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WO2022015138A1 - Agent antiseptique déposable par aspersion ou inhalation dans le système du tractus respiratoire inférieur - Google Patents

Agent antiseptique déposable par aspersion ou inhalation dans le système du tractus respiratoire inférieur Download PDF

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Publication number
WO2022015138A1
WO2022015138A1 PCT/MX2020/050020 MX2020050020W WO2022015138A1 WO 2022015138 A1 WO2022015138 A1 WO 2022015138A1 MX 2020050020 W MX2020050020 W MX 2020050020W WO 2022015138 A1 WO2022015138 A1 WO 2022015138A1
Authority
WO
WIPO (PCT)
Prior art keywords
antiseptic agent
respiratory tract
antiseptic
lower respiratory
iodine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/MX2020/050020
Other languages
English (en)
Spanish (es)
Inventor
Héctor SILVA CASTRO
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to PCT/MX2020/050020 priority Critical patent/WO2022015138A1/fr
Publication of WO2022015138A1 publication Critical patent/WO2022015138A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics

Definitions

  • antiseptics are well known and used to disinfect various surfaces, including skin surfaces, however, antiseptics have not been used to reach the lower tract of the respiratory system reaching the alveoli and disinfecting the outer surface of the lungs , on the other hand, multiple devices have been used to introduce medications into the body that can reach the respiratory tract system, such as inhalation devices, ultrasound inhalation, vaporization or aerosols, so that the medication is pulverized to a very small size for that can reach the respiratory tract.
  • inhalation devices such as inhalation devices, ultrasound inhalation, vaporization or aerosols
  • CN205569364 refers to a medical fixation device for disinfection, made up of a bottle that in its upper part provides an entry of antiseptic and inhalable solution through the head of the phlegm tube that is inserted into the mouth, the bottom of the bottle is provided with the antiseptic from which the solution is drawn, and the outlet of the antiseptic solution is provided with the shut-off valve, depending on whether it is opened or closed.
  • ES2325951 discloses a dosage device for topically administering a pharmaceutical formulation to the skin of a mammal, the device comprises a casing capable of containing at least one unit dose of a pharmaceutical formulation comprising a drug and a vehicle; an applicator adapted for topical administration; applying a unit dose of the pharmaceutical formulation directly to the skin; and an actuator, in which after activation, the device is capable of measuring a unit dose of the pharmaceutical formulation external to the device, from the housing to the applicator.
  • JP2009526064 discloses a medicament including a solution containing pleconaril or a pharmaceutically acceptable salt thereof, wherein at least one solvent comprising said solution is a glyceride oil dissolving pleconaril, and the solution is suitable for administration by inhalation as an aerosol mist.
  • US6196218 this document relates to an inhaler that provides a controlled delivery of an inhalant and includes an inhaler housing and a mouthpiece attached to the inhaler housing, a piezoelectric dispensing head is attached to the inhaler housing and configured to engage the chamber dispensing, the piezoelectric dispensing head includes a number of delivery channels and a number of delivery nozzles, the set of delivery channels are formed with actuatable walls made at least partially of a piezoelectric material, the application of an electric field to the walls Selected laterals reduce a volume in an associated channel and create a pressure pulse of fluid substance in the associated channel through a dispensing nozzle.
  • Document GB179142 refers to a device to allow the inhalation of gas that has a powder in suspension, preferably a calcareous salt, comprises a cylindrical body, formed with one or more air inlet openings, and provided with a cover provided with a electric lamp or other means of heating, in front of the body and separated from it by a partition is a chamber in which is mounted a rotating brush adapted to be operated by hand or otherwise, above the chamber the cover is equipped with an inhalation mouthpiece and a joint piece is also installed, which allows the device to be connected to an antiseptic gas reservoir, in operation, the air passing through the openings is heated by the lamp and passes into the mouthpiece, joining in its passage through the reservoir gas, the release of the brush bristles throws the powder previously placed on the brush or fed onto the brush and the emission gas carries it to cape.
  • a powder in suspension preferably a calcareous salt
  • CN101528290 discloses an actuator for an inhaler for administering drug by inhalation, comprising a casing for receiving a canister comprising a body including a base and a head and defining a chamber for containing the drug and a valve stem extending from the body and from which the administered drug is used by actuating the canister, an outlet through which an in-use user inhales, and a mouthpiece assembly providing drug delivery through the outlet, wherein the mouthpiece assembly nozzle comprises a nozzle block for receiving the valve stem of the container as a separately formed component, a nozzle outlet that is fluidly connected to the nozzle block and includes an outlet port through which the medicament is delivered in use
  • Suspension formulations include aqueous suspensions, pharmaceutical particles, and optionally suspending agents, antiseptics, wetting agents, and antiseptic agents. ionicity adjustment.
  • the present invention relates to an antiseptic agent that can be deposited by spraying or inhalation orally or nasally for deposition in the lower respiratory tract system, comprising an apparatus chosen from an inhaler device with a pressurized cartridge, a fine mist inhaler device, an inhaler device of dry powder, a nebulization device, a vaporization device, an ultrasonic nebulizer device, a pneumatic or jet-type nebulizer device, capable of storing an antiseptic composition with at least one dose of multi-particles of an antiseptic formulation, it being understood that when This antiseptic is used on skin, disinfectants are for another type of surface, the antiseptic used is to disinfect at least part of the lower respiratory tract system, reaching the reservoir of infection in the lower respiratory tract system, distributing said device after the actuation of at least one predetermined dose rminated of said multi-particles, the predetermined dose being distributed from the device substantially by spray, in which said antiseptic particles have an average diameter of less than 5
  • Said antiseptic agent is broad-spectrum, acting against viruses or bacteria, helping in the infection phase, this antiseptic agent is preferably of low toxicity that can be absorbed by the human body without toxic damage to treat lung infections and where the antiseptic composition is of low moderate irritability being below 8.9 as the test methodology Hen 's egg.
  • the antiseptic composition used contains antiseptics of low toxicity and moderate, slight to no irritation reaction, cataloged based on the methodology of the mucosal irritation test with chorioallantoic membrane. hen egg or test Hen 's egg chorioallantoic membrane test on (HETCAM) applied within 5 minutes. Where the semi quantitative irritability values according to Spielmann thrown by the test are considered below 8.9, so that they do not cause severe irritation in the lungs.
  • the particle size of a composition determines whether the composition can reach the lungs or not, since if the particle size is greater than 5 pm, the particles have strong inertia, so they are deposited in the nasopharynx and epiglottis by turbulent flow, are responsible for systemic effects.
  • the particle size is less than 5 pm, they have little inertia, and the particles are deposited in the lower respiratory tract by means of a laminar flow.
  • the antiseptic agent used is chosen from oxidants such as hydrogen peroxide below 2 percent, chloramine, acid hypochlorous or potassium permanganate; acids and alkalis such as lactic acid, citric acid, ascorbic acid, acetic acid, sodium hydroxide, chlorine dioxide; heavy metals such as silver nitrate, silver sulfadiazine, silver sulfate, merbromine[(2'7'-Dibromo-3',6'-dihydroxy-3-oxospiro[isobenzofuran- (3H),9'-[9H]xanthen] -4'-yl)hydroxy
  • antiseptic agents were chosen because they are of low toxicity, which also depends on the concentration of the antiseptic agent, and low to moderate irritability, and many of them can be naturally absorbed by the body into the blood or naturally disposed of. , without causing severe damage to the user, the invention therefore focuses on the combination of a device capable of dispersing orally or nasally an antiseptic agent of those mentioned above with a particle size of less than 5 pm so that it is deposited in the tract lower respiratory tract, and more specifically reaching the reservoir of infection in the lower respiratory tract, such as the lungs and alveoli.
  • the antiseptic agent is ethyl alcohol or citric acid or ascorbic acid or lactic acid or contains iodine (iodinated), it is absorbed and/or discarded naturally by the patient's body, since these components are included in the body of the patient, such as in the blood, naturally or they may be contained in the body of the patient and be disposed of naturally.
  • Another object of the present invention is an antiseptic agent depositable by spraying or inhalation in the lower respiratory tract system for use in the treatment of the lungs.
  • kits for applying an antiseptic agent in the lower respiratory tract system consisting of a device chosen from a pressurized cartridge inhaler device, a fine mist inhaler device, a dry powder inhaler device , a nebulizing device, a vaporizing device, an ultrasonic nebulizing device, or a pneumatic or jet-type nebulizing device, containing at least one dose of an antiseptic agent, for delivering the antiseptic when actuated by means of an actuator.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Organic Chemistry (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention porte sur la combinaison d'un dispositif capable de disperser par voie orale ou nasale, un agent antiseptique à faible toxicité et à irritabilité faible ou modérée avec une granulométrie inférieure à 5 μm pour qu'il se dépose dans le tractus respiratoire inférieur, comme dans la trachée, les bronches, les poumons et les alvéoles, arrivant au réservoir de l'infection, lequel dispositif est sélectionné entre un dispositif d'inhalation avec cartouche sous pression, un dispositif d'inhalation à brouillard fin, un dispositif d'inhalation de poudre sèche, un dispositif de nébulisation, un dispositif de vaporisation, un dispositif de nébulisation par ultrasons ou un dispositif de nébulisation pneumatique ou du type à jet.
PCT/MX2020/050020 2020-07-16 2020-07-16 Agent antiseptique déposable par aspersion ou inhalation dans le système du tractus respiratoire inférieur Ceased WO2022015138A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/MX2020/050020 WO2022015138A1 (fr) 2020-07-16 2020-07-16 Agent antiseptique déposable par aspersion ou inhalation dans le système du tractus respiratoire inférieur

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/MX2020/050020 WO2022015138A1 (fr) 2020-07-16 2020-07-16 Agent antiseptique déposable par aspersion ou inhalation dans le système du tractus respiratoire inférieur

Publications (1)

Publication Number Publication Date
WO2022015138A1 true WO2022015138A1 (fr) 2022-01-20

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/MX2020/050020 Ceased WO2022015138A1 (fr) 2020-07-16 2020-07-16 Agent antiseptique déposable par aspersion ou inhalation dans le système du tractus respiratoire inférieur

Country Status (1)

Country Link
WO (1) WO2022015138A1 (fr)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB763168A (en) * 1953-12-31 1956-12-12 Abbott Lab Inhalant preparation
KR20060109097A (ko) * 2005-04-15 2006-10-19 양원동 기능성 코 흡입기
US20080195033A1 (en) * 2004-11-23 2008-08-14 International Bio-Therapeutic Research Inc. Method of Delivery of Therapeutic Metal Ions, Alloys and Salts
US20100224185A1 (en) * 2006-08-22 2010-09-09 Glaxo Group Limited Actuator for an inhaler
US20110262420A1 (en) * 2008-12-03 2011-10-27 Ltt Bio-Pharma Co., Ltd. Inhalant comprising modified superoxide dismutase

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB763168A (en) * 1953-12-31 1956-12-12 Abbott Lab Inhalant preparation
US20080195033A1 (en) * 2004-11-23 2008-08-14 International Bio-Therapeutic Research Inc. Method of Delivery of Therapeutic Metal Ions, Alloys and Salts
KR20060109097A (ko) * 2005-04-15 2006-10-19 양원동 기능성 코 흡입기
US20100224185A1 (en) * 2006-08-22 2010-09-09 Glaxo Group Limited Actuator for an inhaler
US20110262420A1 (en) * 2008-12-03 2011-10-27 Ltt Bio-Pharma Co., Ltd. Inhalant comprising modified superoxide dismutase

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