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WO2022065350A1 - Appareil d'émulsification d'agent chimique - Google Patents

Appareil d'émulsification d'agent chimique Download PDF

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Publication number
WO2022065350A1
WO2022065350A1 PCT/JP2021/034746 JP2021034746W WO2022065350A1 WO 2022065350 A1 WO2022065350 A1 WO 2022065350A1 JP 2021034746 W JP2021034746 W JP 2021034746W WO 2022065350 A1 WO2022065350 A1 WO 2022065350A1
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WO
WIPO (PCT)
Prior art keywords
syringe
vial
connection portion
connection
drug
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2021/034746
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English (en)
Japanese (ja)
Inventor
直也 片岡
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nipro Corp
Original Assignee
Nipro Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nipro Corp filed Critical Nipro Corp
Priority to JP2022552023A priority Critical patent/JP7613474B2/ja
Publication of WO2022065350A1 publication Critical patent/WO2022065350A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/22—Valves or arrangement of valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle

Definitions

  • the present disclosure relates to a drug emulsifying device, particularly to a drug emulsifying device used for preparing an emulsified preparation for injection.
  • an aqueous drug and an oily drug are suspended and emulsified to prepare a preparation for injection.
  • an aqueous vaccine preparation and an oily adjuvant may be mixed and emulsified for use in order to promote an immune response.
  • a method for emulsifying a small amount of a drug a method using two syringes and an emulsifying filter is known (see, for example, Patent Document 1). By connecting a syringe containing an aqueous drug and a syringe containing an oily drug with an emulsifying filter sandwiched between them and pumping them alternately, both drugs can be mixed and emulsified.
  • the drug solution is transferred from the vial to the syringe using a syringe equipped with an transfer needle, and then the transfer needle is removed from the syringe and attached to the emulsification filter. Operation is required.
  • the inside of the syringe becomes an open system, so that the contents may leak.
  • An object of the present disclosure is to make it possible to realize a drug emulsifying device capable of emulsifying a drug contained in a vial without changing a syringe.
  • a first syringe connection portion and a second syringe connection portion to which a syringe is connected, and a first syringe connection portion and a second syringe connection portion are connected to each other, respectively.
  • the flow path switching unit that switches between the first connection state that is not connected and the second connection state in which the first syringe connection portion and the second syringe connection portion are connected to each other, and the first connection state.
  • emulsification by switching the flow path, emulsification can be sequentially performed by moving the drug between syringes, and the operability can be greatly improved.
  • One aspect of the drug emulsifying device may further include a second vial connection that is connected to the second syringe connection and not to the first syringe connection in the first connection state.
  • the drug can be transferred from each vial to each syringe for emulsification.
  • One aspect of the drug emulsifying device may further include an identification label that enables identification between the first vial connection and the second vial connection.
  • the first vial connection and the second vial connection may each have a transfer needle that is punctured into the plug, and the transfer needle may have a ventilation filter. ..
  • the flow path switching portion is a four-way stopcock that switches between the first connection state and the second connection state by rotating the rotating portion by a predetermined angle, and the rotating portion has a predetermined angle. It may have a rotation limiting unit that limits the rotation so as not to rotate. With such a configuration, it is possible to prevent a situation in which an operation is performed in an incorrect connection state of a flow path.
  • a prefilled syringe containing a drug in advance can be connected to the second syringe port.
  • the drug emulsifying device of the present disclosure it is possible to emulsify a drug without performing a syringe replacement operation.
  • FIG. 1 is a schematic diagram showing a drug emulsifying device according to an embodiment.
  • FIG. 2 is a schematic view showing a state in which a vial and a syringe are attached to the drug emulsifying device according to the embodiment.
  • FIG. 3 is an exploded perspective view showing an example of the flow path switching unit.
  • FIG. 4 is a perspective view showing a transfer needle.
  • FIG. 5 is a cross-sectional view showing a transfer needle.
  • 6 (a) to 6 (d) are schematic views showing the emulsification operation by the drug emulsification device according to the embodiment in order.
  • FIG. 7 is a plan view showing an example of a package of a drug emulsifying device according to an embodiment.
  • FIG. 8 is a perspective view showing a modified example of the flow path switching portion.
  • FIG. 9 is an exploded perspective view showing a modified example of the flow path switching portion.
  • the drug emulsifying device 100 has a first vial connection portion 111 and a second vial connection portion 112, and a first syringe connection portion 113 and a second syringe. It includes a connection portion 114, a flow path switching portion 115, and an emulsification filter 116.
  • the first flow path 141 connects the first vial connection portion 111 and the first syringe connection portion 113
  • the second flow path 142 connects the second vial connection portion 112 and the first vial connection portion 113.
  • the first connection state connecting the syringe connection portion 114 of 2 and the first flow path 141 connect the first syringe connection portion 113 and the second syringe connection portion 114, and the second flow path 142.
  • the emulsification filter 116 is arranged between the first syringe connection portion 113 and the first flow path 141. Therefore, in the first connection state, it is located between the first syringe connection portion 113 and the first vial connection portion 111, and in the second connection state, it is located between the first syringe connection portion and the second vial connection portion 111. It is located between the syringe connection portion 114 and the syringe connection portion 114.
  • the emulsification filter 116 is not between the second vial connection portion 112 and the second syringe connection portion 114 in the first connection state, but the first syringe connection portion 113 and the second syringe connection portion 114 in the second connection state. If it can be located between the syringe connection portion 114, it can be arranged at another position.
  • the first vial 211 containing the first drug is connected to the first vial connection portion 111, and the second vial 212 containing the second drug is connected to the second vial connection portion 112. Will be done.
  • the first drug is an aqueous drug such as a vaccine
  • the second drug is an oily drug such as an adjuvant.
  • the flow path switching unit 115 may have any configuration as long as it can switch between the first connection state and the second connection state, and is, for example, a four-way stopcock 120 as shown in FIG. Can be done.
  • the four-way stopcock 120 shown in FIG. 3 has a cylindrical main body portion 125 and a plug portion 126 inserted into the opening of the main body portion 125.
  • a plug cap 127 having an outer diameter larger than that of the opening of the main body 125 is formed on the upper portion of the plug portion 126, and a handle 128 having four arms extending in a plane cross shape is provided on the upper portion of the plug cap 127.
  • a handle 128 having four arms extending in a plane cross shape is provided on the upper portion of the plug cap 127.
  • connection port protrudes from the main body 125 in four directions.
  • the four connection ports include a first male connector 121 and a second male connector 122, and a first female connector 123 and a second female connector 124.
  • the first female connector 123 is arranged adjacent to the first male connector 121 and the second female connector 124.
  • the first male connector 121 and the second male connector 122 have a collar 135 for locking
  • the first female connector 123 and the second female connector 124 have a male screw 134 for locking. Have.
  • a first flow path 141 and a second flow path 142 are formed in the plug portion 126, and when the plug portion 126 is in the first rotation position, the first flow path 141 is the first male.
  • the connector 121 and the first female connector 123 are connected, and the second flow path 142 is in the first connection state in which the second male connector 122 and the second female connector 124 are connected.
  • the first flow path 141 connects the first male connector 121 and the second male connector 122, and the first is The flow path 142 of 2 is in the second connection state in which the first female connector 123 and the second female connector 124 are connected.
  • the handle 128 and the connection port are arranged so that the four arms of the handle 128 and the four connection ports overlap at the first rotation position and the second rotation position. By doing so, when the plug portion 126 deviates from the first rotation position and the second rotation position, it can be easily noticed, and erroneous operation can be less likely to occur.
  • the handle 128 is not limited to such a configuration.
  • a plurality of protrusions 131 protruding outward in the radial direction are formed on the upper portion of the main body portion 125 so as to abut on the convex portion 132 provided at the lower end of the plug cap 127.
  • the protrusion 131 and the protrusion 132 function as a rotation limiting portion that prevents the plug portion 126 from rotating by 90 ° or more.
  • the transfer needle 150 is connected to the first male connector 121 and the second male connector 122 to become the first vial connection portion 111 and the second vial connection portion 112.
  • a filter unit including an emulsification filter 116 is connected to the first female connector 123 to become a first syringe connection portion 113, and the second female connector 124 becomes a second syringe connection portion 114.
  • the transfer needle 150 may be any as long as it can be connected to the vial containing the drug, and can be configured as shown in FIGS. 4 and 5, for example.
  • the transfer needle 150 shown in FIGS. 4 and 5 includes a needle 151 punctured by a stopper body 214 made of rubber or the like that seals the opening of the vial, a female connector 152 provided at the base of the needle 151, and a needle 151. It has a cover 153 that surrounds the cover.
  • the needle 151 has a liquid passage 161 connecting the first opening 155 and the female connector 152, and a ventilation path connected to the second opening 156 on the tip end side of the needle 151 with respect to the first opening 155. It has 162 and.
  • the ventilation path 162 communicates with the outside of the transfer needle 150 at the base of the needle 151 via the ventilation filter 163.
  • the cover 153 has a tongue piece-shaped portion 164 that is expanded by the crimp top of the vial, and is formed so as to fit into the mouth of the vial. Further, the tongue piece-shaped portion 164 is formed with a stepped portion 165 that engages with the lower end portion of the crimp top, and once it is externally fitted into the vial, it cannot be easily removed.
  • a vial dropout prevention mechanism By providing such a vial dropout prevention mechanism, it is possible to prevent the vial from falling off during operation, and the operator can concentrate on the operation of the syringe, so that the burden on the operator can be reduced.
  • the dropout prevention mechanism is not limited to such a configuration as long as the vial can be prevented from falling off. Further, the dropout prevention mechanism may or may not be provided as needed.
  • the transfer needle 150 of this embodiment is connected to the male connector of the 4-way stopcock 120, which is the flow path switching portion 115, by the female connector 152.
  • the female connector 152 of the transfer needle 150 is provided with a male screw 158, and the collar 135 provided on the first male connector 121 and the second male connector 122 of the four-way plug 120 can be screwed. ..
  • the connection portion between the flow path switching portion 115 and the transfer needle 150 in a luer lock structure, the flow path switching portion 115 and the transfer needle 150 can be firmly connected.
  • the transfer needle 150 may be separable from the flow path switching portion 115, or may not be separable. To prevent separation, for example, the collar 135 and the male screw 158 may be adhered or welded together.
  • connection portion between the flow path switching portion 115 and the transfer needle 150 does not have to have a luer lock structure, and may be connected by a connector having no lock mechanism. Further, the flow path switching portion 115 and the transfer needle 150 may be connected without a connector, or the flow path switching portion 115 and the transfer needle 150 may be integrally molded.
  • the emulsification filter 116 is a filter unit housed in a housing having a male connector and a female connector.
  • the male connector of the filter unit is connected to the first female connector 123 of the four-way stopcock 120, which is the flow path switching portion 115.
  • the male connector of the filter unit and the first female connector 123 may be separable or may be inseparably bonded or welded.
  • the connection portion between the filter unit and the connection port of the flow path switching portion 115 may have a luer lock structure.
  • the emulsification filter 116 may be incorporated in the housing of the flow path switching portion 115 instead of being an independent filter unit.
  • the emulsification filter 116 may be any as long as it can form an emulsified emulsion of the first agent and the second agent, and can be, for example, an inorganic or organic porous membrane. Of these, a porous glass filter or the like having a pore diameter of about 0.05 ⁇ m to 20 ⁇ m is preferable.
  • a hydrophilic filter can be used to form an O / W emulsion in which oil droplets are dispersed in an aqueous phase, and in the case of a porous glass filter, it is preferable to hydrophilize the surface of the filter.
  • a hydrophobic filter When forming a W / O emulsion in which water droplets are dispersed in an oil phase, a hydrophobic filter can be used, and in the case of a porous glass filter, it is preferable to hydrophobize the filter surface.
  • the size of the emulsification filter 116 depends on the amount of the drug to be treated, but in the case of a normal injectable drug, the diameter can be about 5 mm to 10 mm.
  • the first syringe 221 and the second syringe 222 are connected to the first syringe connection portion 113 and the second syringe connection portion 114, respectively.
  • the first syringe 221 and the second syringe 222 are not particularly limited, but a syringe having a lock collar is preferable. By screwing the lock collar of the syringe with the male screw provided at the syringe connection portion, it is possible to prevent the syringe from coming off during the operation. It is also possible to use a syringe having a laminated gasket that is less likely to expand due to oil, or a two-piece syringe without a gasket. By using such a syringe, oil resistance and slidability can be improved.
  • the drug emulsifying device 100 of the present embodiment can be used, for example, as follows. First, as shown in FIG. 6A, a first vial 211 containing a dry aqueous agent is connected to the first vial connection portion 111, and an oil-based agent is connected to the second vial connection portion 112. Connect the second vial 212 that contains it. Further, the first syringe 221 containing the solution of the first drug is connected to the first syringe connection portion 113, and the second syringe 222 is connected to the second syringe connection portion 114.
  • the solution in the first syringe 221 is extruded, moved into the first vial 211, and the first. Dissolve the drug. If the first drug has been dissolved in advance, the drug dissolution operation is not necessary.
  • the dissolved first drug in the first vial 211 is moved into the first syringe 221 while the flow path switching portion 115 remains in the first connected state.
  • the second drug in the second vial 212 is moved into the second syringe 222. Since the transfer needle 150 of the present embodiment has a ventilation path 162 having a ventilation filter 163, air bubbles in the syringe can be easily removed when the drug is transferred from the vial to the syringe. ..
  • the flow path switching portion 115 is set to the second connection state, and the first syringe 221 and the second syringe 222 are alternately pumped to the first drug and the first. While mixing with the agent of 2, it is passed through the emulsification filter 116 to form an emulsion. Then, the mixed drug is housed in the first syringe 221 or the second syringe 222, removed from the flow path switching portion, and then a needle is attached to the tip of the syringe to puncture subcutaneously or the like.
  • the first agent is made aqueous
  • the second agent is oily
  • the emulsification filter 116 is hydrophobic
  • the aqueous first agent passes through the emulsification filter 116 first, so that the W / O is performed.
  • An example of forming an emulsion is shown.
  • it is also possible to form an O / W emulsion by making the first agent oily, the second agent aqueous, and the emulsification filter 116 hydrophilic.
  • the vial containing the oil-based drug may be connected to the first vial connection portion 111, and the vial containing the aqueous drug may be connected to the second vial connection portion 112.
  • the vial containing the aqueous drug is connected to the first vial connection portion 111
  • the vial containing the oily drug is connected to the second vial connection portion 112
  • the emulsification filter is connected to the second syringe connection portion 114. It may be connected between the flow path switching unit 115 and the flow path switching unit 115.
  • the first vial 211 is connected to the first vial connection portion 111
  • the second vial 212 is connected to the second vial connection portion 112. It is important to. Therefore, it is preferable to provide an identification display so that the first vial connecting portion 111 and the second vial connecting portion 112 can be easily identified.
  • the identification display may be any display such as a character display, a symbol display, and a color display, and a plurality of displays may be combined. Further, the identification display can be, for example, a sticker indicating a vial or contents to be connected to the vial connection portion.
  • erroneous connection can be prevented.
  • the user can easily grasp the combination of the vial connection portion and the vial, and it is possible to prevent erroneous operation.
  • the identification display is not limited to the sticker, and may not be provided directly on the first vial connection portion 111 and the second vial connection portion 112.
  • the first vial connection portion 111 and the second vial connection can be connected by providing some indication at the position of the flow path switching portion 115 on the first vial connection portion 111 side or the position on the second vial connection portion 112 side. It can be distinguished from the unit 112.
  • information for identification can be described in the attached documents and the like.
  • the shape of the vial connection portion and the vial is adjusted so that the second vial 212 cannot be attached to the first vial connection portion 111 and the first vial 211 cannot be attached to the second vial connection portion 112. It is also possible to set.
  • the first vial connection portion 111 and the first vial 211 are in parallel, and the second vial connection portion 112 and the second vial 212 are in parallel.
  • the user can be guided to connect the first vial 211 to the first vial connection 111 and the second vial 212 to the second vial connection 112.
  • the arrangement of each constituent member in the package 301 can be fixed.
  • the vials are arranged so as to be parallel to the vial connection portion, but the vials can be arranged on the extension line of the vial connection portion. It is also possible to guide the user by providing a display unit such as an arrow indicating what should be connected to the package.
  • the flow path switching portion 115 is a four-way stopcock 120 as shown in FIG. 3, the first flow path colored in the first color on the two arms corresponding to the first flow path 141 of the handle 128.
  • a display 128a can be provided, and a second flow path display 128b colored in a second color can be provided on the two arms that coincide with the second flow path 142.
  • the first flow path display 128a and the second flow path display 128b are not limited to color-coded displays, and may be displayed by symbols or characters, or may be a combination thereof. In addition to this, various displays can be performed to facilitate grasping the connection state. For example, a linear display unit connecting 128a can be provided to display the flow path.
  • the flow path switching unit 115 can also be a vertical four-way stopcock 180 as shown in FIGS. 8 and 9.
  • the four-way stopcock 180 is provided with a first male connector 181 and a second female connector 184 on the first surface, and a second male connector 182 and a first female connector 183 are provided on the second surface. There is.
  • the first male connector 181 and the first female connector 183 are connected in the first connected state, and the second male connector 182 and the second female connector 184 are connected.
  • the first male connector 181 and the second male connector 182 are connected, and the first female connector 183 and the second female connector 184 are connected.
  • the four-way stopcock 180 contains a rotating portion 193 sandwiched between an upper support 192 and a lower support 194 in a housing formed by a cylindrical case 195 having an opening on the side surface and a cover 191.
  • the side opening of the housing is provided with a central angle in the range of 90 °.
  • the case 195 is provided with a first male connector 181 and a second female connector 184, and the cover 191 is provided with a second male connector 182 and a first female connector 183.
  • the first male connector 181 and the second female connector 184 are arranged at positions facing each other with the center of the case 195 interposed therebetween, and the second male connector 182 and the first female connector 183 are located at the center of the cover 191. It is placed at a position opposite to each other.
  • the cover 191 is attached to the case 195, what is the line connecting the first male connector 181 and the second female connector 184 and the line connecting the second male connector 182 and the first female connector 183? Go straight.
  • the upper support 192 and the lower support 194 are disk-shaped, and their positions are fixed in the housing.
  • the upper support 192 is provided with through holes at positions corresponding to the second male connector 182 and the first female connector 183, and the lower support 194 is provided with the first male connector 181 and the second female.
  • a through hole is provided at a position corresponding to the connector 184.
  • the rotating portion 193 is provided with a first flow path 141 and a second flow path 142.
  • the first flow path 141 and the second flow path 142 are circumferential grooves penetrating the rotating portion 193 provided in a range where the central angle is 90 °, and are located at positions facing the center of the rotating portion 193. It is provided.
  • the rotating portion 193 has a lever 196 that projects radially outward. The lever 196 protrudes outward from the side opening of the housing, and the rotating portion 193 can be rotated by operating the lever 196.
  • the side opening of the housing has a central angle of 90 °, and the rotation angle of the rotating portion 193 is limited to 90 °.
  • the lever 196 When the lever 196 is brought into contact with one end of the side opening, the first flow path 141 connects the first male connector 181 and the first female connector 183, and the second flow path 142 becomes the second.
  • the first connection state is set in which the 2 male connector 182 and the 2nd female connector 184 are connected.
  • the lever 196 is rotated 90 ° until it abuts on the other end of the side opening, the first flow path 141 connects the first male connector 181 and the second male connector 182, resulting in a second flow.
  • the road 142 is in the second connection state in which the first female connector 183 and the second female connector 184 are connected.
  • an identification display between the first vial connection portion 111 and the second vial connection portion 112 can be provided. Further, it is possible to provide an identification display between the first connection state and the second connection state.
  • the flow path switching unit 115 connects the first vial connection portion 111 and the first syringe connection portion 113, and the second vial connection portion 112 and the second syringe connection portion 114 in the first connection state. If the first syringe connection portion 113 and the second syringe connection portion 114, and the first vial connection portion 111 and the second vial connection portion 112 can be connected in the second connection state, what kind of configuration is used? May be good.
  • the flow path switching unit 115 may have a lock mechanism that prevents the flow path switching unit 115 from returning to the first connection state once the first connection state is switched to the second connection state.
  • a lock mechanism that prevents the flow path switching unit 115 from returning to the first connection state once the first connection state is switched to the second connection state.
  • a lock mechanism When a lock mechanism is provided, various configurations are conceivable, but in the case of a four-way stopcock as shown in FIG. 3, for example, a claw-shaped protrusion 132 can be overcome in only one direction near the protrusion 131 of the main body 125. If the portion is provided, the lock mechanism can be easily formed.
  • one syringe can be a prefilled syringe pre-filled with the drug.
  • the drug to be placed in the prefilled syringe is preferably an aqueous drug.
  • the flow path switching unit does not switch the four-way flow path, but may switch the three-way flow path.
  • a cartridge connection is provided in addition to the syringe connection, vial connection, and prefilled syringe connection, the mixed drug is stored in the cartridge, and the cartridge is used as the administration device.
  • the drug may be administered subcutaneously or the like.
  • one of the syringes is a prefilled syringe
  • the identification display of the syringe connection portion various indications can be used in the same manner as the identification display of the vial connection portion.
  • the shape of the prefilled syringe connection and the normal syringe connection can be different so that only the correct syringe connection can be connected.
  • the drug emulsifying device of the present disclosure can emulsify the drug contained in the vial without replacing the syringe, and is useful in the medical field and the like.

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  • Heart & Thoracic Surgery (AREA)
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Abstract

Cet appareil d'émulsification d'agent chimique comprend : une première partie de connexion de seringue 113 et une seconde partie de connexion de seringue 114 destinées à être connectées à des seringues respectives ; et une unité de commutation de trajet d'écoulement 115 pour commuter entre un premier état de connexion dans lequel la première partie de connexion de seringue 113 et la seconde partie de connexion de seringue 114 ne sont pas connectées l'une à l'autre, et un second état de connexion dans lequel la première partie de connexion de seringue 113 et la seconde partie de connexion de seringue 114 sont connectées l'une à l'autre. Une première partie de connexion de flacon 11 est disposée de manière à être connectée à la première partie de connexion de seringue 113 mais pas connectée à la seconde partie de connexion de seringue 114 dans le premier état de connexion. Un filtre d'émulsification 116 est disposé sur un trajet d'écoulement connectant la première partie de connexion de seringue 113 et la seconde partie de connexion de seringue 114 dans le second état de connexion.
PCT/JP2021/034746 2020-09-24 2021-09-22 Appareil d'émulsification d'agent chimique Ceased WO2022065350A1 (fr)

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JP2022552023A JP7613474B2 (ja) 2020-09-24 2021-09-22 薬剤乳化器具

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JP2020-160077 2020-09-24
JP2020160077 2020-09-24

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
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JP2012533716A (ja) * 2009-07-20 2012-12-27 ダンカン、デービット、アール． 複数ポート付きストップコックバルブおよび流れ指定システム
JP2016150924A (ja) * 2015-02-18 2016-08-22 エス・ピー・ジーテクノ株式会社 医薬用乳化製剤及びその製造方法
JP2018511419A (ja) * 2015-04-15 2018-04-26 ゲルベＧｕｅｒｂｅｔ 医療用活栓、このような活栓を含むキット、及び混合物又はエマルションを調製するための方法

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JP2018511419A (ja) * 2015-04-15 2018-04-26 ゲルベＧｕｅｒｂｅｔ 医療用活栓、このような活栓を含むキット、及び混合物又はエマルションを調製するための方法

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