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WO2022067003A1 - Appareil et procédés pour le traitement d'une maladie ou d'une affection - Google Patents

Appareil et procédés pour le traitement d'une maladie ou d'une affection Download PDF

Info

Publication number
WO2022067003A1
WO2022067003A1 PCT/US2021/051900 US2021051900W WO2022067003A1 WO 2022067003 A1 WO2022067003 A1 WO 2022067003A1 US 2021051900 W US2021051900 W US 2021051900W WO 2022067003 A1 WO2022067003 A1 WO 2022067003A1
Authority
WO
WIPO (PCT)
Prior art keywords
disorder
disease
thread
therapeutic agent
hollow thread
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2021/051900
Other languages
English (en)
Inventor
Xiaodong Wu
Christopher J. WU
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of WO2022067003A1 publication Critical patent/WO2022067003A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0021—Catheters; Hollow probes characterised by the form of the tubing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/16804—Flow controllers
    • A61M5/16813—Flow controllers by controlling the degree of opening of the flow line
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/16877—Adjusting flow; Devices for setting a flow rate
    • A61M5/16881—Regulating valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/172—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/172—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic
    • A61M5/1723—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic using feedback of body parameters, e.g. blood-sugar, pressure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
    • A61M25/0074—Dynamic characteristics of the catheter tip, e.g. openable, closable, expandable or deformable
    • A61M25/0075—Valve means
    • A61M2025/0076—Unidirectional valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
    • A61M25/0074—Dynamic characteristics of the catheter tip, e.g. openable, closable, expandable or deformable
    • A61M2025/0079—Separate user-activated means, e.g. guidewires, guide tubes, balloon catheters or sheaths, for sealing off an orifice, e.g. a lumen or side holes, of a catheter

Definitions

  • Embodiment 8 the apparatus of any of embodiments 1-7, wherein the apparatus comprises a plurality of thread elements.
  • valves 217/217’ and the transducers 221/221’ can be controlled such that only the valves 217’ near a site of disease or disorder are opened and the therapeutic agent is released only near the site of disease or disorder, or that only the transducer 221’ near a site of the disease or disorder is emitting EM wave cytotoxic to tumor cells or immune stimulatory signals to induce anti-tumor immunity.
  • the control of the valves 217/217’ is, depending the types of the valves 217/217’, by the processor or triggered externally by signals such as radiation, sound, and other elements known in the art.
  • the implanted elements of the apparatus 100 are removable. In some embodiments, the implanted elements of the apparatus 100 are configured such that these elements can remain in the brain for, e.g., long-term monitoring or further therapeutic intervention.
  • the instant specification is directed to a method of treating, ameliorating, and/or preventing a disease or disorder in a subject.
  • GBM is a locally infiltrative brain malignancy without a well-defined border; surgical resection cannot be extended to obtain a tumor free margin. Therefore, adjuvant chemotherapy and radiation therapy (RT) are required after surgery, and the clinical efficacy of these two modalities is so far limited.
  • chemotherapy for brain tumors must cross the blood-brain-barrier (BBB) to have a therapeutic effect; poor BBB penetration can lead to limited anticancer activity despite systemic toxi cities.
  • BBB blood-brain-barrier
  • the dose is limited by RT tolerance of the normal brain parenchyma.
  • the apparatus described in the instant specification is particularly useful for treating, ameliorating, and/or preventing malignant gliomas such as glioblastoma, at least because the implanted hollow thread can transport therapeutic agents across the blood-brain barrier, and the openings and the valves allow the therapeutic agent(s) to be released in a precise and controlled manner directly at the sites of glioblastoma.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Anesthesiology (AREA)
  • Public Health (AREA)
  • Vascular Medicine (AREA)
  • Biophysics (AREA)
  • Pulmonology (AREA)
  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne un appareil pour administrer un agent thérapeutique à un site d'une maladie ou d'une affection. L'appareil comprend un réservoir conçu pour stocker un agent thérapeutique, un filetage creux ayant un canal de distribution et une ouverture, ainsi qu'une pompe conçue pour entraîner un écoulement de l'agent thérapeutique depuis le réservoir dans le canal de distribution et sortir à travers l'ouverture. L'invention concerne également une méthode de traitement, d'amélioration et/ou de prévention d'une maladie ou d'une affection à l'aide de l'appareil.
PCT/US2021/051900 2020-09-25 2021-09-24 Appareil et procédés pour le traitement d'une maladie ou d'une affection Ceased WO2022067003A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063198062P 2020-09-25 2020-09-25
US63/198,062 2020-09-25

Publications (1)

Publication Number Publication Date
WO2022067003A1 true WO2022067003A1 (fr) 2022-03-31

Family

ID=80845855

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2021/051900 Ceased WO2022067003A1 (fr) 2020-09-25 2021-09-24 Appareil et procédés pour le traitement d'une maladie ou d'une affection

Country Status (1)

Country Link
WO (1) WO2022067003A1 (fr)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6350253B1 (en) * 1999-07-19 2002-02-26 I-Flow Corporation Catheter for uniform delivery of medication
US20050137659A1 (en) * 2003-12-18 2005-06-23 Garabedian Robert J. Tissue treatment system and method for tissue perfusion using feedback control
US7662140B2 (en) * 2002-12-23 2010-02-16 Medtronic, Inc. Method of delivering drug to brain via spinal cord
US20200085375A1 (en) * 2018-09-14 2020-03-19 Neuralink Corp. Electrode fabrication and design
US20210162119A1 (en) * 2017-12-08 2021-06-03 Advanced Microfluidics Sa Drug delivery device

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6350253B1 (en) * 1999-07-19 2002-02-26 I-Flow Corporation Catheter for uniform delivery of medication
US7662140B2 (en) * 2002-12-23 2010-02-16 Medtronic, Inc. Method of delivering drug to brain via spinal cord
US20050137659A1 (en) * 2003-12-18 2005-06-23 Garabedian Robert J. Tissue treatment system and method for tissue perfusion using feedback control
US20210162119A1 (en) * 2017-12-08 2021-06-03 Advanced Microfluidics Sa Drug delivery device
US20200085375A1 (en) * 2018-09-14 2020-03-19 Neuralink Corp. Electrode fabrication and design

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