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WO2021159191A1 - Dispositif porte-plaquette connecté à un serveur externe - Google Patents

Dispositif porte-plaquette connecté à un serveur externe Download PDF

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Publication number
WO2021159191A1
WO2021159191A1 PCT/BR2020/050579 BR2020050579W WO2021159191A1 WO 2021159191 A1 WO2021159191 A1 WO 2021159191A1 BR 2020050579 W BR2020050579 W BR 2020050579W WO 2021159191 A1 WO2021159191 A1 WO 2021159191A1
Authority
WO
WIPO (PCT)
Prior art keywords
pill
patient
time
blister
external server
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/BR2020/050579
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English (en)
Portuguese (pt)
Inventor
Rodrigo Hernandez DE LUZIA GURDOS
Gabriela DE OLIVEIRA AMANCIO BALAZINI
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Smartpills Servicos De Informacao Ltda
Original Assignee
Smartpills Servicos De Informacao Ltda
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smartpills Servicos De Informacao Ltda filed Critical Smartpills Servicos De Informacao Ltda
Publication of WO2021159191A1 publication Critical patent/WO2021159191A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/03—Containers specially adapted for medical or pharmaceutical purposes for pills or tablets
    • A61J1/035—Blister-type containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/03—Containers specially adapted for medical or pharmaceutical purposes for pills or tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
    • A61J7/04—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
    • A61J7/04—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers
    • A61J7/0409—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers with timers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D83/00—Containers or packages with special means for dispensing contents
    • B65D83/04—Containers or packages with special means for dispensing contents for dispensing annular, disc-shaped, spherical or like small articles, e.g. tablets or pills
    • B65D83/0445—Containers or packages with special means for dispensing contents for dispensing annular, disc-shaped, spherical or like small articles, e.g. tablets or pills all the articles being stored in individual compartments
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients

Definitions

  • the present model refers to an electronic blister pack iot (internet of things) device, adaptable to the portfolio, which signals and monitors the use of the drug, reusable that is produced to adapt to the layout of the drug brand portfolio specific.
  • the WHO defines adherence as the extent to which people's behavior (including medication consumption) corresponds to the recommendations agreed with a health provider (SABATÉ, 2003). Monitoring medication adherence can be done with direct measures or indirect. Direct ones include expected concentrations of drug markers from laboratory tests with patient fluids, which are impractical on a large scale due to the high associated costs. Indirects include secondary database analysis, based on the amount of refills ordered versus the amount predicted as per the medical prescription.
  • MEMS Medical Events Monitoring System
  • Smart Blister Smart Blister
  • MEMS is recognized as the most reliable non-invasive method for assessing patient adherence (BERTHOLET ET AL, 2000), and is therefore commonly used as a reference for testing the effectiveness of other methods and in trials. clinical trials.
  • its cost according to Lam and Fresco (2015) reaches $274 per user, being impractical in many cases.
  • Smarts are blister packs with a look identical to the originals in which when a pill is detached a signal is emitted to a device with microcontroller that records the event. In this case, there is the advantage of using the original drug packaging and less propensity for the user to activate the mechanism out of curiosity or accident,
  • GG25 There are some devices used commercially such as the "Med-ic” (Med-ic from Information Mediary Corporation, Ottawa, Canada) is composed of a thin wire connected to a microchip that crosses each capsule of the card and breaks when the capsule is removed. The packages in this case need to be activated by an Information Mediary Corporation device and then the packages must be scanned by the same device to collect the data recorded on the microchip. In a study with malaria treatment patients in Africa, data from 21% of the packages could not be used due to a defect in the card or inability to download the data. Even so, it was possible to carry out the study that revealed a significant difference in adherence to medication at the prescribed time between the subjective measures and measures with the device, evidencing possible bias of the participants when answering the questionnaires.
  • Med-ic Med-ic from Information Mediary Corporation, Ottawa, Canada
  • the He ⁇ ping HandTM device from Bang & O ⁇ ufsen Medi com, Denmark, developed its bespoke solution for the pharmaceutical industry AstraZeneca with the aim of being a "new patient monitor that measures patient compliance".
  • the "Helping Hand TM” is a product that reminds the patient when to take medication/pills.
  • the purpose behind the device is to motivate and guide the patient to seek and maintain a high rate of compliance with the prescribed medication.
  • the device can be used by physicians to help motivate their patients to continue taking their full course of medication.
  • the unique software reminds the user to take the medication and helps the patient keep track of how well they are taking the medication.
  • the patient receives feedback via a visual signal (red, yellow or green).
  • a bluetooth application To upload data there is a bluetooth application.
  • the device can work via a USB wired cable or via a wireless transponder solution.
  • [0026JO Clyk is the smart pill dispenser from Bayer Healthcare Pharmaceuticals - Bayer Pharma AG co-developed with Balda Medical. This pill dispenser comes with an LCD display and is designed to be used for 2 years. It is specifically designed to help women follow a new oral treatment within a single flexible long-term consumption regimen to give the woman the option to plan her menstruation period.
  • the dispenser can be used globally due to the use of universal symbols.
  • Clyk provides a daily reminder through its visual and audible alarm, but also advises the woman if the pills are wrong and advises her if additional supportive contraception is needed.
  • the dispenser guides the woman through her cycle and the 4-day free interval. It has no internet connection and no bluetooth or wi-fi modules, so it is offline,
  • [0028JO US20170465G1 document teaches devices for monitoring the distribution of a fluid from a container employing a sensor unit that may include a light emitting diode in the opposite direction of the photodetector and also communication via 3G with a cell phone. The document also teaches alert sent to the user which can be a light emitter such as an LED, or a signal sent to a remote computer.
  • WO 2017176571 deals with method and apparatus for automatic monitoring of the drug status content of a blister card. Each tablet location on the blister card is operatively coupled to a different sensor that detects whether the tablet location is occupied and/or a dispensing event at the tablet location.
  • Alternative detection approaches are based on optical, acoustic and tactile sensors which interrogate the dispensing region at each pill location or the pills themselves to determine if the pills were dispensed.
  • the sensors interface with a mobile app that provides user instructions to help improve drug regimen compliance.
  • real-time data transmission technology which can be, but not limited to, wi-fi, bluetooth, low-frequency radio, RFID, 2,3,4 and 5g, avoiding the need for daily pairing of the application with the device;
  • Fioravanti et al (2015) and Sabin et al (2015) indicate that sending personalized content in text has proven to have a positive impact on patient empowerment, self-management and adherence to prescriptions;
  • the user does not need to remove and place the biister in the device every time she takes the tablet, in such a way that she only needs to perform this activity when the card runs out, thus inserting a new one;
  • the device was designed to be recharged every 3 months, using a rechargeable lithium battery
  • the product is designed to have a shelf life of 36 months.
  • Figure 1 Front view of the device turned off (Figure IA), schematic with all lights on (Figure 1B);
  • Figure 2 Operation of the signaling/timer light bar, where at 5 the bar is completely lit and at 6 completely off, the middle images being the intermittent intervals, The way the lights come on and off, as well as its intensity and color, can signal from time to synchronization, among other things.
  • the "unprotected" icon is displayed, which signals when the treatment is no longer highly efficient according to the package insert and, due to the incorrect use of the treatment. recommended, was considered at risk;
  • PCB board and its main electronic components its function is, on a single board, to scan the bister tablets that are coupled/aligned to the perforations of the same through optical sensor/permissiveness of the medium, to memorize the information of the moment changing the state of the card (status is understood as the quantity and position of tablets present and/or absent), processing the information and remotely sending this data to an external receiver;
  • Figure 4 Schematic of the electronic circuit of the optical sensor that identifies the presence or absence of the bister pill at a pre-established frequency of time.
  • Figure 5 Format of the printed circuit board with the function of the individual reading of a tablet
  • Figure 6 Prototypes for testing individual reading for the presence or absence of a pill
  • - Figure 8 Illustrates in the image on the left the reading pattern of the optical signal when the tablet is present, on the right the signal when the tablet is not present, the axes.
  • the firmware identifies the difference to conclude whether or not the tablet is present.
  • the x axis is time and the y amplitude of the signal measured in electrical voltage of the received signal, in this graph 1024 will represent about 3.3V;
  • This model is a custom-designed blister holder device in such a way that each type of card needs a bister holder designed according to its dimensions, for the perfect fit, emphasizing that the patient does not need to open more than once the device during the use cycle of a card, performing the extraction of the compressed via an extractor button (2).
  • the device is characterized by having four macro functions, namely:
  • the patient extracts the tablet through an extractor button, with it being expelled through a hole in the device (with this the patient only needs to open and close the device, to insert a card in it, once per cycle of use , for example a pack of 30 pills, with the use of 2 pills a day, only needs to be changed every 15 days, like a refill);
  • (j) indicates the battery charge through the RGB LED, alternating its color to indicate that the battery has a low charge, that the device is charging and finally when the battery is already fully recharged;
  • (k) knows when the device drawer is opened and closed due to an electronic contact switch.
  • the device has light emitters that create a visible communication with the patient, a communication that alerts the patient when to take the pill, which or which pills should be taken at that moment and informs, also visually, how much time is left for the pill yet can be taken correctly according to the patient's treatment.
  • the device then monitors in real time when a tablet is extracted from the pack using optical sensors positioned on an electronic pcb, in such a way that for each tablet there is a light emitter and a light receiver positioned diametrically opposite, whose tablet is the physical barrier . Once the tablet is extracted, light arrives at its receiver and the microcontroller + program understands which tablet was extracted and at what time. This is only possible because the microcontroller performs a card scan at costly time intervals.
  • the device sends and stores data to an external server through machine to machine (iot) communication protocols such as wi-fi, blueiooth, beacon, radio and other available data transmission technologies. Finally, it signals the patient when the use of his card due to the treatment was wrong, alerting him that he is at risk.
  • machine to machine iot
  • the device represents an evolution in relation to the state of the art presented for continuous use medicines that are in the bister format because through optical sensors it identifies in real time when a tablet is extracted from its original bister, in addition to having a visual alert system that signals to the patient, through a series of light emitters, when, which and how many pills he should use at that moment, while monitoring the pill extraction event, all using the same light emission system and without the need for any type of change in the blister. It is important to mention that the light emitter is positioned 180 degrees from the board to optimize the arrival of light on the receiver.
  • the device also requires the least possible amount of interaction on the part of the patient, in addition to being careful not to change their routine and habits that affect the use of their medicine, thus seeking only to offer tools that help them to improve their treatment adherence and get information on when she is not protected, which in the medical literature, for oral contraceptives, means below 91% effectiveness.
  • the device sends personalized messages to the user and displays to her in the format of a visual, sound or smartphone vibration message, in order to remind her to take her medication at the correct time and what do when one or more pills are not taken, always following the directions of the medicine package insert.
  • the device can also be customized for continuous use oral contraceptives, provided they are sold in the form of a card. Therefore, the blister pack device must be specially designed for each type/layout of contraceptive pack, taking into account the width, length, height and dimension of the pills, all with the aim of achieving a perfect fit. It is highlighted again that the patient does not need to open the device more than once during the cycle of using a card, removing the pill through an extractor button (2). The device is then characterized by the same functions described above, as follows:
  • the risk icon lights up only when the user is unprotected, which means that the contraceptive, due to misuse, is showing an efficacy equal to or less than 91%, that is, about 100 times more risk than in protection with correct use (99.8%), according to the package insert,
  • the bister-carrier device connected to an external server comprises: a) a device that needs to be sized/designed for each different type of card layout, as it requires a perfect fit between the card and it, thus preventing the pharmaceutical industry from changing the shape of their blister packs on the production line; b) a signaling/timer light bar (3) indicative of safe time interval of pill consumption according to the medicine package insert; c) individual light signals on each pill cap, informing which, how many and when to take them, and may also use different signaling colors, personalized according to the patient's treatment; d) a "risk" icon (4) that signals when the patient, due to poor adherence to treatment, is at risk according to their package insert/clinical studies, also informing via application what should be done; e) pill extractor button (2) which prevents the pack from having to be removed from the device daily, in such a way that the pack is placed in full inside it and is only removed after all the pills have been taken. The user presses the extractor button,
  • ® have a personalized interface to receive patient information, store it and transmit it to the device; ® manage points a, b ; ced above;
  • FIG. 1 shows a front view of the device, turned off ( Figure IA), schematic ( Figure !B), comprising a flexible synthetic polymer cover that allows light to pass only in specific places, which are recessed into the part for this purpose. leaving the site thinner and thus translucent (1), the pill or pill extractor button and pill or pill taking indicator (2), indicator/timer bar indicative of the safe pill consumption interval (3) and the "unprotected" icon.
  • [0044JA Figure 2 in the annex indicates the operation of the timer bar and "unprotected" icon that, through the emission of internal light of the device, indicates the maximum time for the pill to be consumed (5), the timer bar completely erased, indicates the end the time of ingestion of the pill (6) and the "unprotected” icon lit, which indicates low adherence to the treatment and/or misuse of the medication (7),
  • Figure 3 attached indicates the PCB board (8) comprising a rechargeable lithium battery (9), a phototransistor that identifies the passage of light (10), the side light emitter (11), wireless communication module (bluetooth, low frequency radio, wifi, 3g, 4g, 5g,...) (12), the USB output for battery charging (13) and the microcontroller (14).
  • a rechargeable lithium battery 9
  • a phototransistor that identifies the passage of light
  • the side light emitter 11
  • wireless communication module blue, low frequency radio, wifi, 3g, 4g, 5g,
  • the USB output for battery charging (13)
  • microcontroller 14
  • Wireless communication module blue, radio frequency, wifL
  • One of the embodiments of the device uses a light source, which has the function of signaling the moment of taking the tablet visually to the user through the selective permissiveness of light on the polymer membrane (in specific places where we want it to the light passes), and to determine, in conjunction with a phototransistor that acts as a receiver, whether the pills are present or not.
  • a light source which has the function of signaling the moment of taking the tablet visually to the user through the selective permissiveness of light on the polymer membrane (in specific places where we want it to the light passes), and to determine, in conjunction with a phototransistor that acts as a receiver, whether the pills are present or not.
  • the blister is made of transparent pvc plastic, where the tablets are stored, sealed by aluminum.
  • the technology can be used both in plastic-aluminum and aluminum-aluminum blisters. While in the first case the light passes through the plastic due to its translucency property, in the second case the light passes through a permanent channel in the aluminum that is generated by deformation by the impact of the internal pin of the extractor button, which through the pressure exerted by the patient's finger to extract the tablet, it deforms a channel shape in the aluminum, which thanks to its inelastic property, allows light to pass from the emitter to the receiver in a continuous way.
  • Tests were performed with several LEDs and phototransistors to determine effectiveness in detecting the presence of pills in contraceptive packs.
  • test cases For the evaluation of the devices, a table was created that correlates the emitters and receivers in test cases. These test cases consider the sending and receiving capability of each device to combine them in tests that can provide satisfactory results. Some cases will be assembled in such a way as to allow performing more than one test with a single prototype, accelerating the evaluation of different combinations.
  • the tests were carried out with modulation of the emitted light. Modulation allows that, even with external light similar to that emitted by the emitter used, it is possible to identify if the emitter is performing a test.
  • the polymer in order to reduce interference caused by external light, the polymer should have an ideal combination of thickness and opacity, such that the lighter the shade used in the polymer, the thicker it needs to be.
  • the attached Figure 5 shows the format of the printed circuit board for individual reading of a tablet.
  • the prototype's printed circuit board has a circular hole in the center to fit a pack of test pills and exposes the component connections on the edge for use in the test equipment.
  • the values can range from 0 to 1023.
  • the tablet exit hole has also been sized both in width and depth to ensure that the tablet does not get stuck in it when ejected, resulting in the patient's eminent need to use the finger/nail to detach it from the hole.
  • This feature is very important because this action can lead to pushing part of the aluminum from the blister into the cavity where the tablet was accommodated, generating noise in the light passage between the emitter and receiver, which can produce false negatives in the system's scanning.
  • the orifice has a radius 25% greater than the tablet and its depth cannot exceed 75% of the height of the tablet.
  • the device scans the card and sends the information to the server or application; h) the application, in turn, starts to exactly mirror the current state of the card with the same quantity and sequence of pills; i) at the time of taking the next pill, a light signal on the cap of the respective pill to be taken will light up; j) at the same time, the timer bar will also light up, indicating how much time is left for taking the tablet within a safe interval; k) when extracting the tablet by squeezing the cap, the user removes the tablet through the exit hole, the sensor identifies that the tablet has
  • the application informs you what should be done in accordance with the best practices described in the package insert of your respective contraceptive; o) when using all the pills in the pack, the user opens the drawer, removes the pack, inserts a new one and closes the drawer, thus the cycle from i to I is repeated.
  • the user has the time information that she took each of her pills, available in the form of a history on a calendar, in such a way that she can identify patterns that are useful for her treatment.
  • the application also has the intelligence to suggest changing the tablet's usage time from the moment it registers that there is a usage pattern different from the one configured. [0076]In the same app she can enter additional information about her menstrual and sexual cycle, making it a complete schedule.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medical Informatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Primary Health Care (AREA)
  • Mechanical Engineering (AREA)
  • Medicinal Preparation (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

Le présent modèle concerne un dispositif porte-plaquette personnalisé de sorte que chaque type de boîte nécessite un porte-plaquette conçu selon ses dimensions, en vue d'un emboîtement parfait, le patient n'ayant pas besoin d'ouvrir plus d'une fois le dispositif pendant le cycle d'utilisation d'une boîte, réalisant l'extraction du comprimé au moyen d'un bouton d'extraction (2). Le dispositif se caractérise en ce qu'il présente des macro-fonctions, deux d'entre elles étant indiquées ci-dessous : - informer visuellement le patient, au moyen d'un ou de plusieurs émetteurs de lumière, de préférence des DEL, sur l'heure à laquelle il doit prendre son comprimé, sur la quantité de comprimés à prendre, sur le temps restant pour qu'il puisse prendre la pilule dans le bon intervalle de temps et sur le risque qu'encourt le patient s'il observe mal son traitement (4) ; - surveiller en temps réel, au moyen d'un système de balayage de la plaquette, le moment où se produit un événement d'extraction du comprimé. Intérieurement, ce dispositif comprend un microcontrôleur (14) avec programme.
PCT/BR2020/050579 2020-02-13 2020-12-23 Dispositif porte-plaquette connecté à un serveur externe Ceased WO2021159191A1 (fr)

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BRBR202020003089-8 2020-02-13
BR202020003089-8U BR202020003089U2 (pt) 2020-02-13 2020-02-13 Dispositivo porta-blíster conectado a um servidor externo

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Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0662224A1 (fr) * 1992-09-21 1995-07-12 Medical Microsystems, Inc. Distributeur d'articles sous surveillance
WO2002005039A1 (fr) * 2000-07-07 2002-01-17 Ddms Holdings, L.L.C. Systeme de gestion de l'administration de medicaments
WO2009000383A2 (fr) * 2007-06-22 2008-12-31 Alcan Technology & Management Ltd. Système de contrôle de la prise de médicaments
US20160158109A1 (en) * 2013-08-13 2016-06-09 Next Paradigm Inc. Electronic pill box with detachable day module
US10058485B2 (en) * 2014-03-03 2018-08-28 Manrex Pty. Ltd. Improvements relating to blister package compliance
US10083594B2 (en) * 2016-04-08 2018-09-25 QuantaEd, LLC Apparatus and method for improved drug regimen compliance

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0662224A1 (fr) * 1992-09-21 1995-07-12 Medical Microsystems, Inc. Distributeur d'articles sous surveillance
WO2002005039A1 (fr) * 2000-07-07 2002-01-17 Ddms Holdings, L.L.C. Systeme de gestion de l'administration de medicaments
WO2009000383A2 (fr) * 2007-06-22 2008-12-31 Alcan Technology & Management Ltd. Système de contrôle de la prise de médicaments
US20160158109A1 (en) * 2013-08-13 2016-06-09 Next Paradigm Inc. Electronic pill box with detachable day module
US10058485B2 (en) * 2014-03-03 2018-08-28 Manrex Pty. Ltd. Improvements relating to blister package compliance
US10083594B2 (en) * 2016-04-08 2018-09-25 QuantaEd, LLC Apparatus and method for improved drug regimen compliance

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