WO2021224947A1

WO2021224947A1 - Formulation of acute respiratory disease control formulation

Info

Publication number: WO2021224947A1
Application number: PCT/IR2020/050022
Authority: WO
Inventors: Mehdi NOROUZI; Majid LA'L ROSHAN; Hassan SHADEMANI
Original assignee: Individual
Current assignee: Individual
Priority date: 2020-05-02
Filing date: 2020-07-17
Publication date: 2021-11-11
Anticipated expiration: 2022-11-02

Abstract

Occurrence of the covid-19 epidemic in 2020 and becoming a global concern has led us to develop a coronavirus medicine with cooperation of medical experts to treat hospitalized patients. Herbal formulations with broad-spectrum antiviral effects were produced for the first time and was sent to medical centers for clinical trials. patent registration of this herbal formulation seems necessary in prevention and control of covid 19. According to previous studies, each of the herbal components of the formulation has significant antiviral and antitussive effects. Herbal formulations contain garlic, fennel, savory, Persian hogweed, thymes and clove and opium which have antiviral effects and improve immune and respiratory systems. After analyzing the trial datas, it was found that most patients were improved after taking this medication and lung and other organ involvements have rapidly improved.

Description

Title of Invention :

Formulation of Acute Respiratory Disease Control Formulation

Technical field of related invention

[Herba I and industrial pharmacy, treatment of infectious diseases, especially viral]

Technical problem and description of invention goals

[COVID-19 belongs to the Coronaviridae family (CoV), ssRNA + viruses, which are widely distributed among humans and other mammals and cause a wide range of infections, from cold symptoms to fatal respiratory diseases. The virus is also zoonotic and can be transmitted between humans and animals. The death rate of this new CoV in China is about 2%, which is lower than the mortality of SARS and MERS. Common symptoms of infection include respiratory symptoms, fever, cough, shortness of breath. In more severe cases, the infection can cause pneumonia, acute respiratory syndrome, kidney failure, and even death. These symptoms may appear 2-14 days after exposure to the virus. So far, no specific or FDA-approved treatment for COVID-19 infection has been approved. The researchers reported some treatments for COVID-19, such as remdesivir or chloroquine and a lopinavir-ritonavir combination protein inhibitor previously used to treat SARS-CoV and MERS-CoV, but their effect is still unclear and needs to be evaluated.

In December 2019, a new coronavirus (SARS-CoV-2) was discovered and identified in cases of viral pneumonia in Wuhan, H ubei Province, China. It was then named by the World Health Organization (WFIO) on January 12, 2020. The following month, 19-COVID spread rapidly in H ubei province and other countries. Moreover, the sharp increase in the number of patients caused widespread panic among the people.

Coronaviruses are RNA viruses that are widely spread among humans, other mammals, and birds and cause respiratory, intestinal, liver, and neurological diseases. The four viruses 229 E, OC43, NL63, and HKU1 are very common and usually cause cold symptoms in people with defective immune systems. Two other species - Acute Respiratory Coronavirus (SARS-CoV) and Middle East Respiratory Coronavirus (MERS-CoV) are zoonotic and have been linked to fatal diseases.

It should be noted that most cases lead to death in vulnerable populations and have special medical conditions such as suppression of the immune system, diabetes, hypertension and cardiovascular disease. But what has caused global concern is the rapid transition from human to human, which has led to its widespread transition in many countries around the world. Clinical guidance from the World Health Organization (WHO) and the Centers for Disease Control and Prevention (CDC) includes prompt supportive care such as oxygen therapy, fluid intake, and antimicrobials (if sepsis is present). So in the current crisis, finding a cure can be a great help to the international community.

A description of the status of previous knowledge and a history of advances in the invention of claims.

[So far, the use of recommended dietary regimens for the treatment of patients with COVID-19 has failed to control the coronavirus epidemic. Occasionally there are conflicting reports of the effects of certain medications, such as Tamiflu, hydroxychloroquine, chloroquine, and azithromycin, and many of their dietary supplements, none of which guarantee definitive treatment. Herbs used in traditional Iranian medicine have potential medical effects. Prescriptions and formulations available in Iranian medical books have been widely used to treat respiratory diseases and there are numerous articles about medical effectiveness of these plants. Suitable anti-COVID-19 with minimal side effects can counteract this pandemic.

The herbal formulation contains many phytochemicals and active ingredients with antiviral effects that have been repeatedly demonstrated in previous studies.

Garlic: In today's medicine, various studies have been conducted on garlic and its antimicrobial and antiviral effects. In one study, it was used as a preventative factor against colds in 146 people as a sample, and the study found that people who took allicin supplements were less likely to catch colds during the study period. In another study on the embryo of a chicken, its antiviral effects on the influenza virus H9N2 were proven. Another study on the antiviral properties of garlic extract found that garlic have the inhibitory properties against the influenza A virus (H1N1) pdm09 by inhibiting the synthesis of the virus's nucleoprotein and its polymerase activity.

Fennel: The antiviral effects of the essential oil and extract of this plant have been reported in several studies.

Savory: It has antimicrobial, antifungal, anti-inflammatory and anti-viral properties.

Golpar: It is a plant with a warm nature and its chemical compounds include methyl butyrate, acetate ethyl butyrate, acethyl acetate hexhyl and some other acids. In traditional medicine, this plant is used as a remedy for bloating, indigestion, appetizing, stomach tonic, antimicrobial and antiseptic. In addition, it has antibacterial, antifungal and antioxidant effects.

Thyme Shirazi: The effects of thyme against Herpes simplex type 1 have been proven in all stages of the disease. The phenolic compounds in thyme, such as thymol and carvacrol prevent viral replication by inhibiting protein synthesis, or RNA, and limit the entry of the virus into host cells by disrupting haemaglutinin activity. In a randomized, double-blind study of 40 asthmatic patients, thyme extract improved FEV1, and the rate of wheezing and plasma levels of N02 was reduced in these patients. Also in the animal model, thyme extract reduced the expression of the gene for inflammatory cytokines (IL-4, IL- 17, TGF-b) and increased anti-inflammatory cytokines (IFN-y) and FOXP3 in splenocytes and suppressed Th2 and Thl7 cells in mice.

Clove: Groups of phenolic and alkamide compounds have been shown to have antiviral and antifungal properties, respectively, which can prevent or control upper respiratory tract infections (URIs). In addition, its strong antiviral activity has been attributed to several viruses, including type IV H3N2. It also effectively reverses the inflammatory responses caused by the virus in cultured epithelial cells. Recent studies have shown that the preparation of the extract at non-toxic concentrations of certain species and parts of the plant has potent antiviral activity, especially against membrane-containing viruses. In addition, all human influenza viruses (including Tamiflu-resistant strains), as well as herpes simplex virus, respiratory viruses, and rhinoviruses, were highly sensitive to the standard Akinase extract. Opium: Provides ample evidence of drug use to treat acute and chronic pain. Flowever, the doctor must consider the risks of abuse and dependence and its side effects when using the opioids. These compounds have long been used as sedatives and painkillers. Since the nineteenth century, with the separation of opium alkaloids and the administration of these substances, their medical use has increased. Various pharmaceutical groups of opioids are still the strongest painkillers, although their effectiveness has been questioned for some types of pain.]

Provide a solution to the existing technical problem along with a detailed and sufficient and integrated description of the invention .

[Preparing an antiviral syrup and performing a precise clinical trial under epidemic conditions could be a way to measure the effectiveness of a herbal formulation in Covid-19 disease. To extract the contents that are more likely to affect coronavirus based on Iranian medicine, the book Al-Adawiya Reservoir was used. First, a list of related diseases, including lung diseases, as well as lesions, was provided. This list includes 101 diseases. The medicinal effects, which were generally associated with these diseases or the strengthening of the lungs or the strengthening of the body, were then prepared as a separate list of 77 verbs. Then, using text mining methods in R software, the contents mentioned in the section of verbs and their properties of one of the listed diseases or verbs were extracted. For each of the items, a list of all diseases or verbs mentioned in the section on verbs and their properties was prepared.

Ingredients of the syrup, consisting of plants: Shirazi thyme with the scientific name of Zataria multiflora Boiss., Garlic with the scientific name of Alium Sativum., Angelica with the scientific name of Fleracleum persicum Foeniculum vulgare and opium.

Preparation of plant extracts: For this purpose, compared to the total weight of the final extract, 2.5% savory, 2.5% fennel, 2% angelica, 15% chopped garlic,

1% thyme thyme and 0.57% cloves and 0.57 % Of the opium were prepared and after transfer to the percolator, a sufficient amount of hydroalcoholic solvent of 30. C was added to them. Extraction was performed at 55. C for 7 days. After the seventh day, the extract was smoothed. The schematic representation of the extract steps is summarized in Figure 1-1 .

Syrup preparation: Compared to the total weight of the syrup, 50% of the extracts of the mentioned plants were mixed with 20% of honey and after some time of continuous mixing at room temperature, it was adjusted to specific with pure water. Filling operations were performed on 120 ml bottles, (labeling and jet printing of syrup )Figure 1-2 .

The formulation of the drug for the control of acute respiratory diseases is summarized in Table 1-1 and the formulation of the final syrup is summarized in Table 1-2 .]

Table 1-1- Formulation of acute respiratory disease control drug used in the final syrup

Table 1-2 - Formulation of syrup control of acute respiratory diseases

Explain shapes, maps and diagrams

Figure 1-1- Schematic representation of extraction steps

Figure 1-2- Schematic representation of the steps of making syrup

Clear and accurate explanation of advantages of the claimed invention compared to previous ones

Presenting effective herbal formulations to control acute respiratory [- diseases

Reduction of the risk of mortality in acute respiratory patients with covid 19 - Controling the coronavirus epidemic at the national and international levels - Prevention of disease -

Preventing heavy medical costs due to hospitalization of patients with covid- - 19

The return of the normal economic and social situation of the people to the - period before the disease outbreak] Explain at least one practical method for using the invention Use of this product is as follows:

For treatment: the first and second day 10 ml every 4 days and from the third day to the end of the fifth day every 10 ml every 6 hours.

[ For prevention: twice a day, morning and night, 10 ml each time

Explicit mention of industrial application of invention

It has medical use control and treatment of acute respiratory diseases in medicine.]

Claims

What is claimed:

Claim 1:

It is claimed that the drug for control of acute respiratory diseases includes the following ingredients:

Savory (Satureja hortensis) 2.5%

Fennel (Foeniculum vulgare) 2.5%

Persian (Heracleum persicum) 2%

Shirazi Thyme (Zataria multiflora Boiss) 1%

Garlic (Alium Sativum) 15%

Clove (Eugenia caryophyllus) 0.57%

Opium is 0.57%

Claim 2:

According to Claim 1, the named combination drug is dissolved in 27 to 30 degree alcohol as a solvent.

Claim 3:

According to Claim 1 and 2, the combination drug is used in conjunction with a sweetener.