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WO2021101169A2 - Casque de photothérapie pour patients atteints de la maladie d'alzheimer - Google Patents

Casque de photothérapie pour patients atteints de la maladie d'alzheimer Download PDF

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Publication number
WO2021101169A2
WO2021101169A2 PCT/KR2020/015907 KR2020015907W WO2021101169A2 WO 2021101169 A2 WO2021101169 A2 WO 2021101169A2 KR 2020015907 W KR2020015907 W KR 2020015907W WO 2021101169 A2 WO2021101169 A2 WO 2021101169A2
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WIPO (PCT)
Prior art keywords
alzheimer
phototherapy
headset
disease
lobe
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Ceased
Application number
PCT/KR2020/015907
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English (en)
Korean (ko)
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WO2021101169A3 (fr
Inventor
윤영철
하동환
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Industry Academic Cooperation Foundation of Chung Ang University
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Industry Academic Cooperation Foundation of Chung Ang University
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Publication of WO2021101169A2 publication Critical patent/WO2021101169A2/fr
Publication of WO2021101169A3 publication Critical patent/WO2021101169A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M21/00—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0601—Apparatus for use inside the body
    • A61N5/0603—Apparatus for use inside the body for treatment of body cavities
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/0618—Psychological treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/0622—Optical stimulation for exciting neural tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M21/00—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis
    • A61M2021/0005—Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis by the use of a particular sense, or stimulus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/05—General characteristics of the apparatus combined with other kinds of therapy
    • A61M2205/051—General characteristics of the apparatus combined with other kinds of therapy with radiation therapy
    • A61M2205/052—General characteristics of the apparatus combined with other kinds of therapy with radiation therapy infrared
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0635—Radiation therapy using light characterised by the body area to be irradiated
    • A61N2005/0643—Applicators, probes irradiating specific body areas in close proximity
    • A61N2005/0645—Applicators worn by the patient
    • A61N2005/0647—Applicators worn by the patient the applicator adapted to be worn on the head
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/065—Light sources therefor
    • A61N2005/0651—Diodes
    • A61N2005/0652—Arrays of diodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
    • A61N2005/0659—Radiation therapy using light characterised by the wavelength of light used infrared

Definitions

  • the present invention relates to a phototherapy device, and more specifically, to a phototherapy headset for Alzheimer's disease patients, which enhances the Alzheimer's disease suppression and treatment effect by contrasting light through the inside of the nose to stimulate the medial temporal lobe.
  • AD Alzheimer's disease
  • amyloid plaques caused by accumulation of beta-amyloid in the brain and neurofibrillary tangles caused by hyperphosphorylated tau protein present in neurons.
  • the location of the initial lesion is the medial temporal area including the hippocampus, and then the lesion is enlarged to the parietal area.
  • the default mode network which is an area of the brain that becomes active when you are in a vague state or falls into a dream, is a network of neurons spread across the medial prefrontal cortex, posterior cortex, and parietal cortex, which is highly related to cognitive function. It is highly related to the pathology of Alzheimer's disease.
  • 1 is a distribution diagram of a default mode network and beta-amyloid plaques of Alzheimer's disease.
  • acetylcholinease inhibitor that inhibits the breakdown of acetylcholine in the nerve junction, which is a symptom-improving drug that improves cognitive function.
  • near infrared is used in various diagnostic medical devices because it can transmit several centimeters with photons of 700-1100 nm.
  • One of them is a pulse oximeter. It is also used as transcranial cerebral oximetry through bones.
  • Alzheimer's disease shows abnormalities in the hippocampus and the medial temporal lobe and parietal lobe, which are surrounding areas, from the beginning, causing symptoms of Alzheimer's disease dementia.
  • the medial parietal area and frontal lobe which are part of the default mode network related to cognitive function, are also major pathologies of Alzheimer's disease.
  • the present invention is to solve the problems of the prior art Alzheimer's disease suppression and treatment techniques, phototherapy for patients with Alzheimer's disease that enhances Alzheimer's disease suppression and treatment effects by allowing light to be irradiated through the inside of the nose to stimulate the medial temporal lobe Its purpose is to provide a headset.
  • the present invention is a phototherapy for Alzheimer's disease patients in which light is focused through the inside of the nose and the stimulation site of the LED is changed to the upper part to effectively stimulate the medial temporal lobe and parietal lobe including the hippocampus, which is the main location of the pathology of Alzheimer's disease. Its purpose is to provide a headset.
  • the present invention provides a medial temporal lobe including the hippocampus through a nasal probe located in the nasal cavity having an infrared (810nm) LED capable of gamma (40Hz) and alpha (10Hz) flicker.
  • the purpose of this study is to provide a phototherapy headset for Alzheimer's disease patients that can effectively stimulate the temporal lobe.
  • the present invention stimulates the dorsolateral parietal lobe by moving the stimulation position upward from the dorsolateral temporal lobe stimulation position, and stimulates the medial frontal lobe and the inner parietal lobe.
  • the purpose of this is to provide a phototherapy headset for Alzheimer's disease patients with improved Alzheimer's suppression and treatment effects by providing maximum access to the Papez's circuit involved in the memory production process.
  • the present invention is a patient with Alzheimer's disease that selects the location of the cerebrum of the photostimulation and adjusts the frequency of the blinking stimulus of infrared rays by reflecting the brain waves of individual patients, thereby effectively performing phototherapy for Alzheimer's disease treatment. Its purpose is to provide a phototherapy headset for the patient.
  • a plurality of irradiation means such as LEDs are provided to enable selection of the irradiation angle, irradiation intensity, and flicker degree in each region of the regions in which each stimulation means is located inside the headset of the helmet structure, so that it is precisely at the position where stimulation is required. It is an object of the present invention to provide a phototherapy headset for Alzheimer's disease patients that enables effective phototherapy (photic modulation).
  • the phototherapy headset for a patient with Alzheimer's disease for achieving the above object includes optical stimulation means for selectively inducing synchronized gamma vibration and alpha vibration in at least one brain region of an individual, and the light
  • the stimulation means comprise an intranasal infrared LED probe to be placed in the nasal cavity to stimulate the medial temporal lobe including the hippocampus.
  • the light stimulation means characterized in that it comprises a light stimulation means each configured at a position for stimulating a dorsolateral parietal lobe, a frontal lobe, or a medial parietal lobe.
  • the intranasal infrared LED probe has an irradiation intensity of ⁇ 80mW, and is configured at a position to stimulate the dorsolateral parietal lobe, the frontal lobe, or the medial parietal lobe.
  • the light stimulation means are characterized by having an irradiation intensity of ⁇ 100mW.
  • the optical stimulation means includes an infrared (810nm) LED that can be switched to blinking of gamma and alpha frequencies, and the blinking of a gamma wave by the wavelength adjusting means is an alpha wave within 30-40Hz.
  • Flicker is characterized in that it is controlled in the range of 8-12Hz.
  • the phototherapy headset for patients with Alzheimer's disease for achieving another object is gamma and gamma to increase the vibration of the reduced gamma wave and alpha wave obtained from quantitative brain waves of Alzheimer's disease patients.
  • a phototherapy control unit that controls to provide the flicker of the alpha frequency; a therapeutic light irradiator that irradiates light to irradiate the target site for phototherapy under the control of the phototherapy controller; a wavelength that controls the flicker of gamma and alpha frequencies within a certain range It characterized in that it comprises a; control means; light stimulation means for irradiating the flicker of the gamma and alpha frequency of the range adjusted by the wavelength control means to the target site selected by the control of the phototherapy control unit; and characterized in that it comprises a.
  • the light stimulation means is an intranasal infrared LED probe to be located in the nasal cavity so as to stimulate the medial temporal lobe including the hippocampus, the dorsolateral parietal lobe or the frontal lobe, or It characterized in that it comprises light stimulation means each configured at a position to stimulate the medial parietal lobe.
  • 10 in the power spectrum of gamma and alpha waves obtained by quantitative EEG of Alzheimer's disease patients with reduced oscillations of gamma and alpha waves. It is characterized in that the vibration (oscillation) is recovered by stimulating by controlling the flicker of the LED of the light stimulation means in the range of -20% increase.
  • the phototherapy headset has a helmet shape that can wrap the head inward, and is used to stimulate the dorsolateral parietal lobe, the frontal lobe, and the medial parietal lobe, etc.
  • Light stimulation means and power supply means are provided, and an intranasal infrared LED probe for stimulating a medial temporal lobe is connected to the headset body.
  • the light stimulation means is a plurality of LEDs having different irradiation directions and irradiation intensity in each area are arranged in one row or multiple rows, and a specific number or a specific position of LEDs is selected from among a plurality of arranged LEDs to direct light to the target area. It is characterized in that to investigate.
  • the light stimulation means has a plurality of LEDs in each area, and analyzes the image data acquired during the diagnosis process for Alzheimer's disease suppression and treatment in order to select a specific number or specific location of the LEDs to determine the shape and size of the patient's head. , It is characterized in that a specific number or LEDs of a specific location are selected based on this by extracting location information requiring stimulation.
  • the phototherapy headset for Alzheimer's disease patients according to the present invention as described above has the following effects.
  • the light is contrasted through the inside of the nose, and the stimulation site of the LED is changed to the upper part, so that the medial temporal lobe and parietal lobe including the hippocampus, which are the major locations of Alzheimer's disease, can be effectively stimulated.
  • the default mode network and memory It increases the effectiveness of Alzheimer's disease suppression and treatment by maximizing access to Papez's circuit, which is involved in the production process.
  • the location of the cerebrum of the photostimulation is selected, and the frequency of the blinking stimulus of infrared rays is adjusted by reflecting the brain waves of individual patients, so that the phototherapy (photic modulation) for the treatment of Alzheimer's disease can be effectively performed.
  • a plurality of irradiation means such as LEDs are provided to select the irradiation angle, irradiation intensity, and degree of flicker in each area of the areas where each stimulation means is located inside the headset of the helmet structure, so that phototherapy is precisely where stimulation is required. (photic modulation) can be effectively performed.
  • 1 is a distribution diagram of a default mode network and beta-amyloid plaques of Alzheimer's disease
  • FIGS. 2A and 2B are configuration diagrams showing a target site during phototherapy using a phototherapy headset for a patient with Alzheimer's disease according to the present invention.
  • FIG. 3 is an outer and inner configuration diagram of a phototherapy headset for a patient with Alzheimer's disease according to the present invention
  • FIG. 4 is a circuit diagram of a phototherapy headset for a patient with Alzheimer's disease according to the present invention
  • FIGS. 2A and 2B are diagrams showing a target site during phototherapy using a phototherapy headset for a patient with Alzheimer's disease according to the present invention.
  • the phototherapy headset for patients with Alzheimer's disease is a nasal probe located in the nasal cavity having an infrared (810 nm) LED capable of gamma (40 Hz) and alpha (10 Hz) flicker.
  • the medial temporal lobe, including the hippocampus, can be effectively stimulated.
  • the default mode network and memory It has a structure that can increase Alzheimer's disease suppression and treatment effects by making it as close as possible to the Papez's circuit, which is involved in the production process.
  • the present invention may include a configuration in which a position of the cerebrum of the photostimulation is selected, and the frequency of the blinking stimulus of infrared rays is adjusted by reflecting an EEG of an individual patient.
  • a plurality of light stimulation means such as LEDs are provided to enable selection of the irradiation angle, irradiation intensity, and degree of flicker in each of the areas in which each stimulation means is located inside the headset of the helmet structure, so that it is precisely at the position where stimulation is required It may include a configuration to effectively perform phototherapy (photic modulation).
  • the light stimulation means may be arranged in a row or multiple rows of LEDs with different irradiation directions in each area, and accurately target light by selecting a specific number or LEDs at a specific location from among a plurality of LEDs arranged in this way.
  • the phototherapy effect can be enhanced by irradiating the area.
  • the present invention may include the following configuration to select a specific number or a specific location of the LEDs.
  • image data acquired during a diagnosis process for suppression and treatment of Alzheimer's disease are analyzed to extract the shape of the patient's head, the size of the head, and location information that requires stimulation, and arrange it inside the headset of the helmet structure based on this. It is to select a specific number or a specific location of the LEDs among the plurality of LEDs.
  • analyzing the image data to extract the patient's head shape, head size, and location information requiring stimulation is a widely used technique, and a detailed description thereof will be omitted.
  • the present invention in order to effectively stimulate the medial temporal lobe and parietal lobe including the hippocampus, which are the major locations of the pathology of Alzheimer's disease, the present invention is different from stimulating the lateral temporal lobe or the occipital area.
  • the stimulation part of the LED is placed at the top.
  • a nasal probe to be placed in the nasal cavity was prepared to stimulate the medial temporal lobe including the hippocampus with infrared (810nm) LEDs capable of flickering gamma (40Hz) and alpha (10Hz).
  • the dorsolateral parietal lobe it moved upward from the dorsolateral temporal lobe stimulation position.
  • the default mode network and Papez's circuit which is involved in the process of memory generation, can be approached as much as possible, thereby improving the effectiveness of Alzheimer's disease suppression and treatment. Have.
  • FIG. 3 is an outer and inner configuration diagram of a phototherapy headset for a patient with Alzheimer's disease according to the present invention.
  • a probe was made through the nose and LEDs to stimulate both parietal lobes, frontal and parietal lobes were placed to stimulate the pathology of Alzheimer's disease more than conventional lateral temporal lobe stimulation and visual stimulation. Target location and allow you to control functions.
  • the main gamma waves and alpha waves obtained by quantitative EEG of individual patients In the range of 10-20% increase in the power spectrum, it is possible to restore the oscillation by controlling the flicker of the LED and stimulating it.
  • the headset according to the present invention has a helmet shape that can be positioned and wrapped around the head as shown in FIG. 3, and the dorsolateral parietal lobe, the frontal lobe, and the medial parietal lobe ( Medial parietal lobe), light stimulation means (120a) (120b) (120c) (120d) for stimulating, etc. are provided, and an intranasal infrared LED probe 110 for stimulating the medial temporal lobe is a headset It is configured by being connected to the main body 100.
  • the light stimulation means (120a) (120b) (120c, 120d) may be arranged in one row or multiple rows of LEDs having different irradiation directions in each installation area, among a plurality of LEDs arranged in this way. It is configured so that it is possible to accurately irradiate light onto a target site by selecting a specific number or a specific location of LEDs.
  • the present invention analyzes the image data acquired during the diagnosis process for Alzheimer's disease suppression and treatment, extracts the patient's head shape, head size, and location information that requires stimulation, and is based on this. It is possible to select and control the optical stimulation means.
  • the phototherapy headset for a patient with Alzheimer's disease having such a structure selects the position of the optical stimulation means in consideration of the location of the pathology in the brain of Alzheimer's disease and the default mode network, and quantitative EEG of the Alzheimer's disease patient.
  • Photic modulation headset to provide increased gamma and alpha frequency flicker in the range of 10-20% to increase the vibration of the reduced gamma wave and alpha wave obtained in ).
  • Infrared light which flickers at 40Hz, can affect the metabolism of beta-amyloid, a major cause of Alzheimer's disease.
  • the use of the phototherapy headset for Alzheimer's disease patients according to the present invention can be expected to improve the pathologic mechanism and cognitive function of Alzheimer's disease.
  • a detailed circuit configuration of a phototherapy headset for a patient with Alzheimer's disease according to the present invention will be described as follows.
  • FIG. 4 is a circuit diagram of a phototherapy headset for a patient with Alzheimer's disease according to the present invention.
  • the phototherapy headset for patients with Alzheimer's disease provides flickering of gamma and alpha frequencies to increase the vibration of reduced gamma waves and alpha waves obtained from quantitative brain waves of Alzheimer's patients.
  • the phototherapy control unit 40 for controlling the light treatment the therapeutic light irradiation unit 41 for irradiating light to irradiate the target site for phototherapy under the control of the phototherapy control unit 40, and the blinking schedule of gamma and alpha frequencies.
  • the medial temporal lobe stimulation part 44 is an intranasal infrared LED probe for stimulating a medial temporal lobe.
  • the light stimulation means are lateral parietal lobe stimulation (45), lateral frontal lobe stimulation (46), medial parietal lobe stimulation to stimulate the dorsolateral parietal lobe, frontal lobe, and medial parietal lobe. Includes part 47.
  • the phototherapy headset for a patient with Alzheimer's disease has a built-in power supply unit 42 for a light source for irradiating treatment light to increase user convenience.
  • the phototherapy control unit 40 may track a trend in the degree of improvement of the patient's condition using data on changes in brain waves and use time of the patient to perform phototherapy control in a direction that can increase the treatment effect.
  • the phototherapy headset for patients with Alzheimer's disease includes an infrared (810nm) LED that can be switched to blinking of gamma and alpha frequencies.
  • the flicker of the gamma wave can be controlled within 30-40Hz by the wavelength control means 43 and the flicker of the alpha wave can be controlled in the range of 8-12Hz.
  • the intranasal infrared LED probe to be located in the nasal cavity to stimulate the medial temporal lobe including the hippocampus has an irradiation intensity of ⁇ 80mW, and the dorsolateral parietal lobe and frontal lobe It is preferable that the light stimulation means for stimulating the medial parietal lobe have an irradiation intensity of ⁇ 100mW.
  • the phototherapy headset for patients with Alzheimer's disease selects the cerebral position of the photostimulation based on the theoretical background and concept of the pathologic mechanism of Alzheimer's disease, and reflects the brain waves of individual patients, and the frequency of the flickering stimulation of infrared rays. By controlling, it is possible to effectively perform photic modulation for Alzheimer's disease treatment.
  • the phototherapy headset for Alzheimer's disease patients according to the present invention described above is a nasal probe located in the nasal cavity having an infrared (810nm) LED capable of gamma (40Hz) and alpha (10Hz) flickering (The medial temporal lobe including the hippocampus can be effectively stimulated through a nasal probe.
  • the present invention relates to a phototherapy device, and more specifically, to a phototherapy headset for Alzheimer's disease patients, which enhances the Alzheimer's disease suppression and treatment effect by contrasting light through the inside of the nose to stimulate the medial temporal lobe.

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Abstract

La présente invention concerne un casque de photothérapie pour patients atteints de la maladie d'Alzheimer, qui envoie un rayonnement lumineux par l'intérieur du nez pour permettre au lobe temporal médian d'être stimulé, ce qui permet d'améliorer l'effet d'inhibition et de traitement de la maladie d'Alzheimer. Le casque est pourvu d'un moyen de stimulation photique pour induire sélectivement des oscillations gamma et des oscillations alpha synchrones dans au moins une région cérébrale d'un individu, le moyen de stimulation photique comprenant une sonde à DEL infrarouge intra-nasale qui doit être positionnée dans la cavité nasale pour stimuler le lobe temporal médian, comprenant l'hippocampe.
PCT/KR2020/015907 2019-11-18 2020-11-12 Casque de photothérapie pour patients atteints de la maladie d'alzheimer Ceased WO2021101169A2 (fr)

Applications Claiming Priority (2)

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KR1020190147755A KR102467533B1 (ko) 2019-11-18 2019-11-18 알츠하이머병 환자를 위한 광조사 헤드셋
KR10-2019-0147755 2019-11-18

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WO2021101169A2 true WO2021101169A2 (fr) 2021-05-27
WO2021101169A3 WO2021101169A3 (fr) 2021-07-15

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CN115212467A (zh) * 2022-07-26 2022-10-21 丹阳慧创医疗设备有限公司 一种用于治疗阿尔兹海默症的光治疗设备的头帽
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CN115944857A (zh) * 2022-12-30 2023-04-11 浙江莱恩海思医疗科技有限公司 头戴式治疗仪
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CN115999071A (zh) * 2022-12-30 2023-04-25 浙江莱恩海思医疗科技有限公司 头戴式治疗仪
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CN111032151B (zh) * 2017-09-18 2022-12-13 卢.利姆 用于利用光生物调节的自动个人化脑部调节的系统及方法

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CN113827869B (zh) * 2021-11-12 2023-05-16 江西希尔康泰制药有限公司 阿尔茨海默症治疗仪用高电位超短波信号调节控制系统
CN115212467A (zh) * 2022-07-26 2022-10-21 丹阳慧创医疗设备有限公司 一种用于治疗阿尔兹海默症的光治疗设备的头帽
CN115212467B (zh) * 2022-07-26 2025-11-07 丹阳慧创医疗设备有限公司 一种用于治疗阿尔兹海默症的光治疗设备的头帽
CN115300805A (zh) * 2022-08-29 2022-11-08 上海近则生物科技有限责任公司 一种基于近红外光生物调节的头戴式脑部治疗仪
CN115944857A (zh) * 2022-12-30 2023-04-11 浙江莱恩海思医疗科技有限公司 头戴式治疗仪
CN115970177A (zh) * 2022-12-30 2023-04-18 浙江莱恩海思医疗科技有限公司 头戴式治疗仪及其控制方法
CN115999071A (zh) * 2022-12-30 2023-04-25 浙江莱恩海思医疗科技有限公司 头戴式治疗仪
CN116036486A (zh) * 2022-12-30 2023-05-02 浙江莱恩海思医疗科技有限公司 头戴式治疗仪

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