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WO2021240713A1 - Dispositif et programme d'assistance pour radiothérapie - Google Patents

Dispositif et programme d'assistance pour radiothérapie Download PDF

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Publication number
WO2021240713A1
WO2021240713A1 PCT/JP2020/021077 JP2020021077W WO2021240713A1 WO 2021240713 A1 WO2021240713 A1 WO 2021240713A1 JP 2020021077 W JP2020021077 W JP 2020021077W WO 2021240713 A1 WO2021240713 A1 WO 2021240713A1
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Prior art keywords
irradiation
actual
information
dose distribution
radiation
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Ceased
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PCT/JP2020/021077
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English (en)
Japanese (ja)
Inventor
光宏 中村
勁峰 今西
良一 今中
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E Growth Co Ltd
Kyoto University NUC
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E Growth Co Ltd
Kyoto University NUC
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Priority to PCT/JP2020/021077 priority Critical patent/WO2021240713A1/fr
Publication of WO2021240713A1 publication Critical patent/WO2021240713A1/fr
Anticipated expiration legal-status Critical
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy

Definitions

  • the present invention relates to a method and a program for calculating the actual dose distribution actually applied to a patient by using the patient's respiratory waveform at the time of radiotherapy, the patient's biological image corresponding to each respiratory phase, and the irradiation device log.
  • Radiation therapy is currently being applied to cancer treatment.
  • the dose distribution is calculated after defining the area of interest (irradiation target area and risk area) information in advance for the patient's biological image, and then formulating an irradiation plan such as irradiation angle and irradiation energy.
  • the calculation result is visually displayed by superimposing it on the 2D tomographic image or 3D image of the biological image displayed on the display for visual evaluation, and the dose distribution to be irradiated for each region of interest is aggregated and DVH (dose). It will be implemented as a safe treatment plan after being evaluated by volume histogram).
  • Patent Document 1 after associating the three-dimensional CT image with the information on the elapsed time from the start to the end of the radiation therapy based on the treatment plan, the information on the elapsed time and a series of three-dimensional CT images are used. Information on fluctuations in the target area is interpolated for each period of irradiation, and the dose distribution is calculated based on the information on fluctuations in the target area obtained by the interpolation. Further, in Patent Document 2, when irradiation is performed according to a treatment plan, it is appropriately determined whether or not the formed dose distribution is within an acceptable range for treatment even if the factors of movement and deformation differ depending on the irradiation target. When it falls within the permissible range, it is irradiated with radiation.
  • Patent Document 3 calculates the irradiation amount of the particle beam during the irradiation position change even in the continuous scanning irradiation in which the particle beam is irradiated even during the irradiation position change, and is based on the irradiation amount of the particle beam during the irradiation position change. It is characterized in that the dose distribution of the particle beam to a moving target is calculated.
  • the interruption / resumption of irradiation according to the patient's respiratory condition on the day of treatment is manually instructed, or, as in the prior art, it is instructed to irradiate within a certain respiratory phase width at the time of treatment planning.
  • the irradiation device automatically determines the output of radiation according to the instructions, but the actual dose distribution actually irradiated is planned depending on the patient's respiratory disturbance, accuracy of the treatment device, and changes in the condition of internal organs during treatment. There is a difference from the dose distribution at the time. At present, no means of assessing the difference is considered. Therefore, since the treatment is performed over multiple days of irradiation as if it was irradiated as planned, the overall difference becomes larger, which may lead to a decrease in the tumor control rate and an increase in the incidence of adverse events.
  • the present invention calculates the actual dose for each treatment day, calculates the difference from the plan, and reflects it in the next and subsequent treatment plans, and statistically tumor control rate and adverse events.
  • the purpose is to realize a means for evaluating treatment results such as incidence.
  • the first invention is a device for calculating the actual irradiation results actually irradiated to a patient in radiation therapy for a radiation-irradiated portion accompanied by respiratory movement, and breathing. It is a radiation irradiation performance calculation device including an information receiving unit, an irradiation information receiving unit, and a multiphase irradiation information generation unit.
  • the respiratory information reception unit receives respiratory transition information such as the patient's respiratory waveform at the time of treatment.
  • the respiratory information receiving unit reads the patient's respiratory waveform with a time stamp at the time of treatment, and extracts one or more respiratory phase transition information representing inspiration, exhalation, or an intermediate state thereof.
  • the irradiation information receiving unit receives irradiation information recorded as a time-series log of the irradiation direction, output, irradiation field size, energy, and other states of the irradiation device at the time of treatment.
  • the multi-phase irradiation information generation unit executes a synchronization process using a time stamp on the respiratory phase transition information extracted by the respiratory information receiving unit and the irradiation information acquired by the irradiation information receiving unit. Actual irradiation information for each phase for the above phases is generated.
  • the irradiation information of the radiation irradiation device is divided and aggregated for each respiratory phase during actual treatment, and the actual irradiation information that is indispensable for calculating the actual dose distribution for each phase for one or more phases is generated. can.
  • the second invention is different from the first invention in that it has a multi-phase bioimage receiving unit that accepts multi-dimensional bioimages such as CT and MRI in one or more respiratory phases of a patient for each phase, and multi-phase irradiation. It is a radiation irradiation actual calculation device further provided with a multi-phase actual dose distribution calculation unit that calculates the actual dose distribution for each phase by using the actual irradiation information for each phase generated by the information generation unit.
  • the third invention is modified based on the non-rigid body alignment process with respect to the actual dose distribution for each one or more phases calculated by the multi-phase actual dose distribution calculation unit with respect to the second invention. It is a radiation irradiation actual calculation device further equipped with a total actual dose distribution calculation unit that performs total processing and calculates the total actual dose distribution.
  • the fourth invention is a dose display color map for the third invention, which defines the total actual dose distribution calculated by the total actual dose distribution calculation unit and the color assignment according to the magnitude of the dose value. It is a radiation irradiation actual calculation device further equipped with an actual dose distribution display unit that colors each pixel of a 2D tomographic image of a biological image or each voxel of a 3D image and displays it on a display.
  • the difference between the planned dose distribution calculated in advance at the time of treatment planning and the total actual dose distribution calculated by the total actual dose distribution calculation unit is calculated for the third invention. Then, the dose difference display color map that determines the color allocation according to the magnitude of the difference value is accepted, and each pixel of the 2D tomographic image of the biological image or each voxel of the 3D image is colored and displayed on the display. It is a radiation irradiation record calculation device further provided with a display unit.
  • the sixth invention accepts one or more area of interest information defined in the biological image and the total actual dose distribution calculated by the total actual dose distribution calculation unit for the third invention. It is a radiation irradiation actual calculation device further provided with an interest area dose calculation unit for calculating an interest area actual dose which is an actual dose irradiated for each area of interest.
  • the dose actually irradiated can be aggregated and analyzed for each region of interest.
  • the seventh invention is calculated for the sixth invention by the area of interest planned dose, which is the planned irradiation dose to one or more areas of interest calculated in advance at the time of treatment planning, and the area of interest dose calculation unit.
  • This is a radiation irradiation actual calculation device provided with an area of interest difference dose display unit that receives one or more actual doses in the area of interest, calculates a difference for each area of interest, and displays the difference.
  • the difference between the actually irradiated dose and the planned dose can be statistically fed back visually for each region of interest.
  • the eighth invention is a total actual dose distribution storage unit that stores the total actual dose distribution calculated for each time in the radiation therapy performed over a plurality of times with respect to the third invention. Accept the total actual dose distribution stored in the total actual dose distribution storage unit for the second and subsequent treatments, perform deformation and total processing based on the non-rigid body alignment process, and irradiate over the entire treatment day. It is a radiation irradiation actual calculation device further equipped with an actual accumulated dose distribution calculation unit for calculating the accumulated dose distribution which is the accumulated dose distribution in.
  • the irradiation information receiving unit can reproduce the irradiation delay and the irradiation position shift due to the mechanical characteristics of the irradiation apparatus. It is a radiation irradiation result calculation device that performs processing on the radiation irradiation information.
  • the irradiation information receiving unit is an irradiation result calculation device that receives photon irradiation information of an X-ray irradiation device or the like.
  • the irradiation information receiving unit is an irradiation result calculation device that receives particle beam irradiation information such as a proton beam irradiation device.
  • the twelfth invention is a device for statistically processing the relationship between a plurality of actual doses and the degree of improvement of a case in radiation therapy for an irradiation unit accompanied by respiratory movement, and is a device for statistically processing the relationship between the treatment results information storage unit and the treatment results information storage unit.
  • a tumor control rate calculation device including a performance tumor control rate calculation unit.
  • the treatment record information storage unit accumulates the actual dose in the region of interest for one or more cases and the therapeutic effect indicating the degree of improvement in each case.
  • the actual control rate calculation unit performs statistical processing on the actual dose in the region of interest and the therapeutic effect for a plurality of cases stored in the treatment actual information storage unit.
  • the thirteenth invention is an apparatus for statistically processing the relationship between a plurality of actual doses and the occurrence of complications in a case in radiation therapy for a radiation-irradiated portion accompanied by respiratory movement, and stores adverse event actual information. It is an adverse event occurrence rate calculation device including a unit and an actual adverse event occurrence rate calculation unit.
  • the adverse event record information storage unit stores the actual dose in the region of interest for one or more cases and the adverse event occurrence information indicating whether or not an adverse event has occurred in each case.
  • the actual adverse event occurrence rate calculation unit performs statistical processing on the actual dose in the region of interest and the presence or absence of the occurrence of adverse events for a plurality of cases stored in the treatment performance information storage unit.
  • the fourteenth invention is a radiotherapy planning support device based on an actual dose in radiotherapy for a radiotherapy portion accompanied by respiratory movement, and is an M (m) for a patient who is treated two or more times. M is an integer of 2 or more)
  • the accumulated dose distribution storage unit that stores the accumulated dose distribution for the treatments up to the M-1st treatment, and the accumulated dose distribution and the patient imaged in advance or on the day of treatment.
  • Radiation therapy plan equipped with an accumulated dose distribution display calculation unit that performs calculation of display by coloring a biological image, and a treatment plan support unit that supports the decision to increase or decrease the dose for the area of interest in the treatment plan after the first M + 1. It is a support device.
  • the actual dose actually irradiated to the patient can be calculated with high accuracy.
  • the tumor control rate and the adverse event occurrence rate of radiotherapy for a plurality of patients are statistically calculated. can do.
  • the accumulated actual dose can be used for the treatment planning support.
  • the block diagram of the tumor control rate calculation apparatus in the twelfth embodiment The block diagram of the adverse event occurrence rate calculation apparatus in 13th Embodiment.
  • the block diagram of the radiation therapy plan support apparatus in 14th Embodiment The figure which shows the CPU bus configuration.
  • FIG. 1 is a block diagram of the radiation irradiation performance calculation device 1 according to the first embodiment.
  • the radiation irradiation result calculation device 1 includes a respiration information receiving unit 102, an irradiation information receiving unit 103, and a multi-phase irradiation information generation unit 104. Further, the radiation irradiation result calculation device 1 is connected to the respiratory information storage device 100 and the radiation irradiation information storage device 101.
  • the connection between the radiation irradiation record calculation device 1, the respiratory information storage device 100, and the radiation irradiation information storage device 101 may be in any form such as wired or wireless.
  • FIG. 2 is a flowchart of a process implemented by the radiation irradiation result calculation device 1 in the case of generating radiation actual irradiation information.
  • Step S201 the respiration information receiving unit 102 acquires respiration information including a time stamp such as a patient's respiration waveform at the time of radiotherapy, which is stored in the respiration information storage device 100.
  • a time stamp such as a patient's respiration waveform at the time of radiotherapy
  • Step S202 In step S202, the respiratory information receiving unit 102 extracts the acquired respiratory information as one or more respiratory phase information.
  • the respiratory phase information is information obtained by dividing a continuous respiratory waveform that transitions from exhalation to inspiration and from inspiration to exhalation into discrete phases, and time stamp information such as a start time and an end time for each phase. include.
  • the respiratory information acquired in step S201 may be respiratory phase information.
  • the extraction process of the respiratory phase information in step S202 may be omitted.
  • Step S203 the irradiation information receiving unit 103 receives irradiation information stored in the irradiation information storage device 101, which is recorded at the time of performing radiation therapy, including time stamps such as rotation, irradiation direction, and irradiation energy of the irradiation device. get.
  • the irradiation information acquisition process in step S203 may be performed before the respiratory information reading process in step S201.
  • Step S204 the multi-phase irradiation information generation unit 104 receives the respiratory phase information extracted by the respiratory information receiving unit 102 and the irradiation information acquired by the irradiation information receiving unit, and is based on the time stamp included in both information. By performing the time synchronization process, the respiratory phase at each time in the irradiation information is specified.
  • Step S205 the multi-phase irradiation information generation unit 104 divides and aggregates the irradiation information for each phase based on the respiratory phase specified in step S204, and multi-phase actual irradiation as the actual irradiation information for one or more respiratory phases. Generate information.
  • Step S206 In step 206, the multi-phase irradiation information generation unit 104 outputs the multi-phase actual irradiation information generated in step S205.
  • FIG. 3 is a block diagram of the radiation irradiation performance calculation device 2 according to the second embodiment.
  • the radiation irradiation actual calculation device 2 further includes a multi-phase biological image reception unit 301 and a multi-phase actual dose distribution calculation unit 302 with respect to the image processing device 1 in the first embodiment. Further, the radiation irradiation result calculation device 2 is further connected to the multi-phase biological image storage device 300.
  • the connection between the radiation irradiation record calculation device 2 and the multi-phase biological image storage device 300 may be in any form such as wired or wireless.
  • FIG. 4 is a flowchart of the process implemented by the radiation irradiation actual calculation device 2 in the case of generating the multi-phase actual dose distribution information.
  • Step S401 FIG. 4 shows that after the actual irradiation information is output in step S206 similar to FIG. 2, in step S401 of the second embodiment, the multiphase bioimage receiving unit 301 is stored in the multiphase bioimage storage device 300. Acquire multi-phase biometric information for each respiratory phase to be processed.
  • the multi-phase bioimage information may be bioimage information acquired before the treatment date, or may be bioimage information acquired on the treatment day.
  • the multiphase biological image acquisition process in step S401 may be performed before the respiratory information reading process in step S201 or the irradiation information reading process in step 203.
  • Step S402 In step S202, the multi-phase actual dose distribution calculation unit 302 uses the multi-phase actual irradiation information generated in step 206 and the multi-phase biological image acquired in step 401 as the actual multi-phase actual dose distribution information for each phase. Calculate the distribution.
  • Step S403 In step 403, the multi-phase actual dose distribution calculation unit 302 outputs the multi-phase actual dose distribution information generated in step S402.
  • FIG. 5 is a block diagram of the radiation irradiation performance calculation device 3 according to the third embodiment.
  • the radiation irradiation actual calculation device 3 further includes a total actual dose distribution calculation unit 501 with respect to the image processing device 2 in the second embodiment.
  • FIG. 6 is a flowchart of the process implemented by the radiation irradiation actual calculation device 3 in the case of generating the total actual dose distribution information.
  • Step S601 FIG. 6 shows that after the multi-phase actual dose distribution information is output in step S403 similar to FIG. 4, in step S601 of the third embodiment, the total actual dose distribution calculation unit 501 has the reference phase from the multi-phase bioimage.
  • the actual dose distribution for each phase in the multi-phase actual dose distribution information is aligned with the reference phase, and the image is deformed according to the biometric image of the reference phase. Calculate the actual dose distribution.
  • Non-rigid body alignment processing for biological images includes, for example, processing using the B-Spline method and processing using the Free Form Deformation method, but other known methods can be used. It may be used.
  • Step S602 In step S602, the total actual dose distribution calculation unit 501 calculates the total actual dose distribution information by summing up the actual dose distribution for each phase with respect to the reference biological image generated in step 601.
  • Step S603 In step 603, the total actual dose distribution calculation unit 501 outputs the total actual dose distribution information generated in step S602.
  • FIG. 7 is a block diagram of the radiation irradiation performance calculation device 4 according to the fourth embodiment.
  • the radiation irradiation actual calculation device 4 further includes an actual dose distribution display unit 702 with respect to the image processing device 3 in the third embodiment.
  • the radiation irradiation result calculation device 4 is further connected to the color map storage device 700 and the display device 701.
  • the connection between the radiation irradiation record calculation device 4 and the color map storage device 700 and the display device 701 may be connected in any form such as wired or wireless.
  • FIG. 8 is a flowchart of the process implemented by the radiation irradiation actual calculation device 4 when displaying the actual dose distribution information.
  • Step S801): 8 shows the total actual dose distribution information output in step S603 similar to FIG. 6, and then in step S801 of the fourth embodiment, the actual dose distribution display unit 702 displays the output total actual dose distribution and step S601.
  • the biological image of the reference phase selected in step 1 and the color map information stored in the color map storage device 700 are acquired.
  • Step S802 In step S802, the actual dose distribution display unit 702 performs display operations such as coloring processing based on the color map acquired in each pixel of the 2D tomographic image of the biological image of the reference phase or each voxel of the 3D image.
  • the display calculation result is output to the display device 701.
  • FIG. 9 shows, as an example, the result of extracting four respiratory phases from one respiratory waveform and dividing the irradiation information.
  • the processing target is not limited to the type of each parameter such as the rotation of the device and the irradiation direction. ..
  • the respiratory information receiving unit 102 extracts four respiratory phases (p0 to p3) from the patient's respiratory waveform (VLog) obtained during radiotherapy, and the irradiation information receiving unit 103 extracts irradiation information (BLog).
  • the multi-phase irradiation information generation 104 performs time synchronization processing of Blog and VLog to specify the respiratory phase at each time in the irradiation information, and divides and aggregates the four-phase actual irradiation information. (BP0 to BP3) can be generated.
  • the total actual dose distribution calculation unit 501 performs the reference phase by the non-rigid body alignment process. After generating the actual dose distribution PA'transformed from PA based on PBase, the total actual dose is calculated by total processing, and the display calculation is performed based on the color map CMap to generate the display result PSum with high accuracy. The total actual dose distribution can be calculated and presented visually.
  • FIG. 11 is a block diagram of the radiation irradiation performance calculation device 5 according to the fifth embodiment.
  • the radiation irradiation actual calculation device 5 further includes an actual dose distribution difference display unit 1101 with respect to the image processing device 3 in the third embodiment.
  • the radiation irradiation result calculation device 5 is further connected to the planned dose distribution storage device 1100, the color map storage device 700, and the display device 702.
  • the connection between the radiation irradiation actual calculation device 4 and the planned dose distribution storage device 1100, the color map storage device 700, and the display device 702 may be connected in any form such as wired or wireless.
  • FIG. 12 is a flowchart of the process implemented by the radiation irradiation actual calculation device 5 when displaying the actual dose distribution difference information.
  • Step S1201 After outputting the total actual dose distribution information in step S603 of FIG. 6, in step S1201 of the fifth embodiment, the actual dose distribution difference display unit 1101 outputs the planned dose distribution information calculated at the time of drafting the radiotherapy plan to the planned dose. Obtained from the distribution storage device 1100, the difference from the total actual dose distribution is calculated.
  • Step S1202 In step S1202, the actual dose distribution difference display unit 1101 is based on the difference display color map acquired from the color map storage device 700 for each pixel of the 2D tomographic image of the biological image of the reference phase or each voxel of the 3D image. After performing a display calculation such as a coloring process, the difference display calculation result is output to the display device 702.
  • FIG. 13 is a block diagram of the radiation irradiation performance calculation device 6 according to the sixth embodiment.
  • the irradiation actual result calculation device 6 further includes an interest region actual result distribution calculation unit 1301 with respect to the image processing device 3 in the third embodiment.
  • the radiation irradiation actual calculation device 6 calculates the total actual dose distribution information calculated by the total actual dose distribution calculation unit, and the region of interest for the reference phase biological image from the multiphase bioimage storage device. By accepting information and calculating the actual dose in the region of interest, which is the actual dose applied to each region of interest, the strength of the actual dose for each region of interest can be evaluated with high accuracy.
  • FIG. 14 is a block diagram of the radiation irradiation performance calculation device 7 according to the seventh embodiment.
  • the radiation irradiation actual calculation device 7 further includes a region of interest difference dose distribution calculation unit 1401 with respect to the image processing device 3 in the third embodiment.
  • the radiation irradiation result calculation device 7 further connects the planned dose distribution storage device 1100.
  • the connection between the radiation irradiation record calculation device 7 and the planned dose distribution storage device 1100 may be connected in any form such as wired or wireless.
  • the radiation irradiation actual calculation device 7 includes the total actual dose distribution information calculated by the total actual dose distribution calculation unit and the region of interest for the reference phase biological image from the multiphase bioimage storage device. Radiation as planned by receiving information and planned dose distribution information calculated at the time of treatment planning from the information and planned dose distribution storage device, and calculating and presenting the difference between the actual dose distribution and the planned dose distribution irradiated for each region of interest. It is possible to evaluate with high accuracy whether the treatment has been performed.
  • FIG. 15 is a block diagram of the radiation irradiation performance calculation device 8 according to the eighth embodiment.
  • the radiation irradiation actual calculation device 8 further includes a total actual dose distribution storage unit 1500 and an actual accumulated dose distribution calculation unit 1501 for the image processing device 3 in the third embodiment.
  • the overall dose distribution calculated at the time of irradiation planning and the actual dose distribution are calculated as the number of irradiations increases at the current treatment site. Since there is no means to evaluate the difference from the irradiation results, it may lead to a decrease in the therapeutic effect and an increase in the incidence of adverse events.
  • the irradiation actual dose calculation device 8 stores the total actual dose distribution in each treatment calculated by the total actual dose distribution calculation unit 501 in the total actual dose distribution storage unit 1500, and the second and subsequent times.
  • the total actual dose distribution calculation unit 1501 performs non-rigid alignment processing for the total actual dose distribution stored in the total actual dose distribution storage unit 1500 for each treatment day based on the biological image of the reference phase. By transforming and adding up with, the actual dose distribution accumulated by irradiation over all the treatment days up to that point can be calculated with high accuracy. By doing so, it is possible to correctly evaluate the already performed radiotherapy, and it is possible to lead to safe radiotherapy implementation by referring to it at the time of later treatment planning.
  • an irradiation device for radiation therapy causes irradiation delay and irradiation position shift due to mechanical characteristics for each type of device. Preferably, these mechanical properties are reflected when the actual dose information is generated.
  • the irradiation information receiving unit 103 reproduces the irradiation delay and the deviation of the coordinate values of the irradiation position based on the statistical method, and obtains the irradiation information such as the angle of the irradiation device, the irradiation position, and the output energy.
  • the statistical method includes, for example, a process using an error generation method according to a normal distribution or a Gaussian distribution, but other known methods may be used.
  • FIG. 16 is a block diagram of the tumor control rate calculation device according to the twelfth embodiment.
  • the tumor control rate calculation device includes a treatment record information storage unit 1600 and a record tumor control rate calculation unit 1601.
  • the tumor control rate calculation device stores the actual accumulated dose distribution for one or more cases and the improvement degree information of the case in the treatment record information storage unit 1600.
  • the actual tumor control rate calculation unit 1601 acquires the actual accumulated dose distribution and the degree of improvement of cases corresponding to a specific tumor type from the treatment actual information storage unit 1600, and obtains the actual tumor control. Calculate the rate. By doing so, it is possible to analyze a statistically correct actual tumor control rate based on the actual dose distribution.
  • FIG. 17 is a block diagram of the adverse event occurrence rate calculation device according to the thirteenth embodiment.
  • the adverse event occurrence rate calculation device includes an adverse event actual information storage unit 1700 and an actual adverse event occurrence rate calculation unit 1701.
  • the tumor control rate calculation device stores the actual accumulated dose distribution for one or more cases and information on the presence or absence of occurrence of adverse events in the cases in the adverse event actual information storage unit 1700.
  • the actual adverse event occurrence rate calculation unit 1701 uses the adverse event actual information storage unit 1700 to display the actual accumulated dose distribution of cases corresponding to a specific tumor type and information on the presence or absence of adverse events. And calculate the actual adverse event occurrence rate. By doing so, it is possible to analyze the statistically correct incidence of adverse events based on the actual dose distribution.
  • the specific tumor types in the twelfth and thirteenth embodiments are, for example, lung cancer and pancreatic cancer, but may be calculated for each site of occurrence such as right lung cancer and left lung cancer.
  • FIG. 18 is a block diagram of the radiation therapy planning support device according to the 14th embodiment.
  • the radiation therapy planning support device includes an actual accumulated dose distribution storage unit 1800 and an actual accumulated dose distribution display unit 1801. Further, the radiation therapy planning support device is connected to the multi-phase biological image storage device 300, the display device 701, and the input device 1803. The connection between the radiation therapy planning support device, the multi-phase biological image storage device 300, the display device 701, and the input device 1803 may be connected in any form such as wired or wireless.
  • the accumulated dose distribution display calculation unit 1801 is the accumulated dose up to M-1 stored in the accumulated dose distribution storage unit 1800.
  • the biometric image is processed.
  • the treatment plan support unit receives the input information from the input device and the biological image processed by the accumulated dose distribution display calculation unit 1801 and presents the treatment plan support information to the display device based on the accumulated dose distribution. It can support the formulation of highly accurate radiotherapy plans.
  • the display device in each of the above embodiments includes a liquid crystal monitor, a tablet device having a display screen, and the like.
  • the input device in each of the above embodiments includes a mouse, a keyboard and the like.
  • the output in each of the above-described embodiments is a concept including transmission of generated information via a wired or wireless communication line, output to a recording medium such as an optical disk, a magnetic disk, or a semiconductor memory. ..
  • each block may be individually integrated into one chip by a semiconductor device such as an LSI, or may be integrated into one chip so as to include a part or all of the blocks.
  • LSI Although it is referred to as LSI here, it may be referred to as IC, system LSI, super LSI, or ultra LSI depending on the degree of integration.
  • the method of making an integrated circuit is not limited to the LSI, and may be realized by a dedicated circuit or a general-purpose processor.
  • An FPGA Field Programmable Gate Array
  • a reconfigurable processor that can reconfigure the connection and settings of the circuit cells inside the LSI may be used.
  • a part or all of the processing of each functional block of each of the above embodiments may be realized by a program. Then, a part or all of the processing of each functional block of each of the above embodiments is performed by the central processing unit (CPU) in the computer. Further, the program for performing each process is stored in a storage device such as a hard disk or a ROM, and is read and executed in the ROM or in the RAM.
  • a storage device such as a hard disk or a ROM
  • each process of the above embodiment may be realized by hardware, or may be realized by software (including the case where it is realized together with an OS (operating system), middleware, or a predetermined library). Further, it may be realized by mixed processing of software and hardware.
  • OS operating system
  • middleware middleware
  • predetermined library a predetermined library
  • the hardware configuration for example, CPU, GPU, ROM, RAM, input unit, output unit, etc.
  • the hardware configuration for example, CPU, GPU, ROM, RAM, input unit, output unit, etc.
  • FIG. 16 is busted. (Hardware configuration connected by Bus) may be used to realize each functional unit by software processing.
  • each functional unit of the above embodiment is realized by software
  • the software may be realized by using a single computer having the hardware configuration shown in FIG. 19, or a plurality of computers. It may be realized by the distributed processing using.
  • execution order of the processing methods in the above-described embodiment is not necessarily limited to the description of the above-mentioned embodiment, and the execution order can be changed without departing from the gist of the invention.
  • a computer program that causes a computer to perform the above-mentioned method and a computer-readable recording medium that records the program are included in the scope of the present invention.
  • the computer-readable recording medium include flexible disks, hard disks, CD-ROMs, MOs, DVDs, DVD-ROMs, DVD-RAMs, next-generation optical disks, and semiconductor memories.
  • the computer program is not limited to the one recorded on the recording medium, and may be transmitted via a telecommunication line, a wireless or wired communication line, a network represented by the Internet, or the like.

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Abstract

Par le passé, dans le domaine de la radiothérapie, l'attention se portait principalement sur la conception d'un régime thérapeutique associé au mouvement respiratoire du corps humain. L'invention concerne un dispositif et un programme permettant d'évaluer les performances d'irradiation réelles en tenant compte du mouvement respiratoire ainsi que du changement d'état d'un organe du corps le jour du traitement. Selon l'invention, la prise en compte d'une mesure relative à la transition respiratoire pendant la radiothérapie, d'une mesure relative à la précision d'un dispositif d'irradiation et d'une mesure relative à l'état d'un organe du corps permet de diviser des informations d'irradiation et de calculer indépendamment les distributions de dose d'irradiation par rapport aux éléments distincts des informations d'irradiation, au moyen d'informations relatives aux formes d'onde respiratoire pendant le traitement, d'un journal de dispositif d'irradiation et d'une image de corps vivant correspondant à une phase respiratoire. Il est ainsi possible de calculer la dose réellement irradiée avec une précision élevée.
PCT/JP2020/021077 2020-05-28 2020-05-28 Dispositif et programme d'assistance pour radiothérapie Ceased WO2021240713A1 (fr)

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