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WO2021252891A3 - In silico generated target lists - Google Patents

In silico generated target lists Download PDF

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Publication number
WO2021252891A3
WO2021252891A3 PCT/US2021/037004 US2021037004W WO2021252891A3 WO 2021252891 A3 WO2021252891 A3 WO 2021252891A3 US 2021037004 W US2021037004 W US 2021037004W WO 2021252891 A3 WO2021252891 A3 WO 2021252891A3
Authority
WO
WIPO (PCT)
Prior art keywords
dysfunctional
methods
cells
preferentially expressed
markers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2021/037004
Other languages
French (fr)
Other versions
WO2021252891A2 (en
Inventor
Ronald Herbst
Yang Lee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pyxis Oncology Inc
Original Assignee
Pyxis Oncology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pyxis Oncology Inc filed Critical Pyxis Oncology Inc
Publication of WO2021252891A2 publication Critical patent/WO2021252891A2/en
Publication of WO2021252891A3 publication Critical patent/WO2021252891A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B5/00—ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression

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  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Evolutionary Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Physiology (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The invention relates to methods for identifying gene targets by interrogating genes preferentially expressed with dysfunctional T cell markers, systems for generating an in silico target list preferentially expressed with dysfunctional T cell markers and with or without regulatory T cells (Treg) markers, methods of treating cancer by interrogating genes preferentially expressed with dysfunctional T cell markers and with or without Treg markers, methods of treating cancer by interrogating genes preferentially expressed by T effector cells and not by dysfunctional T cells or regulatory T cells (Tregs), and methods of treating autoimmune disease.
PCT/US2021/037004 2020-06-11 2021-06-11 In silico generated target lists Ceased WO2021252891A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US202063037687P 2020-06-11 2020-06-11
US63/037,687 2020-06-11
US202063040600P 2020-06-18 2020-06-18
US63/040,600 2020-06-18

Publications (2)

Publication Number Publication Date
WO2021252891A2 WO2021252891A2 (en) 2021-12-16
WO2021252891A3 true WO2021252891A3 (en) 2022-01-20

Family

ID=76744990

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2021/037004 Ceased WO2021252891A2 (en) 2020-06-11 2021-06-11 In silico generated target lists

Country Status (1)

Country Link
WO (1) WO2021252891A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20180100201A1 (en) * 2015-06-29 2018-04-12 The Broad Institute Inc. Tumor and microenvironment gene expression, compositions of matter and methods of use thereof
WO2018209324A2 (en) * 2017-05-11 2018-11-15 The Broad Institute, Inc. Methods and compositions of use of cd8+ tumor infiltrating lymphocyte subtypes and gene signatures thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20180100201A1 (en) * 2015-06-29 2018-04-12 The Broad Institute Inc. Tumor and microenvironment gene expression, compositions of matter and methods of use thereof
WO2018209324A2 (en) * 2017-05-11 2018-11-15 The Broad Institute, Inc. Methods and compositions of use of cd8+ tumor infiltrating lymphocyte subtypes and gene signatures thereof

Also Published As

Publication number Publication date
WO2021252891A2 (en) 2021-12-16

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