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WO2022040110A3 - Alkylating agent and combinations in the treatment of immune-related and liver diseases, alzheimer's diseases and fibrosis diseases - Google Patents

Alkylating agent and combinations in the treatment of immune-related and liver diseases, alzheimer's diseases and fibrosis diseases Download PDF

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Publication number
WO2022040110A3
WO2022040110A3 PCT/US2021/046193 US2021046193W WO2022040110A3 WO 2022040110 A3 WO2022040110 A3 WO 2022040110A3 US 2021046193 W US2021046193 W US 2021046193W WO 2022040110 A3 WO2022040110 A3 WO 2022040110A3
Authority
WO
WIPO (PCT)
Prior art keywords
diseases
treatment
alzheimer
fibrosis
nafld
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2021/046193
Other languages
French (fr)
Other versions
WO2022040110A2 (en
Inventor
Sheng Liu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of WO2022040110A2 publication Critical patent/WO2022040110A2/en
Publication of WO2022040110A3 publication Critical patent/WO2022040110A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/554—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being a steroid plant sterol, glycyrrhetic acid, enoxolone or bile acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/131—Amines acyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Botany (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

This application provides compositions and methods useful in the treatment of immune-related diseases, inflammation related diseases, Non-Alcoholic Fatty Liver Disease (NAFLD), Nonalcoholic Steatohepatitis (NASH), liver cirrhosis, Alzheimer's diseases, fibrosis diseases and Drug Induced Liver Injury (DILI). Additionally, this invention related to novel compositions and methods to screen drugs for the treatment of the diseases. The invention contemplates that methoxyamine (MOA), alone or with other drugs shall be used as a treatment for aldehyde and ketone related immune-related and inflammation diseases, NAFLD, NASH, liver cirrhosis, Alzheimer's diseases, fibrosis diseases and DILL Specifically, the invention contemplates that methoxyamine, alone or with other potential drugs in sequence or in combination, shall be used as a treatment for NAFLD, NASH and liver cirrhosis Alzheimer's diseases, fibrosis diseases, and the invention contemplates that methoxyamine with obeticholic acid in sequence or in combination, shall be used as a treatment for NAFLD, NASH and liver cirrhosis.
PCT/US2021/046193 2020-08-18 2021-08-17 Alkylating agent and combinations in the treatment of immune-related and liver diseases, alzheimer's diseases and fibrosis diseases Ceased WO2022040110A2 (en)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US202063067209P 2020-08-18 2020-08-18
US202063067288P 2020-08-18 2020-08-18
US202063067225P 2020-08-18 2020-08-18
US63/067,225 2020-08-18
US63/067,209 2020-08-18
US63/067,288 2020-08-18
US202063109843P 2020-11-04 2020-11-04
US63/109,843 2020-11-04

Publications (2)

Publication Number Publication Date
WO2022040110A2 WO2022040110A2 (en) 2022-02-24
WO2022040110A3 true WO2022040110A3 (en) 2022-03-31

Family

ID=80323195

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2021/046193 Ceased WO2022040110A2 (en) 2020-08-18 2021-08-17 Alkylating agent and combinations in the treatment of immune-related and liver diseases, alzheimer's diseases and fibrosis diseases

Country Status (1)

Country Link
WO (1) WO2022040110A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115887472B (en) * 2022-10-28 2024-03-19 广州医科大学 Application of sodium mannite in preparation of medicines for treating pulmonary fibrosis diseases

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020103228A1 (en) * 1999-10-06 2002-08-01 Torrent Pharmaceuticals Ltd. Composition and method for use of pyridinium derivatives in cosmetic and therapeutic applications
WO2017210147A1 (en) * 2016-05-29 2017-12-07 Wei Jia Liver disease-related biomarkers and methods of use thereof
WO2018104916A1 (en) * 2016-12-09 2018-06-14 Cadila Healthcare Limited Treatment for primary biliary cholangitis

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020103228A1 (en) * 1999-10-06 2002-08-01 Torrent Pharmaceuticals Ltd. Composition and method for use of pyridinium derivatives in cosmetic and therapeutic applications
WO2017210147A1 (en) * 2016-05-29 2017-12-07 Wei Jia Liver disease-related biomarkers and methods of use thereof
WO2018104916A1 (en) * 2016-12-09 2018-06-14 Cadila Healthcare Limited Treatment for primary biliary cholangitis

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BURCHAM P.C., KERR P.G., FONTAINE F.: "The antihypertensive hydralazine is an efficient scavenger of acrolein", REDOX REPORT., CHURCHILL LIVINGSTONE, EDINBURGH., GB, vol. 5, no. 1, 1 February 2000 (2000-02-01), GB , pages 47 - 49, XP055921801, ISSN: 1351-0002, DOI: 10.1179/rer.2000.5.1.47 *
ELLIS, E.M.: "Reactive carbonyls and oxidative stress: Potential for therapeutic intervention", PHARMACOLOGY & THERAPEUTICS, ELSEVIER., GB, vol. 115, no. 1, 1 July 2007 (2007-07-01), GB , pages 13 - 24, XP022134151, ISSN: 0163-7258, DOI: 10.1016/j.pharmthera.2007.03.015 *
HEIDARI REZA, NIKNAHAD HOSSEIN, JAMSHIDZADEH AKRAM, AZARPIRA NEGAR, BAZYARI MANDANA, NAJIBI ASMA: "Carbonyl Traps as Potential Protective Agents against Methimazole-Induced Liver Injury ", JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, WILEY, US, vol. 29, no. 4, 1 April 2015 (2015-04-01), US , pages 173 - 181, XP055921802, ISSN: 1095-6670, DOI: 10.1002/jbt.21682 *

Also Published As

Publication number Publication date
WO2022040110A2 (en) 2022-02-24

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