0.01 % - 10.0 % (w/w); (e) a chelating agent is EDTA disodium powder in the range of 0.01 % - 5.0 % (w/w); wherein the one or more quaternary ammonium compound and the antimicrobial agent is in the weight ratio range of 1:100 to 100: 1. In another embodiment of the present disclosure, (a) one more quaternary ammonium compound is a combination of alkyl dimethyl benzyl ammonium chloride, octyl decyl dimethyl ammonium chloride, di decyl dimethyl ammonium chloride, di octyl dimethyl ammonium chloride in the range of 0.1 % - 5.0 % (w/w), preferably 0.2 % - 2.0 % (w/w), preferably 0.3 % - 0.5 % (w/w); (b) an antimicrobial agent is hydroxy dichlorodiphenyl ether in the range of 0.1 % - 5.0 % (w/w), preferably 0.15 % - 0.5 % (w/w); (c) a surfactant is a combination of lauryl amine oxide and alcohol ethoxylate in the range of 0.2 % - 5.0 % (w/w), preferably 0.3 % - 2.0 % (w/w), preferably 0.8 % - 1.2 % (w/w); (d) a polymer is acrylic acid copolymer in the range of 0.1 % - 5.0 % (w/w), preferably 0.2 % - 2.0 % (w/w), preferably 0.25 % - 0.5 % (w/w); (e) a chelating agent is EDTA disodium powder in the range of 0.01 % - 5.0 % (w/w), preferably 0.03 % - 2.0 % (w/w), preferably 0.05 % - 1.0 % (w/w), wherein the one or more quaternary ammonium compound and the antimicrobial agent is in the weight ratio range of 10: 1 to 1:10.

[0052] In an embodiment of the present disclosure, there is provided a surface cleaning composition comprising: (a) one or more quaternary ammonium compound is a combination of alkyl dimethyl benzyl ammonium chloride, octyl decyl dimethyl ammonium chloride, di decyl dimethyl ammonium chloride, di octyl dimethyl ammonium chloride in the range of 0.04 % - 40.0 % (w/w); (b) an antimicrobial agent is hydroxy dichlorodiphenyl ether in the range of 0.01 % - 10.0 % (w/w); (c) a surfactant is a combination of lauryl amine oxide and alcohol ethoxylate in the range of 0.02 % - 20.0 % (w/w); (d) a polymer is acrylic acid copolymer in the range of 0.01 % - 10.0 % (w/w); (e) a chelating agent is EDTA disodium powder in the range of 0.01 % - 5.0 % (w/w); (f) an active of essential oil is thymol in the range of 0.0 % - 5.0 % (w/w); (g) a pH stabilizer is triethanolamine in the range of 0.01 % - 5.0 % (w/w); (h) a corrosion inhibitor is sodium metasilicate pentahydrate in the range of 0.01 % - 5.0 % (w/w); (i) a high boiling point solvent is glycol ethers in the range of 1.0 % - 3.0 % (w/w); (j) an antioxidant is butylated hydroxy toluene in the range of 0.0 to 5 % (w/w); (k) a perfume in the range of 0.2 % to 0.6 % (w/w); and (1) water (q.s), wherein the one or more quaternary ammonium compound and the antimicrobial agent is in the weight ratio range of 1: 100 to 100: 1. In another embodiment of the present disclosure, (a) one or more quaternary ammonium compound is a combination of alkyl dimethyl benzyl ammonium chloride, octyl decyl dimethyl ammonium chloride, di decyl dimethyl ammonium chloride, di octyl dimethyl ammonium chloride in the range of 0.1 % - 5.0 % (w/w), preferably 0.2 % - 2.0 % (w/w), preferably 0.3 % - 0.5 % (w/w); (b) an antimicrobial agent is hydroxy dichlorodiphenyl ether in the range of 0.1 % - 5.0 % (w/w), preferably 0.15 % - 0.5 % (w/w); (c) a surfactant is a combination of lauryl amine oxide and alcohol ethoxylate in the range of 0.2 % - 5.0 % (w/w), preferably 0.3 % - 2.0 % (w/w), preferably 0.8 % - 1.2 % (w/w); (d) a polymer is acrylic acid copolymer in the range of 0.1 % - 5.0 % (w/w), preferably 0.2 % - 2.0 % (w/w), preferably 0.25 % - 0.5 % (w/w); (e) a chelating agent is EDTA disodium powder in the range of 0.1 % - 3.0 % (w/w), preferably 0.3 % - 1.2 % (w/w); (f) an active of essential oil is thymol in the range of 0.0 % - 5.0 % (w/w), preferably 0.02 % - 3.0 % (w/w), preferably 0.05 % - 1.5 % (w/w); (g) a pH stabilizer is triethanolamine in the range of 1.0 % - 4.0 % (w/w), preferably 2.8 % - 3.2 % (w/w); (h) a corrosion inhibitor is sodium metasilicate pentahydrate in the range of 0.0.5 % - 2.0 % (w/w), preferably 0.1 % - 1.2 % (w/w); (i) a high boiling point solvent is glycol ethers in the range of 1.1 % - 2.7 % (w/w), preferably 1.5 % -2.5 % (w/w); (j) an antioxidant is butylated hydroxy toluene in the range of 0.0 to 5 % (w/w); (k) a perfume in the range of 0.2 % to 0.5 % (w/w), preferably 0.3 % -0.45 % (w/w); and (1) water (q.s), wherein the one or more quaternary ammonium compound and the antimicrobial agent is in the weight ratio range of 1: 10 to 10: 1.

[0053] In an embodiment of the present disclosure, there is provided a surface cleaning composition comprising: (a) one or more quaternary ammonium compound is a combination of alkyl dimethyl benzyl ammonium chloride, octyl decyl dimethyl ammonium chloride, di decyl dimethyl ammonium chloride, di octyl dimethyl ammonium chloride in the range of 0.04 % - 40.0 % (w/w); (b) an antimicrobial agent is hydroxy dichlorodiphenyl ether in the range of 0.01 % - 10.0 % (w/w); (c) a surfactant is a combination of lauryl amine oxide and alcohol ethoxylate in the range of 0.02 % - 20.0 % (w/w); (d) a polymer is acrylic acid copolymer in the range of 0.01 % - 10.0 % (w/w); (e) a chelating agent is EDTA disodium powder in the range of 0.01 % - 5.0 % (w/w); (f) a pH stabilizer is triethanolamine in the range of 0.01 % - 5.0 % (w/w); (g) a corrosion inhibitor is sodium metasilicate pentahydrate in the range of 0.01 % - 5.0 % (w/w); (h) a high boiling point solvent is glycol ethers in the range of 1.0 % - 3.0 % (w/w); (i) an antioxidant is butylated hydroxy toluene in the range of 0.0 to 5 % (w/w); (j) a perfume in the range of 0.2 % to 0.6 % (w/w); and (k) water (q.s), wherein the one or more quaternary ammonium compound and the antimicrobial agent is in the weight ratio range of 1: 100 to 100: 1.

[0054] In an embodiment of the present disclosure, there is provided a process of preparing the surface cleaning composition as described herein, the process comprising: (a) mixing the one or more quaternary ammonium compound, the surfactant, the polymer, the chelating agent, and water to obtain a reaction mixture; (b) dissolving the antimicrobial agent in the high boiling point solvent to obtain a blend; and (c) contacting the reaction mixture, the blend, the pH stabilizer, the antioxidant, the corrosion inhibitor, and the perfume to obtain the composition, wherein the one or more quaternary ammonium compound and the antimicrobial agent is in the weight ratio range of 1 : 100 to 100: 1.

[0055] In embodiment of the present disclosure, there is provided a process of preparing the surface cleaning composition as described herein, the process comprising: (a) mixing the one or more quaternary ammonium compound, the surfactant, the polymer, the chelating agent, and water to obtain a reaction mixture; (b) dissolving the antimicrobial agent in the high boiling point solvent to obtain a blend; and (c) contacting the reaction mixture, the blend, the pH stabilizer, the antioxidant, the corrosion inhibitor, the perfume, and optionally the active of essential oil to obtain the composition, wherein the one or more quaternary ammonium compound and the antimicrobial agent is in the weight ratio range of 1: 100 to 100: 1.

[0056] In an embodiment of the present disclosure, there is provided a process of preparing the surface cleaning composition comprising: (i) one or more quaternary ammonium compound; (ii) an antimicrobial agent; (iii) a surfactant; (iv) a polymer; and (v) a chelating agent, the process comprising: (a) mixing the one or more quaternary ammonium compound, the surfactant, the polymer, the chelating agent, and water to obtain a reaction mixture; (b) dissolving the antimicrobial agent in the high boiling point solvent to obtain a blend; and (c) contacting the reaction mixture, the blend, the pH stabilizer, the antioxidant, the corrosion inhibitor, and the perfume to obtain the composition, wherein the one or more quaternary ammonium compound and the antimicrobial agent is in the weight ratio range of 1:100 to 100:1.

[0057] In an embodiment of the present disclosure, there is provided a surface cleaning composition as described herein, for use in cleaning hard surface.

[0058] In an embodiment of the present disclosure, there is provided a surface cleaning composition as described herein, for use in cleaning hard surface, wherein the surface is hard and non-porous, and selected from glass, plastics, ceramics, or metals.

[0059] In an embodiment of the present disclosure, there is provided a surface cleaning composition as described herein, for use in germ kill, comprising killing or inhibiting the growth of a microorganism.

[0060] In an embodiment of the present disclosure, there is provided a surface cleaning composition as described herein, wherein the composition provides sanitization of surface for up to 24 hours post treatment.

[0061] In an embodiment of the present disclosure, there is provided a surface cleaning composition as described herein, for use in germ kill, comprising killing or inhibiting the growth of a microorganism, wherein the microorganism is selected from bacteria, virus, and fungi.

[0062] In an embodiment of the present disclosure, there is provided a surface cleaning composition as described herein, for use in germ kill, comprising killing or inhibiting the growth of a microorganism selected from bacteria, virus, and fungi, wherein the virus is an enveloped or a non-enveloped virus; and the enveloped or non-enveloped virus is selected from influenza virus, coronavirus, adenovirus, poliovirus, rotavirus, or murine virus.

[0063] In an embodiment of the present disclosure, there is provided use of the surface cleaning composition as described herein as surface cleaner, wherein, the surface is hard and non-porous, and selected from glass, plastics, ceramics, or metals. [0064] In an embodiment of the present disclosure, there is provided use of the surface cleaning composition as described herein for germ kill, comprising killing or inhibiting the growth of a microorganism, wherein the microorganism is selected from bacteria, virus, and fungi.

[0065] In an embodiment of the present disclosure, there is provided use of composition as described herein for germ kill, comprising killing or inhibiting the growth of a microorganism selected from bacteria, virus, and fungi, wherein the virus is an enveloped or a non-enveloped virus; and the enveloped or non-enveloped virus is selected from influenza virus, coronavirus, adenovirus, poliovirus, rotavirus, or murine virus.

[0066] Although the subject matter has been described in considerable detail with reference to certain embodiments thereof, other embodiments are possible. As such, the spirit and scope of the disclosure should not be limited to the description of the embodiments contained herein.

EXAMPLES [0067] The disclosure will now be illustrated with the working examples, which is intended to illustrate the working of disclosure and not intended to take restrictively to imply any limitations on the scope of the present disclosure. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood to one ordinary person skilled in the art to which this disclosure belongs. Although methods and materials similar or equivalent to those described herein can be used in the practice of the disclosed methods and compositions, the exemplary methods, devices and materials are described herein. It is to be understood that this disclosure is not limited to particular methods, and experimental conditions described, as such methods and conditions may apply.

Materials and Methods

[0068] For the purpose of the present disclosure, the components to prepare the composition of the present disclosure were procured commercially with the CAS numbers as given below in Table 1: Table 1

EXAMPLE 1

Process of preparing the cleaning composition-1

[0069] A surface cleaning composition- 1 as per the present disclosure was prepared by following a series of steps carried out at room temperature (25 °C) and atmospheric pressure. The mixing speed was maintained between 25-180 rpm. All the components as disclosed in Table 2 were included in the composition according to the weight ranges as mentioned. The weight percentages mentioned in the below table were calculated with respect to the total weight of the composition. Table 2

[0070] Initially, a mixture of quaternary ammonium compounds comprising 0.1 % (w/w) of alkyl dimethyl benzyl ammonium chloride, 0.1 % (w/w) of octyl decyl dimethyl ammonium chloride, 0.05 % (w/w) of di decyl dimethyl ammonium chloride, and 0.2 % (w/w) of di octyl dimethyl ammonium chloride, a solution of surfactants comprising 0.5 % (w/w) of lauryl amine oxide and 0.5 % (w/w) of alcohol ethoxylate, 0.3 % (w/w) of acrylic acid homopolymers or copolymers, and 2 % (w/w) of disodium salt of EDTA were mixed in demineralized water so as to completely dissolve all the components added and obtain a reaction mixture. To this reaction mixture, a blend of 2.0 % (w/w) of dipropylene glycol n-butyl ether and 0.2 % (w/w) of hydroxy dichlorodiphenyl ether was added followed by addition of 3.0 % (w/w) of triethanolamine, 0.3 % (w/w) of sodium metasilicate pentahydrate and 0.3 % of perfume. All the components were mixed well for complete dissolution to obtain the composition of the present disclosure. Sodium metasilicate pentahydrate buffered the pH of the composition between 9.0 to 9.5. The composition was further subjected to various tests and analysis to assess its antimicrobial efficacy when applied to hard surfaces, such as metal, glass, ceramics, and plastics.

EXAMPLE 2

Assessment for Antimicrobial and Cleaning efficacy [0071] The bacterial kill efficacy of the present surface cleaning composition- 1 was tested using the European Suspension Test BS EN1276. The test provided quantitative results for the bactericidal activity against a set of 4 standard bacterial strains Escherichia coli ATCC 10536, Staphylococcus aureus ATCC 6538, Enterococcus hirae ATCC 10541, and Pseudomonas aeruginosa ATCC 15442.

[0072] BS EN1276: The disinfecting properties of the composition were measured by its bactericidal activity using the method laid out in British Standard EN 1276 "Chemical disinfectants and antiseptics - Quantitative suspension test for the evaluation of bactericidal activity of, chemical disinfectants and antiseptics used in food, industrial, domestic and institutional areas (Phase 2, step 1)”. This is a standard issued by the European Committee for Standardization and is applicable to chemical disinfectants and antiseptics to be used in food, industrial, domestic, and institutional areas where disinfection or antisepsis are indicated.

[0073] The test comprises mixing 1 ml of the test bacterial preparation with 1 ml of an interfering substance either in simulating "clean" conditions, wherein the interfering substance comprises of 0.03% bovine albumin, or in simulating "dirty" conditions, wherein the interfering substance comprises 0.3% bovine albumin. To this mixture was added, 8 ml of the composition under test and was allowed a ten-minute contact time. After a ten-minute contact time, 1ml of the mixture was removed and was immediately mixed with 9 ml of a recovery/neutralizer solution, to inactivate the killing action of the composition. After neutralization, the sample was plated on petri plates to evaluate the viability reduction of bacteria post exposure to the test composition. The reduction in viable counts was then calculated and expressed as logarithms to base 10.

[0074] As a standard parameter in BS EN1276, 5 log reduction (99.999% kill) in the viable count of the bacteria qualifies for a disinfectant product claim. Table 3 presents antimicrobial data on a representative composition of the surface cleaner. The test results obtained using the present composition on the bacterial strains as per EN 1276, are illustrated in Table 3 which clearly demonstrates a >4 log reduction for all the standard test bacterial strains, and further demonstrates an exceptionally high bacterial kill of 99.99 % to 100 %.

Table 3

[0075] Further, the bactericidal, yeasticidal and fungicidal activity of the present composition on non-porous hard surfaces was assessed following the European suspension standard test BS EN13697. BS EN 13697 is a phase 2 step 2 carrier test performed on surface disinfectants intended for use without mechanical action in medical area, food, industrial, domestic, and institutional areas to test the efficacy of the product against bacteria and /or fungi and /or yeast. The European suspension standard test BS EN13697 is performed to determine the antibacterial and the antifungal activity of a chemical formulation or products thereof to form a homogenous, physically stable preparation for ready to use purpose. BS EN 13697 was performed to assess the bactericidal, fungicidal and yeasticidal activity on hard non-porous surfaces, of the representative composition disclosed herein. The anti- bacterial activity against a set of 4 standard bacterial strains Escherichia coli ATCC 10536, Staphylococcus aureus ATCC 6538, Enterococcus hirae ATCC 10541, and Pseudomonas aeruginosa ATCC 15442 were determined. The anti-yeast and anti- fungal activity against two most commonly encountered disease-causing species Candida albicans ATCC 10231 and Aspergillus brasiliensis ATCC 16404 respectively, were also determined based on log reduction values obtained in the viable counts.

[0076] Table 4 presents antimicrobial data as per EN13697, against a set of 4 standard bacterial strains Escherichia coli ATCC 10536, Staphylococcus aureus ATCC 6538, Enterococcus hirae ATCC 10541, and Pseudomonas aeruginosa ATCC 15442 with the representative composition- 1 of the surface cleaner. The test results obtained clearly demonstrate a >4 log reduction for all the standard test bacterial strains and further demonstrates an exceptionally high kill of 99.99 % to 100 %.

Table 4

[0077] Table 5 represents the results obtained using the representative surface cleaning composition- 1 on the Candida albicans ATCC 10231 (yeast) and Aspergillus brasiliensis ATCC 16404 (fungus) strains, as per EN 13697, expressed in terms of log reduction and % kill. The data in Table 5 clearly shows greater than 3 log reduction or greater than 99.9% kill for the standard yeast and greater than 2 log reduction or greater than 99 % kill for the standard fungi test organism.

Table 5

[0078] The representative composition- 1 of the present disclosure was also assessed for its antiviral efficacy against Escherichia MS2 enveloped virus. Escherichia MS2 is a non-enveloped, icosahedral virus which lacks a lipid envelope. As a result, MS2 is generally resistant to chemical disinfectants and is also able to withstand several environmental stressors like temperature changes, desiccation, and osmotic pressure. MS2 is therefore generally considered more resistant to inactivation than enveloped viruses, but is more sensitive to inactivation than other small non-enveloped viruses, hence, was used as a viral representative for screening of antiviral efficacy. The present composition when challenged with MS2 demonstrate more than 99% antiviral activity against MS2. Such data promises good results when the antiviral efficacy tests are carried out against the widespread pandemic causing coronavirus. Surprisingly, the present composition, optionally comprising thymol, also exhibited appreciable antiviral efficacy against coronavirus.

EXAMPLE 3

Preparation of cleaning composition-!

[0079] A surface cleaning composition-2 including thymol (EPA registered) as the active of essential oil was prepared as per the present disclosure. To prepare the composition a series of steps were followed. All the components as disclosed in Table 6 were included in the composition according to the weight ranges as mentioned. The weight percentages mentioned in the below table were calculated with respect to the total weight of the composition.

Table 6

[0080] A mixture of quaternary ammonium compounds comprising 0.1 % (w/w) of alkyl dimethyl benzyl ammonium chloride, 0.1 % (w/w) of octyl decyl dimethyl ammonium chloride, 0.05 % (w/w) of di decyl dimethyl ammonium chloride, and 0.2 % (w/w) of di octyl dimethyl ammonium chloride, a solution of surfactants comprising 0.5 % (w/w) of lauryl amine oxide and 0.5 % (w/w) of alcohol ethoxylate, 0.3 % (w/w) of acrylic acid homopolymers or copolymers, and 2 % (w/w) of disodium salt of EDTA were mixed in demineralized water (DM) so as to completely dissolve all the components added and obtain a reaction mixture. To this reaction mixture, a blend of 2.0 % (w/w) of dipropylene glycol n-butyl ether and 0.2 % (w/w) of hydroxy dichlorodiphenyl ether was added followed by addition of 3.0 % (w/w) of triethanolamine, 0.3 % (w/w) of sodium metasilicate pentahydrate, 0.05 % (w/w) of thymol, 0.01 % (w/w) of butylated hydroxy toluene, and 0.3 % of perfume. All the components were mixed well for complete dissolution to obtain the composition of the present disclosure. Sodium metasilicate pentahydrate buffered the pH of the composition between 9.0 to 9.5.

EXAMPLE 4

Preparation of cleaning composition-3 and the assessment for antimicrobial and cleaning efficacy

[0081] In an example, a surface cleaning composition-3 as per the present disclosure was prepared by following a series of steps carried out at room temperature (25°C) and atmospheric pressure. The mixing speed was maintained between 25-180 rpm. All the components as disclosed in Table 7 were included in the composition according to the weight ranges as mentioned. The weight percentages mentioned in the below table were calculated with respect to the total weight of the composition. The cleaning composition was prepared by the process of the present disclosure, as described in Example 1. The pH of the composition was adjusted between 9.0 to 9.5.

Table 7

[0082] The composition-3 was subjected to various tests and analysis to assess its antimicrobial efficacy and degreasing/cleaning efficacy when applied to hard surfaces, such as metal, glass, ceramics, and plastics. Antimicrobial efficacy assessment

[0083] The cleaning composition-3 was assessed for antibacterial, antifungal, and antiviral efficacy using standard tests. The bactericidal, yeasticidal and fungicidal activity of the composition-3 on non-porous hard surfaces was assessed using the European suspension standard test BS EN13697. [0084] BS EN 13697: Non-porous surface test for chemical disinfectant and antiseptics, is a phase 2 step 2 carrier test performed on surface disinfectants intended for use without mechanical action in medical area, food, industrial, domestic, and institutional areas to test the efficacy of the product against bacteria and /or fungi and /or yeast. The European suspension standard test BS EN 13697 is performed to determine the antibacterial and the antifungal activity of a chemical formulation or products thereof to form a homogenous, physically stable preparation for ready to use purpose. BS EN 13697 was performed to assess the bactericidal, fungicidal or yeasticidal activity on hard non-porous surfaces, of the composition-3 disclosed herein.

[0085] The antibacterial data of the composition-3 against a set of 4 standard bacterial strains Escherichia coli ATCC 10536, Staphylococcus aureus ATCC 6538, Enterococcus hirae ATCC 10541, and Pseudomonas aeruginosa ATCC 15442 was assessed with a contact time of five minutes. The test results in Table 8 clearly demonstrate a >5 log reduction for all the standard test bacterial strains and further demonstrate an exceptionally high kill of 99.999 % to 100 %. The composition-3 of the present disclosure passes the acceptance criteria of more than 4 log reduction for bacteria, as per EN 13697.

Table 8

[0086] The anti-yeast and anti-fungal activity against two most commonly encountered disease-causing species Candida albicans ATCC 10231 and Aspergillus brasiliensis ATCC 16404 respectively, were also analysed based on log reduction values in the viable counts obtained with a ten-minute contact time, as shown in Table 9. The data obtained clearly shows greater than 6 log reduction or greater than 99.9999% kill for the standard yeast and greater than 3 log reduction or greater than 99.9 % kill for the standard fungi test organism. Thus, the composition-3 of the present disclosure passes the acceptance criteria of more than 3 log reduction for fungicidal activity, as per EN 13697.

Table 9

[0087] The composition-3 was also assessed for its antiviral efficacy. The antiviral activity of the composition was assessed against Escherichia virus MS2 (MS2 bacteriophage). MS2 bacteriophage is a non-enveloped virus that is resistant to general chemical disinfectants, environmental stressors like temperature changes, desiccation, and osmotic pressure. The standard test performed to check the effectiveness of the composition against MS2 bacteriophage was EN 13697. The composition and MS2 bacteriophage were allowed ten-minute contact time.

[0088] Similarly, the antiviral activity of the composition-3 against Human Coronavirus 229E was also assessed with a contact time of ten minutes. Human coronavirus 229E (HCoV-229E) is a species of coronavirus which infects humans and bats. It is an enveloped, single-stranded RNA virus, which generally causes mild to moderate upper-respiratory tract illness.

[0089] The effectiveness of the composition against HCoV-229E was analyzed using EN 14476: 2019. The virucidal efficacy against MS2 and Human coronavirus 229E, of the composition-3 is shown in Table 10.

Table 10

Residual self-sanitizing activity assessment

[0090] The residual self-sanitizing activity determining the stability of the composition-3 performance was assessed using the standard test PAS 2424.

[0091] PAS 2424: It is a quantitative surface test for evaluation of residual antimicrobial (bactericidal and/or yeasticidal) efficacy of liquid chemical disinfectants on hard non-porous surfaces. The activity of composition or active substances is determined using the test under the conditions in which they are used in accordance with BS EN 13697.

[0092] The test was performed to determine the 24 hours residual antibacterial efficacy of the composition-3 of the present disclosure against a set of 4 standard bacterial strains Escherichia coli ATCC 10536, Staphylococcus aureus ATCC 6538, Enterococcus hirae ATCC 10541, and Pseudomonas aeruginosa ATCC 15442, where a ten-minute contact time was allowed. To pass the PAS 2424 test and to claim a disinfectant product, a log 3 reduction (99.9% kill) of the bacteria must be attained. The residual antibacterial data of the composition-3 is shown in Table 11.

Table 11

[0093] The antibacterial efficacy of the composition was also assessed under conditions of storage stability for nine weeks, under the conditions of 40 °C/ 80% relative humidity, and at room temperature, respectively. The 24 hours residual protection of the composition for a nine week stored sample is shown in Table 12.

Table 12

[0094] It is clear from the Tables 11 and 12 that the composition-3 of the present disclosure is surprisingly stable in its performance and provides 24 hours protection against microorganism like bacteria even with cleaning composition which have undergone 9 weeks of stability studies, on exposure to elevated storage conditions of temperature and humidity.

Cleaning efficacy assessment [0095] The cleaning efficacy of the surface cleaning composition-3 was assessed against soil, grease, and grime. To determine the effective removal of grease using the composition, the surface of a white or off-white glazed ceramic tile of dimension of 11.75 inch x 7.75 inch, was covered with 5 gm of grease composition. The grease composition comprised of 4.90 gm of edible oil and 0.1 gm of turmeric, imparting a yellowish to brown shade to the surface, as shown in Figure 1(a). The grease covered surface was left for a period of 30 hours.

[0096] The grease covered surface was then contacted with the surface cleaning composition of present disclosure using a pump spray. The pump spray delivered an average of 0.7310 gm of the composition per spray application. The total amount of composition required to clean 5 gm of grease was calculated to be 36.3 gm. The composition was left on the surface for a contact time of 5 minutes. The surface was then manually cleaned using a dry wipe and hard water, followed by air drying. The color of the surface returned to white or off white, and was very close to the original, as shown in Figure 1(b).

[0097] The cleaning effect was evident from the visual color difference between the original tile and greased tile cleaned after the application of composition-3. The difference was measured using reflectance spectroscopy to quantify the extent of cleaning of the soiled white tile after the application of the composition followed by water rinsing and dabbing the surface gently with a dry cloth. The reemission value of the original tile before and after the grease coating are 81.43 and 5.20, respectively. After the cleaning of the grease coated tile using the composition-3, the reemission value is 80.54. The small difference in reemission values confirm the cleaning effect of the composition of the present disclosure. The color difference between the original tile surface and greased tile after cleaning with the composition is very small (-0.818), which indicates that the composition of the present disclosure is highly efficient in removing grease from a hard nonporous surface, in addition to antimicrobial performance. EXAMPLE 5

Effect of components of surface cleaning composition on the antimicrobial efficacy [0098] The example involves the study of effect of components on the antimicrobial performance of the surface cleaning composition as prepared in Example 4. The study was performed using comparative compositions Cl, C2 and C3 prepared as per the prescribed weight ratio ranges in Table 13, to understand influence on the anti- microbial or germ kill properties of the cleaning compositions in relation to its activity against both Gram-positive and Gram-negative bacteria, yeasts, fungi and its virucidal efficacies. The cleaning compositions were prepared by the process of the present disclosure, as described in Example 1.

Table 13

[0099] The comparative compositions Cl, C2 and C3 were prepared by employing the same method as given in Example 4. However, the comparative composition Cl does not include the antimicrobial agent (hydroxy dichlorodiphenyl ether). Similarly, the comparative composition C2 is prepared without the chelating agent (EDTA disodium) and the comparative composition C3 does not include the polymer (acrylic acid homopolymers or copolymers).

Antimicrobial efficacy assessment of compositions Cl, C2 and C3

[0100] The cleaning composition Cl , C2, and C3 were assessed for antibacterial, antifungal, and antiviral efficacy as per the standard tests. The standard test performed to check the antimicrobial and/or disinfecting effectiveness of Cl , C2, and C3 were European suspension standard test BS EN 13697. BS EN 13697 is carrier test performed on surface disinfectants and it was performed to assess the bactericidal, fungicidal or yeasticidal activity on hard non-porous surfaces.

[0101] The antibacterial data of each of the comparative composition against a set of 4 standard bacterial strains Escherichia coli ATCC 10536, Staphylococcus aureus ATCC 6538, Enterococcus hirae ATCC 10541, and Pseudomonas aeruginosa ATCC 15442 was assessed with a contact time of five minutes, as shown in Table 14.

Table 14

[0102] The antiviral activity of the composition was assessed against Escherichia virus MS2 (MS2 bacteriophage) as shown in Table 15. MS2 bacteriophage is a non-enveloped virus that is resistant to general chemical disinfectants, environmental stressors like temperature changes, desiccation, and osmotic pressure. The standard test performed to check the effectiveness of the composition against MS2 bacteriophage was ASTM 2783. The composition and MS2 bacteriophage was allowed ten-minute contact time.

Table 15

[0103] It is observed that the virucidal efficacies of these three compositions against non-enveloped virus is more than 99.9 %.

[0104] The anti-yeast and anti-fungal activity of the compositions against Candida albicans ATCC 10231 and Aspergillus brasiliensis ATCC 16404 respectively, were analysed based on log reduction values in the viable counts obtained with a ten- minute contact time as per EN 13697, as shown in Table 16.

Table 16

[0105] As evident from data in Tables 14, 15, and 16, the composition Cl without the antimicrobial agent (hydroxy dichlorodiphenyl ether) while demonstrating good antibacterial and antiviral efficacy, exhibited weak antifungal efficacy. This indicates that there exists a synergism between the components of the present disclosure towards overall germ-kill efficacies, wherein the germ covers bacteria, virus, fungi, and yeast. Similarly, the composition C2 without the chelating agent (EDTA), although meeting the antibacterial and antiviral efficacy standard fell short of clearing the standard for efficacy against fungi. Thus, EDTA in the cleaning composition helps in enhancing the antimicrobial properties.

[0106] Composition C3 without the polymer also failed to exhibit antifungal efficacy. This shows that the combination of blend of antimicrobial quaternary ammonium compounds, hydroxy dichlorodiphenyl ether and EDTA in C3 did not clear the EN 13697 germ-kill assay for fungi, indicating the synergistic effect of polymer along with these components. Therefore, the above data demonstrates the criticality of each components of the surface cleaning composition of the present disclosure, wherein each component work synergistically in conjunction with each other to provide surprising results in terms of overall antimicrobial activity. In other words, it is observed that the exclusion of even one of the ingredients from the cleaning composition, results in overall efficacies compromised against fungi.

[0107] Overall, the above examples clearly illustrate the surprising activity of the surface cleaning composition-3 of Example 4, in terms of high overall antimicrobial efficacy against germs, such as bacteria, yeast, fungi and viruses, when the surface cleaning composition is sprayed and left to stand on hard nonporous surfaces for ten minutes. The composition additionally provides protection against germs for 24 hours and a performance stability for a period of at least 9 weeks.

ADVANTAGES OF THE PRESENT DISCLOSURE

[0108] The above-mentioned implementation examples as described on this subject matter and its equivalent thereof have many advantages, including those which are described.

[0109] The present disclosure discloses a composition for the purpose of cleaning contaminated hard surfaces and shows efficacy over a wide range of disease-causing microbes including Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Enterococcus hirae, Candida albicans and Aspergillus brasiliensis . The composition described in the present disclosure comprises a combination of quaternary ammonium compounds and antimicrobial agent along with a film forming polymer which together impart a synergistic effect to the overall antimicrobial efficacy, with an excellent outcome of above 99.9%' kill rate. The specific combination of the quaternary ammonium compounds and antimicrobial agent with the surfactants and along with film forming polymers further provides an instantaneous action against the germs within 10 minutes of contact application and also offers up to 24-hours of residual self sanitization on hard non-porous surfaces by virtue of germ killing efficiency. Further, the composition can be effectively used to disinfect all the commonly used, both flat and curved surfaces, such as glass, plastics, ceramics, or metals. It also effectively removes soil, grease and grime attached to a surface. The components included in the proposed composition are abundantly available and inexpensive and the process of its preparation is also quite simple and rapid. Hence, the composition of the present disclosure is an ideal candidate to replace the existing cleaning products available in the market. A unique feature of this water-based composition is the assurance of an up to 24-hour germ protection on hard surfaces post application, which is normally not exhibited by the conventional spray cleaners available in market.

Claims

I/We Claim:

1. A surface cleaning composition comprising:

(a) one or more quaternary ammonium compound;

(b) an antimicrobial agent;

(c) a surfactant;

(d) a polymer; and

(e) a chelating agent, wherein the one or more quaternary ammonium compound and the antimicrobial agent is in the weight ratio range of 1: 100 to 100:1.

2. The composition as claimed in claim 1, wherein the one or more quaternary ammonium compound and the antimicrobial agent is in the weight ratio range of 1: 10 to 10:1.

3. The composition as claimed in claim 1, wherein the one or more quaternary ammonium compound is selected from alkyl dimethyl benzyl ammonium chloride, octyl decyl dimethyl ammonium chloride, di decyl dimethyl ammonium chloride, di octyl dimethyl ammonium chloride, alkyl dimethyl ethyl benzyl ammonium chloride, or combinations thereof; the antimicrobial agent is selected from hydroxy dichlorodiphenyl ether, trichlorocarbanilide, chloro xylenol, bromo nitro propanediol, chloro cresols, polychloro hydroxy phenolic compounds, or combinations thereof; the surfactant is selected from lauryl amine oxide, alcohol ethoxylate, lauryl myristyl amine oxide, cocoamidopropyl amine oxide, cocoamidopropyl betaine, coco betaine, hydroxysultaines, alcohol ethoxylate propoxylates, nonyl phenol ethoxylates, or combinations thereof; the polymer is selected from acrylic acid homopolymers or copolymers, methacrylic acid derivatives, polyvinyl pyrrolidone, polyvinyl alcohol, hydroxyethyl cellulose, hydroxypropyl methyl cellulose, or combinations thereof; and the chelating agent is selected from ethylenediaminetetraacetic acid (EDTA) disodium, EDTA tetrasodium, 1- hydroxyethylidene- 1 , 1 -diphosphomc acid (HEDP), diethylenetriamine penta(methylene phosphonic acid) (DTPMP), ethylenediamine tetra(methylene phosphonic acid) (EDTMP), diethylenetriaminepentaacetic acid (DTPA), sodium gluconate, methylglycinediacetic acid sodium salt, or combinations thereof. The composition as claimed in claim 1, wherein the composition further comprises a pH stabilizer, a corrosion inhibitor, a high boiling point solvent, an antioxidant, a perfume, and optionally an active of essential oil. The composition as claimed in claim 4, wherein the pH stabilizer is selected from triethanolamine, monoethanolamine, diethanolamine, sodium bicarbonate, sodium carbonate, potassium carbonate, sodium hydroxide, or combinations thereof; the corrosion inhibitor is selected from sodium metasilicate pentahydrate, sodium silicate, sodium metasilicate nonahydrate, or combinations thereof; the high boiling point solvent is selected from glycol ethers, methyl alcohol, ethyl alcohol, isopropyl alcohol, benzyl alcohol, or combinations thereof; the antioxidant is selected from butylated hydroxy toluene, butylated hydroxy anisole, benzophenone-3, benzophenone-4, or combinations thereof; and the active of essential oil selected from thymol, eugenol, menthol, geraniol, verbenone, eucalyptol, pinocarvone, cedrol, anethol, carvacrol, hinokitiol, berberine, ferulic acid, cinnamic acid, methyl salicylic acid, methyl salicylate, terpineol, or combinations thereof. A surface cleaning composition comprising:

(a) one or more quaternary ammonium compound is a combination of alkyl dimethyl benzyl ammonium chloride, octyl decyl dimethyl ammonium chloride, di decyl dimethyl ammonium chloride, di octyl dimethyl ammonium chloride in the range of 0.04 % - 40.0 % (w/w);

(b) an antimicrobial agent is hydroxy dichlorodiphenyl ether in the range of 0.01 % - 10.0 % (w/w); (c) a surfactant is a combination of lauryl amine oxide and alcohol ethoxylate in the range of 0.02 % - 20.0 % (w/w);

(d) a polymer is acrylic acid copolymer in the range of 0.01 % - 10.0 % (w/w); and

(e) a chelating agent is EDTA disodium powder in the range of 0.01 % - 5.0 % (w/w); wherein the one or more quaternary ammonium compound and the antimicrobial agent is in the weight ratio range of 1 : 100 to 100: 1.

7. A surface cleaning composition comprising:

(b) an antimicrobial agent is hydroxy dichlorodiphenyl ether in the range of 0.01 % - 10.0 % (w/w);

(c) a surfactant is a combination of lauryl amine oxide and alcohol ethoxylate in the range of 0.02 % - 20.0 % (w/w);

(d) a polymer is acrylic acid copolymer in the range of 0.01 % - 10.0 % (w/w);

(e) a chelating agent is EDTA disodium powder in the range of 0.01 % - 5.0 % (w/w);

(f) an active of essential oil is thymol in the range of 0.0 % - 5.0 % (w/w);

(g) a pH stabilizer is triethanolamine in the range of 0.01 % - 5.0 % (w/w);

(h) a corrosion inhibitor is sodium metasilicate pentahydrate in the range of 0.01 % - 5.0 % (w/w);

(i) a high boiling point solvent is glycol ethers in the range of 1.0 % - 3.0 % (w/w); (j) an antioxidant is butylated hydroxy toluene in the range of 0.0 % - 5 % (w/w);

(k) a perfume in the range of 0.2 % to 0.6 % (w/w); and

(l) water (q.s), wherein the one or more quaternary ammonium compound and the antimicrobial agent is in the weight ratio range of 1 : 100 to 100: 1.

8. A process of preparing the surface cleaning composition as claimed in claim 1, the process comprising:

(a) mixing the one or more quaternary ammonium compound, the surfactant, the polymer, the chelating agent, and water to obtain a reaction mixture;

(b) dissolving the antimicrobial agent in the high boiling point solvent to obtain a blend; and

(c) contacting the reaction mixture, the blend, the pH stabilizer, the antioxidant, the corrosion inhibitor, the perfume, and optionally the active of essential oil to obtain the composition, wherein the one or more quaternary ammonium compound and the antimicrobial agent is in the weight ratio range of 1: 100 to 100:1.

9. The composition as claimed in claim 1, for use in cleaning hard surface.

10. The composition as claimed in claim 9, wherein the surface is hard and non- porous, and selected from glass, plastics, ceramics, or metals.

11. The composition as claimed in claim 1, for use in germ kill, comprising killing or inhibiting the growth of a microorganism.

12. The composition as claimed in claim 11, wherein the composition provides sanitization of surface for up to 24 hours post treatment.

13. The composition as claimed in claims 11, wherein the microorganism is selected from bacteria, virus, and fungi.

14. The composition as claimed in claim 13, wherein the virus is an enveloped or a non-enveloped virus; and the enveloped or non-enveloped virus is selected from influenza virus, coronavirus, adenovirus, poliovirus, rotavirus, or murine virus. 15. Use of the composition as claimed in any one of the claims 1 - 7 as surface cleaner, wherein, the surface is hard and non-porous, and selected from glass, plastics, ceramics, or metals.

16. Use of the composition as claimed in any one of the claims 1 - 7 for germ kill, comprising killing or inhibiting the growth of a microorganism, wherein the microorganism is selected from bacteria, virus, and fungi.

17. Use of the composition as claimed in claim 16, wherein the virus is an enveloped or a non-enveloped virus; and the enveloped or non-enveloped virus is selected from influenza virus, coronavirus, adenovirus, poliovirus, rotavirus, or murine virus.