WO2021213753A1 - Environmentally friendly cosmetic sunscreen - Google Patents

Abstract

The invention relates to a cosmetic preparation in the form of an oil-in-water emulsion or ethanol solution containing a) at least one UV filter from the group of triazine derivatives, b) caprylic/capric acid triglyceride (INCI: Caprylic/Capric triglyceride), and c) one or more water-in-oil emulsifiers from the group of polyglyceryl compounds.

Description

description

Environmentally friendly cosmetic sunscreen

The present invention relates to a cosmetic preparation in the form of an O / W emulsion or ethanolic solution containing a) at least one UV filter from the group of triazine derivatives b) caprylic / capric acid triglyceride (INCI: Caprylic / Capric triglyceride) c) one or more W / O emulsifiers from the group of polyglyceryl compounds.

The trend away from elegant paleness towards “healthy, sporty brown skin” has been unbroken for years. In order to achieve this, people expose their skin to solar radiation, as this causes pigment formation in the sense of melanin. However, the ultraviolet radiation of sunlight also has a damaging effect on the skin. In addition to the acute damage (sunburn), long-term damage such as an increased risk of developing skin cancer occurs with excessive exposure to light from the UVB range (wavelength: 280-320 nm). The excessive exposure to UVB and UVA radiation (wavelength: 320-400 nm) also leads to a weakening of the elastic and collagen fibers of the connective tissue. This leads to numerous phototoxic and photoallergic reactions and leads to premature aging of the skin.

To protect the skin, a number of light protection filter substances have therefore been developed that can be used in cosmetic preparations. These UVA and UVB filters are summarized in most industrialized countries in the form of positive lists such as Annex 6 of the Cosmetics Ordinance.

The large number of commercially available sunscreens should not, however, obscure the fact that these prior art preparations have a number of disadvantages. l Cosmetic sunscreens contain a large number of ingredients which are necessary so that the preparation offers sufficient UV protection, is sensorially attractive and, in particular in water sports activities, has sufficient water resistance.

In order to achieve high sun protection factors, the use of UV filters based on triazine derivatives is almost indispensable. In order to keep these poorly soluble compounds in solution or to get them in solution at all in the recipe, a number of oil components are used. In the past, the use of UV filters that are liquid at room temperature, such as octocrylene or 4-methoxycinnamic acid 2-ethylhexyl ester (INCI octyl methoxycinnamate), has proven to be particularly ingenious.

The disadvantage of the state of the art is the fact that some scientists suspect that the use of these substances could be problematic with regard to their biological effectiveness and degradability. The risk of substances being unintentionally conveyed into the skin is also discussed for some UV filters from the group of oil components that are liquid at room temperature.

Another important group of ingredients in sunscreens are the synthetic polymers, which, for example, contribute to the water resistance of the product as film formers such as vinylpyrrolidone / hexadecene copolymers or such as gel formers based on polyacrylates (polyacrylates, cross-linked acrylate / C10-C30 alkyl acrylate polymers) ensure the viscosity and stability of the preparation. Some scientists assume that these substances are more difficult to biodegrade. For others, these substances simply count as “microplastics”.

Whether and to what extent such concerns, assessments, and classifications are justified can be left open in the context of the present disclosure and left to further scientific discussion. The fact is, however, that there is an increasing desire among consumers for sunscreens that are free from such ingredients.

It was therefore the object of the present invention to develop a cosmetic sunscreen which is free from these ingredients, is temperature and storage stable and has adequate water resistance. In particular, a sunscreen based on triazine derivatives should be developed as a UV filter in which the triazine derivatives are stable are present in dissolved form without being present in UV filters that are liquid at room temperature, such as 3- (4-methylbenzylidene) camphor, 2-hydroxy-4-methoxybenzophenone (INCI: Oxybenzon), 4-methoxycinnamic acid-2-ethylhexyl ester (INCI Octylmethoxycinnamate), ethylhexyl -2-cyano-3,3-diphenyl acrylate must be dissolved.

The object is surprisingly achieved by a cosmetic preparation in the form of an O / W emulsion or ethanolic solution containing a) at least one UV filter from the group of triazine derivatives b) caprylic / capric acid triglyceride (INCI: caprylic / capric triglyceride) c) one or several W / O emulsifiers from the group of polyglyceryl compounds.

The person skilled in the art knows a number of sunscreens with triazine derivatives and caprylic / capric acid triglyceride (INCI: Caprylic / Capric triglyceride), but it was surprising and unforeseeable for the person skilled in the art that the addition of W / O emulsifiers from the group of polyglyceryl compounds reduced the solubility Increased triazine derivatives in the oil phase and thus the storage and temperature stability of the preparation overall improved, so that the preparations without 3- (4-methylbenzylidene) camphor, 2-hydroxy-4-methoxybenzophenone (INCI: Oxybenzone), 4-methoxycinnamic acid-2 -ethylhexyl ester (INCI Octylmethoxycinnamate), ethylhexyl-2-cyano-3,3-diphenyl acrylate as "solvents" for the triazines can be formulated.

According to the invention, it is advantageous if the UV filter or filters are selected from the group of triazine derivatives from the compounds 2,4,6-tris- [anilino- (p-carbo-2'-ethyl-1'-hexyloxy) ] -1, 3,5-triazine (INCI: Ethylhexyl Triazone) and 2,4-bis - {[4- (2-ethyl-hexyloxy) -2-hydroxy] - phenyl} -6- (4-methoxyphenyl) - 1,3,5-triazine (INCI: bis-ethylhexyloxyphenol methoxyphenyl triazine).

Embodiments of the present invention which are advantageous according to the invention are characterized in that one or more W / O emulsifiers from the group of polyglyceryl compounds are selected from the group of compounds diisostearoyl polyglyceryl-3 dimer dilinoleates, polyglyceryl-3 diisostearates.

It is advantageous for the purposes of the present invention if the preparation is free from polyacrylates, crosslinked acrylate / C10-C30 alkyl acrylate polymers and vinylpyrrolidone / hexadecene copolymers. In addition, it is preferred according to the invention if the preparation is free of 3- (4-methylbenzylidene) camphor, 2-hydroxy-4-methoxybenzophenone (INCI: Oxybenzon), 4-methoxycinnamic acid-2-ethylhexyl ester (INCI Octylmethoxycinnamate), ethylhexyl 2-cyano-3,3-diphenyl acrylate (INCI: octocrylene, parabens (especially methyl, propyl and butyl paraben), methyl isothiazolinone, chloromethyl isothiazolinone and DMDM hydantoin,

Polyethylene glycol ethers or polyethylene glycol esters.

It is also advantageous according to the invention if the preparation is free from 2-ethylhexyl 2-hydroxybenzoate (INCI: ethylhexyl salicylate) and 3,3,5-trimethylcyclohexyl 2-hydroxybenzoate (INCI: homosalate).

The preparation according to the invention can be present in two advantageous embodiments: as an O / W emulsion (oil-in-water emulsion) and as an ethanolic solution, which can optionally be thickened to form a gel.

The first embodiment of the present invention which is advantageous according to the invention is characterized in that the preparation is in the form of an O / W emulsion. It should be noted that the person skilled in the art distinguishes hydrodispersions from O / W emulsions according to the invention on the basis of the emulsifier content. It is advantageous according to the invention if the preparation is in the form of an O / W emulsion.

In such a case it is advantageous according to the invention if, as O / W emulsifiers, one or more compounds are selected from the group consisting of glyceryl stearate citrate, glyceryl stearate (self-emulsifying), stearic acid, stearate salts, polyglyceryl 3-methylglycose distearate, sodium cetearyl sulfate, potassium cetearyl phosphate, and polyglyceryl phosphate Sodium stearoyl glutamate. can be used.

For the O / W emulsions according to the invention, it is advantageous according to the invention if the preparation contains caprylic / capric acid triglyceride (INCI: Caprylic / Capric triglyceride) in a concentration of 0.5 to 20% by weight, based on the total weight of the preparation. The concentration range from 1 to 18% by weight, based on the total weight of the preparation, is preferred according to the invention

For the O / W emulsions according to the invention it is advantageous according to the invention if the preparation contains W / O emulsifiers from the group of polyglyceryl compounds in one Concentration of 0.1 to 5% by weight, based on the total weight of the preparation, contains.

For the O / W emulsions according to the invention it is preferred according to the invention if the preparation contains the compound diisostearoyl polyglyceryl-3-dimer-dilinoleate as W / O emulsifiers from the group of polyglyceryl compounds.

For the O / W emulsions according to the invention, it is advantageous according to the invention if the preparation contains UV filters from the group of triazine derivatives in a total amount of 0.1 to 15% by weight, based on the total weight of the preparation.

When using triazine derivatives, a distinction can be made between three cases:

If the O / W emulsion according to the invention contains only the triazine derivative 2,4,6-tris- [anilino- (p-carbo-2'-ethyl-1'-hexyloxy)] - 1,3,5-triazine (INCI: ethylhexyl Triazone), it is advantageous according to the invention to use this compound in a concentration of 0.1 to 5% by weight, based on the total weight of the O / W emulsion.

If the O / W emulsion according to the invention contains only the triazine derivative 2,4-bis - {[4- (2-ethylhexyl oxy) -2-hydroxy] phenyl} -6- (4-methoxyphenyl) -1, 3 , 5-triazine (INCI: bis-ethylhexyloxyphenol methoxyphenyl triazine), it is advantageous according to the invention to use this compound in a concentration of 0.1 to 10% by weight, based on the total weight of the O / W emulsion.

If, on the other hand, the preparation contains both triazine derivatives which are advantageous according to the invention, it is advantageous according to the invention to use 2,4,6-tris- [anilino- (p-carbo-2'-ethyl-1'-hexyloxy)] -1, 3,5- triazine (INCI: Ethylhexyl Triazone) in a concentration of 0.1 to 10% by weight and 2,4-bis - {[4- (2-ethyl-hexyloxy) -2-hydroxy] -phenyl} -6- (4 -methoxyphenyl) -1, 3,5-triazine (INCI: bis-ethylhexyloxyphenol methoxyphenyl triazine) in a concentration of 0.1 to 5% by weight, each based on the total weight of the O / W emulsion.

In the second advantageous embodiment according to the invention, the preparation according to the invention is in the form of an ethanolic solution. According to the invention, such preparation forms are advantageously characterized in that the ethanol content is from 30 to 70% by weight, based on the total weight of the preparation.

In the ethanolic solutions, the embodiments advantageous according to the invention are characterized in that the preparation contains caprylic / capric acid triglyceride (INCI: Caprylic / Capric triglyceride) in a concentration of 0.1 to 20% by weight, based on the total weight of the preparation. The concentration range from 3 to 10% by weight, based on the total weight of the preparation, is preferred according to the invention.

The ethanolic solutions advantageous according to the invention are characterized in that the preparation contains W / O emulsifiers from the group of polyglyceryl compounds in a concentration of 0.1 to 5% by weight, based on the total weight of the preparation.

For the ethanolic solutions according to the invention, it is preferred according to the invention if the preparation contains the compound diisostearoyl polyglyceryl-3-dimer-dilinoleate as W / O emulsifiers from the group of polyglyceryl compounds.

For the ethanolic solutions according to the invention, it is advantageous according to the invention if the preparation contains UV filters from the group of triazine derivatives in a total amount of 0.1 to 15% by weight, based on the total weight of the preparation.

When using triazine derivatives, a distinction can be made between three cases:

If the ethanolic solution according to the invention contains only the triazine derivative 2,4,6-tris- [anilino- (p-carbo-2'-ethyl-1'-hexyloxy)] - 1,3,5-triazine (INCI: Ethylhexyl Triazone), Thus it is advantageous according to the invention to use this compound in a concentration of 0.1 to 5% by weight, based on the total weight of the preparation.

If the ethanolic solution according to the invention contains only the triazine derivative 2,4-bis - {[4- (2-ethylhexyloxy) -2-hydroxy] -phenyl} -6- (4-methoxyphenyl) -1, 3,5-triazine ( INCI: bis-ethylhexyloxyphenol methoxyphenyl triazine), it is advantageous according to the invention to use this compound in a concentration of 0.1 to 10% by weight, based on the total weight of the preparation. If, on the other hand, the preparation contains both triazine derivatives which are advantageous according to the invention, it is advantageous according to the invention to use 2,4,6-tris- [anilino- (p-carbo-2'-ethyl-1'-hexyloxy)] -1, 3,5- triazine (INCI: Ethylhexyl Triazone) in a concentration of 0.1 to 5% by weight and 2,4-bis - {[4- (2-ethyl-hexyloxy) -2-hydroxy] -phenyl} -6- (4 -methoxyphenyl) -1, 3,5-triazine (INCI: bis-ethylhexyloxyphenol methoxyphenyl triazine) in a concentration of 0.1 to 10% by weight, based in each case on the total weight of the preparation.

According to the invention, the ethanolic solutions can advantageously contain one or more thickeners. According to the invention, the following compounds can preferably be used: carboxymethyl hydroxypropyl guar gum, ethyl cellulose, hydroxypropyl cellulose.

It is advantageous according to the invention if the preparation according to the invention is transparent. According to the invention, a preparation is considered to be transparent if it is possible to see with the naked eye in daylight through a disposable cuvette (Brand Brand, 2.5ml, wavelength range: 220nm-900nm) filled with the preparation according to the invention. Characters (font type Arial font size 8) that are located immediately behind the disposable cuvette must be clearly recognizable and legible.

It is advantageous according to the invention if the preparation according to the invention is 4- (tert-butyl) -4'-methoxydibenzoylmethane and / or (2 - [- 4- (diethylamino) -2-hydroxybenzoyl] benzoic acid hexyl ester (INCI: Diethylamino Hydroxybenzoyl Hexyl Benzoate) contains.

It is advantageous according to the invention if the preparation contains xanthan gum (INCI: Xanthan Gum).

In such a case, the embodiments preferred according to the invention are characterized in that the preparation contains xanthan gum (INCI: Xanthan Gum) in a concentration of 0.05 to 2% by weight, based on the total weight of the preparation.

It is advantageous according to the invention if the preparation contains tapioca starch.

In such a case, the embodiments preferred according to the invention are characterized in that the preparation contains tapioca starch in a concentration of 0.1 to 4% by weight, based on the total weight of the preparation. It is advantageous according to the invention if the preparation contains distarch phosphate.

In such a case, the embodiments preferred according to the invention are characterized in that the preparation contains distarch phosphate in a concentration of 0.1 to 2% by weight, based on the total weight of the preparation.

Advantageous embodiments within the meaning of the present invention are characterized in that the preparation contains phenoxyethanol, ethylhexylglycerol and / or 4-hydroxyacetophenone.

It is also advantageous according to the invention if the preparation contains one or more alkanediols from the group of compounds 1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol, 1,2-decanediol, 2-methyl-1,3 -propanediol contains.

Embodiments of the present invention which are advantageous according to the invention are characterized in that the preparation has one or more compounds selected from the group of compounds alpha-lipoic acid, folic acid, phytoene, D-biotin, coenzyme Q10, alpha-glucosyl rutin, carnitine, carnosine, natural and / or synthetic isoflavonoids, flavonoids, creatine, creatinine, taurine, b-alanine, panthenol, magnolol, honokiol, tocopheryl acetate, dihydroxyacetone; Thiamidol; 8-hexadecene-1, 16-dicarboxylic acid, glycerylglycose, (2-hydroxyethyl) urea, vitamin E or its derivatives, hyaluronic acid and / or its salts and / or licochalcone A contains.

The preparation according to the invention can advantageously contain humectants. Moisturizers are substances or mixtures of substances that give cosmetic preparations the property of reducing the moisture release of the horny layer (also called transepidermal water loss (TEWL)) and / or the hydration of the skin after application or distribution on the skin surface To positively influence the horny layer.

Advantageous humectants (moisturizers) for the purposes of the present invention are, for example, glycerol, lactic acid and / or lactates, in particular sodium lactate,

Butylene Glycol, Propylene Glycol, Biosaccaride Gum-1, Glycine Soy, Ethylhexyloxyglycerin, Pyrrolidoncarboxylic Acid and Urea. It is also particularly advantageous to use polymeric To use moisturizers from the group of water-soluble and / or water-swellable and / or water-gellable polysaccharides. For example, hyaluronic acid, chitosan and / or a fucose-rich polysaccharide, which is filed in the Chemical Abstracts under the registry number 178463-23-5 and z. B. is available under the name Fucogel®1000 from SOLABIA SA. Moisturizers can also be used advantageously as anti-wrinkle ingredients to protect against skin changes such as those caused by skin changes. B. occur in skin aging, can be used.

The cosmetic preparations according to the invention can also advantageously, although not necessarily, contain fillers which, for. B. further improve the sensory and cosmetic properties of the formulations and, for example, induce or intensify a velvety or silky feel on the skin. Advantageous fillers for the purposes of the present invention are starch and starch derivatives (such as tapioca starch, distarch phosphate, aluminum or sodium starch, octenyl succinate and the like),

Pigments, which neither mainly have a UV filter nor a coloring effect (such as boron nitride etc.) and / or Aerosile ^® (CAS No. 7631-86-9) and / or talc and / or polyethylene, nylon.

Embodiments of the present invention which are advantageous according to the invention are characterized in that the preparation has one or more oils selected from the group of the compounds butylene glycol dicaprylate / dicaprate, phenethyl benzoate, C12-15 alkyl benzoate, dibutyl adipate; Diisopropyl sebacate, dicaprylyl carbonate, di-C12-13 alkyl tartrates, butyloctyl salicylate, diethylhexyl syringylidene malonate, hydrated castor oil dimerate, triheptanoin, C12-13 alkyl lactate, C16-17, alkyl benzoate, propylheptyl caprylate, diethyl hexiglycer 2,6 caprylate - Contains naphthalate, octyldodecanol, caprylic / capric triglyceride, ethylhexyl cocoate.

It is preferred according to the invention if the preparation contains dibutyl adipate, dicaprylyl carbonate, butylene glycol dicaprylate / dicaprate and / or C12-C15 alkyl benzoate.

The water phase of the preparations according to the invention can advantageously contain customary cosmetic auxiliaries, such as, for example, glycerol.

It is preferred according to the invention if the preparation according to the invention contains glycerol in a concentration of 0.1 to 15% by weight, based on the total weight of the preparation.

It is also advantageous for the purposes of the present invention if the preparation according to the invention has one or more perfumes selected from the group of compounds Limonene, citral, linalool, alpha-isomethylionone, geraniol, citronellol, 2-isobutyl-4-hydroxy-4-methyltetrahydropyran, 2-tert-pentylcyclohexyl acetate, 3-methyl-5-phenyl-1-pentanol, 7-acetyl-1, 1, 3,4,4,6-hexamethyltetralin, adipic acid diester, alpha-amylcinnamaldehyde, alpha-methylionone, amyl C-butylphenylmethylpropionalcinnamal, amyl salicylate, amylcinnamyl alcohol, anisalcohol, benzoin, benzyl alcohol, benzylbenzoate, benzylesalcinnamylate, benzyl benzoate, benzylesalcinnamylate, benzylbenzoate, benzylesalphene oil, benzylbenzoate, benzyl cinnamylate, benzoylesalphenal oil, benzylbenzoate, benzyl cinnotylate , Cedrol, Cinnamal, Cinnamyl Alcohol, Citronellylmethylcrotonat, Lemon Oil, Coumarin, Diethylsuccinate, Ethyllinalool, Eugenol, Evernia Furfuracea Extract, Evernia Prunastri Extract, Farnesol, Guaiac Wood Oil, Hexylcinnamal, Lemon Theate Oil, Lemon Theate Oil, Lemon Theate Oil, Pc, Lemonetharone Oil, Lemon Theate Contains nutmeg oil, rosemary oil, sweet orange oil, terpineol, tonka bean oil, triethyl citrate and / or vanillin.

In addition, the preparations according to the invention can contain the ingredients customary for cosmetic sunscreens in the customary use concentrations.

Comparison attempt

The inventive effect could be demonstrated with the help of the following experiments:

The triazine derivative was heated to 80-90 ° C. in the cosmetic oil and dissolved with stirring for 30 minutes, then the w / o emulsifier would be added and brought to room temperature with stirring.

Method:

The analysis of the light filter was carried out according to GTM LC099-12 with one double determination each.

Before weighing in, the supernatant solution was filtered in each case (0.2 μm or 0.45 μm PTFE).

Examples

The following examples are intended to illustrate the present invention without restricting it. Unless otherwise stated, all quantities, proportions and percentages are based on the weight and the total amount or the total weight of the preparations.

Claims

Claims 1 . Cosmetic preparation in the form of an O / W emulsion or ethanolic solution containing a) at least one UV filter from the group of triazine derivatives b) caprylic / capric acid triglyceride (INCI: Caprylic / Capric triglyceride) c) one or more W / O emulsifiers the group of polyglyceryl compounds. 2. Cosmetic preparation according to claim 1, characterized in that the UV filter or filters are selected from the group of triazine derivatives from the compounds 2,4,6-tris [anilino- (p-carbo-2'-ethyl-1) '-hexyloxy)] -1, 3,5-triazine (INCI: Ethylhexyl Triazone) and 2,4-bis - {[4- (2-ethyl-hexyloxy) -2-hydroxy] -phenyl} -6- (4 -methoxyphenyl) -1, 3,5-triazine (INCI: bis-ethylhexyloxyphenol methoxyphenyl triazine). 3. Cosmetic preparation according to one of the preceding claims, characterized in that one or more W / O emulsifiers from the group of polyglyceryl compounds are selected from the group of compounds diisostearoyl polyglyceryl-3 dimer dilinoleates, polyglyceryl-3 diisostearates and polyglyceryl-4 diisostearates / Polyhydroxystearates / sebacates. 4. Cosmetic preparation according to one of the preceding claims, characterized in that the preparation is free from polyacrylates, crosslinked acrylate / C10-C30 alkyl acrylate polymers and vinylpyrrolidone / hexadecene copolymers. 5. Cosmetic preparation according to one of the preceding claims, characterized in that the preparation is free from 3- (4-methylbenzylidene) camphor, 2- hydroxy-4-methoxybenzophenone (INCI: Oxybenzone), 4-methoxycinnamic acid-2-ethylhexyl ester ( INCI Octylmethoxycinnamate), ethylhexyl-2-cyano-3,3-diphenyl acrylate (INCI: octocrylene, parabens (especially methyl, propyl and butyl paraben), methylisothiazolinone, chloromethyl isothiazolinone and DMDM hydantoin, polyethylene glycol ethers or polyethylene glycol esters. 6. Cosmetic preparation according to one of the preceding claims, characterized in that the preparation is free from 2-ethylhexyl 2-hydroxybenzoate (INCI: ethylhexyl salicylate) and 3,3,5-trimethylcyclohexyl 2-hydroxybenzoate (INCI: homosalate). 7. Cosmetic preparation according to one of the preceding claims, characterized in that the preparation is in the form of an O / W emulsion. 8. Cosmetic preparation according to claim 7, characterized in that one or more compounds selected from the group glyceryl stearate citrate, glyceryl stearate (self-emulsifying), stearic acid, stearate salts, Polyglyceryl 3-methylglycose distearate, sodium cetearyl sulfate, potassium cetyl phosphate, polyglyceryl 10 stearate, sodium stearoyl glutamate. 9. Cosmetic preparation according to one of claims 7 to 8, characterized in that the preparation contains caprylic / capric acid triglyceride (INCI: Caprylic / Capric triglyceride) in a concentration of 0.5 to 20% by weight, based on the total weight of the preparation . 10. Cosmetic preparation according to one of claims 7 to 9, characterized in that the preparation contains W / O emulsifiers from the group of polyglyceryl compounds in a concentration of 0.1 to 5% by weight, based on the total weight of the preparation. 11. Cosmetic preparation according to one of Claims 7 to 10, characterized in that the preparation contains UV filters from the group of triazine derivatives in a total amount of 0.1 to 15% by weight, based on the total weight of the preparation. 12. Cosmetic preparation according to claim 1 to 6, characterized in that the preparation is in the form of an ethanolic solution. 13. Cosmetic preparation according to claim 12, characterized in that the ethanol content is from 30 to 70% by weight, based on the total weight of the preparation. 14. Cosmetic preparation according to one of claims 12 to 13, characterized in that the preparation contains caprylic / capric acid triglyceride (INCI: Caprylic / Capric triglyceride) in a concentration of 0.1 to 20% by weight, based on the total weight of the preparation . 15. Cosmetic preparation according to one of claims 12 to 14, characterized in that the preparation contains W / O emulsifiers from the group of polyglyceryl compounds in a concentration of 0.1 to 5% by weight, based on the total weight of the preparation. 16. Cosmetic preparation according to one of claims 12 to 15, characterized in that the preparation contains UV filters from the group of triazine derivatives in a total amount of 0.1 to 15% by weight, based on the total weight of the preparation. 17. Cosmetic preparation according to one of claims 12 to 15, characterized in that the preparation contains one or more thickeners.