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WO2021008462A1 - Structure d'emballage et procédé d'emballage de patch l'utilisant - Google Patents

Structure d'emballage et procédé d'emballage de patch l'utilisant Download PDF

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Publication number
WO2021008462A1
WO2021008462A1 PCT/CN2020/101379 CN2020101379W WO2021008462A1 WO 2021008462 A1 WO2021008462 A1 WO 2021008462A1 CN 2020101379 W CN2020101379 W CN 2020101379W WO 2021008462 A1 WO2021008462 A1 WO 2021008462A1
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WO
WIPO (PCT)
Prior art keywords
layer
packaging
packaging container
cell membrane
container
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CN2020/101379
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English (en)
Chinese (zh)
Inventor
高爽
王娟
谭玉琴
靳新
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BOE Technology Group Co Ltd
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BOE Technology Group Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BOE Technology Group Co Ltd filed Critical BOE Technology Group Co Ltd
Publication of WO2021008462A1 publication Critical patent/WO2021008462A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D77/00—Packages formed by enclosing articles or materials in preformed containers, e.g. boxes, cartons, sacks or bags
    • B65D77/04—Articles or materials enclosed in two or more containers disposed one within another
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D77/00—Packages formed by enclosing articles or materials in preformed containers, e.g. boxes, cartons, sacks or bags
    • B65D77/10—Container closures formed after filling
    • B65D77/12—Container closures formed after filling by collapsing and flattening the mouth portion of the container and securing without folding, e.g. by pressure-sensitive adhesive, heat-sealing, welding or applying separate securing members
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/18—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents providing specific environment for contents, e.g. temperature above or below ambient
    • B65D81/22—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents providing specific environment for contents, e.g. temperature above or below ambient in moist conditions or immersed in liquids

Definitions

  • the embodiment of the present disclosure relates to a packaging structure and a method for packaging film using the packaging structure.
  • cell membrane structure has been increasingly applied to various technical fields such as engineering and medicine.
  • cell membranes prepared by methods such as temperature-sensitive petri dishes have been widely used in heart repair and corneal repair in the fields of tissue engineering and regenerative medicine.
  • the membrane itself is soft and adherent, the membrane is easily damaged during storage or transportation, which seriously affects the performance of the membrane.
  • the packaging structure includes a first packaging container and at least one second packaging container.
  • the second packaging container is configured to be placed in the first packaging container.
  • the first packaging container is configured to contain liquid
  • the second packaging container includes a first layer and a second layer opposite to each other, and the first layer and the second layer are configured to contain a film, so The position between the first layer and the second layer for containing the diaphragm is in fluid communication with the inside of the first packaging container.
  • the second packaging container includes a hard material to provide support for the membrane.
  • At least one of the first layer and the second layer includes the hard material, and there is provided between the first layer and the second layer There is a gap for accommodating the diaphragm.
  • the size of the gap in a direction perpendicular to the first layer or the second layer is 20 ⁇ m-1000 ⁇ m.
  • the size of the gap in a direction perpendicular to the first layer or the second layer is 100 ⁇ m-200 ⁇ m.
  • the edge portion of the first layer and the edge portion of the second layer are connected to each other by a rigid structure.
  • the material of the first layer and the material of the second layer are flexible materials
  • the second packaging container includes the first layer and the The supporting structure between the second layers, the material of the supporting structure is the hard material.
  • the membrane is located between the first layer and the supporting structure, or between the second layer and the supporting structure.
  • At least one of the first layer and the second layer includes at least one hole, and the hole is configured to make the first layer and the The position between the second layers for containing the film is in fluid communication with the inside of the first packaging container.
  • the size of the hole is 0.1mm-5mm.
  • the edge portion of the first layer and the edge portion of the second layer are connected to each other, and the connected portion includes at least one gap, and the gap is It is configured to fluidly communicate the position between the first layer and the second layer for accommodating the film sheet with the inside of the first packaging container.
  • At least one of the first layer and the second layer is a membrane material with permeability.
  • the first packaging container is a sealed container, and the volume of the first packaging container is not less than 0.5 ml.
  • the material of the first packaging container and the material of the second packaging container are biocompatible polymer materials.
  • the at least one second packaging container includes a plurality of second packaging containers, and the plurality of second packaging containers are respectively located in different areas of the first packaging container Inside.
  • the membrane is a cell membrane
  • the first packaging container is configured to contain a cell membrane protective solution or a cell culture fluid.
  • the second packaging container is fixed in the first packaging container.
  • At least one embodiment of the present disclosure further provides a method for packaging a film using the packaging structure of any embodiment of the present disclosure.
  • the method for packaging the film includes: placing the film in the second packaging container. Between the first layer and the second layer, the second packaging container is packaged; and the second packaging container is placed in the first packaging container containing the liquid to package the first packaging container.
  • packaging the second packaging container includes: thermocompression packaging the edge portion of the first layer and the edge portion of the second layer.
  • packaging the first packaging container includes mechanically packaging the first packaging container.
  • FIG. 1A and 1B are schematic diagrams of a packaging structure provided by some embodiments of the present disclosure.
  • FIG. 2 is a schematic cross-sectional view of a second packaging container in the packaging structure shown in FIG. 1A;
  • FIG. 3 is a schematic diagram of another packaging structure provided by some embodiments of the disclosure.
  • FIG. 4 is a schematic diagram of still another packaging structure provided by some embodiments of the present disclosure.
  • Figure 5 is a schematic diagram of yet another packaging structure provided by some embodiments of the present disclosure.
  • FIG. 6 is a flowchart of a method for packaging film sheets provided by some embodiments of the present disclosure.
  • the membrane In the process of packaging, storage and transportation of the membrane, it is often necessary to provide a relatively stable liquid environment for the membrane.
  • the cell membrane needs to be stored in a certain amount of cell protection solution or cell culture fluid to maintain its cell activity and function Sex.
  • the membrane itself is soft, adherent and has poor mechanical properties, when the membrane is stored in a liquid environment, it will be damaged by the liquid shearing force, prone to wrinkles, folding, etc., which makes the membrane The film is damaged, causing damage to the performance of the diaphragm.
  • At least one embodiment of the present disclosure provides a packaging structure and a method of using the packaging film.
  • the packaging structure is provided with the first packaging container and the second packaging container, which can not only provide the required stable liquid environment for the membrane, but also reduce the damage of the liquid shear force to the membrane, and reduce the wrinkles or folding of the membrane. In order to improve the stability of the film in the process of packaging, storage or transportation.
  • At least one embodiment of the present disclosure provides a packaging structure that includes a first packaging container and at least one second packaging container.
  • the second packaging container is configured to be placed in the first packaging container; the first packaging container is configured to contain liquid; the second packaging container includes a first layer and a second layer opposite to each other, and the first layer and the second layer The space between is configured to contain the film; the position between the first layer and the second layer for containing the film is in fluid communication with the inside of the first packaging container.
  • the second packaging container is configured to be placed in the first packaging container means that the size or volume of the second packaging container is designed to be placed in the first packaging container without its structure being damaged and losing its Features.
  • the second packaging container can be placed in the first packaging container without folding or bending itself.
  • the film can be placed in the second packaging container, and then the second packaging container can be placed in the first packaging container for transportation and preservation, etc.; the second packaging container containing the film can also be removed from the first packaging container. Take it out of the packaging container.
  • FIG. 1A is a schematic diagram of a packaging structure provided by some embodiments of the present disclosure.
  • the packaging structure 10 includes a first packaging container 110 and a second packaging container 120.
  • the second packaging container 120 is located in the first packaging container 110.
  • the first packaging container 110 is configured to contain a liquid 130.
  • the second packaging container 120 includes a first layer 121 and a second layer 122 opposite to each other, and the film 140 is arranged between the first layer 121 and the second layer 122.
  • the position between the first layer 121 and the second layer 122 for accommodating the film 140 is in fluid communication with the interior of the first packaging container 110, that is, the interior of the first packaging container 110 and the second packaging container 120 are used for accommodating the film.
  • the positions of 140 can be exchanged for liquids, and the liquid 130 contained in the first packaging container 110 can flow between the first layer 121 and the second layer 122, so that the diaphragm 140 is in contact with the liquid 130 to provide the diaphragm 140 The required liquid environment.
  • the packaging structure 10 can realize fluid communication between the position for accommodating the film 140 in the second packaging container 120 and the inside of the first packaging container 110, and further provide storage of the film through the liquid 130 contained in the first packaging container 110 140 required stable liquid environment.
  • the second packaging container 120 accommodates the film 140 between the first layer 121 and the second layer 122, so that the film 140 is in a limited space, so as to prevent the film 140 from causing large-scale damage in a liquid environment.
  • the movement reduces the damage of the liquid shearing force to the diaphragm 140, so that the diaphragm 140 is not prone to wrinkles, folding, etc., thereby reducing the possibility of damage to the performance of the diaphragm 140 during packaging, storage, or transportation.
  • the stability of the film 140 stored in the packaging structure 10 is improved.
  • the liquid 130 can provide the membrane 140 with the required stable liquid environment.
  • the liquid 130 can maintain the acid-base balance and osmotic pressure balance of the liquid environment where the membrane 140 is located, or provide the membrane 140 with required nutrients such as nutrients. Wait.
  • the membrane 140 may be a cell membrane
  • the liquid 130 contained in the first packaging container 110 may be a corresponding cell membrane protective solution or cell culture fluid, etc., so as to provide nutrients required by the cell membrane and maintain the cell membrane.
  • the acid-base balance of the liquid environment improves the stability of the cell membrane during storage or transportation.
  • the embodiments of the present disclosure take the membrane as a cell membrane and the liquid contained in the first packaging container as a cell membrane protective liquid as an example, to specifically describe the packaging structure provided by some embodiments of the present disclosure, but this does not constitute an implementation of the present disclosure.
  • the membrane can also be other functional membranes or other types of membranes.
  • the first packaging container can also contain different liquids according to different actual needs, which is not limited in the embodiments of the present disclosure. .
  • the material of the first packaging container 110 and the material of the second packaging container 120 may be biocompatible polymer materials, such as polycaprolactone (PCL), polylactic acid ( PLA), polyethylene (PE), polypropylene (PP), polyterephthalic acid (PET) and other materials. Since the biocompatible polymer material has good cell compatibility and will not react with the cell membrane protective liquid 130, neither the first packaging container 110 nor the second packaging container 120 will affect the cell membrane protective liquid 130 or the cell membrane. The sheet 140 produces undesirable effects, thereby further maintaining the stability of the liquid environment in which the cell membrane 140 is located, and reducing or avoiding damage to the performance of the cell membrane 140.
  • the biocompatible polymer material can also be a material that also includes other functions (such as providing structural support functions), so that the first packaging container 110 and the second packaging container 120 have both biocompatibility and structural properties.
  • the second packaging container 120 may include a hard material to provide support for the cell membrane 140, such as mechanical support, so as to further reduce the impact of liquid shear on the cell membrane 140 located between the first layer 121 and the second layer 122. damage.
  • the hard materials here are relative to flexible materials. The use of hard materials is mainly to provide sufficient mechanical support for the cell membranes, reducing or avoiding the cell membranes from wrinkling and being damaged during transportation or storage. Bending, tearing, etc. For example, the bending strength and thickness of the hard material can be selected so that it can play the above-mentioned supporting role.
  • Figure 2 is a schematic cross-sectional view of a second packaging container in the packaging structure shown in Figure 1A.
  • the first layer 121 and the second layer 122 may be hard materials, and a gap 123 is provided between the first layer 121 and the second layer 122 to accommodate the cell membrane 140.
  • the first layer 121 and the second layer 122 can be Hard material, so that the first layer 121 and the second layer 122 provide support for the cell membrane 140 located between the first layer 121 and the second layer 122, so as to reduce the damage to the cell membrane 140 caused by the liquid shearing force.
  • the cell membrane 140 is wrinkled or folded, so that the cell membrane 140 remains flat, thereby improving the stability of the cell membrane 140 contained in the second packaging container 120.
  • the second packaging container 120 can have as small an internal volume as possible, that is, reduce the size of the gap 123 as much as possible, for example, reduce the gap 123 in a vertical position.
  • the size dh of the gap 123 in the direction perpendicular to the first layer 121 or the second layer 122 can be set to 20 ⁇ m-1000 ⁇ m, for example, it can be further set to 50 ⁇ m-300 ⁇ m, so as to reduce the impact of liquid shear on the cell membrane 140.
  • the damage of the cell membrane 140 is reduced, and the cell membrane 140 can be kept flat.
  • it can also prevent the first layer 121 or the second layer 122 from squeezing the cell membrane 140 and causing the cell membrane 140 to be damaged or crushed.
  • the size dh of the gap 123 in the direction perpendicular to the first layer 121 or the second layer 122 can be further set to 100 ⁇ m-200 ⁇ m, so as to reduce the liquid shear force as much as possible.
  • the damage to the cell membrane 140 prevents the cell membrane 140 from folding or wrinkling, so that the cell membrane 140 always maintains a flat state.
  • the edge portion of the first layer 121 and the edge portion of the second layer 122 may be connected to each other through the hard structure 124.
  • the hard structure 124 may include the same hard biocompatible polymer material as the first layer 121 and the second layer 122 to support the first layer 121 and the second layer 122 so that the first layer 121 and the second layer A gap 123 is formed between the layers 122 to accommodate the cell membrane 140.
  • a certain thickness of hard material may be sandwiched between the edge portion of the first layer 121 and the edge portion of the second layer 122 to form the rigid structure 124, and then A gap 123 capable of storing the cell membrane 140 is formed between the first layer 121 and the second layer 122.
  • the edge portion of the first layer 121 and the edge portion of the second layer 122 can be encapsulated by methods such as thermocompression packaging, so that the first layer 121 and the second layer 122
  • the rigid structure 124 and the rigid structure 124 form a space for accommodating the cell membrane sheet 140.
  • the first layer 121, the second layer 122, and the rigid structure 124 may form the second packaging container 120 approximately in the shape of a bag.
  • the inner edge L1 of the edge portion of the first layer 121 or the second layer 122 may be used as the packaging line
  • the first layer 121 and the second layer 122 are encapsulated to form the second packaging container 120, so as to prevent the hard structure 124 from contacting the cell membrane 140 and prevent the hard structure 124 from unnecessarily affecting the cell membrane 140.
  • the rigid structure 124 may cover all the edge portions of the first layer 121 and all the edge portions of the second layer 122, so as to prevent the cell membrane sheet 140 from moving outside the second packaging container 120, thereby
  • the first layer 121 and the second layer 122 are used to provide support for the cell membrane 140 and reduce the damage to the cell membrane 140 by the liquid shearing force.
  • FIG. 1A and FIG. 2 the rigid structure 124 may cover all the edge portions of the first layer 121 and all the edge portions of the second layer 122, so as to prevent the cell membrane sheet 140 from moving outside the second packaging container 120, thereby
  • the first layer 121 and the second layer 122 are used to provide support for the cell membrane 140 and reduce the damage to the cell membrane 140 by the liquid shearing force.
  • the hard structure 124 can also be arranged at intervals between the edge portion of the first layer 121 and the edge portion of the second layer 122, that is, only a part of the edge portion of the first layer 121 and the second layer 122 A certain thickness of hard material is sandwiched between a part of the edge portion of the package structure, thereby reducing the manufacturing cost of the packaging structure 10 and simplifying the manufacturing process of the packaging structure 10.
  • the embodiment of the present disclosure does not limit the location of the hard structure 124 at the edge portion of the first layer 121 or the edge portion of the second layer 122.
  • the rigid structure 124 may also be provided only on two opposite sides or edges of the first layer 121 or the second layer 122. They are arranged at the four vertices of the edge portion of the first layer 121 or the second layer 122, which is not limited in the embodiment of the present disclosure.
  • the outline of the second packaging container 120 is square, that is, the outlines of the first layer 121 and the second layer 122 are square, while the other
  • the contours of the first layer 121 and the second layer 122 can also be circular, elliptical, or set to other suitable shapes according to the contour of the cell membrane 140, which is not limited in the embodiments of the present disclosure.
  • first layer 121 and the second layer 122 are completely the same, while in some other embodiments of the present disclosure, in order to facilitate packaging,
  • the first layer 121 and the second layer 122 may also be configured in different shapes from each other, or the size of the first layer 121 may also be slightly larger or slightly smaller than the size of the second layer 122, which is not limited in the embodiment of the present disclosure.
  • the hard structure 124 may also be integrally formed with the first layer 121 or the second layer 122.
  • the hard structure 124, the first layer 210 and the second layer 220 may be integrally formed with Containers with opening and closing functions, such as box-shaped containers or other containers with switch functions.
  • the cell membrane sheet 140 can be placed in the second packaging container 120 by opening the second packaging container 120 The second packaging container 120 is closed so that the cell membrane sheet 140 is located in the inner space of the second packaging container 120, that is, the position between the first layer 121 and the second layer 122.
  • the second packaging container 120 is used to provide support for the cell membrane sheet 120, and to prevent the cell membrane sheet 140 from moving in a large range, thereby reducing the damage to the cell membrane sheet 140 by the liquid shear force, and reducing the occurrence of wrinkles or folding of the cell membrane sheet 140. , Thereby improving the stability of the cell membrane 140.
  • the integrally formed second packaging container may be a three-dimensional structure with a regular shape, such as a cylinder, a cube, etc., or a three-dimensional structure with an irregular shape, such as a combination of several different container forms.
  • a regular shape such as a cylinder, a cube, etc.
  • a three-dimensional structure with an irregular shape such as a combination of several different container forms.
  • the integrally formed second packaging container may realize the opening or closing function through a mechanical structure such as a screw thread or a buckle, or may realize the opening or closing function through gluing or other means, which is not limited in the embodiments of the present disclosure.
  • both the first layer 121 and the second layer 122 are made of hard materials.
  • one of the first layer 121 and the second layer 122 is made of hard materials and the other is made of flexible materials. material.
  • the material of the first layer 121 and the material of the second layer 122 may also be flexible materials, and the second packaging container 120 includes a material between the first layer 121 and the second layer 122.
  • Support structure the material of the support structure is a hard material, and the second packaging container 120 provides support for the cell membrane 140 located between the first layer 121 and the second layer 122 through the support structure to reduce the impact of liquid shear Damage to the cell membrane 140.
  • the support structure may be a sheet structure
  • the cell membrane 140 may be located between the first layer 121 and the sheet support structure, or it may be located between the second layer 122 and the sheet support structure, thereby reducing the cell membrane. Wrinkles or folds occur in 140, which improves the stability of the cell membrane 140 stored in the second packaging container 120.
  • the sheet structure may be set to cover the entire area of the first layer 121 or the second layer 122, or may be set only between the edge portion of the first layer 121 and the edge portion of the second layer 122.
  • the implementation of the present disclosure The example does not restrict this.
  • the supporting structure may also be a hollow structure with a three-dimensional space, and the cell membrane 140 may be accommodated in the hollow structure, which is not limited in the embodiment of the present disclosure.
  • the cell membrane sheet when both the first layer and the second layer are made of flexible materials, the cell membrane sheet can also be directly placed between the first layer and the second layer, and the first layer can be thermally press packaged.
  • the edge portion of the layer and the edge portion of the second layer form a second packaging container in the form of a bag.
  • the first layer and the second layer can be attached to both sides of the cell membrane, thereby reducing the damage to the two sides of the cell membrane due to the liquid shearing force to a certain extent.
  • the second layer is made of flexible materials, so it will not squeeze the cell membrane or cause damage to the cell membrane.
  • the contour and size of the first packaging container can be adjusted accordingly according to the actual size or contour of the second packaging container.
  • the inner volume thickness of the first packaging container can be appropriately reduced to avoid the second packaging container.
  • the packaging container moves or rotates in a large range in the first packaging container, thereby reducing the damage to the cell membrane by the liquid shearing force and keeping the cell membrane in a flat state.
  • At least one of the first layer 121 and the second layer 122 includes at least one hole 125, and the hole 125 is configured to allow the space between the first layer 121 and the second layer 122 to accommodate
  • the position of the cell membrane 140 is in fluid communication with the inside of the first packaging container 110.
  • the liquid exchange between the inside of the first packaging container 110 and the position in the second packaging container 120 for accommodating the cell membrane sheet 140 is realized, so that the cell membrane sheet protection solution 130 contained in the first packaging container 110 can pass through the hole 125 flows into the second packaging container 120 to provide the liquid environment required by the cell membrane 140, such as maintaining the acid-base balance of the liquid environment in which the cell membrane 140 is located or providing nutrients required by the cell membrane 140, etc., thereby improving the second The stability of the cell membrane sheet 140 stored in the packaging container 120.
  • first layer 121 and the second layer 122 may each be provided with a plurality of holes 125 to maintain the balance of the osmotic pressure at each position on the upper and lower surfaces of the cell membrane 140, and to make each part of the cell membrane 140 and the cell membrane protective liquid 130 fully contacts, thereby improving the stability of the cell membrane sheet 140 contained in the second packaging container 120.
  • the size (e.g., diameter) of the hole 125 may be 0.1mm-5mm, so as to prevent the cell membrane sheet 140 from moving outside of the second packaging container 120, so that the cell membrane sheet 140 contained in the second packaging container 120 can be in contact with the cell membrane.
  • the sheet protection liquid 130 is in full contact, so that the cell membrane sheet 140 is in a stable liquid environment.
  • the shape of the hole 125 is circular, while in some other embodiments of the present disclosure, the shape of the hole 125 may also be set to a square or other shapes.
  • the embodiment of the present disclosure does not limit the number or arrangement of the holes 125, which can satisfy the fluid communication between the inside of the first packaging container 110 and the position in the second packaging container 120 for containing the cell membrane sheet 140 OK.
  • at least one of the first layer 121 and the second layer 122 may further include a mesh structure, which is not limited in the embodiments of the present disclosure.
  • the cell membrane is in fluid communication with the inside of the first packaging container.
  • the edge portion of the first layer 121 and the edge portion of the second layer 122 may not be completely enclosed, for example It is possible to encapsulate only the edge portion provided with the hard material 124 or to seal only individual points of the edge portion, so that the cell membrane sheet protection solution 130 in the first packaging container 110 can flow into the second packaging container 120 and the cell membrane through these gaps.
  • the sheet 140 contacts to provide the cell membrane sheet 140 with the required stable liquid environment.
  • the packaging structure provided by the embodiments of the present disclosure can also be realized between the interior of the first packaging container 110 and the position where the cell membrane 140 is stored in the second packaging container 120 through other mechanical exchange methods or a combination of multiple methods.
  • the fluid communication is not limited by the embodiments of the present disclosure.
  • the first packaging container 110 is a sealed container, and the volume of the first packaging container 110 is not less than 0.5 ml, so that the first packaging container 110 passes through the cell membrane sheet protection solution 130 contained in the first packaging container 110.
  • the cell membrane 140 stored in the packaging container 120 provides the required stable liquid environment while isolating the fluid communication between the interior of the first packaging container 110 and the external environment, thereby preventing the external environment from affecting the cell membrane contained in the first packaging container 110.
  • the sheet protection solution 130 causes adverse effects, and further prevents the external environment from causing adverse effects on the cell membrane sheets 140 stored in the second packaging container 120, thereby maintaining the stability of the cell membrane sheets 140 packaged by the packaging structure 10.
  • the volume of the first packaging container 110 can be adjusted accordingly according to different actual needs, so that the first packaging container 110 can contain different amounts of cell membrane sheet protection solution 130, thereby Different cell membranes 140 provide different nutrients and acid-base balance, and meet the requirements of different types of cell membranes 140 or different transportation distances that need to be stored for different times.
  • the first packaging container 110 may be made of a hard material, so as to prevent the external environment from damaging the cell membrane protection solution 130 and the second packaging container 120 contained in the first packaging container 110, thereby preventing the external environment from affecting the stored cell membrane 140 Cause adverse effects.
  • the first packaging container 110 may be a container in the form of a square bag.
  • the method of thermocompression packaging can be used to encapsulate the edge portions corresponding to any three sides of the first packaging container 110 and inject the cell membrane sheet protection solution 130 into the first packaging container 110, and then The packaged second packaging container 120 is placed in the first packaging container 110 containing the cell membrane sheet protection solution 130 and encapsulates the remaining edge portion of the first packaging container 110, thereby completing the entire process of packaging the cell membrane sheet 140 with the packaging structure 10.
  • the first packaging container 110 may also have a circular, elliptical or other contours, and the first packaging container 110 may also be packaged in other ways. The disclosed embodiment does not limit this.
  • the first packaging container may also be a box-shaped container or other three-dimensional structure container with a certain height, so that the inside of the first packaging container and the second packaging container can be better Fluid communication is achieved between the positions where the cell membrane is placed.
  • FIG. 3 is a schematic diagram of another packaging structure provided by some embodiments of the disclosure.
  • the packaging structure 20 includes a first packaging container 210 and a second packaging container 220.
  • the second packaging container 220 has basically the same structure and function as the second packaging container 120 shown in FIG. 1A or 1B. , I won’t repeat it here.
  • the first packaging container 210 is a cuboid box-shaped container and has a certain height.
  • the box-shaped first packaging container 210 can realize switching and switching through mechanical structures such as threads or buckles or other suitable structures. Closed, the embodiment of the present disclosure does not limit this.
  • the cell membrane sheet 240 contained in the second packaging container 220 can more fully contact the cell membrane sheet protection solution 230 contained in the first packaging container 210, and thereby The acid-base and osmotic pressure of the cell membrane 240 are maintained in a better balance state, and the liquid environment of the cell membrane 240 is more stable, thereby further improving the stability of the cell membrane 240 packaged by the packaging structure 20 .
  • first packaging container 210 is a rectangular box-shaped container, it can better protect the cell membrane sheet protective solution 230 and the second packaging container 220 contained therein to a certain extent, and the box-shaped second A packaging container 210 is also more convenient for storage or transportation.
  • FIG. 4 is a schematic diagram of yet another packaging structure provided by some embodiments of the present disclosure.
  • the packaging structure 30 includes a first packaging container 310 and a second packaging container 320.
  • the material of the second packaging container 320 may be a membrane material with permeability, for example, at least one of the first layer and the second layer of the second packaging container 320 is a membrane material with permeability.
  • the membrane material can permeate substances such as sugars, proteins, polypeptides, and inorganic salts.
  • the membrane material can be a cellulose membrane, a polymer non-woven membrane, or the like.
  • the cell membrane sheet protective solution 330 contained in the first packaging container 310 can directly penetrate into the second packaging container 320 through, for example, the first layer or the second layer of the second packaging container 320, so as to provide the cell membrane sheet 340 with required And maintain the acid-base balance of the liquid environment in which the cell membrane 340 is located, so that the cell membrane 340 is in a stable liquid environment, and the stability of the cell membrane 340 packaged by the packaging structure 30 is improved.
  • the packaging structure 30 can also reduce the manufacturing cost of the second packaging container 320 and simplify the manufacturing process of the second packaging container 320, thereby facilitating mass production and application.
  • only one second packaging container 120 is provided in the first packaging container 110, while in some embodiments of the present disclosure, the first packaging container A plurality of second packaging containers can also be arranged inside.
  • first packaging container whether it is one or more second packaging containers, after being put into the first packaging container, they can be fixed in the first packaging container, which can reduce the relative movement between the first packaging container and the second packaging container , Better protect the cell membrane.
  • FIG. 5 is a schematic diagram of still another packaging structure provided by some embodiments of the present disclosure.
  • a plurality of second packaging containers 420 are respectively located in different areas of the first packaging container 410, so that the cell membrane sheets 440 contained in the plurality of second packaging containers 420 can be all the same as the cell membrane sheet protection solution 430.
  • the different areas of the first packaging container 410 can be separated from each other, so that each second packaging container 420 is confined in a limited space, so that each second packaging container 420 is between each other.
  • There is no mutual contact or mechanical collision thereby avoiding the occurrence of wrinkles or folding between the cell membrane sheets 440 due to, for example, mechanical collisions, and further improving the stability of the cell membrane sheets 440 packaged by the packaging structure 40.
  • the cells of the cell membrane sheet refer to all animal and plant-derived cells; the cell membrane sheet refers to a sheet-like multicellular structure prepared in any manner.
  • the preparation method includes but not It is limited to mechanical peeling, addition of agents that promote the peeling of cells from the culture container, and the use of petri dishes that can change the surface properties of the petri dishes by changing temperature, light intensity, and magnetic field.
  • At least one embodiment of the present disclosure further provides a method for packaging a film using the packaging structure of any one of the embodiments of the present disclosure.
  • the method for packaging the film includes: placing the film on the first layer of the second packaging container and Between the second layers, the second packaging container is sealed; and the second packaging container is placed in the first packaging container containing the liquid to seal the first packaging container.
  • FIG. 6 is a flowchart of a method for packaging film sheets provided by some embodiments of the present disclosure.
  • the method of packaging film includes the following steps.
  • Step S110 Place the film between the first layer and the second layer of the second packaging container, and package the second packaging container.
  • Step S120 placing the second packaging container in the first packaging container containing the liquid, and packaging the first packaging container.
  • the method of packaging the membrane specifically includes the following steps.
  • Step S210 The cell membrane sheet 240 is placed between the first layer and the second layer of the second packaging container 220, and the edge portion of the first layer and the edge portion of the second layer are heat-packed.
  • Step S220 The first packaging container 210 is filled with the cell membrane protection solution 230, the second packaging container 220 is placed in the first packaging container 210 containing the cell membrane protection solution 230, and the first packaging container 210 is mechanically packaged.
  • mechanically packaging the first packaging container 210 includes performing the first packaging container 210 through the mechanical structure of the first packaging container 210, such as a screw thread or a buckle. It is packaged to isolate the first packaging container 210 from fluid communication with the external environment.
  • the packaging film with the packaging structure can provide the liquid environment required by the film during storage or transportation, and reduce the damage caused by the liquid shearing force to the film.
  • the sheet is wrinkled or folded, which improves the stability of the diaphragm.

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  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Packages (AREA)

Abstract

L'invention concerne une structure d'emballage (10) et un procédé d'emballage d'un patch (140) l'utilisant. La structure d'emballage (10) comprend un premier récipient d'emballage (110) et au moins un second récipient d'emballage (120). Le second récipient d'emballage (120) est conçu pour être placé dans le premier récipient d'emballage (110). Le premier récipient d'emballage (110) est conçu pour contenir du liquide (130). Le second récipient d'emballage (120) comprend une première couche (121) et une seconde couche (122) opposées l'une à l'autre. La première couche (121) et la seconde couche (122) sont conçues pour recevoir le patch (140). La position entre la première couche (121) et la seconde couche (122) où le patch (140) est logé est en communication fluidique avec l'intérieur du premier récipient d'emballage (110). La structure d'emballage (10) peut fournir l'environnement liquide requis pour le patch (140) et réduire l'endommagement du patch (140) par la force de cisaillement de liquide.
PCT/CN2020/101379 2019-07-15 2020-07-10 Structure d'emballage et procédé d'emballage de patch l'utilisant Ceased WO2021008462A1 (fr)

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CN201910637374.7 2019-07-15
CN201910637374.7A CN112224667A (zh) 2019-07-15 2019-07-15 包装结构及利用其包装膜片的方法

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WO2021008462A1 true WO2021008462A1 (fr) 2021-01-21

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CN115735905A (zh) * 2022-11-30 2023-03-07 京东方科技集团股份有限公司 细胞膜片冻存装置、细胞膜片降温装置

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