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WO2021205155A3 - Thymidines modifiées en c5 - Google Patents

Thymidines modifiées en c5 Download PDF

Info

Publication number
WO2021205155A3
WO2021205155A3 PCT/GB2021/050839 GB2021050839W WO2021205155A3 WO 2021205155 A3 WO2021205155 A3 WO 2021205155A3 GB 2021050839 W GB2021050839 W GB 2021050839W WO 2021205155 A3 WO2021205155 A3 WO 2021205155A3
Authority
WO
WIPO (PCT)
Prior art keywords
aminooxy
modified
nucleic acid
acid synthesis
novo nucleic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2021/050839
Other languages
English (en)
Other versions
WO2021205155A2 (fr
Inventor
Michael CHUN HAO CHEN
Michal ROBERT MATUSZEWSKI
Martin Fox
Gordon ROSS MCINROY
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nuclera Ltd
Original Assignee
Nuclera Nucleics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nuclera Nucleics Ltd filed Critical Nuclera Nucleics Ltd
Publication of WO2021205155A2 publication Critical patent/WO2021205155A2/fr
Publication of WO2021205155A3 publication Critical patent/WO2021205155A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/30—Nucleotides
    • C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Saccharide Compounds (AREA)
  • Phenolic Resins Or Amino Resins (AREA)

Abstract

La présente invention concerne un composé selon la formule (1c) ou (1d) : dans laquelle, R1, R2, R3 et R4 sont tels que décrits dans la description.
PCT/GB2021/050839 2020-04-06 2021-04-06 Thymidines modifiées en c5 Ceased WO2021205155A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB2005043.1 2020-04-06
GBGB2005043.1A GB202005043D0 (en) 2020-04-06 2020-04-06 C5-modified Thymidines

Publications (2)

Publication Number Publication Date
WO2021205155A2 WO2021205155A2 (fr) 2021-10-14
WO2021205155A3 true WO2021205155A3 (fr) 2021-11-18

Family

ID=70769009

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2021/050839 Ceased WO2021205155A2 (fr) 2020-04-06 2021-04-06 Thymidines modifiées en c5

Country Status (2)

Country Link
GB (1) GB202005043D0 (fr)
WO (1) WO2021205155A2 (fr)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8034923B1 (en) * 2009-03-27 2011-10-11 Steven Albert Benner Reagents for reversibly terminating primer extension
WO2016128731A1 (fr) * 2015-02-10 2016-08-18 Nuclera Nucleics Ltd Nouvelle utilisation
WO2017058953A1 (fr) * 2015-09-28 2017-04-06 The Trustees Of Columbia University In The City Of New York Dérivés nucléotidiques et leurs méthodes d'utilisation
WO2019097233A1 (fr) * 2017-11-14 2019-05-23 Nuclera Nucleics Ltd Dérivés nucléotidiques contenant des fractions masquées d'amine et leur utilisation dans le cadre d'une synthèse enzymatique d'acides nucléiques avec et sans gabarit

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201503534D0 (en) 2015-03-03 2015-04-15 Nuclera Nucleics Ltd Novel method
GB201512372D0 (en) 2015-07-15 2015-08-19 Nuclera Nucleics Ltd Novel method

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8034923B1 (en) * 2009-03-27 2011-10-11 Steven Albert Benner Reagents for reversibly terminating primer extension
WO2016128731A1 (fr) * 2015-02-10 2016-08-18 Nuclera Nucleics Ltd Nouvelle utilisation
WO2017058953A1 (fr) * 2015-09-28 2017-04-06 The Trustees Of Columbia University In The City Of New York Dérivés nucléotidiques et leurs méthodes d'utilisation
WO2019097233A1 (fr) * 2017-11-14 2019-05-23 Nuclera Nucleics Ltd Dérivés nucléotidiques contenant des fractions masquées d'amine et leur utilisation dans le cadre d'une synthèse enzymatique d'acides nucléiques avec et sans gabarit

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DANIEL HUTTER ET AL: "Labeled Nucleoside Triphosphates with Reversibly Terminating Aminoalkoxyl Groups", NUCLEOSIDES, NUCLEOTIDES & NUCLEIC ACIDS, vol. 29, no. 11-12, 30 November 2010 (2010-11-30), pages 879 - 895, XP055010178, ISSN: 1525-7770, DOI: 10.1080/15257770.2010.536191 *
SEBASTIAN PALLUK ET AL: "De novo DNA synthesis using polymerase-nucleotide conjugates", NATURE BIOTECHNOLOGY, vol. 36, no. 7, 18 June 2018 (2018-06-18), New York, pages 645 - 650, XP055529953, ISSN: 1087-0156, DOI: 10.1038/nbt.4173 *

Also Published As

Publication number Publication date
GB202005043D0 (en) 2020-05-20
WO2021205155A2 (fr) 2021-10-14

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