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WO2021144843A1 - Composition de biocosmétique - Google Patents

Composition de biocosmétique Download PDF

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Publication number
WO2021144843A1
WO2021144843A1 PCT/JP2020/000870 JP2020000870W WO2021144843A1 WO 2021144843 A1 WO2021144843 A1 WO 2021144843A1 JP 2020000870 W JP2020000870 W JP 2020000870W WO 2021144843 A1 WO2021144843 A1 WO 2021144843A1
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Prior art keywords
biocosmetic
skin
stem cell
cell culture
composition according
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English (en)
Japanese (ja)
Inventor
牧野　一郎
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Harbor Links Japan Inc
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Harbor Links Japan Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations

Definitions

  • the present invention relates to a biocosmetic composition based on regenerative medicine technology. ..
  • Cosmetics have long been manufactured and used from various plant-derived ingredients as raw materials, but recently, cosmetics containing animal-derived ingredients have been used for skin deterioration due to aging, for example, formation of wrinkles and stains. There are many commercially available products for the purpose of preventing wrinkles and improving moisturizing properties. Further, for the same purpose, cosmetics and the like containing a culture supernatant of cells have been developed, and human lung smooth muscle cells, epithelial cells, fibroblasts and the like are cultured, and the cell crushed product or the cell crushed product or the like is developed. It has been proposed to use the culture supernatant as a cosmetic composition (Patent Document 1).
  • the biocosmetic composition according to the first aspect of the present invention that solves the above problems includes a human stem cell culture solution and proteoglycan, aquatide (hexacarboxymethyl dipeptide-) as a stem cell support component that draws out the power of the human stem cell culture solution. 12), characterized by blending one or more royal biosites (proteins derived from royal jelly).
  • the biocosmetic composition according to the second aspect of the present invention which solves the above problems, is a component of the biocosmetic composition according to the first aspect, further according to the genetic tendency of the person who uses the biocosmetic composition. It is characterized by blending.
  • the biocosmetic composition according to the third aspect of the present invention which solves the above-mentioned problems, is the biocosmetic composition according to the second aspect. It is characterized by being classified into three types: a stain type, a wrinkle type in which wrinkles are likely to occur on the skin, and a dry type in which the skin is easily dried.
  • the biocosmetic composition according to the fourth aspect of the present invention which solves the above-mentioned problems, causes the occurrence of stains when the genetic tendency is classified into a stain type in the biocosmetic composition according to the third aspect. It is characterized by blending an anti-stain component that suppresses it. It is desirable to add APPS, AA-2G, and Amitose as anti-stain components.
  • the biocosmetic composition according to the fifth aspect of the present invention which solves the above-mentioned problems, causes wrinkles when the genetic tendency is classified into a wrinkle type in the biocosmetic composition according to the third aspect. It is characterized by blending an anti-wrinkle component that suppresses it. It is desirable to add nalsgen, progerin, and liftrin as anti-wrinkle components.
  • the biocosmetic composition according to the sixth aspect of the present invention which solves the above problems, is a moisturizer that retains moisture when the genetic tendency is classified into a dry type in the biocosmetic composition according to the third aspect. It is characterized by blending ingredients. As a moisturizing ingredient, it is desirable to blend HA-4, human nanoceramide, hyalooritagone, and hyalorepair.
  • the biocosmetic composition according to the seventh aspect of the present invention which solves the above problems, is characterized in that the biocosmetic composition according to the first aspect contains nicotinamide mononucleotide instead of the human stem cell culture medium. And.
  • the human stem cell culture medium contained in the biocosmetic composition of the present invention is effective in the fields of regenerative medicine and cosmetology because it contains abundant growth factors.
  • the power of the human stem cell culture solution can be maximized.
  • the bio-cosmetic composition of the present invention is more troublesome for skin by blending ingredients according to the genetic tendency of the user, that is, by knowing the result of the genetic test and knowing the natural skin quality. It is more likely to lead to a fundamental solution and is useful for efficient skin beautification.
  • Table 1 shows the components to be blended in the biocosmetic composition according to Example 2 of the present invention.
  • Table 2 shows the components to be blended in the biocosmetic composition according to Example 2 of the present invention.
  • Table 3 shows the components to be blended in the biocosmetic composition according to Example 2 of the present invention.
  • Table 4 shows the components to be blended in the biocosmetic composition according to Example 3 of the present invention.
  • Table 5 shows the components to be blended in the biocosmetic composition according to Example 3 of the present invention.
  • Table 6 shows the components to be blended in the biocosmetic composition according to Example 3 of the present invention.
  • Table 7 shows the components to be blended in the biocosmetic composition according to Example 4 of the present invention.
  • Table 8 shows the components to be blended in the biocosmetic composition according to Example 4 of the present invention.
  • Table 9 shows the components to be blended in the biocosmetic composition according to Example 4 of the present invention.
  • Table 10 shows the components to be blended in the biocosmetic composition according to Example 4 of the present invention.
  • the biocosmetic composition of the present invention has been completed based on regenerative medicine technology, and has the first feature of blending a human stem cell culture solution.
  • Human stem cell culture medium Since human stem cell culture medium is rich in growth factors, it is a useful component that is considered to be effective in the fields of regenerative medicine and cosmetology and is expected in the future. It strongly works on important components such as fibroblasts, hyaluronic acid, collagen, and elastin, which are important for the skin. Therefore, human stem cell culture medium has the power to be reborn (turnover). It has an excellent active cycle consisting of secretory power that keeps the balance of moisturizing and barrier power that protects from external stimuli.
  • the human stem cell culture medium is 100% domestically produced, a fresh genuine raw material (excluding any additives or heat), and a completely serum-free medium (without worrying about allergies).
  • the biocosmetic composition of the present invention has a second feature in that the following three types of fortifying components are blended as stem cell support components that maximize the power of the human stem cell culture solution.
  • Proteoglycan is a complex of sugar and protein with a special structure, which is being studied by Hirosaki University in Aomori Prefecture, and is a kind of complex sugar. It supports the action and production of collagen and hyaluronic acid, and works on skin spots, wrinkles, and sagging. In addition, it cares for moisturizing action and elasticity.
  • Hyaluronic acid contains as much as 6 liters of water per gram, but proteoglycans have more water retention and elasticity.
  • EGF human oligopeptide-1
  • proteoglycan forms a moisturizing cycle that forms the foundation of hyaluronic acid support ⁇ skin support and firmness ⁇ collagen support ⁇ moisturizing ⁇ hyaluronic acid support.
  • Hexacarboxymethyl dipeptide-12 is a component that received a lot of attention after receiving the GOLD Award as "Aquatide” (registered trademark) at “in-cosmetics asia", the largest exhibition of personal care raw materials in Asia in 2016. .. Aquatide, which is also called the third moisturizer, works with the idea of "enhancing the nurturing power" while the conventional care is superficial care of "covering” and “holding”. Aquatide has the same effect as "autophagy,” which is the function of cells to break down their own components. Winner of the Nobel Prize ⁇ The function of autophagy is an epoch-making function that recognizes and eats accumulated garbage derived from aging. In other words, the dust derived from aging is abnormally detected and autophagy decomposes.
  • Royal biosite Royal biosite is a hydrolyzate of a protein derived from royal jelly. Received the BSB Innovation Prize awards 2017. Royal jelly is a nutritious special diet given only to queen bees and larvae of queen bee candidates. In other words, the rare ingredient contained in royal jelly becomes royal biosite. Royal biosite has excellent ability to support collagen production.
  • the bio-cosmetic composition of the present invention can be utilized as a semi-ordered beauty essence with a genetic test by blending components according to the genetic tendency of the user.
  • the genetic tendency is classified into three types according to the result of the genetic test: a spot type in which spots are likely to occur on the skin, a wrinkle type in which wrinkles are likely to occur on the skin, and a dry type in which the skin is easily dried. Spot types are people who carry the genetic risk of spots.
  • a wrinkle type is a person who carries the genetic risk of wrinkles.
  • a dry type is a person who carries a genetic risk of dryness.
  • the present invention contains an anti-wrinkle component, an anti-stain component, and a moisturizing component that work on each risk.
  • the genetic test in the genetic test, it is possible to examine three genes related to spots, wrinkles, and dryness, which are the three major causes of skin troubles, and to know the genetic tendency such as skin quality and risk. Therefore, it is possible to measure the skin tendency of the user and provide the most suitable cosmetic composition. In other words, knowing the results of genetic tests and knowing the natural skin quality will increase the possibility that it will lead to a more fundamental solution to skin problems, which will be useful for efficient skin beautification.
  • the mucus collected from the mouth of the user is subjected to the following method. For the stain-related gene (Mn-SOD), it is examined whether or not sufficient antioxidant oxygen can be produced in the body.
  • ⁇ APPS (penetrating vitamin C) APPS is a state-of-the-art vitamin C derivative that penetrates at 100 times the penetration rate (intracellular ascorbic acid concentration) of conventional vitamin C derivatives (water-soluble VCs).
  • ⁇ AA-2G (complex function vitamin C) L-ascorbic acid 2-glucoside (AA-2G) promotes the production of hyaluronic acid (hyaluronic acid concentration).
  • Amitose moisture-sensitive vitamin C
  • Amitose is superior to conventional vitamin C derivatives in that it is easy to get used to, has no squeak, is smooth, has a moist feeling, is soft, and is not sticky.
  • the moisturizing power is improved and the feeling of use is not sticky.
  • HA-4 The world's smallest hyaluronic acid "HA-4" is about 1/1750 of the high molecular weight hyaluronic acid in terms of diameter. It is the world's smallest hyaluronic acid with a molecular weight of 820 DA, and because it has a small molecular weight and a high affinity with the skin, it is quickly absorbed and moisturizes the skin.
  • Human nanoceramide has the same structure as ceramide present in human skin. Ceramide keeps the inside of the skin moisturized and helps the barrier function to protect the skin from external stimuli. Above all, "human ceramide", which has the same structure as human skin, is encapsulated in nano size to surely enhance the penetrating power.
  • -Hyaloligo Hyalooligo is a penetrating hyaluronic acid developed by Kewpie Corp., which is 1/100 the size of conventional hyaluronic acid. By making hyaluronic acid nano-sized, the permeability into the epidermis is enhanced.
  • Hyaluronic acid that has penetrated into the epidermis stores about 6,000 times its own weight of water, creates gaps between cells, and smoothes the flow of nutrients.
  • Hyaluronic acid is a repair-type hyaluronic acid developed by Kewpie Corp. that repairs the lamellar structure and prepares the barrier function.
  • Hyaluronic acid is hyaluronic acid in which a hydrophobic group is added to a part of hydrophilic sodium hyaluronate.
  • Hyaluronic acid, which has moisturizing power is given the function of approaching the barrier function.
  • the biocosmetic composition of the present invention has been completed based on regenerative medicine technology, and is further characterized in that nicotinamide mononucleotide is blended in place of the human stem cell culture medium.
  • Nicotinamide mononucleotide (abbreviation: NMN) is a material that is the source of biological substances (amino acids, proteins, etc.) that make up everything from skin, hair, muscles, and bones, and is the activity of longevity genes. Expected as a chemical component. Therefore, even when nicotinamide mononucleotide is added instead of the human stem cell culture medium, the same action and effect as described above can be obtained.
  • the present invention will be specifically described below based on examples.
  • FIG. 1 is a conceptual diagram of a process for producing a biocosmetic composition according to an embodiment of the present invention.
  • three types of biocosmetic compositions are produced according to each type of genetic tendency. That is, as shown in FIG. 1, first, the user is classified into three types, wrinkle type 11, stain type 12, and dry type 13, by genetic test 10.
  • Wrinkle-related genes are examined for glycation risk. This is because if it is easily saccharified, the quality of collagen and elastin, which are constituents of the dermis, is likely to deteriorate and wrinkles are likely to occur.
  • the stain gene (Mn-SOD) examines whether the body can make enough antioxidant enzymes. This is because if the ability to make antioxidant enzymes is low, active oxygen will accumulate and stains will easily occur.
  • the dry gene (PON1) examines whether lipid peroxide is likely to be produced. This is because lipid peroxide decomposes the lamellar structure (barrier function), which makes it easier for moisture in the skin to escape, resulting in dry skin.
  • a domestic human stem cell culture solution 20 and a stem cell support component 30 are blended, and further, an anti-wrinkle component 41, an anti-stain component 42, or a moisturizing component 43 is blended according to each type 11, 12, and 13. .
  • the compounding component when classified into wrinkle type 11 is a combination of the domestic human stem cell culture solution 20 and the stem cell support component 30, which are common components, and the anti-wrinkle component 41.
  • the compounding component when classified into the stain type 12 is the addition of the anti-stain component 42 to the domestic human stem cell culture solution 20 and the stem cell support component 30, which are common components.
  • the compounding component is a mixture of the domestic human stem cell culture solution 20 and the stem cell support component 30, which are common components, and the moisturizing component 43.
  • Domestic human stem cell culture medium 20 A domestic human stem cell culture supernatant is commonly mixed. For example, it is desirable to add 100% pure domestic human stem cell culture solution "JMSC-CM” (trade name). "JMSC-CM” is a fresh “pure raw material” that does not add any additives or heat. In addition, because it is cultivated in a completely serum-free medium, there is no concern about allergies. In addition, the stem cell culture medium contains more FGF7 (dermis cell growth factor) and collagen 6A3 than other companies' products, and is expected to have a high anti-aging effect. FGF7 (fibroblast growth factor) is a component involved in the skin barrier function that promotes cell proliferation of the epithelial system. collagen6A3 is a component that forms the stroma. It is involved in the firmness of the skin.
  • FGF7 fibroblast growth factor
  • collagen 6A3 is a component that forms the stroma. It is involved in the firmness of the skin.
  • Ste cell support component 30 As a stem cell support component, the following three types of fortifying components (1) proteoglycan, (2) aquatide, and fortifying component (3) are commonly blended.
  • Proteoglycan exerts the following eight actions.
  • -Skin elasticity improving effect In the human monitor test, the elasticity of the skin was improved.
  • ⁇ Rough skin improving effect The amount of scales decreased in the human monitor test.
  • ⁇ Moisturizing effect In the human monitor test, the amount of water and oil in the keratin increased. In addition, it was confirmed that the water content was maintained.
  • -Wrinkle improving effect In the human monitor test, the increase in wrinkle cotton length and total area at the outer corner of the eye could be suppressed.
  • ⁇ Whitening effect Suppressed melanin production by B16 mouse melanoma cells. Improved pigmentation in human monitor studies.
  • ⁇ EGF-like action (epidermal cell proliferation promoting action) Promotes cell proliferation of human epidermal cells.
  • -Hyaluronic acid production promoting action Promotes hyaluronic acid production by human normal dermal fibroblasts.
  • ⁇ Type I collagen production promoting action Promotes type I collagen production by human normal dermal fibroblasts.
  • Aquatide (In-Cosmetics ASIA 2016 Gold Award Winner) Aquatide has the following functions. ⁇ Strengthening the barrier function While supporting moisturizing power, it leads to skin that is difficult for external stimuli to invade. ⁇ Antioxidant By increasing the high oxidizing power of the skin, various skin problems can be prevented. ⁇ Abnormality detection Detects abnormalities in genes and proteins involved in cell maintenance and supports repair. ⁇ Autophagy Autophagy is the decomposition of generated waste products by the autophagy of mitochondria.
  • Royal Biosite (In-Cosmetics 2017 Gold Award Winner) Royal biosite is a rare component of royal jelly and has the following effects. ⁇ Improvement of rough skin It improves rough skin by reducing skin irritation to various chemical substances that cause irritation (preservatives, surfactants, etc.). ⁇ Promotion of collagen production It promotes collagen production in a concentration-dependent manner with respect to human-derived fibroblasts.
  • Stain type 12 For those classified as stain type 12, (1) APPS, (2) AA-2G, and (3) amitose are further added and blended as anti-stain component 42.
  • Amitose moistureturizing vitamin C
  • the moisturizing power is improved and a non-sticky feeling is realized.
  • Amitose is superior to conventional vitamin C derivatives in that it is easy to get used to, has no squeak, is smooth, has a moist feeling, is soft, and is not sticky.
  • HA4 HA4 is the world's smallest hyaluronic acid with a molecular weight of 820DA. In general, components with a molecular weight of 1,000 DA or less are said to have skin permeability. HA4 is also known to produce heat shock protein (HSP72) without the addition of heat stress. Heat shock proteins are thought to contribute to skin aging by reducing oxidative stress.
  • Hyalooligo penetration type hyaluronic acid
  • Hyalooligo increased the permeability into the epidermis by nanonizing hyaluronic acid.
  • Hyaluronic acid that permeates the epidermis stores about 6,000 times its own weight of water, creates gaps between cells, and smoothes the flow of nutrients and waste products.
  • Hyalooligo is 15 to 25 nm, which is 1/100 the size of conventional hyaluronic acid. Since it is nano-sized, it penetrates into the keratin of the skin and strongly moisturizes it.
  • Hyaluronic acid (repaired hyaluronic acid) Hyalo repair repairs the lamellar structure and prepares the barrier function. Hyaluronic acid, which has moisturizing power, is given the function of approaching the barrier function.
  • Example 2 This example relates to a biocosmetic composition for a person classified as a wrinkle type, as shown in the tables of FIGS. 2-4.
  • Example 3 This example relates to a biocosmetic composition for a person classified as a stain type, as shown in the tables of FIGS. 5-7.
  • Example 4 This example relates to a biocosmetic composition for a person classified as a dry type, as shown in the tables of FIGS. 8-11.
  • Example 5 This example relates to a biocosmetic composition corresponding to a person classified as wrinkle type 11.
  • the compounding components of this example are as follows, and are characterized in that nicotinamide mononucleotide is blended in place of the human stem cell culture medium.
  • Nicotinamide mononucleotide (abbreviation: NMN) is a nucleotide derived from ribose and nicotinamide. It is a coenzyme present in all species and is contained in various nutrient sources such as milk. Nicotinamide mononucleotide is a material that is the source of in vivo substances (amino acids, proteins, etc.) that compose all of skin, hair, muscles, and bones, and is expected to be an activating component of longevity genes.
  • in vivo substances amino acids, proteins, etc.
  • Proteoglycan It has EGF-like action, promotes hyaluronic acid production, and improves rough skin.
  • Aquatide In-Cosmetics 2016 Gold Award Winner
  • It has functions such as moisturizing barrier function, suppression of waste generation (antioxidant), repair of abnormal proteins (anti-stress protein), decomposition of waste products (autophagy function: Nobel Prize for elucidation of autophagy function).
  • Royal Biosite In-Cosmetics 2017 Gold Award Winner
  • Hyaluronic acid (HA-4) ⁇ Water retention and maintenance of intercellular spaces (for substance metabolism and cell migration) Since it is the world's smallest class hyaluronic acid (ultra-low molecular weight with a molecular weight of 800), its penetrating power is significantly different from that of conventional hyaluronic acid.
  • Narsgen (patented ingredient researched and developed by Kyoto University) It has effects such as promoting collagen production, promoting elastin production, and promoting HSP47 production. HSP47 is a molecular chaperone involved in collagen folding.
  • Progerin In-Cosmetics 2012 Gold Award Winner
  • It has functions such as suppressing the accumulation of aging proteins and protecting hyaluronic acid.
  • It It has functions such as strengthening the network between liftnin collagens and strengthening the adhesion with the basal layer.
  • Example 6 This example relates to a biocosmetic composition corresponding to a person classified as spot type 12.
  • the compounding components of this example are as follows, and are characterized in that nicotinamide mononucleotide is blended in place of the human stem cell culture medium.
  • Nicotinamide mononucleotide (abbreviation: NMN) is a nucleotide derived from ribose and nicotinamide. It is a coenzyme present in all species and is contained in various nutrient sources such as milk. Nicotinamide mononucleotide is a material that is the source of in vivo substances (amino acids, proteins, etc.) that compose all of skin, hair, muscles, and bones, and is expected to be an activating component of longevity genes.
  • in vivo substances amino acids, proteins, etc.
  • Proteoglycan It has EGF-like action, promotes hyaluronic acid production, and improves rough skin.
  • Aquatide In-Cosmetics 2016 Gold Award Winner
  • It has functions such as moisturizing barrier function, suppression of waste generation (antioxidant), repair of abnormal proteins (anti-stress protein), decomposition of waste products (autophagy function: Nobel Prize for elucidation of autophagy function).
  • Royal Biosite In-Cosmetics 2017 Gold Award Winner
  • Hyaluronic acid (HA-4) ⁇ Water retention and maintenance of intercellular spaces (for substance metabolism and cell migration) Since it is the world's smallest class hyaluronic acid (ultra-low molecular weight of 800 molecular weight) The penetrating power is significantly different from that of conventional hyaluronic acid.
  • APPS penetrating vitamin C
  • AA-2G sustained stable vitamin C
  • Amitose moisture-driven vitamin C
  • Example 7 This example relates to a biocosmetic composition corresponding to a person classified as dry type 13.
  • the compounding components of this example are as follows, and are characterized in that nicotinamide mononucleotide is blended in place of the human stem cell culture medium.
  • Nicotinamide mononucleotide (abbreviation: NMN) is a nucleotide derived from ribose and nicotinamide. It is a coenzyme present in all species and is contained in various nutrient sources such as milk. Nicotinamide mononucleotide is a material that is the source of in vivo substances (amino acids, proteins, etc.) that compose all of skin, hair, muscles, and bones, and is expected to be an activating component of longevity genes.
  • in vivo substances amino acids, proteins, etc.
  • Proteoglycan It has EGF-like action, promotes hyaluronic acid production, and improves rough skin.
  • Aquatide In-Cosmetics 2016 Gold Award Winner
  • It has functions such as moisturizing barrier function, suppression of waste generation (antioxidant), repair of abnormal proteins (anti-stress protein), decomposition of waste products (autophagy function: Nobel Prize for elucidation of autophagy function).
  • Royal Biosite In-Cosmetics 2017 Gold Award Winner
  • Hyaluronic acid (HA-4) ⁇ Water retention and maintenance of intercellular spaces (for substance metabolism and cell migration) Since it is the world's smallest class hyaluronic acid (ultra-low molecular weight with a molecular weight of 800), its penetrating power is significantly different from that of conventional hyaluronic acid.
  • Human ceramide This is a nano-sized component of ceramide having a lamellar structure.
  • Hyalooligo penetrating hyaluronic acid
  • Hyaluronic acid (repaired hyaluronic acid) It has the function of repairing the lamellar structure.
  • biocosmetic composition based on the regenerative medicine technique of the present invention is widely available in industry.

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Abstract

Selon l'invention, un ou plusieurs éléments parmi un protéoglycane, un aquatide （hexacarboxyméthyldipeptide-12） et un biocyte royal（protéine dérivée de la gelée royale） sont mélangés à une solution de culture de cellules souches humaines en tant que composants supports de cellules souches exploitant la force de ladite solution de culture de cellulse souches humaines. Ainsi, l'objet de l'invention se révèle efficace dans le domaine de la médecine régénératrice et de l'esthétique en raison de facteurs de croissance contenus en abondance dans la solution de culture de cellules souches humaines, et il est possible en outre d'exploiter au maximum la force de la solution de culture de cellules souches humaines au moyen des trois sortes de composants supports de cellules souches.
PCT/JP2020/000870 2020-01-14 2020-01-14 Composition de biocosmétique Ceased WO2021144843A1 (fr)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7376758B1 (ja) 2023-07-11 2023-11-09 株式会社Cel-Ena 肌美容方法
WO2025013894A1 (fr) * 2023-07-11 2025-01-16 株式会社Cel-Ena Méthode d'embellissement de la peau, méthode de perméation cutanée à composants multiples et système de perméation cutanée à composants multiples
WO2025084391A1 (fr) * 2023-10-20 2025-04-24 一丸ファルコス株式会社 COMPOSITION ORALE CONTENANT DU β-NMN ET DU PROTÉOGLYCANE

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Publication number Priority date Publication date Assignee Title
JP7376758B1 (ja) 2023-07-11 2023-11-09 株式会社Cel-Ena 肌美容方法
WO2025013894A1 (fr) * 2023-07-11 2025-01-16 株式会社Cel-Ena Méthode d'embellissement de la peau, méthode de perméation cutanée à composants multiples et système de perméation cutanée à composants multiples
JP2025012050A (ja) * 2023-07-11 2025-01-24 株式会社Cel-Ena 肌美容方法
JP2025013265A (ja) * 2023-07-11 2025-01-24 株式会社Cel-Ena 肌美容方法、組成物キット、複数成分肌浸透方法、および複数成分肌浸透システム
JP7690707B2 (ja) 2023-07-11 2025-06-11 株式会社Cel-Ena 肌美容方法、組成物キット、複数成分肌浸透方法、および複数成分肌浸透システム
WO2025084391A1 (fr) * 2023-10-20 2025-04-24 一丸ファルコス株式会社 COMPOSITION ORALE CONTENANT DU β-NMN ET DU PROTÉOGLYCANE

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