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WO2021118318A3 - Novel indole derivative and use thereof - Google Patents

Novel indole derivative and use thereof Download PDF

Info

Publication number
WO2021118318A3
WO2021118318A3 PCT/KR2020/018213 KR2020018213W WO2021118318A3 WO 2021118318 A3 WO2021118318 A3 WO 2021118318A3 KR 2020018213 W KR2020018213 W KR 2020018213W WO 2021118318 A3 WO2021118318 A3 WO 2021118318A3
Authority
WO
WIPO (PCT)
Prior art keywords
indole derivative
novel indole
present
end products
advanced glycation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2020/018213
Other languages
French (fr)
Korean (ko)
Other versions
WO2021118318A2 (en
Inventor
박명규
이은주
서승용
이산하
이정은
김선여
홍성민
이재혁
강민철
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Metacen Therapeutics
Original Assignee
Metacen Therapeutics
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Metacen Therapeutics filed Critical Metacen Therapeutics
Publication of WO2021118318A2 publication Critical patent/WO2021118318A2/en
Publication of WO2021118318A3 publication Critical patent/WO2021118318A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/116—Heterocyclic compounds
    • A23K20/132—Heterocyclic compounds containing only one nitrogen as hetero atom
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2200/00—Function of food ingredients
    • A23V2200/30—Foods, ingredients or supplements having a functional effect on health
    • A23V2200/32—Foods, ingredients or supplements having a functional effect on health having an effect on the health of the digestive tract
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2200/00—Function of food ingredients
    • A23V2200/30—Foods, ingredients or supplements having a functional effect on health
    • A23V2200/322—Foods, ingredients or supplements having a functional effect on health having an effect on the health of the nervous system or on mental function
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2200/00—Function of food ingredients
    • A23V2200/30—Foods, ingredients or supplements having a functional effect on health
    • A23V2200/328—Foods, ingredients or supplements having a functional effect on health having effect on glycaemic control and diabetes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Food Science & Technology (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Mycology (AREA)
  • Animal Husbandry (AREA)
  • Nutrition Science (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to a novel indole derivative and a use thereof. The novel indole derivative of the present invention captures methylglyoxal (MGO), which is a major precursor of advanced glycation end products, and exhibits an excellent cytoprotective effect, thus finding advantageous applications in preventing or treating diseases associated with advanced glycation end products.
PCT/KR2020/018213 2019-12-13 2020-12-11 Novel indole derivative and use thereof Ceased WO2021118318A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20190166432 2019-12-13
KR10-2019-0166432 2019-12-13

Publications (2)

Publication Number Publication Date
WO2021118318A2 WO2021118318A2 (en) 2021-06-17
WO2021118318A3 true WO2021118318A3 (en) 2021-07-29

Family

ID=76330224

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2020/018213 Ceased WO2021118318A2 (en) 2019-12-13 2020-12-11 Novel indole derivative and use thereof

Country Status (2)

Country Link
KR (1) KR102323893B1 (en)
WO (1) WO2021118318A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20220167441A (en) * 2021-06-11 2022-12-21 주식회사 메타센테라퓨틱스 Novel indole derivatives and their use for treating advanced glycation end products related diseases
KR20220167804A (en) * 2021-06-11 2022-12-22 주식회사 메타센테라퓨틱스 Composition for treating advanced glycation endproducts related diseases comprising indole derivatives
KR20230168288A (en) 2022-06-03 2023-12-14 주식회사 메타센테라퓨틱스 Novel strain having resistance against methylglyoxal and use thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR0171579B1 (en) * 1989-02-08 1999-02-01 에밀리오 엠 루이즈 Indole derivatives
US20040167119A1 (en) * 2003-02-11 2004-08-26 Pharmacopeia, Inc 2-(aminomethyl) arylamide analgesics
KR100807718B1 (en) * 2006-10-17 2008-02-28 한국생명공학연구원 Pharmaceutical composition for the prevention and treatment of metabolic diseases containing indole derivatives as an active ingredient
US9353078B2 (en) * 2013-10-01 2016-05-31 New York University Amino, amido and heterocyclic compounds as modulators of rage activity and uses thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103755686B (en) * 2014-01-23 2016-05-11 中国药科大学 The piperidyl with platelet aggregation inhibitory activity replaces 5-hydroxyryptophan derivative

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR0171579B1 (en) * 1989-02-08 1999-02-01 에밀리오 엠 루이즈 Indole derivatives
US20040167119A1 (en) * 2003-02-11 2004-08-26 Pharmacopeia, Inc 2-(aminomethyl) arylamide analgesics
KR100807718B1 (en) * 2006-10-17 2008-02-28 한국생명공학연구원 Pharmaceutical composition for the prevention and treatment of metabolic diseases containing indole derivatives as an active ingredient
US9353078B2 (en) * 2013-10-01 2016-05-31 New York University Amino, amido and heterocyclic compounds as modulators of rage activity and uses thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CRUCES, M. ; ELORRIAGA, C. ; FERNANDEZ-ALVAREZ, E. ; LOPEZ, O.N.: "Acetylenic and allenic derivatives of 2-(5-methoxyindolyl) methylamine: synthesis and evaluation as selective inhibitors of the monoamine oxidases A and B", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 25, no. 3, 1 April 1990 (1990-04-01), pages 257 - 265, XP023870613, ISSN: 0223-5234, DOI: 10.1016/0223-5234(90)90209-L *
DATABASE REGISTRY 13 April 2007 (2007-04-13), ANONYMOUS: "1H-Indole-3-acetic acid, .alpha.-amino-5-hydroxy-, methyl ester (CA INDEX NAME)", XP055830828, retrieved from STN Database accession no. 2089704-91-4 *

Also Published As

Publication number Publication date
KR20210076857A (en) 2021-06-24
WO2021118318A2 (en) 2021-06-17
KR102323893B1 (en) 2021-11-10

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