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WO2021007626A1 - Médicament oral pour traiter le lipœdème - Google Patents

Médicament oral pour traiter le lipœdème Download PDF

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Publication number
WO2021007626A1
WO2021007626A1 PCT/BR2019/000026 BR2019000026W WO2021007626A1 WO 2021007626 A1 WO2021007626 A1 WO 2021007626A1 BR 2019000026 W BR2019000026 W BR 2019000026W WO 2021007626 A1 WO2021007626 A1 WO 2021007626A1
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lipedema
disease
treating
treatment
oral medication
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Portuguese (pt)
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Daniel Augusto BENITTI
Alexandre CAMPOS MORAES AMATO
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/01—Hydrocarbons
    • A61K31/015—Hydrocarbons carbocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • A61K31/09—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon having two or more such linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4525—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/42—Cucurbitaceae (Cucumber family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system

Definitions

  • the present invention refers to a new and unprecedented drug for the treatment of “Lipedema”, which is a chronic hereditary dysfunction of fat distribution characterized by an increase in subcutaneous adipose tissue (lipohypertrophy), through a formulation that has been shown to be efficient in the treatment of the disease, using several components: Citrus sinensis, Curcumin, Piperina, among others.
  • the present invention aims to offer an appropriate treatment to people who develop Lipedema, through a remedy and a treatment that also consists of a creamy formulation, to be treated more specifically in another application for an invention patent, making unprecedented treatment in the world. Although it is a common disease that affects 11% of women, it is rarely diagnosed and, when diagnosed, there is no treatment available on the market.
  • the medicine is composed of: dry extract of cataloupe melon; Pyrroloquinoline Quinona; Citrus sinensis; Curcumin; Piperine; Lutein, Astaxanthin; Selenium chelate; Vitamin C; Quercetin and Bromelain.
  • Cantaloupe melon (Cucumis melo L.) is a bioavailable form of superoxide dismutase (SOD). SOD reduces oxidative stress by catalyzing the dismutation of superoxide into oxygen and hydrogen peroxide.
  • SOD causes the protection of cognitive function against stress, prevents diseases related to the metabolic syndrome, acts in the prevention of the preclinical stage of atherosclerosis by inhibiting vascular inflammation, decreasing the risk of cardiovascular diseases, decreasing the accumulation of lactic acid during exercise and promotes immune modulation. In the skin, it reduces the signs of aging, helping to maintain the structural integrity of the skin and collagen, in preventing allergies, in preparing the skin for sun exposure, in addition to reducing changes in post-inflammatory and solar hyperpigmentation. (References: Stejnborn, AS; Cloarec, M; Nakajima, S).
  • Metoxantin Pyrroloquinoline quinone is a tricyclic quinone that functions as a coenzyme in various bacterial oxide reductase reactions. Also known as methoxyantin, it is considered 100 times more potent than vitamin C, found naturally in foods such as: fermented soybeans, kiwi, parsley, green peppers, spinach, green tea, among others (RUCKER, 2001; TSUGE, 2005) - it is a essential nutrient that the organism cannot synthesize, being a cofactor of oxide-reduction reactions, acting as a powerful antioxidant, with the ability to neutralize free radicals, superoxides and hydroxides, resulting in the reduction of early cell aging, with the consequence of promoting healthy aging.
  • Citrus sinensis is an extract obtained from Moro Vermelha Vermelha, also known as false blood.
  • Moro red orange (Citrus sinensis L.) contains a variety of phytochemical components that contribute to the flavor and properties of the fruit. These substances include sugars like sucrose, fructose and glucose; organic acids (mainly citric, malic and isocitric acid); carotenoids, such as xanthophylls and carotenes; vitamins such as vitamin C, A, B1, B6 and B3; aromatic compounds, including various esters, alcohols, ketones, lactones and volatile hydrocarbons, in addition to polyphenols such as 8-hydroxycinnamic acid and bioflavonoids.
  • Bioflavonoids are composed of several phytochemicals, among which anthocyanins and flavanones stand out, which are present in the species extract in at least 90%. Studies indicate that these assets are responsible for limiting body weight gain, improving insulin sensitivity and decreasing serum triglyceride and total cholesterol levels.
  • Citrus sinensis also has anti-inflammatory, antioxidant and cardioprotective activities.
  • Citrus Sinensis can be beneficial for cholesterol control as well as weight reduction.
  • Curcuma longa is traditionally used for multiple 5
  • the rhizomes being the main part of the plant used in the preparations.
  • Rhizomes are mainly used to treat: skin wounds (327-332), flatulence (330, 333, 334), dyspepsia (330, 335, 336), arthritis (327, 337), gastritis (334, 335) , liver disorders (332, 338), jaundice (330, 332), cough (327, 339) and skin diseases (337), such as dermatitis (334, 340), dermatomycosis (341), scabies (330, 342), skin infections (343) and skin parasites (344).
  • rhizomes are also popularly reported in cases of: diabetes (327), leprosy (344), hirsutism (344), ulcers caused by HPV (344), itchy skin rashes (345), smallpox (328) , chickenpox (328), malaria (346), postpartum bleeding (347), muscle injury (348), asthma (330), worms (342), tonic, revitalizer, stimulant (332, 336), fever, diarrhea, expectorant and anti-inflammatory (334).
  • Piperine (4) is composed of a group 1, 3-benzodioxola (subunit A), next to a chain of pentadiene acid (subunit B) and the fragment piperidine (subunit C).
  • Piperic acid the acyl portion of the piperine molecule (subunits A and B)
  • Lutein is a type of carotenoid and, like all others, is not produced by the human body. It has important functions: it is a natural filter of blue light, which protects the eyes and skin from damage arising in daily life due to exposure to daylight and artificial lighting. environments. It is also a relevant antioxidant that provides protection against oxidative damage from “free radicals” produced by ultraviolet light, cigarette smoke and pollution.
  • the best natural sources of lutein are green and leafy vegetables, such as kale, spinach, chicory, celery and lettuce, green vegetables, orange-red tubers, fresh herbs and egg yolk.
  • Astaxanthin a carotenoid belonging to the xanthophyll class, has aroused great interest due to its antioxidant capacity and possible role in reducing the risk of some diseases. Astaxanthin can be found naturally in microalgae such as Haematococcus pluvialis and in the yeast Phaffia rhodozyma as it has also been considered the main carotenoid in salmon and crustaceans. Shrimp processing residues, usually discarded, are also an important source of astaxanthin.
  • the antioxidant activity of astaxanthin has demonstrated an important function in the modulation of biological functions related to lipid peroxidation, having beneficial effects in chronic diseases such as cardiovascular diseases, macular degeneration and cancer. Research has shown satisfactory effects of astaxanthin obtained from natural sources as well as that obtained synthetically, however studies in humans are limited to the use of natural sources.
  • organic minerals are minerals linked to an amino acid and have a greater capacity to be absorbed by the body. They can be of three types: 1. Mineral Amino Acid Chelate: when a mineral molecule is linked to a specific amino acid. It is easily assimilated by the body. 2. Mineral Complex Amino Acid: (specific and nonspecific) when a mineral molecule is linked to a complex amino acid. It is less absorbed than the previous one. 3. Mineral Proteinate: when a mineral molecule is linked to a polypeptide complex. It is the least absorbed of the three types: The difference between the three types is in the molecular weight, the constant stability of bonds and the amino acids used.
  • Chelated minerals have the advantage of being better bioavailable (up to 90% absorption, against 10 to 20% of inorganic minerals), without interfering with the absorption of other nutrients, without having side effects, or causing doppig.
  • medical prescription must be taken into account. If the request is only the pure mineral, which we call elementary content, the factor must be applied. If the prescription is chelated, no. To be sure at the time of prescription, the ideal is to evaluate by the prescribed dosage, so we know if the elementary is prescribed or not.
  • Selenium offers protection against several cancers and, in fact, against a wide spectrum of diseases such as: chronic diseases, such as arterosclerosis (coronary artery disease, cerebrovascular disease and peripheral vascular disease), cancer, degenerative joint disease (arthritis), cirrhosis and chronic obstructive pulmonary disease (emphysema).
  • chronic diseases such as arterosclerosis (coronary artery disease, cerebrovascular disease and peripheral vascular disease)
  • cancer degenerative joint disease (arthritis), cirrhosis and chronic obstructive pulmonary disease (emphysema).
  • Quercetin is an antioxidant flavonoid, which is present in food in the form of natural glycosides and can be found in vegetables, fruits and juices.
  • flavonoids especially Quercetin, have been studied in recent decades, highlighting the antioxidant, anticarcinogenic potential and their protective effects on the renal, cardiovascular and hepatic systems. It is also a powerful antioxidant and free anti-radicals, reducing the risk of death from coronary heart disease and decreasing the incidence of myocardial infarction.
  • Bromelain is a digestive enzyme of plant origin - Ananas comosus with anti-inflammatory action. In addition to its anti-inflammatory action, its efficiency in inhibiting the development of cancer cells has been studied. Recommendation for use Low Dosages: 50 to 100 mg / day, Larger Dosages: 500 mg / day Used in inflammatory processes of traumatic origin, infectious, vascular and rheumatic surgery. Properties Digestive enzyme, it has an anti-inflammatory action produced by the fibrinolytic and anti-fibriniquinic action of bromelains. Indications Used in inflammatory processes of traumatic origin, infectious surgery, vascular and rheumatic. Bromelain can also be used as an aid in digestion and for the treatment of high-grade burns.
  • Vitamin C ascorbic acid
  • the nutrient also has a strong antioxidant action, fighting free radicals.
  • Vitamin C increases the production of white blood cells, cells that are part of the immune system and that have the function of fighting microorganisms and foreign structures in the body.
  • the nutrient also increases the levels of antibodies in the body. Thus, the nutrient helps to strengthen the immune system, making our body less susceptible to disease.
  • Vitamin C prevents skin aging as it is essential for the natural production of collagen by the body.
  • Collagen is a protein that provides support and firmness to the skin.
  • vitamin C has an antioxidant action, that is, it neutralizes free radicals, protecting the skin against collagen degradation.
  • Vitamin C increases the bioavailability of non-heme iron, that of plant origin, in the body.
  • Vitamin C contributes to prevent vision problems due to aging. This is because the nutrient is one of the factors for the prevention of macula degeneration, part of the retina responsible for the perception of details. Other nutrients that prevent the problem are beta-carotene, vitamin E, zinc and copper.
  • Lipedema is a dysfunction of fat distribution, affecting almost exclusively women, whose tissues are structured differently from men.
  • the predisposition for lipedema is likely to be genetic.
  • the cause of this chronic disease is usually hormonal changes in the body, which happen during puberty, pregnancy or menopause. If the condition already exists, the symptoms are likely to worsen at these times in life.
  • Lipedema is characterized by an increase in subcutaneous adipose tissue (lipohypertrophy), swelling in the second half of the day and pain in the legs.
  • the fat cells of the lipedema have a different constitution, e.g. the fat reserve in the belly.
  • Lipedema is not a fat reserve due to excessive weight, but rather a pathological change in adipose tissue. However, excessive weight and weight fluctuations have a negative effect on lipedema.
  • lipedema is symmetrical: it causes changes in the "spine" type and deformations of the legs. Hips, thighs and legs are typically bulky.
  • Fig. 1 It shows an illustrative view of legs with lipedema swelling in early to more advanced stages; 41. Fig. 2 - It shows an illustrative view of the arm with swelling of the lipedema;
  • Fig. 3 - Shows an illustrative view of the thighs with swelling of the lipedema
  • Fig. 4 - It presents a view of the biosynthetic proposal scheme for the formation of piperine
  • Fig. 5 - Displays a view of the chemical component curcumin scheme.
  • the “ORAL MEDICATION TO TREAT LIPEDEMA is characterized by being a drug formulation for oral use for the treatment of lipedema (1) in humans (H) containing: dry melon extract cataloupe equivalent to 480UI super oxide dismutase (2), pyrroloquinoline quinone 5 mg (3), citrus sinensis 400 mg (4), curcumin 100 mg (5), piperine 2 mg (6), lutein 5 mg (7), astaxanthin 1 mg (8), selenium chelate 100 mcg (9), vitamin C 100 mg (10), quercetin 300mg (11) and bromelain 180mg (12).

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Abstract

Le présent produit à trouve une utilisation dans le secteur pharmaceutique. La présente invention concerne un nouveau médicament inédit destiné au traitement du « lipœdème », qui est une dysfonction héréditaire chronique de la distribution de graisse, se caractérisant par une augmentation du tissu adipeux sous-cutané (lipo-hypertrophie), au moyen d'une formulation qui s'est révélée efficace dans le traitement de la maladie, plusieurs constituants étant utilisés : Citrus sinensis, curcumine et pipérine, entre autres.
PCT/BR2019/000026 2019-07-12 2019-08-06 Médicament oral pour traiter le lipœdème Ceased WO2021007626A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
BR102019014449-1A BR102019014449A2 (pt) 2019-07-12 2019-07-12 medicamento oral para tratar lipedema
BRBR102019014449-1 2019-07-12

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WO2021007626A1 true WO2021007626A1 (fr) 2021-01-21

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160081974A1 (en) * 2014-09-18 2016-03-24 Research & Business Foundation Sungkyunkwan University Composition for preventing or treating edema containing flavonoid compound

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160081974A1 (en) * 2014-09-18 2016-03-24 Research & Business Foundation Sungkyunkwan University Composition for preventing or treating edema containing flavonoid compound

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BOMBARDELLI, E.: "Phytosome: new cosmetic delivery system", BOLLETTINO CHIMICO FARMACEUTICO ( ITALY, vol. 130, 1991, pages 431 - 438, XP009032219 *
LEMAIRE B.; LE QUÉRÉ S.; SIMONEAU G.; LACAN D.: "Clinical trial of a natural and bioactive melon SuperOxide Dismutase (SOD B Dimpless®) on cellulite", PHYTOTHÉRAPIE, SPRINGER-VERLAG, PARIS, FR, vol. 14, no. 1, 29 September 2015 (2015-09-29), FR, pages 23 - 28, XP035895696, ISSN: 1624-8597, DOI: 10.1007/s10298-015-0977-4 *
NOUROLLAHI, S. ET AL.: "Bucher's broom and selenium improve lipedema: a retrospective case study", ALTERNATIVE AND INTEGRATIVE MEDICINE, vol. 2, no. 4, 2013, pages 1 - 7, XP055784233 *
RUSSE LL, Y.: "Curcumin for lipedema", SMORE NEWSLETTERS, 2015, pages 1 - 3, XP055784237, Retrieved from the Internet <URL:https://www.smore.com/5sg6c-curcumin-for-lipedema> [retrieved on 20190919] *

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