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WO2021167454A1 - Dispositifs d'injection pour dispositifs portables - Google Patents

Dispositifs d'injection pour dispositifs portables Download PDF

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Publication number
WO2021167454A1
WO2021167454A1 PCT/NL2021/050106 NL2021050106W WO2021167454A1 WO 2021167454 A1 WO2021167454 A1 WO 2021167454A1 NL 2021050106 W NL2021050106 W NL 2021050106W WO 2021167454 A1 WO2021167454 A1 WO 2021167454A1
Authority
WO
WIPO (PCT)
Prior art keywords
needle
container
injection device
injection
plunger unit
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/NL2021/050106
Other languages
English (en)
Inventor
Amber Hélène Tamara WITTEMAN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of WO2021167454A1 publication Critical patent/WO2021167454A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3293—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles characterised by features of the needle hub
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/329—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles characterised by features of the needle shaft
    • A61M5/3291—Shafts with additional lateral openings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/34—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub
    • A61M5/343—Connection of needle cannula to needle hub, or directly to syringe nozzle without a needle hub
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M2005/14506—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons mechanically driven, e.g. spring or clockwork
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/3129—Syringe barrels
    • A61M2005/314—Flat shaped barrel forms, e.g. credit card shaped
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A61M2005/31518—Piston or piston-rod constructions, e.g. connection of piston with piston-rod designed to reduce the overall size of an injection device, e.g. using flexible or pivotally connected chain-like rod members

Definitions

  • the present invention relates to injection devices, in particular compact injection devices for wearable devices, for instance watches or other personal items.
  • Epinephrine injection syringes also called Epipen
  • Epinephrine injection syringes are widely used for treating life- threatening allergic reactions and present themselves in the form of auto-injectors with the shape of a pen. Patients have to carry these injection devices at all time with them.
  • the existing injection devices are bulky and inherently do not cover the risk of not having the injection device at disposal at the crucial moment.
  • WO 2014/096957 A2 discloses such a pen-shaped injector.
  • An object of the invention is to provide a compact and/or easy to use injection device, in particular capable of being integrated in a wearable device.
  • an injection device for injecting a fluid in a person, comprising a container for containing the fluid, a needle having a hollow core for administering the fluid by injection, said needle being in fluid connection with the container and a plunger unit being moveable with respect to the container, said plunger unit being mechanically connected to the needle.
  • the combination of the plunger unit and the needle is moveable with respect to the container between at least a first position and a second position, wherein in the first position the needle is in a retracted position at least partially enclosed in the container and wherein in the second position the needle is exposed for injection and wherein upon movement from the first to the second position the fluid is urged from the container into the needle.
  • the incorporation of the needle into the plunger unit creates a compact design which can be partially enclosed inside the container self. The compactness of the solution allows meeting the contrary requirements of a certain length of the needle needed for intra-muscular injection and the inherent size constraints, which may be especially relevant in a wearable device like a watch.
  • US 2.605.765 A discloses a wrist watch with an injector mechanism.
  • the disclosed wrist watch is configured for continuous administration of medicinal compositions, not for use with emergencies, such as treating life-threatening allergic reactions.
  • the needle extends from the plunger unit in an injection direction defined by the movement from the first position to the second position.
  • the plunger is located behind the needle with respect to the injection direction, such that the needle is pushed out of the container while the fluid is compressed in the container. In this way a compact solution is created while respecting the constraints of the length of the needle and the quantity of fluid required.
  • the plunger unit or generally the combination of the needle and the plunger unit, comprises a conduit between the hollow core of the needle and the container, in particular the inside thereof.
  • the fluid can flow from the container to the interior of the needle when the plunger is moved, such that the container can be emptied and the fluid can be injected.
  • the plunger unit comprises at least a first aperture debouching in the container and at least a second aperture debouching in the hollow core of the needle.
  • a chamber in the plunger may be created while the fluid is pressured inside said chamber by the movement of the plunger inside the container. In this way, the content of the whole container may be injected.
  • the needle comprises a conduit between the hollow core of the needle and the container, in particular the inside thereof.
  • the conduit may be an aperture in the needle, preferably extending radially and outwardly between its core and its outside layer.
  • a moving mechanism for moving the plunger unit and the needle with respect to the container.
  • the moving mechanism may be included in a common container housing with the container, the plunger and partially the needle or may be an external mechanism mechanically coupled to the container.
  • the plunger unit is moved in translation with respect to the container, preferably along the inside of the common container housing enclosing the container, the plunger and partially the needle, allowing thus the compression of the fluid inside the container.
  • the container may have its own housing and the plunger unit may be moved in translation with respect to the container to compress the housing of the container to decrease its internal volume.
  • the moving mechanism comprises resilient biasing means or mechanism, preferably in the form of a spring member, more preferably a compressed wave spring load.
  • resilient biasing means or mechanism preferably in the form of a spring member, more preferably a compressed wave spring load.
  • the compactness of the injection device is further supported by the compactness of the moving mechanism.
  • other moving mechanisms like user actuated mechanisms or electronically actuated mechanisms or gravity actuated mechanism any other well-known moving mechanism suitable for that use may be envisaged.
  • the biasing mechanism is preferably arranged to bias the plunger unit towards the second position. Activation of the biasing mechanism then moves the plunger unit towards the second position for injection of the fluid.
  • an activation mechanism for activating the moving mechanism.
  • the user may trigger the injection by activating the activation mechanism setting in motion the moving means, moving in turn the needle and the plunger unit to inject the fluid.
  • the activating mechanism may for instance comprise a retaining mechanism for retaining the plunger unit in the first position, wherein activation of the activation mechanism may release the plunger unit, which is preferably biased towards the second position. Releasing the plunger unitwill then result in movement towards the second position.
  • the injection device further comprises a housing, wherein in the first position the needle is entirely enclosed inside said housing. In this position, the needle preferably does not protrude from the housing. In the second position, the needle is exposed for injection outside of said housing.
  • the internal elements like the needle, the plunger unit and the container are protected from external environmental influences, like shocks and dirt while at the same time the user is protected from accidental puncture when the injection device is not used.
  • a needle shield is moveable with respect to the container between a retracted position and a shielded position, said needle shield covering the distal end of the needle when in the shielded position.
  • the needle shield may thereto be provided with suitable engaging members for urging the needle shield towards the shield position upon engagement of the members.
  • the container, the plunger unit and partially the needle are enclosed in a common container housing forming a tubular member extending in the direction of the movement from the first to the second position.
  • the container is a tubular member extending in the direction of the movement from the first to the second position.
  • the tubular member has an oval cross section.
  • the container, respectively the common container housing has a reduced dimension on the shorter side of the oval enabling its integration into a wearable device.
  • the tubular member may have a rectangular cross section with a shorter side, a circular cross section or a free-form section.
  • the needle in the first position the needle is entirely enclosed in the container.
  • the injection device is made as compact as possible.
  • a stand-alone injection device in which the needle is contained inside the container offers the advantage that such device can be used for vaccine or medication injection in subjects who are afraid for the needle. Using said device, vaccines or medication can be administered while the needle remains invisible for the subject who receives the injection.
  • the injection device further comprises a sealing arrangement for sealing the container and the needle from the outside environment.
  • a sealing arrangement for sealing the container and the needle from the outside environment. In this way the fluid in the container and the needle can stay sterile when not used.
  • the sealing arrangement comprises a releasable safety cover covering the distal end of the needle in the first position.
  • a releasable safety cover covering the distal end of the needle in the first position.
  • the needle and the fluid can stay sterile when the injection device is not used and the container may be filled via the needle prior to placing the safety cover.
  • a safety cover release mechanism for releasing the releasable safety cover. In this way a user may first remove the safety cover prior to starting the injection.
  • the sealing arrangement comprises a closable opening.
  • the closable opening may be a rubber stopper or other closable opening suitable material between the injection side and the skin, which may be punctured by the needle upon activation of the injection.
  • a sealing is of particular use on the container in case of a needle entirely enclosed inside the container, but such a sealing could be integrated also in an embodiment with a needle only partially enclosed in the container by placing such a closeable opening on an external housing, for instance the external housing of the watch self. It may further be envisaged to combine the sealings by both a releasable safety cover and a closeable opening for extra safety and hygiene.
  • the sealing arrangement comprises a guiding and sealing element for guiding the needle out of the container and sealing the connection area between the needle and the container.
  • a guiding and sealing element for guiding the needle out of the container and sealing the connection area between the needle and the container.
  • the container further comprises protrusions extending in the container for limiting the movement of the plunger and the needle with respect to the container.
  • the protrusions extending form the side walls of the container serve as abutment points for the plunger which can not move beyond them in the injection direction.
  • Other means for limiting the range of movement of the plunger in the injection direction may be envisaged like extra biasing means.
  • the plunger further comprises at least one air-outlet opening for filing the container.
  • the container may be easily prefilled.
  • an air-outlet opening may be envisaged in the container.
  • a wearable medical device for administering medication/drug comprising an injection device described above.
  • the injection device being compact makes it particularly suitable for wearable medical devices for administering emergency medication or drug, like epinephrine in case of an anaphylactic shock, or insulin for diabetic patients.
  • a watch comprising a wrist band, a display window and an injection device as described above.
  • the injection direction is in a plane parallel to the plane of a substantially flat surface of the back of the watch or of a substantially flat surface of the front of the display window area.
  • the invention is not intended for injection into the skin in contact with the watch but for injection into another part of the body.
  • the wristband is arranged to be wrapped around the arm of a person and the injection direction is in a direction orthogonal to said arm direction.
  • the injection site may be for example an upper thigh of the person and the injection may be administered without removing the watch but by abutting directly one side of the watch to a suitable intra-muscular injection site, preferably an easily accessible injection site like the middle part of a thigh.
  • the injection device could be arranged for other type of injections in general, for instance subcutaneous, intradermal or even intravenous injections, by adapting accordingly the length, and/or diameter of the needle, and/or volume of the container and/or relevant parameters like the direction of injection, the speed of injection among others.
  • the principle of the injection device described here is therefore not limited to intramuscular injection insofar as the concept of a compact device as disclosed here may also be declined accordingly for other types of injection methods.
  • the device could be arranged to remove a fluid from the body, the container could then be arranged to be empty initially and upon movement from the second to the first position, a fluid could be urged from the body into the container.
  • the plunger unit by moving linearly along the inside of the container in that alternative embodiment would then allow decompressing fluid from the body of a person, i.e. pumping the body fluid into the container.
  • Figure 1 illustrates an exploded view of a watch including the injection device
  • Figures 2A to 2C illustrate a longitudinal side view, a transversal cross section view and a top view of an injection device according to an embodiment of the invention
  • Figures 3 to 7 illustrate the successive steps of operation of the injection device in a configuration according to Figure 1 where the elements 700 and 300 have not been represented for the ease of the representation;
  • Figure 8 illustrates a schematic drawing of an alternative embodiment to the embodiment of Figures 2A to 2C with a conduit in the needle;
  • Figure 9 illustrate a longitudinal side view, a transversal cross section view and a top view of an injection device according to another embodiment of the invention.
  • Figure 10 illustrates a transversal cross section of a further embodiment of the invention.
  • FIG. 1 illustrates an exploded view of an intramuscular injection device 100 for injecting a fluid in a person, the device being further incorporated into a watch 1000.
  • the watch 1000 comprises further an external housing and wristband element 200, shock proof foam layers 600 and 700 staggered around the injection device 100 for protecting it against shocks, a safety cover 400, a needle shield 500, a display window 300 that is possibly embodied with a clock function and a battery 800.
  • the external housing and wristband 200 has a compartment 210 combined with an opening 220 for housing several elements (namely the device 100 itself, the safety cover 400 and the needle shield 500), as well as a compartment 260 for the battery 800.
  • the external housing and wristband 200 contains a medication window 230 allowing a user to verify the presence of the medication inside the device 100, activation buttons 240 for activating an injection and safety cover release buttons 250 for releasing a cover around the needle. Further details on these parts will be given in the rest of the description.
  • the watch may be a smart watch provided for instance with an LED-light notification for drug expire date warning, one or more health care apps. one or more health care apps, an internet connection, apps for artificial intelligence data transfer.
  • the fluid contained inside the device 100 may be a drug, a vaccine or any substance that needs to be administered deep in a muscle to be absorbed into the bloodstream quickly in case of a drug , or to optimize immunogenicity in case of a vaccine.
  • Intramuscular injections are absorbed faster than subcutaneous injections because muscle tissue has a greater blood supply than the tissue under the skin.
  • the needle should have an appropriate length, preferably between 0,5 cm and 4 cm for an adult, and less for a child. Further the diameter of the needle should be selected depending on the fluid to be injected and other circumstances obvious to a skilled person.
  • Figure 2A is a longitudinal side view
  • Figure 2B is a transversal cross section view
  • Figure 2C is a top view of the injection device 100 in a first position corresponding to a resting position when the device is not activated by a user, meaning prior to an injection.
  • Figure 2C shows in particular a container 10 for containing the fluid, and a needle 20 for administering the injection, said needle having a hollow core and being in fluid connection with the container 10.
  • the container 10 is a hermetically closed chamber containing the injectable fluid and provides a sterile and protected environment for the fluid.
  • the needle 20 is suitable for administering the injection as discussed above in terms of its length and diameter.
  • the needle 20 has as usual for injection needles a hollow core and a sharp puncturing end.
  • the needle 20 is in fluid connection with the container 10, meaning that the hollow core of the needle 20 communicates with the inside of the container 10 and that the fluid from the container 10 can move between the inside of the container 10 and the inside of the hollow core of the needle 20.
  • the injection device further comprises a plunger unit 30 moveable with respect to the container 10.
  • the plunger unit 30 is also mechanically connected to the needle 20.
  • the mechanical connection between the needle 20 and the plunger unit 30 inhibits any relative movement between the two elements such that the needle 20 is locked to the plunger unit 30.
  • the plunger unit 30 and the needle 20 are fixed together by for instance glue, welding or any other means.
  • the plunger unit 30 can be linearly moved with respect to the container 10.
  • the plunger unit 30 and the container 10 of Figures 2A, 2B and 2C are further enclosed inside a common container housing 50.
  • the container 10 is then actually a portion of the space containing the fluid inside the common container housing 50, while the plunger unit 30 defines a partition between the container 10 and the rest of the space inside the common container housing 50.
  • the plunger unit 30, acting like a piston further fits tightly within the common container housing 50, acting like a cylinder barrel.
  • the plunger unit 30 can be moved in translation along the inside of the common container housing 50 allowing the compression of the fluid inside the container 10.
  • the container housing remains still in the injection direction, because contained inside the compartment 220 of the external housing and wristband element 200.
  • a first option is disclosed in Figures 2A, 2B and 2C by way of a conduit via apertures 31, 32 and 33 in the plunger unit 30 connecting the hollow core of the needle 20 to the inside of the container 10.
  • the plunger unit 30 has a front wall 36 in contact with the liquid in the container 10, a back wall 37 and a peripheral wall 38 extending between the front wall 36 and the back wall 37.
  • the peripheral wall 38 fits tightly the longitudinal walls of the common container housing 50, while the back wall of the plunger unit is in a plane orthogonal to the injection direction A and to the longitudinal direction of the container 10 when in the first position.
  • a plunger chamber 34 is in this manner defined inside the front wall 36, the back wall 37 and the peripheral walls 38 of the plunger unit 30.
  • the front wall 36 of the plunger unit 30 comprises two apertures 31 and 32 debouching in the container 10 and at least a second aperture 33 debouching in the hollow core of the needle 20.
  • the combination of the plunger unit 30 and the needle 20 is moveable with respect to the container 10 and the container housing 50 between at least a first initial resting position as defined in Figure 3 and a second injection position as defined in Figure 6.
  • Figures 4 and 5 show intermediate steps of the operation sequence of the injection device for which the plunger unit and the needle are in intermediate positions between the first and the second extreme positions.
  • Figure 7 shows a final step of the operation sequence of the injection device when the injection is finished and the needle shield 500 is ejected.
  • the needle 20 is in a retracted position at least partially enclosed in the container 10 and more particularly totally enclosed into the housing of the watch 1000.
  • the needle 20 In the first position the needle 20 is actually in its resting position, hidden inside the watch 1000.
  • the first position represents the position, when the needle 20 is retracted at its maximum inside the container 10 and the container housing 50.
  • the needle 20 has a first portion 21 inside the container 10 and inside the container housing 50 and a second portion 22 including the distal end of the needle outside of the container 10 and outside of the container housing 50.
  • the needle 20 extends beyond the container 10 and container housing 50 into an opening 220 inside the watch 1000.
  • the needle has a length of 4cm while the container housing 50 has a length of 3,8cm.
  • the needle is longer than the whole container housing 50 and definitely thus longer than the container 10 inside the container housing 50.
  • the portion 21 has a length of 25 cm and the portion 22 a length of 15cm.
  • the ratio between the enclosed length and the total length is thus here 5/8 but other values may of course be selected depending on the circumstances and how compact the device should be.
  • the size of the container 10 and/or the container housing 50 is dimensioned in part by the quantity of the needed fluid from a medical point. Further although not represented sealing means at the connection part between the container housing 50 and the needle 20 are provided to insure that the container 10 stays a sealed chamber.
  • the needle 20 In the second position as illustrated in Figure 6, the needle 20 is exposed for injection, and extends outside of the watch 1000.
  • the second position represents the extreme limit of the range of movement of the needle 20, when the needle is extended at its maximum outside the container 10 and the container housing 50.
  • the needle 20 is locked into the plunger unit 30 by connecting elements 35 and extends from the plunger unit 30 in an injection direction A defined by the movement from the first position to the second position.
  • the injection direction A extends in a longitudinal direction of the container 10 and the container housing 50.
  • the axis A defined by the needle is parallel to a symmetry axis of the container and the plunger, and the needle 20 is decentred from the axis of symmetry of the plunger unit 30 and/or the container 10.
  • the plunger unit 30 has a conduit formed by apertures between the hollow core of the needle 20 and the container 10.
  • the surface of the front wall 36 in contact with the inside of the container 10 compresses the fluid in the container 10 such that said fluid is pushed, urged, into the apertures 31 and 32 towards the internal chamber 34 of the plunger unit 30, and from the internal chamber 34 into the second aperture 33 towards the hollow core of the needle 20.
  • the necessary quantity of fluid for injection is transferred from the container 10 to the body of the person via the chamber 34 inside the plunger unit 30 and the needle 20.
  • Figure 8 shows an alternative watch 2000 where, the needle 20 comprises a conduit connecting the hollow core of the needle 20 to the inside of the container 10.
  • the conduit is for instance an aperture 25 in the needle 20 extending radially and outwardly between its core and its outside layer.
  • the plunger unit 30 may be a solid plunger wall, and by placing the aperture 25 of the conduit rather at the base of the needle 20, close to the connection means 35 at the connection point to the plunger unit 30, the container 10 may be almost completely emptied.
  • the container 10 may be made as small as the minimum necessary quantity of fluid and the compactness of the design is further increased.
  • Figures 9A-9C show another injection device 100 where the needle 20 is entirely enclosed inside the container 10. Similar references as for the embodiment of Figures 2A-2C will be used for similar elements in Figures 9A-9C.
  • Figure 9A is a longitudinal side view
  • Figure 9B is a transversal cross section view
  • Figure 9C is a top view of the injection device 100 in a first position corresponding to a resting position when the device is not activated by a user, meaning prior to an injection.
  • an injection device in which the needle is contained inside the container offers the advantage that such device can be used for vaccine or medication injection in subjects who are afraid for the needle.
  • vaccines or medication can be administered while the needle remains invisible for the subject who receives the injection.
  • the needle 20 is entirely enclosed in the container 10 and guided during the injection by a guiding and sealing element 70 through a closeable opening 60.
  • the closeable opening 60 may be an internal or external closable opening (e.g. a rubber stopper or other closable opening suitable material) which is punctured by the needle upon activation of the injection.
  • the closeable opening 60 may also be used for filing the container.
  • the guiding and sealing element 70 may be a rubber ring fixed to the wall of the container housing 50 and fit tight around the needle 20 insuring the sealing of the connection area between the container 10 and the needle 20 as well as the guiding of the needle 20 during injection.
  • the element 70 may also be used in embodiments with a needle only partially enclosed and in that case even duplicated on each side (internal and external) of the wall of the container 50 to increase the guidance and the sealing properties.
  • two protrusions 91 and 92 extend in the container 10 from the peripheral wall of the container housing 50 and limit the movement of the plunger 30 and the needle 20 with respect to the container 10. In this way the container may not be totally emptied in order to meet legal medical regulations requiring some fluid to be left over for control.
  • the protrusions 91 and 92 serve as abutment points for the plunger which can not move beyond these points in the injection direction.
  • an air-outlet opening 80 may be provided in the back wall 37 of the plunger 30 to enable filling the container 10.
  • an air-outlet opening may also be used in embodiments with a needle only partially enclosed.
  • the moving mechanism 40 provided for moving the plunger unit 30 and the needle 20 with respect to the container 10 and the container housing 50.
  • the moving mechanism 40 is also included in the container housing 50.
  • the moving mechanism 40 comprises resilient biasing means, in particular a compressed wave spring load.
  • This type of actuator is compact, sufficiently powerful to administer the injection, reliable and can be manually actuated. It is noted that the compactness of the injection device is further supported by the compactness of this moving mechanism as it can also be integrated in the container.
  • the compressed wave spring load 40 is abutted to the bottom surface 51 of the common container 50, the bottom surface 51 of the common container housing being substantially orthogonal to the injection direction A and orthogonal to the longitudinal direction of the container 10 and of the common container housing 50.
  • the spring load 40 is further mechanically connected to the back wall 37 of the plunger unit 30. When released the spring load 40 will transmit a translation movement in the injection direction A to the plunger unit 30 and to the needle 20.
  • Figures 4, 5 and 6 illustrate the different steps of the release of the spring load 40 and the related movement of the plunger 30 and needle 20 with respect to the container 10.
  • An activation mechanism for activating the moving mechanism 40 is present in the injection device.
  • two activation buttons 240 are provided on each side of the external housing and/or wristband 200 of the watch 1000 for simultaneous pressure and secure activation of the injection.
  • the watch 1000 is such that in the first position the needle is entirely enclosed inside the housing of the watch 1000, and that in the second position, the needle 20 is exposed for injection outside of said housing.
  • the external housing and/or wristband element 200 of Figure 1 includes a compartment 210 for housing the common container housing 50 and an opening 220 for housing the portion 22 of the distal end of the needle 20 that is never enclosed in the container housing 50.
  • the opening 220 extends longitudinally in the injection direction A from the compartment 210 mentioned above.
  • a releasable safety cover 400 covering the distal end of the needle 20 when in the first position.
  • the releasable safety cover 400 needs to be removed prior to injection as illustrated in Figure 4.
  • This safety cover 400 has a tubular member 410 closed at one end to form a cap fitting around the needle 20 and sealing the opening 220 from the outside world such that the injection device 100 is totally enclosed inside the watch when not in use.
  • the safety cover 400 insures in particular that the needle end, and as such the fluid inside the container, stays sterile when not used.
  • a safety cover release mechanism 250 is further present for releasing the releasable safety cover 400.
  • the safety cover release mechanism 250 includes for example two side buttons actuated by simultaneous pressure for removal of the cover 400.
  • the removal of the safety cover 400 is illustrated in Figure 5 where the T shaped safety cover 4000 comprising a tubular member 410 and two side arms 420 is removed in the injection direction A.
  • spring means for facilitating the ejection may be envisaged.
  • a further element is presented in the exploded view of Figure 1, the needle shield 500.
  • the needle shield 500 is moveable with respect to the container 10 between a retracted position and a shielded position, and covers a distal portion of the needle 20 when in the shielded position..
  • the operation of that element will now be explained particularly in relation with Figure 7 showing the step of the ejection of the needle shield 500 after the injection has occurred.
  • the needle shield 500 is for example a tubular element 510 with two legs 520 extending further in the tube direction.
  • the needle shield is in its retracted position partially in the opening 220 and partially above the container 50 inside the compartment 210, while enclosing the needle 20.
  • the movement from the retracted position to the shielded position amounts to a translation inside the opening 210 of the housing.
  • the displacement of the needle shield 500 may be realised by resilient biasing means, or other latching mechanisms.
  • the container housing 50 is a tubular member extending in the direction of the movement A from the first to the second position.
  • the tubular member represented in the drawings of Figures 2A-2C, and Figures 9A-9C has an oval cross section such that the container housing has a reduced dimension on the shorter side of the oval enabling its integration into a wearable device. Due to the thinness of the injection device 100 in the short direction of the oval, the device 100 can be easily integrated in a watch 1000 under the display window 300.
  • the tubular member may also have a cylinder shape with a circular cross section as illustrated in Figure 10. Although not all combinations have been explicitly shown, a skilled person would understand that any cross section shape, whether oval, circular or other, may be chosen without restriction to whether a needle is entirely or partially enclosed in the container.
  • the injection direction A is preferably in a plane parallel to the plane of a substantially flat surface of the front or the back of the display window area.
  • the injection direction A is directed thus towards the side of the watch and not the back of the watch, where the display window 300 defines a front side for display of time or other information to the person wearing the watch.
  • the wristband 200 being arranged to be wrapped around the arm of a person, the injection direction is also preferably in a direction orthogonal to said arm direction B, giving the option to position the wrist and thus the watch in immediate contact and orientate the injection direction A orthogonally to the injection site for immediate administration of the injection.
  • the carrier of the watch 1000 may inject himself in the thigh for instance or somebody else in a suitable injection site without removing the wristband 200, by abutting the watch 1000 with the strength of the arm to the injection site.
  • the injection device may be particularly interesting for emergency injections.

Landscapes

  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

La présente invention concerne un dispositif d'injection intra-musculaire (100) permettant d'injecter un fluide dans une personne, comprenant un récipient (10) servant à contenir le fluide, une aiguille (20) servant à administrer l'injection, ladite aiguille ayant un noyau creux et étant en communication fluidique avec le récipient (10), une unité de piston (30) étant mobile par rapport au récipient, ladite unité de piston étant reliée mécaniquement à l'aiguille, la combinaison de l'unité de piston (30) et de l'aiguille (20) étant mobile par rapport au récipient entre au moins une première position et une seconde position, dans la première position, l'aiguille (20) se trouvant dans une position rétractée au moins partiellement enfermée dans le récipient (10) et dans la seconde position, l'aiguille (20) étant exposée pour une injection et, lors du mouvement de la première à la seconde position, le fluide étant poussé à partir du récipient dans l'aiguille.
PCT/NL2021/050106 2020-02-21 2021-02-18 Dispositifs d'injection pour dispositifs portables Ceased WO2021167454A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL2024968A NL2024968B1 (en) 2020-02-21 2020-02-21 Injection devices for wearable devices
NL2024968 2020-02-21

Publications (1)

Publication Number Publication Date
WO2021167454A1 true WO2021167454A1 (fr) 2021-08-26

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PCT/NL2021/050106 Ceased WO2021167454A1 (fr) 2020-02-21 2021-02-18 Dispositifs d'injection pour dispositifs portables

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NL (1) NL2024968B1 (fr)
WO (1) WO2021167454A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022211638A1 (fr) 2021-04-02 2022-10-06 Witteman Amber Helene Tamara Récipient de médicament comprenant une enceinte pourvue d'un revêtement de graphène ou une enceinte en un matériau comprenant du graphène

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2605765A (en) 1947-06-05 1952-08-05 Kollsman Paul Automatic syringe
US3797491A (en) * 1971-02-11 1974-03-19 Ampoules Inc Method of performing an intramuscular injection
WO2003099358A2 (fr) * 2002-05-23 2003-12-04 Seedlings Life Science Ventures, Llc. Appareil et procede d'injection automatique rapide d'un medicament
WO2014096957A2 (fr) 2012-11-09 2014-06-26 Iinjec Technologies Inc. Dispositif et procédé d'administration de fluide
US20190143042A1 (en) * 2017-11-15 2019-05-16 II Peter J. Hughes Epinephrine auto-injecting watch and method of use

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2605765A (en) 1947-06-05 1952-08-05 Kollsman Paul Automatic syringe
US3797491A (en) * 1971-02-11 1974-03-19 Ampoules Inc Method of performing an intramuscular injection
WO2003099358A2 (fr) * 2002-05-23 2003-12-04 Seedlings Life Science Ventures, Llc. Appareil et procede d'injection automatique rapide d'un medicament
WO2014096957A2 (fr) 2012-11-09 2014-06-26 Iinjec Technologies Inc. Dispositif et procédé d'administration de fluide
US20190143042A1 (en) * 2017-11-15 2019-05-16 II Peter J. Hughes Epinephrine auto-injecting watch and method of use

Also Published As

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