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WO2022035334A3 - Procédé d'obtention d'aprotinine et produit obtenu à partir de celui-ci - Google Patents

Procédé d'obtention d'aprotinine et produit obtenu à partir de celui-ci Download PDF

Info

Publication number
WO2022035334A3
WO2022035334A3 PCT/PL2021/050058 PL2021050058W WO2022035334A3 WO 2022035334 A3 WO2022035334 A3 WO 2022035334A3 PL 2021050058 W PL2021050058 W PL 2021050058W WO 2022035334 A3 WO2022035334 A3 WO 2022035334A3
Authority
WO
WIPO (PCT)
Prior art keywords
aprotinin
obtaining
lung tissue
bovine lung
ultrafiltration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/PL2021/050058
Other languages
English (en)
Other versions
WO2022035334A2 (fr
Inventor
Grzegorz CIURA
Magdalena MATWIEJCZYK
Monika BESMAN
Filip Porzucek
Konrad BABIJ
Michał LOBOCKI
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmfactor Sp Z OO
Original Assignee
Pharmfactor Sp Z OO
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmfactor Sp Z OO filed Critical Pharmfactor Sp Z OO
Publication of WO2022035334A2 publication Critical patent/WO2022035334A2/fr
Publication of WO2022035334A3 publication Critical patent/WO2022035334A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • C07K14/8117—Bovine/basic pancreatic trypsin inhibitor (BPTI, aprotinin)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Peptides Or Proteins (AREA)
  • Steroid Compounds (AREA)

Abstract

L'invention a pour objet un procédé d'obtention d'aprotinine, en particulier à partir de poumons de bovins, comprenant séquentiellement les étapes de : broyage, extraction, centrifugation, microfiltration, chromatographie I, concentration I, relargage, filtration, ultrafiltration I, chromatographie II, ultrafiltration II, concentration II, ultrafiltration III, lyophilisation, lavage. L'invention a également pour objet le produit obtenu par le procédé.
PCT/PL2021/050058 2020-08-13 2021-08-11 Procédé d'obtention d'aprotinine et produit obtenu à partir de celui-ci Ceased WO2022035334A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PL434960A PL434960A1 (pl) 2020-08-13 2020-08-13 Sposób otrzymywania aprotyniny oraz produkt otrzymany tym sposobem
PLP.434960 2020-08-13

Publications (2)

Publication Number Publication Date
WO2022035334A2 WO2022035334A2 (fr) 2022-02-17
WO2022035334A3 true WO2022035334A3 (fr) 2022-03-31

Family

ID=77989964

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/PL2021/050058 Ceased WO2022035334A2 (fr) 2020-08-13 2021-08-11 Procédé d'obtention d'aprotinine et produit obtenu à partir de celui-ci

Country Status (2)

Country Link
PL (1) PL434960A1 (fr)
WO (1) WO2022035334A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115259367B (zh) * 2022-07-26 2023-11-17 上海净豚环保科技有限公司 一种食品废水用厌氧颗粒污泥的增殖培菌的方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006042327A2 (fr) * 2004-10-12 2006-04-20 Large Scale Biology Corporation Aprotinine de recombinaison d'origine vegetale et variants d'aprotinine

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006042327A2 (fr) * 2004-10-12 2006-04-20 Large Scale Biology Corporation Aprotinine de recombinaison d'origine vegetale et variants d'aprotinine

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
META A ET AL: "High-yield production and characterization of biologically active recombinant aprotinin expressed in Saccharomyces cerevisiae", PROTEIN EXPRESSION AND PURIFICATION, ACADEMIC PRESS, SAN DIEGO, CA, vol. 66, no. 1, 1 July 2009 (2009-07-01), pages 22 - 27, XP026034147, ISSN: 1046-5928, [retrieved on 20090220], DOI: 10.1016/J.PEP.2009.02.005 *
SIEKMANN J ET AL: "PYROGLUTAMYLAPROTININ A NEW APROTININ HOMOLOGUE FROM BOVINE LUNGS ISOLATION PROPERTIES SEQUENCE ANALYSIS AND CHARACTERIZATION USING PROTON NMR IN SOLUTION", BIOLOGICAL CHEMISTRY HOPPE-SEYLER, vol. 368, no. 12, 1987, pages 1589 - 1596, XP055873843, ISSN: 0177-3593 *
XIN YU ET AL: "Affinity purification of aprotinin from bovine lung : Liquid Chromatography", JOURNAL OF SEPARATION SCIENCE, vol. 38, no. 9, 1 May 2015 (2015-05-01), DE, pages 1441 - 1448, XP055786553, ISSN: 1615-9306, DOI: 10.1002/jssc.201401188 *

Also Published As

Publication number Publication date
WO2022035334A2 (fr) 2022-02-17
PL434960A1 (pl) 2022-02-14

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