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WO2021008087A1 - Procédé de test de sensibilité de contraste basé sur un potentiel visuel de mouvement évoqué - Google Patents

Procédé de test de sensibilité de contraste basé sur un potentiel visuel de mouvement évoqué Download PDF

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Publication number
WO2021008087A1
WO2021008087A1 PCT/CN2019/128993 CN2019128993W WO2021008087A1 WO 2021008087 A1 WO2021008087 A1 WO 2021008087A1 CN 2019128993 W CN2019128993 W CN 2019128993W WO 2021008087 A1 WO2021008087 A1 WO 2021008087A1
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paradigm
contrast
value
contrast sensitivity
visual evoked
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Chinese (zh)
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徐光华
郑小伟
杜成航
张凯
吴一帆
裴晋举
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Xian Jiaotong University
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Xian Jiaotong University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/0016—Operational features thereof
    • A61B3/0025—Operational features thereof characterised by electronic signal processing, e.g. eye models
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/02—Subjective types, i.e. testing apparatus requiring the active assistance of the patient
    • A61B3/022—Subjective types, i.e. testing apparatus requiring the active assistance of the patient for testing contrast sensitivity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/02—Subjective types, i.e. testing apparatus requiring the active assistance of the patient
    • A61B3/028—Subjective types, i.e. testing apparatus requiring the active assistance of the patient for testing visual acuity; for determination of refraction, e.g. phoropters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316—Modalities, i.e. specific diagnostic methods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316—Modalities, i.e. specific diagnostic methods
    • A61B5/369—Electroencephalography [EEG]
    • A61B5/377—Electroencephalography [EEG] using evoked responses
    • A61B5/378—Visual stimuli

Definitions

  • the invention relates to the technical field of brain-computer interface and optometry inspection, in particular to a method for detecting contrast sensitivity based on motion visual evoked potential.
  • Contrast sensitivity is to measure the black and white contrast (contrast) of the object surface required when the visual system recognizes objects of different sizes. It is used to evaluate the ability of the visual system to distinguish objects of different sizes. Therefore, it is a kind of New quantitative inspection method for visual function.
  • Common optometry examinations rely on subjects’ subjective feelings and cooperation.
  • contrast-sensitive examinations require the use of contrast sensitivity difference visual acuity charts, CSV-1000 light boxes and other methods. These methods all need to take the subjective judgment of the subjects as the end of the examination.
  • people with communication problems such as pre-lingual children or toddlers, it is not suitable to use these methods to evaluate visual function; adults may also be affected by environmental factors Misjudgment occurs; false reports and deceptions by the appraiser cannot be ruled out in forensic examination.
  • Brain-computer interface (BCI) and electroencephalogram (EEG), especially scalp electroencephalogram, are new methods for more objective and direct assessment of visual function.
  • many researchers have used scanning visual evoked potential (sVEP), steady-state visual evoked potential (SSVEP), pattern visual evoked potential (PVEP) and other methods to complete the detection of vision and contrast sensitivity.
  • sVEP scanning visual evoked potential
  • SSVEP steady-state visual evoked potential
  • PVEP pattern visual evoked potential
  • the current research mainly focuses on determining the threshold of visual function and observing the EEG response by changing some relevant stimulus parameters.
  • the traditional checkerboard and grating SSVEP or PVEP paradigm is more likely to cause visual fatigue, which leads to reduced signal quality.
  • the purpose of the present invention is to provide a method for detecting contrast sensitivity based on motion visual evoked potentials, by designing a series of concentric rings for contrast sensitivity testing, steady state motion visual evoked potentials (SSMVEP) Paradigm, and put forward the corresponding threshold judgment standard, obtain the objective contrast sensitivity value of EEG, provide an objective and quantitative measurement method for the detection of contrast sensitivity in eye examination.
  • SSMVEP steady state motion visual evoked potentials
  • the contrast sensitivity detection method based on motion visual evoked potential includes the following steps:
  • Concentric circle stimulation paradigm Using the SSMVEP method in the brain-computer interface, the periodic contraction and expansion movement of the paradigm pattern texture is drawn by MATLAB using Psychophysics Toolbox programming, which can stably induce SSMVEP; the movement stimulus target appears as light and dark concentric circles In the ring, the distance between the bright area and the dark area is equal; during the stimulus presentation process, the overall brightness and overall size of the paradigm remain unchanged; the phase of the ring is modulated in a sinusoidal manner, forming periodic reciprocating oscillations in both directions of contraction and expansion, and contraction
  • the flip frequency of the expansion movement is defined as the stimulation frequency, and the movement direction changes twice in one cycle;
  • Contrast scanning gradient of stimulus paradigm Corresponding to the CSV-1000 light box, a series of concentric circle paradigms are designed as the target for SSMVEP contrast sensitivity detection; by adjusting the screen distance and the overall size of the paradigm, the paradigm has a viewing angle of 2 °; Corresponding to the CSV-1000 light box, the paradigm design includes 4 kinds of spatial frequencies 3cpd, 6cpd, 12cpd, 18cpd, the spatial frequency is determined by adjusting the interval of the black and white circle; corresponding to the CSV-1000 light box contrast 0.85log and 2.20log, by adjusting the black circle The gray value of the ring makes the contrast the same; when the space remains unchanged, the contrast increases linearly from 0.85log at 0.15log per second to 2.20log, and the scanning time is 9 seconds; the four spatial frequencies are scanned sequentially ;
  • the computer expands the display to present the stimulus paradigm on the high refresh rate display; during the experiment, the user needs to follow the screen prompts to watch the stimulus paradigm; during the experiment, the subject needs to sit in the laboratory every time Perform a monocular test once; collect the EEG signals generated by the user's gaze paradigm through EEG acquisition equipment, and after amplifying, filtering and A/D conversion, the processed EEG signals are input to the computer and performed by canonical correlation analysis (CCA) Feature extraction
  • CCA canonical correlation analysis
  • Contrast sensitivity threshold judgment Analyze the 9-second SSMVEP signal at each spatial frequency through a rectangular window with a window length of 2 seconds and a slip duration of 1 second, and obtain the typical correlation coefficient versus time curve and the corresponding signal-to-noise ratio SNR, so as to determine the response value of the paradigm; use the SNR value to determine the response value of the CCA spectrum, when the SNR is greater than 1.5, the visual evoked potential is significant, and the response value is 1; when the signal-to-noise ratio is not higher than 1.5, the visual evoked potential Not significant, the response value is 0; SSMVEP contrast sensitivity value is defined as the contrast of the corresponding stimulation paradigm when the final EEG response value is 1;
  • Contrast sensitivity detection result feedback After completing all stimulation paradigms, the user's objective EEG contrast sensitivity is output on the screen.
  • contrast sensitivity threshold determination is specifically: the experimental results show that the CCA value and the signal-to-noise ratio SNR value decrease with the paradigm contrast, and the CCA value and the SNR value both change as the paradigm contrast log value increases. Small; the SNR value is used to determine the response value of the CCA spectrum.
  • the signal-to-noise ratio is defined as the ratio of the square value of the correlation coefficient of the target stimulation frequency 8Hz to the average value of the square value of the correlation coefficient of 10 adjacent points on the CCA spectrum; when the SNR is greater than 1.5 , Indicating that the visual evoked potential is significant, and the response value is 1; when the signal-to-noise ratio is not higher than 1.5, the visual evoked potential is not significant, and the response value is 0; the contrast value corresponding to the final response value of 1 is selected as the contrast at the spatial frequency .
  • the present invention also provides a contrast sensitivity detection system based on motion visual evoked potential, including:
  • the brain-computer interface platform includes a reference electrode, a ground electrode and a measuring electrode. Each electrode is connected to the EEG acquisition module, and the EEG signal is output to the computer after amplification, filtering, and digital-to-analog conversion for further data processing;
  • a computer connected to a display, which is based on the concentric circle stimulus paradigm, the stimulus paradigm contrast scan gradient, the stimulus paradigm is presented, and the contrast sensitivity threshold can be judged as needed, and the threshold can be preset;
  • the display presents the aforementioned paradigm; and according to needs, after all stimulation paradigms are completed, the user’s objective EEG contrast sensitivity is output through the screen, which can be the same display as the paradigm display, or another Separately connected monitor.
  • the present invention proposes a contrast sensitivity detection method based on motion visual evoked potentials, which is simple and quick to operate, and solves the problem that traditional subjective contrast sensitivity tests are not objective enough and are not suitable for infants, pre-lingual children, patients with communication difficulties, and forensic identification.
  • the design of the present invention is based on the concentric ring SSMVEP paradigm, the pattern keeps the brightness constant throughout the movement process, reduces the user's visual fatigue, and improves the interaction performance of the brain-computer interface.
  • the present invention proposes a contrast sensitivity threshold judgment method, which has high accuracy and good repeatability.
  • Figure 1 shows the 4 spatial frequencies 3cpd, 6cpd, 12cpd, 18cpd under a certain contrast.
  • Figure 2 is a schematic diagram of the contrast gradient scan when the spatial frequency of the stimulation paradigm is 3cpd.
  • Figure 3 shows the brain-computer interface platform.
  • Fig. 4 is a schematic diagram showing the variation of typical correlation coefficient value and signal-to-noise ratio value with normal form contrast gradient (3cpd).
  • Figure 5 shows the CCA spectrum of a subject (subjective contrast sensitivity 1.75log/3cpd).
  • Figure 6 is a scatter diagram of the comparison between the objective EEG contrast sensitivity detection value and the subjective contrast sensitivity value (3cpd).
  • the contrast sensitivity detection method based on motion visual evoked potential includes the following steps:
  • Concentric ring stimulation paradigm Using the most practical SSMVEP method in the brain-computer interface, the periodic contraction and expansion movement of the paradigm pattern texture is drawn through MATLAB using Psychophysics Toolbox programming, which can stably stimulate SSMVEP; refer to Figure 1, Movement The stimulus target is expressed as a light and dark concentric ring with the same distance between the bright area and the dark area; during the stimulus presentation process, the overall brightness and overall size of the paradigm remain unchanged; the phase of the ring undergoes a sinusoidal contraction-expansion movement, where:
  • ⁇ (t) is the phase value function of checkerboard contraction-expansion
  • the concentric rings contract, and when the phase function ⁇ (t) changes from ⁇ to 0, the concentric rings expand. In one cycle, two changes in the direction of movement occur.
  • the frequency of the direction change is the motion reversal frequency f, which is twice the motion frequency fc; since SSMVEP is mainly derived from the brain activity stimulated by the direction change, the energy is mainly concentrated on the motion reversal frequency, therefore, the motion reversal frequency is used as the visual stimulus Fundamental frequency
  • Contrast scanning gradient of stimulus paradigm Corresponding to the CSV-1000 light box, a series of concentric circle paradigms are designed as the target for SSMVEP contrast sensitivity detection; by adjusting the screen distance and the overall size of the paradigm, the paradigm has a viewing angle of 2 °;
  • the paradigm design includes 4 kinds of spatial frequencies 3cpd, 6cpd, 12cpd, 18cpd, the spatial frequency is determined by adjusting the black and white circle interval; corresponding to the CSV-1000 light box contrast 0.85log and 2.20log, By adjusting the gray value of the black circle, the contrast is the same as it; referring to Figure 2, with the space remaining unchanged, the contrast increases linearly from 0.85log at 0.15log per second to 2.20log, and the scanning time is 9 seconds; Carry out 4 kinds of spatial frequency paradigm scanning;
  • Contrast sensitivity detection result feedback After completing all stimulation paradigms, the user's objective EEG contrast sensitivity value is output on the screen.
  • the above experiment was performed on a subject (with a subjective contrast sensitivity of 1.75log/3cpd).
  • the subject was placed on the electrodes and the brain-computer interface platform was built, and the paradigm presentation was performed according to the above step 4).
  • the above step 5 perform EEG signal analysis and objective EEG contrast sensitivity threshold determination. Refer to Figure 5 to obtain the paradigm response value: 1,1,1,1,1,1,1,0,0 to obtain the SSMVEP comparison Sensitivity test result: 1.75log/3cpd.
  • the invention uses the brain-computer interface method, does not require subjects to subjectively distinguish and express, that is, it can objectively and quantitatively detect the contrast sensitivity of the user, establishes a good correlation with the subjective psychophysical examination, and realizes , Pre-linguistic children, forensic examinees and other special users' contrast sensitivity objective detection methods.

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Abstract

L'invention concerne un procédé de test de sensibilité de contraste basé sur un potentiel visuel de mouvement évoqué, le procédé consistant : d'abord, à concevoir un paradigme de stimulation d'anneau concentrique, à savoir, un gradient de balayage de contraste de paradigme de stimulation; à établir une plate-forme d'interface cerveau-ordinateur; ensuite, à réaliser l'affichage du paradigme de stimulation; à réaliser une extraction de caractéristiques sur des données d'électroencéphalogramme et à déterminer une valeur de réponse de paradigme par calcul d'un rapport signal sur bruit (SNR) d'un spectre d'analyse de corrélation canonique de telle sorte que la précision d'un test de sensibilité de contraste basé sur un potentiel évoqué visuel de mouvement constant (SSMVEP) soit amélioré; et enfin à renvoyer, par le biais d'un écran, un résultat de test d'objectif d'électroencéphalogramme de sensibilité de contraste. Dans le procédé de test, un groupe de paradigmes de potentiel SSMVEP à balayage d'anneau concentrique pour un test de sensibilité de contraste est conçu et une norme de détermination de seuil correspondante est fournie de telle sorte qu'une valeur de sensibilité de contraste d'objectif d'électroencéphalogramme soit obtenue, ce qui permet de fournir un procédé de mesure objective et quantitative pour tester une sensibilité de contraste dans un examen ophtalmique.
PCT/CN2019/128993 2019-07-17 2019-12-27 Procédé de test de sensibilité de contraste basé sur un potentiel visuel de mouvement évoqué Ceased WO2021008087A1 (fr)

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CN114098767A (zh) * 2021-11-26 2022-03-01 西安交通大学 一种显示器刷新率客观评估选择方法
CN114931353A (zh) * 2022-04-18 2022-08-23 中山大学中山眼科中心 一种便捷的快速对比敏感度检测系统
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CN116919424A (zh) * 2023-08-24 2023-10-24 之江实验室 脑机接口康复方法、装置、电子设备和存储介质
CN118939119A (zh) * 2024-07-29 2024-11-12 上海韶脑传感技术有限公司 一种基于fbcca的视觉注意力自适应方法及系统
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CN112842248B (zh) * 2020-12-31 2021-11-09 北京大学第三医院（北京大学第三临床医学院） 一种动态对比敏感度测试系统及其测试方法
CN113349803B (zh) * 2021-06-30 2022-09-13 杭州回车电子科技有限公司 稳态视觉诱发电位诱发方法、装置、电子装置和存储介质

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CN114098767A (zh) * 2021-11-26 2022-03-01 西安交通大学 一种显示器刷新率客观评估选择方法
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CN118939119A (zh) * 2024-07-29 2024-11-12 上海韶脑传感技术有限公司 一种基于fbcca的视觉注意力自适应方法及系统

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