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WO2021252897A3 - Therapeutic agent delivery systems and methods of forming and uses thereof - Google Patents

Therapeutic agent delivery systems and methods of forming and uses thereof Download PDF

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Publication number
WO2021252897A3
WO2021252897A3 PCT/US2021/037010 US2021037010W WO2021252897A3 WO 2021252897 A3 WO2021252897 A3 WO 2021252897A3 US 2021037010 W US2021037010 W US 2021037010W WO 2021252897 A3 WO2021252897 A3 WO 2021252897A3
Authority
WO
WIPO (PCT)
Prior art keywords
therapeutic agent
methods
delivery system
novel
forming
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2021/037010
Other languages
French (fr)
Other versions
WO2021252897A2 (en
Inventor
Jessica Anne Yu ROVE
Dae Won Park
Adam J. ROCKER
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Colorado System
University of Colorado Colorado Springs
Original Assignee
University of Colorado System
University of Colorado Colorado Springs
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Colorado System, University of Colorado Colorado Springs filed Critical University of Colorado System
Publication of WO2021252897A2 publication Critical patent/WO2021252897A2/en
Publication of WO2021252897A3 publication Critical patent/WO2021252897A3/en
Priority to US18/075,627 priority Critical patent/US20230110354A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Optics & Photonics (AREA)
  • Nanotechnology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A novel therapeutic agent delivery system, methods of use and methods of formation thereof are presented. The novel delivery system is comprised of novel nanoparticles capable of at least partially encapsulating a therapeutic agent such as an anesthetic, antimicrobial, growth factor or protein. The nanoparticles are embedded with in a crosslinked hydrogel. The hydrogel can be administered directly to a patient or may be coated onto a device such as a catheter. The delivery system allows for a sustained release of the therapeutic agent over an extended period of time.
PCT/US2021/037010 2020-06-11 2021-06-11 Therapeutic agent delivery systems and methods of forming and uses thereof Ceased WO2021252897A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US18/075,627 US20230110354A1 (en) 2020-08-19 2022-12-06 Therapeutic agent delivery systems and methods of forming and uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063037856P 2020-06-11 2020-06-11
US63/037,856 2020-06-11

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US18/075,627 Continuation US20230110354A1 (en) 2020-08-19 2022-12-06 Therapeutic agent delivery systems and methods of forming and uses thereof

Publications (2)

Publication Number Publication Date
WO2021252897A2 WO2021252897A2 (en) 2021-12-16
WO2021252897A3 true WO2021252897A3 (en) 2022-02-03

Family

ID=78846585

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2021/037010 Ceased WO2021252897A2 (en) 2020-06-11 2021-06-11 Therapeutic agent delivery systems and methods of forming and uses thereof

Country Status (1)

Country Link
WO (1) WO2021252897A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116650706A (en) * 2023-04-27 2023-08-29 南昌大学 Nanometer dressing capable of forming gel in situ, preparation method, application and drug delivery device thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040241207A1 (en) * 2002-06-05 2004-12-02 Anuj Chauhan Ophthalmic drug delivery system
US20160051469A1 (en) * 2013-05-01 2016-02-25 Daewon Park Biodegradable copolymers, systems including the copolymers, and methods of forming and using same

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040241207A1 (en) * 2002-06-05 2004-12-02 Anuj Chauhan Ophthalmic drug delivery system
US20160051469A1 (en) * 2013-05-01 2016-02-25 Daewon Park Biodegradable copolymers, systems including the copolymers, and methods of forming and using same

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ELENA GIULIANO, DONATELLA PAOLINO, MASSIMO FRESTA, DONATO COSCO: "Drug-Loaded Biocompatible Nanocarriers Embedded in Poloxamer 407 Hydrogels as Therapeutic Formulations", MEDICINES, vol. 6, no. 1, pages 7, XP055728310, DOI: 10.3390/medicines6010007 *
FAMILI AMIN, KAHOOK MALIK Y., PARK DAEWON: "A Combined Micelle and Poly(Serinol Hexamethylene Urea)- Co -Poly( N -Isopropylacrylamide) Reverse Thermal Gel as an Injectable Ocular Drug Delivery System : Micelles and Thermal Gel for Ocular Drug Delivery", MACROMOLECULAR BIOSCIENCE, WILEY-VCH VERLAG GMBH, DE, vol. 14, no. 12, 1 December 2014 (2014-12-01), DE , pages 1719 - 1729, XP055903307, ISSN: 1616-5187, DOI: 10.1002/mabi.201400250 *
LARRAÑETA ENEKO, STEWART SARAH, ERVINE MICHAEL, AL-KASASBEH REHAN, DONNELLY RYAN: "Hydrogels for Hydrophobic Drug Delivery. Classification, Synthesis and Applications", JOURNAL OF FUNCTIONAL BIOMATERIALS, vol. 9, no. 1, 24 January 2018 (2018-01-24), pages 13, XP055903298, DOI: 10.3390/jfb9010013 *
MERINO SONIA, MARTÍN CRISTINA, KOSTARELOS KOSTAS, PRATO MAURIZIO, VÁZQUEZ ESTER: "Nanocomposite Hydrogels: 3D Polymer–Nanoparticle Synergies for On-Demand Drug Delivery", ACS NANO, AMERICAN CHEMICAL SOCIETY, US, vol. 9, no. 5, 4 May 2015 (2015-05-04), US , pages 4686 - 4697, XP055903303, ISSN: 1936-0851, DOI: 10.1021/acsnano.5b01433 *

Also Published As

Publication number Publication date
WO2021252897A2 (en) 2021-12-16

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