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WO2022000038A1 - Agent hydratant antimicrobien et désinfectant pour les mains, le visage et le corps - Google Patents

Agent hydratant antimicrobien et désinfectant pour les mains, le visage et le corps Download PDF

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Publication number
WO2022000038A1
WO2022000038A1 PCT/AU2021/050702 AU2021050702W WO2022000038A1 WO 2022000038 A1 WO2022000038 A1 WO 2022000038A1 AU 2021050702 W AU2021050702 W AU 2021050702W WO 2022000038 A1 WO2022000038 A1 WO 2022000038A1
Authority
WO
WIPO (PCT)
Prior art keywords
composition
zinc
hinokitiol
face
hand
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/AU2021/050702
Other languages
English (en)
Inventor
Dalia Mizikovsky
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astivita Ltd
Advance Nanotek Ltd
Original Assignee
Astivita Ltd
Advance Nanotek Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2020902203A external-priority patent/AU2020902203A0/en
Application filed by Astivita Ltd, Advance Nanotek Ltd filed Critical Astivita Ltd
Publication of WO2022000038A1 publication Critical patent/WO2022000038A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N35/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical
    • A01N35/06—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical containing keto or thioketo groups as part of a ring, e.g. cyclohexanone, quinone; Derivatives thereof, e.g. ketals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
    • A01N59/16—Heavy metals; Compounds thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
    • A01P1/00—Disinfectants; Antimicrobial compounds or mixtures thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/30—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/27—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/35—Ketones, e.g. benzophenone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/007—Preparations for dry skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/10—General cosmetic use

Definitions

  • the present invention relates to the field of moisturising hand, face and body sanitizing products. Specifically, it relates to a moisturising, alcohol-free, antimicrobial composition which can be safely and routinely used for maintaining appropriate hand, face and body hygiene.
  • sanitizing hand-rubs have been utilised.
  • the most common sanitizing compositions utilise a high percentage (> 60%) of alcohol as the main disinfectant agent.
  • these compositions can further dry the skin, and lead to irritant contact dermatitis in some individuals.
  • alcohol-based sanitisers are only effective for the duration that the product remains on the skin.
  • non-alcohol-based products use two categories of active ingredients: benzalkonium chloride and herbal extracts. Although benzalkonium chloride compositions have been shown to be as effective as alcohol-based hand rubs, the chemical has been linked to both irritant and allergic contact dermatitis.
  • Herbal hand sanitizers although less harsh, have been shown to have significantly reduced antimicrobial action compared to alcohol and benzalkonium chloride compositions. Many commercially available herbal sanitisers either contain alcohol or fail to show their anti-microbial data.
  • US Patent Publication No. 20200078281 discloses a personal rinse-off cleansing composition containing Hinokitiol and a 2-pyridinol-N-oxide.
  • the composition is suggested for direct use or for use as a preserving agent.
  • US Patent Publication No. 20150173355A1 details a non-aqueous antimicrobial composition comprising hinokitiol with 1,3-Propanediol or Sorbitan Caprylate.
  • the composition is for use in a variety of personal care and disinfectant solutions.
  • US Patent Publication No. 20030083212 discloses a waterless antimicrobial hand-cleanser that should be wiped off or rinsed off after use.
  • the composition may utilise a number of natural essential oils, in one embodiment containing hinokitiol.
  • the present invention provides a moisturising, hand face and body sanitizing composition for maintaining general hygiene, comprising at least one zinc compound or at least one zinc salt and hinokitiol or a salt thereof in an oil-based emulsion.
  • At least one zinc compound or at least one zinc salt may be selected from one or more of zinc chloride, zinc oxide, zinc myristate, zinc citrate, zinc nitrate, or zinc sulfate, zinc chlorate, zinc phosphate, zinc molybdate, zinc chromate, zinc bromide and zinc iodide.
  • Other zinc salts that are non-toxic may also be used.
  • the zinc salts may be inorganic salts or organic salts.
  • the composition comprises an effective amount of at least one zinc compound or at least one zinc salt and hinokitiol.
  • the weight ratio of the zinc compound and/or zinc salt and the hinokitiol and salts thereof is within the range of 30:1 to 1:1.
  • the composition of the present invention is expected to show broad spectrum antimicrobial properties.
  • the composition is also moisturising to the skin of the hands, face and body.
  • the composition is also expected to persist on the skin after immediate application, and to continue exerting antimicrobial effect.
  • the composition of the present invention is suitable for use in hand, face and body sanitizing and moisturising products, otherwise known as sanitizing hand rub, hand antiseptic, or hand-rub and face creams and body wash or body creams. Products containing this composition may be used regularly and frequently, for extended time-periods without experiencing any adverse effects.
  • composition exploits the combinatorial effect of zinc compounds and hinokitiol to achieve a highly effective hand, face and body sanitizing composition. Both compounds possess individual antimicrobial activities. However, the synergistic interaction between the compounds leads to greatly enhanced antimicrobial action. Additionally, the synergistic interaction creates anti- viral activity, an effect unobserved in the individual compounds.
  • hinokitiol Any therapeutically acceptable salt of hinokitiol or any pharmaceutically acceptable salt of hinokitiol may be used in the present invention. However, preferred embodiments may use hinokitiol.
  • the IUPAC name of hinokitiol is 2-Hydroxy-6-propan-2- ylcyclohepta-2,4,6-trien- 1-one.
  • the present invention provides a method for hand, face and body sanitization without causing irritation or dryness.
  • the composition may comprise a sanitizing hand, face and body mb which may be used by rubbing it onto the hands, face and body.
  • the present invention is not limited by the dispenser in which it is stored or used.
  • the composition has an SPF of greater than 15, or greater than 30, or between 40 and 80, or between 45 and 70, or about 50.
  • the composition includes zinc oxide and the composition has an SPF of greater than 15, or greater than 30, or between 40 and 80, or between 45 and 70, or about 50.
  • the composition of the present invention comprises 13-17% of a mixture of one or more of Theobroma oil, Theobroma cocoa, Theobroma cocoa oil extract; 4-6% alumina powder, 7.5 to 12% zinc oxide, 0 to 12% of a mixture of onr or more of coco-caprylate/caprate and polyglyceryl-3 -polyricinoleate and isostearic acid, 0.1 tol% hinokitiol, 6-10% glycerin derived emulsifying oil, 53 to 58% water and 0.5 to 2% cetyl phosphate.
  • the water and cetyl phosphate may form the aqueous phase and the remaining ingredients may form the oil phase.
  • the composition of the present invention comprises 22 - 55% zinc oxide powder, 3-6% alumina powder, 4-7% jojoba oil, 1-2.5% candelilla wax, 0.1- l%hinokitiol, 9-13% glycerin, 0.5-2% maltodextrin and 26-30% water.
  • the zinc oxide powder may be added as ZinClear XP50, available from Advance Nanotek Pty Ltd.
  • the zinc oxide may be present in an amount of from 43 to 55%, or from 46 to 52%, or from 22 to 28%.
  • the zinc oxide, jojoba oil, candelilla wax and hinokitiol may form the oil phase and the remaining ingredients may form the aqueous phase.
  • the composition is comprised of hinokitiol and a zinc salt or zinc compounds, including but not limited to zinc chloride, zinc oxide, zinc nitrate, zinc chlorate, zinc sulfate, zinc phosphate, zinc molybdate and zinc chromate as the active antimicrobial compounds.
  • the compounds will be dispersed in a moisturizing emulsion (see example 1).
  • This composition may be used as a topically applied hand- sanitizing agent for broad anti-microbial action.
  • the composition would be safe for use on irritated and dried skin, in addition to sensitive skin, where the use of classic hand sanitizers is unadvisable.
  • the hand, face and body sanitizing composition will provide SPF of around 50 in addition to all qualities described previously.
  • the antimicrobial composition is prepared by mixing phase A components and heating the components to 55-60°C. Heat phase B components to same temperature. Combine phase A into phase B slowly, until no phase separation is visible.
  • Ainclear XP50 contains 50% by weight zinc oxide powder and is available form Advance nanotek Pty Ltd.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Organic Chemistry (AREA)
  • Environmental Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Plant Pathology (AREA)
  • Birds (AREA)
  • Pest Control & Pesticides (AREA)
  • Dentistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Agronomy & Crop Science (AREA)
  • Emergency Medicine (AREA)
  • Virology (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)

Abstract

Une intervention fréquente pour maintenir l'hygiène des mains, du visage et du corps est essentielle pour la lutte contre les infections et la prévention des infections respiratoires et gastro-intestinales communes. Cependant, des interventions courantes d'hygiène des mains, du visage et du corps telles que le lavage des mains, du visage et du corps, ainsi que les désinfectants à base d'alcool pour les mains, le visage et le corps assèchent et irritent la peau en cas d'utilisation fréquente et peuvent être inaccessibles pour les individus à la peau sensible ou fragilisée. La présente invention concerne une composition hydratante désinfectante pour les mains, le visage et le corps constituée d'un composé de zinc et d'hinokitiol, ou d'un sel de celui-ci. La composition est non irritante, non asséchante et sans danger pour une utilisation fréquente et cohérente.
PCT/AU2021/050702 2020-06-30 2021-06-30 Agent hydratant antimicrobien et désinfectant pour les mains, le visage et le corps Ceased WO2022000038A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AU2020902203 2020-06-30
AU2020902203A AU2020902203A0 (en) 2020-06-30 Sanitising antimicrobial hand, face and body moisturiser

Publications (1)

Publication Number Publication Date
WO2022000038A1 true WO2022000038A1 (fr) 2022-01-06

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PCT/AU2021/050702 Ceased WO2022000038A1 (fr) 2020-06-30 2021-06-30 Agent hydratant antimicrobien et désinfectant pour les mains, le visage et le corps

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WO (1) WO2022000038A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025003464A1 (fr) * 2023-06-30 2025-01-02 Dutch Renewable Energy B.V. Composition comprenant de l'hinokitiol et du sel de zinc destinée à être utilisée dans le traitement de l'herpès labial

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JPH0797309A (ja) * 1993-08-02 1995-04-11 Otsuka Pharmaceut Co Ltd メタロチオネイン誘導剤及びサンバーンセル産生抑制剤
JPH08208460A (ja) * 1995-02-01 1996-08-13 Otsuka Pharmaceut Co Ltd 抗炎症剤
US5696169A (en) * 1992-03-13 1997-12-09 Otsuka Pharmaceutical Co., Ltd. Antibacterial and antifungal activity method, therapeutic method of infectious diseases and preserving method of cosmetics
JP2002226383A (ja) * 2001-01-30 2002-08-14 Masashi Fujii 持続性広範囲抗微生物スペクトル皮膚外用剤
JP4423350B2 (ja) * 2003-06-13 2010-03-03 地方独立行政法人青森県産業技術センター ヒノキチオール・脂肪酸亜鉛複合錯体及びその製造方法
WO2010055850A1 (fr) * 2008-11-11 2010-05-20 株式会社ピーアンドピーエフ Agent antibactérien moussant de lavage des mains destiné à prévenir une infection par le virus de la grippe
JP2011094087A (ja) * 2009-11-02 2011-05-12 P & P F:Kk インフルエンザウイルス感染を予防するための石鹸
WO2018209382A1 (fr) * 2017-05-17 2018-11-22 Advance NanoTek Ltd. Composition d'écran solaire

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Publication number Priority date Publication date Assignee Title
US5696169A (en) * 1992-03-13 1997-12-09 Otsuka Pharmaceutical Co., Ltd. Antibacterial and antifungal activity method, therapeutic method of infectious diseases and preserving method of cosmetics
JPH0797309A (ja) * 1993-08-02 1995-04-11 Otsuka Pharmaceut Co Ltd メタロチオネイン誘導剤及びサンバーンセル産生抑制剤
JPH08208460A (ja) * 1995-02-01 1996-08-13 Otsuka Pharmaceut Co Ltd 抗炎症剤
JP2002226383A (ja) * 2001-01-30 2002-08-14 Masashi Fujii 持続性広範囲抗微生物スペクトル皮膚外用剤
JP4423350B2 (ja) * 2003-06-13 2010-03-03 地方独立行政法人青森県産業技術センター ヒノキチオール・脂肪酸亜鉛複合錯体及びその製造方法
WO2010055850A1 (fr) * 2008-11-11 2010-05-20 株式会社ピーアンドピーエフ Agent antibactérien moussant de lavage des mains destiné à prévenir une infection par le virus de la grippe
JP2011094087A (ja) * 2009-11-02 2011-05-12 P & P F:Kk インフルエンザウイルス感染を予防するための石鹸
WO2018209382A1 (fr) * 2017-05-17 2018-11-22 Advance NanoTek Ltd. Composition d'écran solaire

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Title
ANONYMOUS: "Best Natural Sunscreen Cheat Sheet", HELLO NATURAL LIVING, 12 August 2019 (2019-08-12), pages 1 - 29, XP05589594, Retrieved from the Internet <URL:http://web.archive.org/web/20190812143119/https://www.hellonaturalliving.com/best-natural-sunscreen-cheat-sheet> [retrieved on 20210810] *
ARIMA Y., NAKAI YORIKO, HAYAKAWA RITSUKO, NISHINO TAKESHI: "Antibacterial effect of beta-thujaplicin on staphylococci isolated from atopic dermatitis: relationship between changes in the number of viable bacterial cells and clinical improvement in an eczematous lesion of atopic dermatitis", JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, vol. 51, no. 1, 1 January 2003 (2003-01-01), pages 113 - 122, XP055895923, DOI: 10.1093/jac/dkg037 *
DATABASE GNPD April 2008 (2008-04-01), BIODERMA: "Mineral SPF 50+ Sun Fluid for Allergic Skin", XP055895936, retrieved from MINTEL Database accession no. 902101 *
RIVERSOL: "Riversol Lightweight Broad Spectrum Sunscreen SPF 30 titanium dioxide, zinc oxide cream", RIVERSOL SKINCARE SOLUTIONS INC, 25 January 2018 (2018-01-25), pages 1 - 4, XP055895929, Retrieved from the Internet <URL:https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=61d06b61-5299-2627-e053-2991aa0a70ed> [retrieved on 20220228] *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025003464A1 (fr) * 2023-06-30 2025-01-02 Dutch Renewable Energy B.V. Composition comprenant de l'hinokitiol et du sel de zinc destinée à être utilisée dans le traitement de l'herpès labial

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