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WO2021181231A3 - Ablation equipment for delivering non-thermal energy to treat target regions of tissue in organs and control method thereof - Google Patents

Ablation equipment for delivering non-thermal energy to treat target regions of tissue in organs and control method thereof Download PDF

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Publication number
WO2021181231A3
WO2021181231A3 PCT/IB2021/051854 IB2021051854W WO2021181231A3 WO 2021181231 A3 WO2021181231 A3 WO 2021181231A3 IB 2021051854 W IB2021051854 W IB 2021051854W WO 2021181231 A3 WO2021181231 A3 WO 2021181231A3
Authority
WO
WIPO (PCT)
Prior art keywords
ablation
tissue
thermal energy
elongated shaft
catheter
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2021/051854
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French (fr)
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WO2021181231A2 (en
Inventor
Randell L. Werneth
Marshall Sherman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Arga Medtech SA
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Arga Medtech SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arga Medtech SA filed Critical Arga Medtech SA
Publication of WO2021181231A2 publication Critical patent/WO2021181231A2/en
Publication of WO2021181231A3 publication Critical patent/WO2021181231A3/en
Priority to US17/939,465 priority Critical patent/US20230241100A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/1206—Generators therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14—Probes or electrodes therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14—Probes or electrodes therefor
    • A61B18/1492—Probes or electrodes therefor having a flexible, catheter-like structure, e.g. for heart ablation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/25—Bioelectric electrodes therefor
    • A61B5/279—Bioelectric electrodes therefor specially adapted for particular uses
    • A61B5/28—Bioelectric electrodes therefor specially adapted for particular uses for electrocardiography [ECG]
    • A61B5/283—Invasive
    • A61B5/287—Holders for multiple electrodes, e.g. electrode catheters for electrophysiological study [EPS]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00345—Vascular system
    • A61B2018/00351—Heart
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
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    • A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
    • A61B2018/00613—Irreversible electroporation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00636—Sensing and controlling the application of energy
    • A61B2018/00642—Sensing and controlling the application of energy with feedback, i.e. closed loop control
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61B2018/00696—Controlled or regulated parameters
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61B2018/00696—Controlled or regulated parameters
    • A61B2018/00732—Frequency
    • A—HUMAN NECESSITIES
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    • A61B2018/00696—Controlled or regulated parameters
    • A61B2018/0075—Phase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
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    • A61B2018/00636—Sensing and controlling the application of energy
    • A61B2018/00696—Controlled or regulated parameters
    • A61B2018/00767—Voltage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61B2018/00773—Sensed parameters
    • A61B2018/00839—Bioelectrical parameters, e.g. ECG, EEG
    • A—HUMAN NECESSITIES
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    • A61B2018/00636—Sensing and controlling the application of energy
    • A61B2018/00898—Alarms or notifications created in response to an abnormal condition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/1206—Generators therefor
    • A61B2018/1226—Generators therefor powered by a battery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/1206—Generators therefor
    • A61B2018/124—Generators therefor switching the output to different electrodes, e.g. sequentially
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/1206—Generators therefor
    • A61B2018/1246—Generators therefor characterised by the output polarity
    • A61B2018/1253—Generators therefor characterised by the output polarity monopolar
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/1206—Generators therefor
    • A61B2018/1246—Generators therefor characterised by the output polarity
    • A61B2018/126—Generators therefor characterised by the output polarity bipolar
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/04—Arrangements of multiple sensors of the same type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/04—Arrangements of multiple sensors of the same type
    • A61B2562/043—Arrangements of multiple sensors of the same type in a linear array
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/04—Arrangements of multiple sensors of the same type
    • A61B2562/046—Arrangements of multiple sensors of the same type in a matrix array
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/25—Bioelectric electrodes therefor
    • A61B5/279—Bioelectric electrodes therefor specially adapted for particular uses
    • A61B5/28—Bioelectric electrodes therefor specially adapted for particular uses for electrocardiography [ECG]
    • A61B5/283—Invasive
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316—Modalities, i.e. specific diagnostic methods
    • A61B5/318—Heart-related electrical modalities, e.g. electrocardiography [ECG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
    • A61B5/6852—Catheters

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Plasma & Fusion (AREA)
  • Otolaryngology (AREA)
  • Cardiology (AREA)
  • Physiology (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Surgical Instruments (AREA)

Abstract

The present invention relates to an ablation equipment (1000) for delivering non-thermal energy, particularly Irreversible Electroporation (IRE) energy, to treat target regions of tissue (41) in organs (44). The ablation equipment (1000) comprises an ablation catheter (1) and a single power source (4). The ablation catheter (1) comprises: a catheter elongated shaft (13) comprising at least an elongated shaft distal portion (17); said catheter elongated shaft (13) comprising a flexible body (27) to navigate through body vessels (208). The ablation catheter (1) further comprises a shaft ablation assembly (20) disposed at said elongated shaft distal portion (17). The shaft ablation assembly (20) comprises at least a plurality of electrodes (3, 30, 31) fixedly disposed at said elongated shaft distal portion (17). All electrodes of said at least a plurality (3, 30, 31) are electrically connected to the single power source (4). The single power source (4) is configured to generate electric voltage signals (Sa, Sb, Va, Vb) to energize each electrode for delivering the non-thermal energy to the tissue (41) to be treated. Each of said electric voltage signals (Sa, Sb, Va, Vb) is a sinusoidal wave, and the single power source (4) is configured to supply at least a first (30) and a second (31) electrodes (30, 31) that are adjacent to each other on said ablation catheter (1), with sinusoidal electric voltage signals in phase with each other or out of phase with each other to generate a unipolar electric field and/or a bipolar electric field for delivering the non-thermal energy to the tissue (41) to be treated.
PCT/IB2021/051854 2020-03-07 2021-03-05 Ablation equipment for delivering non-thermal energy to treat target regions of tissue in organs and control method thereof Ceased WO2021181231A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US17/939,465 US20230241100A1 (en) 2020-03-07 2022-09-07 Ablation Equipment for Delivering Non-Thermal Energy to Treat Target Regions of Tissue in Organs and Control Method Thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202062986683P 2020-03-07 2020-03-07
US62/986,683 2020-03-07

Related Child Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2021/051853 Continuation-In-Part WO2021181230A1 (en) 2020-03-07 2021-03-05 Method for performing non-thermal ablation of a target tissue

Publications (2)

Publication Number Publication Date
WO2021181231A2 WO2021181231A2 (en) 2021-09-16
WO2021181231A3 true WO2021181231A3 (en) 2021-10-21

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PCT/IB2021/051854 Ceased WO2021181231A2 (en) 2020-03-07 2021-03-05 Ablation equipment for delivering non-thermal energy to treat target regions of tissue in organs and control method thereof

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Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12076071B2 (en) 2020-08-14 2024-09-03 Kardium Inc. Systems and methods for treating tissue with pulsed field ablation
CN114010309B (en) * 2021-11-03 2023-10-20 融和医疗科技(浙江)有限公司 ablation system
CN114587562B (en) * 2021-12-03 2022-09-02 杭州睿笛生物科技有限公司 A closed-loop control system for pulse ablation
CN116831714A (en) * 2022-12-30 2023-10-03 杭州维纳安可医疗科技有限责任公司 Ablation system for lung passage and control method, control equipment and medium thereof

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5807324A (en) * 1996-04-01 1998-09-15 Procath Corporation Steerable catheter
US5882346A (en) * 1996-07-15 1999-03-16 Cardiac Pathways Corporation Shapable catheter using exchangeable core and method of use
EP2155096A2 (en) * 2007-05-11 2010-02-24 Ablation Frontiers, Inc. Rf energy delivery system and method
US20120101494A1 (en) * 2010-10-22 2012-04-26 Hadar Cadouri Electrosurgical system with device specific operational parameters
EP2664295A1 (en) * 2012-05-14 2013-11-20 Biosense Webster (Israel), Ltd. Catheter with helical end section for vessel ablation
US20140066913A1 (en) * 2012-09-06 2014-03-06 Medtronic Ablation Frontiers Llc Ablation device and method for electroporating tissue cells
US20160051324A1 (en) * 2011-07-29 2016-02-25 Medtronic Ablation Frontiers Llc Intracardiac tools and methods for delivery of electroporation therapies
US20170035499A1 (en) * 2015-08-06 2017-02-09 Medtronic, Inc. Cardiac pulsed field ablation
WO2019133608A1 (en) * 2017-12-26 2019-07-04 Gala Therapeutics, Inc. Optimization of energy delivery for various applications
WO2021044312A1 (en) * 2019-09-04 2021-03-11 Arga' Medtech Sa Ablation assembly to treat target regions of tissue in organs

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5807324A (en) * 1996-04-01 1998-09-15 Procath Corporation Steerable catheter
US5882346A (en) * 1996-07-15 1999-03-16 Cardiac Pathways Corporation Shapable catheter using exchangeable core and method of use
EP2155096A2 (en) * 2007-05-11 2010-02-24 Ablation Frontiers, Inc. Rf energy delivery system and method
US20120101494A1 (en) * 2010-10-22 2012-04-26 Hadar Cadouri Electrosurgical system with device specific operational parameters
US20160051324A1 (en) * 2011-07-29 2016-02-25 Medtronic Ablation Frontiers Llc Intracardiac tools and methods for delivery of electroporation therapies
EP2664295A1 (en) * 2012-05-14 2013-11-20 Biosense Webster (Israel), Ltd. Catheter with helical end section for vessel ablation
US20140066913A1 (en) * 2012-09-06 2014-03-06 Medtronic Ablation Frontiers Llc Ablation device and method for electroporating tissue cells
US20170035499A1 (en) * 2015-08-06 2017-02-09 Medtronic, Inc. Cardiac pulsed field ablation
WO2019133608A1 (en) * 2017-12-26 2019-07-04 Gala Therapeutics, Inc. Optimization of energy delivery for various applications
WO2021044312A1 (en) * 2019-09-04 2021-03-11 Arga' Medtech Sa Ablation assembly to treat target regions of tissue in organs

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