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WO2022043999A1 - Dispositif inhalateur - Google Patents

Dispositif inhalateur Download PDF

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Publication number
WO2022043999A1
WO2022043999A1 PCT/IL2021/051032 IL2021051032W WO2022043999A1 WO 2022043999 A1 WO2022043999 A1 WO 2022043999A1 IL 2021051032 W IL2021051032 W IL 2021051032W WO 2022043999 A1 WO2022043999 A1 WO 2022043999A1
Authority
WO
WIPO (PCT)
Prior art keywords
aerosol
compound
compounds
class
user
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IL2021/051032
Other languages
English (en)
Inventor
Aaron SCHORR
Nimrod RESHEF
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Myphi Ltd
Original Assignee
Myphi Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Myphi Ltd filed Critical Myphi Ltd
Publication of WO2022043999A1 publication Critical patent/WO2022043999A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
    • A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
    • A24F40/40—Constructional details, e.g. connection of cartridges and battery parts
    • A24F40/46—Shape or structure of electric heating means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/04—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised
    • A61M11/041—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised using heaters
    • A61M11/042—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised using heaters electrical
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
    • A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
    • A24F40/30—Devices using two or more structurally separated inhalable precursors, e.g. using two liquid precursors in two cartridges
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
    • A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
    • A24F40/50—Control or monitoring
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
    • A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
    • A24F40/65—Devices with integrated communication means, e.g. wireless communication means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/02—General characteristics of the apparatus characterised by a particular materials
    • A61M2205/0272—Electro-active or magneto-active materials
    • A61M2205/0294—Piezoelectric materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/35—Communication
    • A61M2205/3546—Range
    • A61M2205/3553—Range remote, e.g. between patient's home and doctor's office
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/50—General characteristics of the apparatus with microprocessors or computers
    • A61M2205/502—User interfaces, e.g. screens or keyboards
    • A61M2205/505—Touch-screens; Virtual keyboard or keypads; Virtual buttons; Soft keys; Mouse touches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/82—Internal energy supply devices
    • A61M2205/8206—Internal energy supply devices battery-operated

Definitions

  • the present invention relates to an inhaler device.
  • Embodiments of the present invention relate to an inhaler device that includes at least two different aerosolization mechanisms and is capable of concomitantly aerosolizing different classes of compounds.
  • Systems for delivering active compounds in a fluid or powder medium such as an aerosol, vapor or micronized powder are widely known in the art. Such systems typically utilize a gas propellant for aerosolizing a liquid compound, a heating element for vaporizing the liquid compound or a carrier for aerosolizing through a vibrating membrane (nebulizer). The aerosolized or vaporized compound can then be delivered pulmonary, orally, or nasally for localized or systemic effects.
  • Numerous types of compounds can be delivered through the pulmonary, oral or nasal route including therapeutic and recreational drugs.
  • an inhaler device comprising a first mechanism configured for converting a first compound of a first class of compounds into a first aerosol; a second mechanism configured for converting a second compound of a second class of compounds into a second aerosol; and a mouthpiece being in fluid communication with the first mechanism and the second mechanism and being for enabling a user to inhale the first aerosol and the second aerosol.
  • the device further comprises a mixing chamber being in fluid communication with the first and the second mechanisms and being for mixing the first aerosol and the second aerosol to provide an aerosolized mixture to the mouthpiece.
  • the device further comprises a controller for controlling a ratio or amount of the first aerosol and/or the second aerosol in the aerosolized mixture.
  • the device further comprises a cartridge including a first reservoir for containing the first compound and a second reservoir for containing the second compound.
  • the controller enables selection of the first compound and the second compound from a plurality of reservoirs of the cartridge.
  • the first compound and the second compound are provided in a liquid material.
  • the first compound and the second compound are provided in a solid material.
  • the first mechanism includes a heating element.
  • the heating element is a thermal printhead.
  • the second mechanism includes a piezo element.
  • the second mechanism is a piezo printhead.
  • the aerosolized mixture has a droplet size of 1 to 200 microns.
  • the controller controls a number of droplets in the first aerosol and the second aerosol.
  • the first class of compounds or the second class of compounds is selected from the group consisting of cannabinoids, terpenes, flavonoids, drugs and flavoring and aroma agents.
  • a method of providing an aerosolized mixture to a subject comprising: converting a first compound of a first class of compounds into a first aerosol; converting a second compound present in a second class of compounds into a second aerosol; and providing the first aerosol and the second aerosol to a mouthpiece for enabling a user to inhale the first aerosol and the second aerosol.
  • a method of sharing a formulation for inhalation comprising uploading to a database a compound profile of a user-generated formulation and providing users with access to said formulation.
  • FIG. 1 is a diagram of one embodiment of the present device.
  • FIG. 2 schematically illustrates the cartridge and extraction mechanism components of the present device.
  • the present invention is of a device which can be used to deliver mixtures of compounds aerosolized from different sources.
  • Such devices that generate aerosols or vapors that include active compounds from cannabis, tobacco, API, herbs or essential oils are known in the art. Such devices typically employ a single vaporization/aerosolization mechanism (e.g., heating element or piezo element) to vaporize or aerosolize the active compounds from stored liquid or solid material.
  • a single vaporization/aerosolization mechanism e.g., heating element or piezo element
  • the profile of compounds extracted and delivered to the user largely depends on the mechanism of vaporization/aerosolization used by the device.
  • ECIG standard atomizer/cartomizer
  • the composition of the aerosol varies from the first to the last inhalation with the first inhalation typically having a higher terpenoid concentration. This is due to the different boiling points and vapor pressure of the compounds in the extract.
  • pressurized cannister inhalers In pressurized cannister inhalers, a user must shake the canister prior to inhaling otherwise the extract in the canister is separated into phases and the resulting delivery is inconsistent.
  • pressurized cannister inhalers use a valve mechanism that requires a carrier-diluted extract to work. As such, these devices do not work with viscous liquids such a cannabis or tobacco extract.
  • an inhaler device capable of concomitantly extracting several classes of compounds each requiring a dedicated extraction (aerosolization/vaporization) mechanism.
  • the present device utilizes two or more extraction mechanisms and two or more reservoirs to aerosolize/vaporize different classes of compounds from one or more states of materials (solid, liquid).
  • the aerosolized compounds can be mixed in the device (mixture chamber) or in the user’s mouth/lungs for delivery.
  • Such a device configuration provides several advantages, including:
  • (x) it can target selective aerosol deposition targets (buccal, bronchi, alveoli).
  • an inhaler device that can be used to deliver compounds including therapeutic compounds, psychoactive compounds and/or flavorants and the like to an oral cavity and/or lungs and/or bronchi of a user.
  • the device includes a first mechanism for converting at least a first compound class into a first aerosol and a second mechanism for converting at least a second compound classes into a second aerosol.
  • the device further includes a mouthpiece for enabling a user to simultaneously inhale the first aerosol and the second aerosol.
  • the device can also include a mixing chamber for mixing the first aerosol and the second aerosol to provide an aerosolized mixture to the mouthpiece and a controller for controlling a ratio or amount of the first aerosol and/or the second aerosol in the aerosolized mixture or in the mouthpiece.
  • the controller can be used to set the type and amount of the compound classes aerosolized and the quantity (droplet number), ratio and droplet size (typically 1-200 microns in diameter) of the compounds provided in the aerosolized mixture. Aerosol droplet size has a great impact on the deposition area of the aerosol, affecting its bioavailability and overall physiological effect. In general, larger droplets deposits in the mouth (> 15 microns). As the diameter is reduced, droplets reach deeper into the respiratory track and to the alveoli ( ⁇ 5 microns).
  • the device further includes a removable cartridge for containing the first material and the second material in separate reservoirs.
  • the first and second materials can be in solid or liquid form and the reservoirs of the cartridge can be adapted to hold solid (e.g., powder) or liquid material.
  • the controller is configured capable of identifying the materials stored in the cartridge and selecting the compound classes to be aerosolized (based on user selection of compounds or final aerosolized mixture type).
  • Aerosol generation is performed by the present device using at least two different mechanisms each responsible for generating aerosol of a different type of starting material or compound class. These mechanisms can be a part of the device or cartridge.
  • compound classes such as terpenes, flavonoids, and cannabinoids have different physical characteristics and a such, require a different aerosol-generating mechanism in order to extract (aerosolize) these active compounds from the source material (e.g., liquid solution, oil).
  • the aerosol generation mechanism used by the present device is defined by several parameters including the viscosity and superficial tension of the source material.
  • Piezo and thermal printheads can generate droplets of a very precise droplet diameter and count.
  • Such technologies can aerosolize compounds with low viscosity (up to 5-10 cp and low superficial tension).
  • compounds of high viscosity e.g., delta9 THC
  • Superficial tension also plays a big role when generating droplet with these technologies.
  • the superficial tension of the compound is directly related to the force required to detach the droplet from the meniscus of the printhead nozzle. The amount of force produced by the piezoelectric and thermal printheads is limited to low superficial tension compounds
  • Piezoelectric and thermal printheads can be used for aerosolizing both terpenes and flavonoids while a thermal piezo needle can be used for the generation of aerosols from highly viscous compounds. While a piezo needle can also generate aerosol without heating from compounds of up to 500 centipoise (cp) in viscosity, it is limited by the physical characteristics of highly viscous compounds. Delta 9 THC has a viscosity of around 1.000.000 at room temp that decreases with elevated temperatures. Delta 9 THC can be aerosolized by heating it to 60 degrees C (to a viscosity of about 500cp) and running it through a piezo needle.
  • Table 1 below provides an exemplary list of compounds classes and the mechanism that can be used to aerosolize/vaporize these compounds from the cartridge-stored material.
  • Figure 1 is diagram illustrating the functional components of the present device which is referred to herein as device 10.
  • Device 10 includes a cartridge 12 having a plurality of reservoirs 14 each containing a different class of compounds in a solid or liquid material.
  • Reservoirs 14 of cartridge 12 can be manufactured using plastic injection molding from non-reactive, non-corrosive, odorless materials (e.g., Polypropylene). Reservoirs 14 can be arrayed in the cartridge assembly in a rectangular, cylindrical or complex shape. The total volume of the cartridge assembly can range between 1 to 200 ml.
  • a mechanism 16 for extracting the compounds from the stored material can be manufactured thru MEMS technology, from silicon base materials, and wiring of electrical conductors. RFID, SIM or similar identification technology can be attached to the cartridge assembly and used to identify it and its contents when mounted in the device.
  • Reservoirs 14 of cartridge 12 can include Phytocannabinoids such as THC, THCA, CBD, CBDA, CBN, CBC, CBG, THCV and/or CBDV; Terpenes/Terpenoids such as Myrcene, Limonene, alpha-pinene, beta-pinene, Terpinolene, Ocimene and/or Humulene; Flavonoids such as cannaflavin A, cannaflavin B, Cannaflabin C, Apigenin and/or Quercitine; Esters such as Isoamyl acetate, 2-pentanol acetate, 2- methyl-1 -propanol, methyl butyrate, ethyl butyrate, ethyl-2-methylbutyrate and/or methyl-2-methylbutyrate and Tobacco flavor or active compounds such as Camphor, Coumarin, Pulegone, Eugenol, Menthol and/or Nicotine.
  • Reservoirs 14 of cartridge 12 can also include Pharmaceutical APIs such as Formoterol fumarate, Glycopyrrolate bromide, Indacaterol maleate, Salmeterol xinafoate, Tiotropium bromide (for treatment of COPD).
  • Pharmaceutical APIs such as Formoterol fumarate, Glycopyrrolate bromide, Indacaterol maleate, Salmeterol xinafoate, Tiotropium bromide (for treatment of COPD).
  • Each reservoir 14 is in fluid communication (via a conduit 15) with one or more extraction mechanisms 16.
  • Each mechanism 16 is configured for aerosolizing/vaporizing a specific class of molecules from the material stored in reservoirs 14.
  • Several types of mechanisms 16 are used by device 10 including, but not limited to, piezo printhead, thermal printhead and piezo needle.
  • the technology is based on a ‘drop on demand’ mechanism in which tiny droplets of the substance (ink in the case of inkjet printheads, Terpenes, Flavonoids and other API’s in the present case) are ejected from a designated orifice in a chamber.
  • the substance in liquid form
  • the substance is held in the chamber while surface tension prevents it from undesired ejection (leakage) through the orifice.
  • a thermal mechanism or piezoelectric mechanism creates pressure boost in the chamber, which overcomes the liquid surface tension in the orifice and a drop in ejected.
  • Each orifice is referred to as nozzle. Different nozzles can be connected to the same chamber.
  • the controller sends a signal (an electric pulse with defined parameters), to each relevant nozzle based on the pixel matrix that was sent to print.
  • the controller can send different signals to different nozzles, according to a predetermined correlation of droplet size to signal form. Within a time interval of 0.5-3 seconds, all the nozzle will eject predetermined amount of droplets enabling generation of an aerosol mixture with a desired compound profile.
  • the data for activation can be loaded to the controller from a data base after the user selects a specific inhalation ‘type’, or profile.
  • a piezo needle can be used with high viscosity compounds when the viscosity of such compounds is reduced by, for example, heating (e.g., the viscosity of Delta 9 THC can be reduced to 500 cp by heating it to 60 Degrees Celsius).
  • a piezo needle is composed of a thin stainless steel cylinder with a piezo transducer soldered to its external wall. The vibration produced by the piezo transducer is transferred to the cylinder thereby generating an aerosol from a high viscosity compound placed therein.
  • a heating element coupled with a thermocouple is positioned around the cylinder of the piezo needle.
  • the cylinder is preheated to lower the viscosity of delta 9 THC following which the piezo transducer is activated to aerosolize it.
  • the thermal-piezo needle can also be used to mimic the profile of some cannabis strains that include low terpene concentrations (0.05%) that cannot be readily metered by a piezo needle or thermal printhead.
  • a thermal-piezo needle extraction mechanism can be used to dispense amounts as little as 100 ug (weight) to a final concentration of 0.05% or less in the aerosolized mixture.
  • FIG. 2 illustrates reservoirs 14 and mechanisms 16 of cartridge 12 in greater detail.
  • This embodiment of cartridge 12 includes micro-reservoirs 50 why are they referred to as both 14 and 50 ??that are configured for containing, for example, terpenes, flavonoids and/or esters (in liquid such as alpha-pinene); each of microreservoirs 50 can be 10-200 microliters in volume.
  • Cartridge 12 can also include a reservoir 52 for containing cannabinoids or other high viscosity compounds (in a liquid such as Delta 9 THC), reservoir 52 can be 0.1-2ml in volume.
  • a piezo or thermal printhead 54 is fluidly connected to each of micro-reservoirs 50 and a piezo needle 56, piezo transducer 58 and heating element 60 not market in the drawing are fluidly connected to reservoir 52.
  • the aerosol generated by each mechanism 16 is directed through a conduit 24 into a mixing chamber 20 that is in fluid communication with a mouthpiece 22.
  • the aerosol generated by each mechanism 16 is directed through a conduit 24 directly into mouthpiece 22.
  • the volume of the aerosol will change with the dose inhaled. For example, a 2 mg dose will be around 2 ul in volume.
  • Mouthpiece 22 and mixing chamber 20 can be manufactured using injection molding approaches from non-reactive odorless materials (e.g., Polypropylene). Mixing chamber 22 and mouthpiece 20 are shaped to avoid turbulence in aerosol flow, avoiding sharp corners and rough inner surface finish. The outer shape of mouthpiece 22 is designed to comfortable conform with the user’s lips.
  • non-reactive odorless materials e.g., Polypropylene
  • Device 10 also includes a controller 30 for controlling device 10 operation ( Figure 1).
  • Controller 30 includes a microcontroller (MCU) 32, an inhalation trigger 34 and related electronics 36.
  • Device 10 further includes a battery 38 for powering controller 30 and a wireless unit for communicating with external devices (e.g., Smartphone).
  • Device 10 further includes a memory for storing formulations and cartridge type identifiers.
  • Controller 30 provides several functions. It identifies the type and content of cartridge 12 inserted in device 10 and controls the aerosolization of the compounds stored therein based on user input.
  • Input can be provided directly to device 10 via a user interface (e.g., touch screen) or indirectly via a connected device (e.g., smartphone).
  • a user can select a formulation (mixture of compounds) for inhalation from a dedicated App on a smartphone.
  • the formulation can be stored on the smartphone or a remote database 40 and downloaded to the user’s smartphone on demand.
  • the data (device 10 settings) for generating the formulation can then be transferred wirelessly from the Smartphone or database 40 (through the wireless unit) to controller 30. Controller 30 then selects the active reservoirs (from which the aerosol is generated) and the aerosolization parameters (droplet size and quantity).
  • controller sends an activation signal to mechanisms 16 to draw the materials having the selected compounds from reservoirs 14 and aerosolize them at mechanisms 16.
  • the generated aerosols are delivered from mechanisms 16 to mouthpiece 22 (directly or through mixing chamber 20) and inhaled by the user.
  • the present system can also be configured to enable sharing of custom formulations between users since any formulation administrable by the present inhaler can be translated to digital data that can be uploaded to the cloud and shared between users.
  • a user downloads a Haze strain metabolic fingerprint from the database to a mobile deice (e.g. smartphone) and decides to modify the terpene profile adding 0.3% of limonene and reducing the concentration of alpha-pinene by 40%.
  • the data representing this newly created custom formulation can then be sent to the inhaler and tested by the user. If this formulation produces a more desirable effect, the user can save the profile/fingerprint data of this new formulation as a file and share this file with other users (e.g., upload to a cloud library of downloadable user formulations or forward it directly to a friend).
  • a user decides to try a popular cannabis strain that is well characterized.
  • the user accesses the dedicated App on a smartphone and selects the desired strain from a list.
  • a cartridge including the compounds listed in Table 2 can be used to replicate the metabolic fingerprint of any recreational strain.
  • An inhalation of 2 mg of delta 9 THC with the corresponding compounds (a recreational dose) characterizing the desired strain will produce a noticeable psychoactive effect.
  • a cartridge of the present device can deliver up to 500 such doses before replacement.
  • the compound-related data is communicated to the user’s phone and transferred wirelessly to the inhaler device.
  • the inhaler indicates to the user the type of cartridge to load into the device and selects from a list of stored materials (see Table 2 below) - the types of compounds to be aerosolized, their droplet size, quantity (droplet number) and ratio.
  • the controller translates the parameters of these different compounds to electric pulses that generate the individual droplets. These droplets are mixed in the mixing chamber during the user inhalation.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne un dispositif inhalateur qui comprend un premier mécanisme configuré pour convertir un premier composé d'une première classe de composés en premier aérosol ; et un deuxième mécanisme configuré pour convertir un deuxième composé d'une deuxième classe de composés en deuxième aérosol. L'inhalateur comprend en outre un embout buccal en communication fluidique avec les premier et deuxième mécanismes pour permettre à un utilisateur d'inhaler ledit premier aérosol et ledit deuxième aérosol et une chambre de mélange facultative.
PCT/IL2021/051032 2020-08-24 2021-08-23 Dispositif inhalateur Ceased WO2022043999A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063069179P 2020-08-24 2020-08-24
US63/069,179 2020-08-24

Publications (1)

Publication Number Publication Date
WO2022043999A1 true WO2022043999A1 (fr) 2022-03-03

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PCT/IL2021/051032 Ceased WO2022043999A1 (fr) 2020-08-24 2021-08-23 Dispositif inhalateur

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116531618A (zh) * 2023-04-15 2023-08-04 广西卜鹿医疗器械有限公司 一种多模式雾化器工作方法、系统及存储介质

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060130829A1 (en) * 2004-12-20 2006-06-22 Sexton Douglas A Inhalation device
US8528544B2 (en) * 2007-05-30 2013-09-10 Canon Kabushiki Kaisha Inhaler
US20140069420A1 (en) * 2011-05-10 2014-03-13 Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung E.V. Controllable fluid sample dispenser and methods using the same
US20180289908A1 (en) * 2016-04-04 2018-10-11 Nexvap Sa Mobile inhaler and a container for using therewith
US20190183177A1 (en) * 2017-12-15 2019-06-20 Rai Strategic Holdings, Inc. Aerosol delivery device with multiple aerosol delivery pathways

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060130829A1 (en) * 2004-12-20 2006-06-22 Sexton Douglas A Inhalation device
US8528544B2 (en) * 2007-05-30 2013-09-10 Canon Kabushiki Kaisha Inhaler
US20140069420A1 (en) * 2011-05-10 2014-03-13 Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung E.V. Controllable fluid sample dispenser and methods using the same
US20180289908A1 (en) * 2016-04-04 2018-10-11 Nexvap Sa Mobile inhaler and a container for using therewith
US20190183177A1 (en) * 2017-12-15 2019-06-20 Rai Strategic Holdings, Inc. Aerosol delivery device with multiple aerosol delivery pathways

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116531618A (zh) * 2023-04-15 2023-08-04 广西卜鹿医疗器械有限公司 一种多模式雾化器工作方法、系统及存储介质

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