WO2021077184A1 - Microfluidic multiprocessor device and use thereof - Google Patents

Abstract

The present invention relates to a microfluidic multiprocessor device that differs through the presence of dispensing/metering and recirculation subsystems, having a microfluidic circuit of the mixer type made from a ceramic material, which is structured with channels with consecutive divisions and junctions horizontally and vertically, forming three-dimensional structures that have been structured to generate an efficient mixing of fluids, including those with high viscosity; and to the use of the circuit of the microfluidic micromixer to generate the mixing of products by means of the microfluidic microchannels.

Description

MICROFLUID MULTIPROCESSOR APPLIANCE AND ITS USE

Field of the invention:

[001] In a comprehensive way, the present invention is inserted in the sector of efficient mixtures of fluids, in particular personal hygiene, perfumery, cosmetics and microfluidics to produce personal hygiene products, perfumery, cosmetics, including personalized products in which the composition of ingredients and / or shade ideal and / or desired by the consumer. More specifically, the invention relates to a system that is formed by a microfluidic multiprocessor, which is composed of sets with a product formulation dispensing and recirculation process that pass through a structured ceramic microfluidic circuit to generate the product mix, thus generating products in a personalized way. This microfluidic multiprocessor for mixing cosmetic products is reusable, easy to operate and airtight.

Basics of the invention:

[002] In the current context of Industry 4.0, the industry has been looking for innovative solutions and technologies that allow the offer of products and services connected to a personalized experience in addition to cost savings, time and processing. In the personal care, perfumery, cosmetics and FMGC (Fast-Moving Consumer Goods or Consumer Packaged Goods) industries this context is no different. The concern with personalization is a trend and products with this characteristic are already available in the market, strengthening the DIY philosophy in the market - or do it yourself.

[003] With regard to personal care products, creams and solutions can be formulated specifically for the type of skin or hair in addition to the desired treatment.

[004] In terms of beauty products and makeup, skin tone is an additional relevant factor when using a particular cosmetic product.

[005] In this case, toning products such as cosmetics, concealers and sunscreens stand out as products that have a greater relationship with skin tone. In particular, cosmetic bases should be produced in colors that can pigment all skin tones, with lighter skin tones being pigmented by 7 to 8 colors of facial bases, while darker skin tones are pigmented in at least 10 to 12 base colors in view of the wide range of skin tones.

[006] With this, the cosmetic industries seek to formulate cosmetic bases in some color variations of facial bases that can meet market demands. Therefore, consumers need to limit themselves in choosing a cosmetic base that most closely matches the color that would be ideal for their skin tone.

[007] Thus, the lack of facial cosmetic bases in specific and individualized colors leads to the need to search for production technologies that allow the consumer to select the color of the ideal base for their skin tone before formulating the final product. Therefore, it is noted the importance of looking for technologies that allow the generation of personalized products and in individual lots.

[008] In this context, microfluidics is a technology that makes it possible to apply the principles of fast and effective processing, showing its potential for the production of personalized cosmetic products.

[009] Microfluidics originated from the need to improve analytical methods, generating faster and more reliable results. Since then, microfluidics has contributed to technological innovations with potential industrial applications in view of the miniaturization of processes that can be precisely controlled and carried out with less operational time, when compared with conventional technologies.

[010] Another advantage of microfluidic circuits is the versatility in terms of microfabrication and microchannel structures, which has made this technology increasingly prominent as a technological innovation. Microfluidic circuits can be built with elastomeric materials, such as polydimethylsiloxane (PDMS), polymethylmethacrylate (PMMA) and also in green ceramics (LTCC, Low Temperature Co-fired Ceramic), the latter presenting as a differential the possibility of building geometries microchannels in three-dimensional structures and the resistance of the ceramic material allows employing high flow rates, withstanding high temperatures and pressures, being reusable and inert to chemical solvents, which makes it attractive for industrial applications.

[011] The vast possibility of applications is another factor that contributes to the interest in this technology and with that, different microfluidic circuit strategies have been developed.

[012] Microfluidic circuits can be configured in microchannels that allow the generation of drops, micro and nanoparticles. There are microchannel geometries that have the ability to form concentration gradients both diffusive and convective, and others that can generate the mix of solutions in microchannels using passive or active systems with the same reproducibility as a conventional process. This diversity of microfluidic systems models leads to a wide range of applications in chemical industries, such as pharmaceuticals and cosmetics.

[013] In the field of cosmetics and makeup, microfluidics can be used as a technology to generate the mixture of ingredients that will result in a homogeneous cosmetic product and the shade desired by the consumer. In this way, the micro-mixer microfluidic circuit can leverage the cosmetic industry bringing innovations in the product production process in a personalized way or even the production of individual batches for screening new products in the factory.

[014] The applications in microfluidics for the cosmetics area have been directed to the development of particles and / or components that could aggregate in the formulation of cosmetics; for investigations of emulsion processes and for skin permeation tests. However, such microfluidic circuits present a study approach more directed to the study of ingredients and / or components that could contribute to cosmetic formulations. In this way, microfluidic circuits are structured for emulsion tests and particle formation and therefore present some critical points / technical problems / limitations, among which the following stand out: the inability to generate fluid mixes, even with viscosities above 2000 CP, does not withstand high pressures and temperatures, is not reusable and is not used for the production of cosmetic products.

[015] Some of the problems / limitations / critical points mentioned above are presented in detail in the documents described below.

[016] The document WO201862970 A1 deals with an integrated dispenser system with microfluidic circuit for the preparation of cosmetic composition by means of instant emulsification produced by microfluidic microchannels. Unlike this patent document, the present invention describes a microfluidic multiprocessor for mixing cosmetic products in a continuous flow and allowing the formulation of customized products.

[017] Document KR20150070920 A is a method of producing lipid microgel vesicles by means of a microfluidic system double emulsion. These vesicles can be applied in cosmetic composition to reduce evaporation and thus improve moisture retention in the cosmetic composition. The present invention differs from patent document KR20150070920 A in that it is a microfluidic circuit applied for mixing miscible fluid processes and not for forming emulsions and / or microparticles.

[018] Document KR20180110257 A is an apparatus for unloading personalized cosmetic products according to the information given by the consumer. The differential of the invention of the proposed microfluidic micro mixer circuit is the use of microfluidic circuit to promote the mixing of cosmetic products, having a fast and efficient fluid mixing process.

[019] Document US2003 / 0069667 A1 deals with a system for dispensing personalized cosmetic formulations. Although this technology presents a microprocessor control system and fluid dispenser with mixer, the present innovation has as a differential the use of a dispensing system based on dosing pumps and a recirculation system integrated to a microfluidic circuit that promotes a more efficient mixing of cosmetic products.

[020] Document KR20050033794 A presents a system for mixing liquids. The invention comprises reservoirs and liquid pumping systems, which are mixed in microfluidic microchannels by diffusion. The present innovation differs from this technology mainly because it is a microfluidic system with structured channels to generate mixture of fluids, including high viscosity, through chaotic advection.

[021] The document US9007588B1 presents an equipment for the production of cosmetic products, having integrated an instrument for measuring texture and skin tone of the user for the formulation of a personalized cosmetic product by means of mechanical mixing and a dispenser that uses peristaltic pumps. The present invention differs from document US9007588B1 mainly because it is a microfluidic mixing system, applied even for high viscosity fluids, to have a dispensing and recirculation process that increase the reproducibility and mixing efficiency for the production of personalized cosmetic products.

Brief description of the invention:

[022] The invention describes a structured microfluidic micro-mixer circuit for the generation of efficient mixtures of fluids, in particular cosmetic products.

[023] More specifically, the invention refers to a microfluidic micro-mixer (B4) integrated with a recirculation circuit (B) for cosmetic products, in which the complete set guarantees the effective mixing of cosmetic products.

[024] The term “microfluidic multiprocessor” refers to the complete mixing and recirculation process, including the microfluidic micro-mixer system. The term “subsystem I” refers to the set that makes up the dosage stage for cosmetic products (A). The term "subsystem II" indicates the set that makes up the stage of recirculation of cosmetic products through the microfluidic system (B). The term “micro mixer” refers to the type of microfluidic system structured to perform the function of mixing fluids within the microchannels (B4).

[025] In the first aspect, this invention consists of a concept of mixing fluids by microfluidic circuit through a process of fluid dispensing / dosing (A) and recirculation integrated into the system (B), called “microfluidic multiprocessor” (Figure 1), which comprises:

- “subsystem I” refers to the process of dispensing / dosing fluids (A), containing: a mounting bracket; at least one dispensing pump for each fluid (A1), preferably a solenoid type pump; control electronics and dedicated software to perform the dispensing / dosing of the fluid volumes by the pumps (C); control computer; at least one reservoir for stocking each fluid (A2 - A3); pipes for transporting fluids in the stock reservoirs for the pumps (A5) and a reservoir for dispensing / recirculating the fluids (A6)

- “subsystem II” refers to the recirculation set (B), containing: a reservoir for dispensing / recirculating fluids (A6); a recirculation pump (B2), preferably a gear-type pump; connection pipes from the dispensing / recirculation reservoir to the pump (B2); pressure sensor (B3); Mounting bracket; microfluidic circuit (B4); piping for transporting fluids from the pump to the microfluidic circuit; pipes for transporting the fluids that circulate through the microfluidic circuit to the dispensing / recirculation reservoir (B1) containing at least one three-way valve (B4); outlet tubing connected to one of the valve paths for dispensing fluids in the reservoir of the formulated cosmetic product.

[026] Since:

- at least one mounting bracket serves to fix the dispensing pumps and can be made with materials in aluminum, stainless steel, acrylic or any other material that supports the pumps, being manufactured, preferably by machining, with acrylic, aluminum or stainless steel materials;

- pumps for dispensing / dosing fluids, which can be of the solenoid, gear, diaphragm and / or peristaltic type, preferably solenoid type pumps and the pump for fluid recirculation by the microfluidic multiprocessor can be of the solenoid, gear, diaphragm and / type or peristaltic, preferably the type of gears, not limited to just this form of pumping;

- software to control the dispensing / dosing of fluid volumes by pumps (C) preferably using virtual instrumentation software;

- pipes (B1) made with resistant and inert material, preferably in stainless steel, not limited to this type of material;

- fixing support for the microfluidic circuit, preferably made of stainless steel, making it possible to manufacture in other materials that provide resistance and have connections for the microfluidic circuit, having at least one inlet and one outlet that connects to the microfluidic circuit.

[027] In a second aspect, this invention relates to a microfluidic mixer system (Figure 2), which comprises:

- use of materials resistant to pressure and temperature and inert to chemical solvents, such as sheets of green ceramic cut in at least four layers that form the walls of the microchannels and the bottom and cover bases of the micro mixer allowing the manufacture of channel structures bi or three-dimensional (2A);

- main body of the micro-mixer structured with channels that have at least one division and junction of the channels in a sequential manner (2A), the which are repeated periodically at least once horizontally and / or vertically to have a bi-directional vertical direction of the microfluidic circuit, preferably vertical and horizontal directions creating three-dimensional channel structures, preferably containing seven units of these channel structures to promote fluid mixing;

- microchannel network structure (2B), which distributes fluids to at least two units in parallel of micro mixers, having at least one main inlet and one outlet; being that the microchannels must be constructed with materials resistant to pressure and temperature to allow the preferential configuration of three-dimensional geometries, preferably using LTCC (Low Temperature Co-fired Ceramics) and / or HTCC (High temperature co-fired ceramics) green ceramic sheets

[028] In addition, the invention describes the use of the microfluidic multiprocessor to mix fluids, including cosmetic products (3-4). The fluids that can be used in the microfluidic circuit include cosmetic products, such as cosmetic bases, moisturizers, creams, makeup pigments, enamels or paints. Fluids can still be used for applications in the pharmaceutical, food and paint industries.

Brief description of the figures:

[029] In order to obtain a total and complete visualization of the object of this invention, the figures to which reference is made are presented:

[030] Figure 1 shows the schematic drawing of the microfluidic micro-mixer circuit, which consists of dispensing / dosing pumps (A); recirculation / dispensing reservoir (A6); pump for recirculation (B2); pressure sensor (B3); microfluidic circuit (B4); three-way valve (A4-B5); final product reservoir (B6). [031] Figures 2A and 2B are schematic drawings representing the mixer-type microfluidic circuit, where (2A) is the unit of microchannel geometry that uses three-dimensional structures with at least two divisions and channel junctions and (2B) is the configuration of the microfluidic circuit with parallel or two-dimensional configuration, configuring a channel distribution network for at least two units of the micro mixer in parallel.

[032] Figure 3 is a graph showing the evaluation of the functionality of the microfluidic multiprocessor using colorimetry techniques to evaluate the mixing effect by the color difference of samples of cosmetic products in light, medium and dark colors with the respective standards. The Delta E method (AEcmc) was used as a basis for this.

[033] Figure 4 is a graph showing the evaluation of the functionality of the microfluidic multiprocessor using colorimetry techniques to evaluate the mixing effect by the color difference of samples of cosmetic products in light, medium and dark colors (Delta E method (AEcmc )) where values below 0.5 indicate a better mixing response.

[034] Figures 5A through 5I represent the evaluation of the color difference by visual analysis of the mixing process, in which Figures A to Fig. Fl show the visual evaluation of the mixing capacity of the microfluidic multiprocessor using light tinted cosmetic products , medium and dark; and Fig. 5I shows the evaluation made by the Delta E method in which the evaluation is made from the measurement of the color distance of the shades of cosmetic bases produced in the microfluidic micro-mixer circuit with their respective standards.

Detailed description of the invention: [035] The invention describes a microfluidic micro mixer circuit, containing a structured microfluidic circuit to generate, as an example, the mixture of cosmetic products, built in ceramic material that gives resistance to the system, being easy to operate and allows reuse.

[036] The microfluidic multiprocessor concept presented by this invention shows as a differential a system of easy assembly and operation, safe for the user and hermetic, thus avoiding external contamination, having as an inventive activity the efficient mixtures of fluids, especially its application in cosmetics.

[037] The microfluidic multiprocessor is composed of two subsystems, subsystem I (A) dedicated to the step of dispensing / dosing fluids in a reservoir and subsystem II (B) performs the process of recirculating the fluids circulating through the microfluidic mixer .

[038] The subsystem I (Fig. 2A) of the microfluidic multiprocessor has as a differential the dispensing and dosing of different products, in the desired concentrations and / or proportions, with dispensing / dosing using pumps of the solenoid type (A1), not being limited to this type of pump, in which the desired volume of each fluid is inserted into a control platform that drives each pump to dump the required volume of each fluid. The fluids are dispensed / dosed in a reservoir (A6) that is used for dispensing and recirculating the fluids through the microfluidic circuit.

[039] Subsystem II (Fig. 2B) that makes up the microfluidic multiprocessor performs the process of recirculating the fluids that are dispensed / dosed in the dispensing / recirculation reservoir (A6) by the microfluidic circuit. [040] In subsystem II (Fig. 2B), the volume of fluids present in the dispensing / dosing reservoir (A6) is recirculated by the microfluidic system, using a recirculation pump (B2), which can be of the gear type, and passing through the microfluidic circuit (B4) to carry out the process of mixing the fluids after several cycles of recirculation.

[041] Thus, the present invention has as a differential the integrated concept of dispensing / dosing and recirculation subsystems of fluids that are mixed by means of a mixer-type microfluidic circuit.

[042] Regarding the mixer type microfluidic circuit (B4), its geometry is configured using the channel model with consecutive divisions and junctions (2A) to generate the mixture of at least two different fluids within the microchannels, that is, a microchannel geometry configured in a three-dimensional form, having at least two divisions and recombination on the x, y and z axes, thus characterizing an original microchannel geometry, composed of a parallelized system of microchannels, having a microchannel distribution network with fluid speeds homogeneous form and reduced head loss between the micro mixer units.

[043] Thus, the mixer-type microfluidic circuit shown in the example was made of ceramic material in LTCC and has as a differential the presence of structures with at least two units of division and junction of the channels in the horizontal and vertical direction, forming three-dimensional structures, having seven units repeated sequentially.

[044] Furthermore, the microchannel geometry configurations of the example mixer allow the mixing of different fluids, including thixotropic fluids and with viscosities above 2000 cP, not being limited to just these types of fluids. [045] EXAMPLE OF CARRYING OUT THE INVENTION

- the microchannel structures were designed in four layers.

- the green ceramic sheets in LTCC were cut with a UV laser to transfer the geometry of the microchannels;

- each layer of green ceramic sheets in LTCC, containing the structures of the microchannels, was aligned and stacked to form the three-dimensional microchannels and the smooth bottom bases and a cover with access holes for entry and exit of fluids;

- the set of layers of green ceramic sheets in LTCC is submitted to a sintering process, which promotes the densification of the microfluidic circuit, structuring the microchannels, through a thermal heating profile, preferably using temperature levels of 450 ° C and 850 ° Ç;

- the access holes for entry and exit of fluids in the cover of the micro mixer can optionally contain connections for pipes for entry and exit of fluids;

- for the construction of the microfluidic circuit, materials resistant to pressure and temperature and inert to chemical solvents are used, preferably green ceramic of the LTCC type;

[046] - The microfluidic circuit is resistant and is reusable through a periodic cleaning and sanitization process

Operational characterizations of the microfluidic micro-mixer circuit:

[047] The microfluidic micro mixer circuit was characterized in terms of operational capacity in terms of dispensing / dosing, flow and pressure supported by the microfluidic circuit and the effect of fluid mixes as a function of the number of recirculations. [048] The dispensing and dosing processes were characterized in terms of precision of dispensed volume, preferably using solenoid type pumps, being possible to dispense even fluids with thixotropic rheological behavior with viscosities above 2000 cP, with a dosing capacity of tens of milliliters .

[049] The mixing and recirculation process of the microfluidic multiprocessor was characterized with respect to the flow and pressure capacity supported by the microfluidic circuit.

[050] The operational capacity of the microfluidic circuit was evaluated with flow rates up to 50 mL min ¹ , resulting in a pressure of 12 bar, not limited to just this ratio of flow rates and the operational capacity of the pump.

[051] In addition, a computer simulation evaluation shows that the induction of advection by the multiple lamination process, caused by the division and recombination of fluid streams proved to be more efficient for mixing cosmetic bases.

[052] The parallel system uses a microchannel distribution network that guarantees control of the magnitude of the speed in the microchannels and reduces the head loss of the system. This fact guarantees the mixing of the cosmetic bases in a homogeneous way in each unit of microfluidic micro mixer in the parallelized system.

[053] In this study, the mixing process was evaluated by the microfluidic circuit of the mixer type presented in this invention, with at least seven fluid recirculations being used by the microfluidic multiprocessor. For this, three shades of cosmetic bases were evaluated: one being light, one medium and one dark. [054] The analysis of the mixing effect generated by the microfluidic circuit was carried out by the Delta E (AEcmc) color difference method, in which the color obtained in each recirculation of the microfluidic multiprocessor was compared with the conventional production method, in this case mechanical agitation, as shown in Figure 3.

[055] In this study it can be seen that, from the fourth recirculation, the effect of mixing cosmetic bases generated values of AEcmc close to the acceptance limit of color variation between sample and the standard (AEcmc <0.05), reaching values within the acceptance limit in the sixth recirculation.

[056] For the light shade (Translucent Beige), up to seven recirculations were performed, and in the sixth recirculation an AEcmc of 0.45 ± 0.14 was obtained, while for the seventh recirculation it was 0.26 ± 0.10 . For medium (Light Brown) and dark (Medium Brown) tones, the AEcmc values for the sixth recirculation were 0.61 ± 0.14 and 0.39 ± 0.07, respectively.

[057] The mixing results using the microfluidic mixer circuit showed the efficiency of the system to generate tones of cosmetic bases with colors within the Delta E (AEcmc) acceptance limit.

[058] In this study it can be seen that the process time and the mixing effect using the parallelized system proved to be applicable for an industrial scale.

[059] Therefore, the microfluidic micromixer circuit was able to generate a homogeneous mixture of fluids through the microchannels, proving to be applicable for the production of customized products.

[060] Therefore, the present invention also provides the use of the microfluidic mixer circuit for the production of cosmetic products, not limited to to this application, individually and or personalized with the ideal composition and / or desired by the consumer.

[061] The innovation and use of the microfluidic multiprocessor is also attributed to the use of a microfluidic circuit with a multiple lamination geometry composed by a three-dimensional structure of double divisions and parallelized that leads to an increase in production, allowing the application even on an industrial scale.

Application of the microfluidic micro-mixer circuit for mixing cosmetic products:

[062] In order to investigate the viability and reproducibility of the mixing process using the microfluidic micro-mixer circuit, the production of eight cosmetic bases was evaluated, in light, medium and dark tones, being compared with their respective standards produced in a conventional manner, as shown in Figure 4.

[063] Each shade of cosmetic base was recirculated at least six times by the recirculation system and at the end of each processing the shade and homogeneity of the samples were analyzed according to the color difference with their patterns, as shown in Figure 4.

[064] Visual and colorimetric analyzes of mixtures of cosmetic bases produced by the microfluidic mixer circuit showed the generation of mixtures with visually homogeneous colors and the comparison of color difference with the standards showed Delta E values within the established limit.

[065] In view of this, the proposed microfluidic micro-mixer circuit, which is composed of a process of dispensing / dosing and recirculation with mixer-type microfluidic circuit, proved to be efficient to generate the mixture of fluids and viable for the production of personalized cosmetic products.

Claims

1. “Microfluidic multiprocessor device” characterized by promoting the dispensing and recirculation of fluids, as well as generating the mixture of fluids in microchannels comprising: - a subsystem I dedicated to the fluid dispensing / dosing process (A) containing: at least one dispensing / dosing pump for each fluid (A1); control electronics and dedicated software for controlling the dispensing / dosing of fluid volumes by pumps (C); control computer; at least one stock reservoir of each fluid (A2; A3); fluid transport pipelines in the stock reservoirs for the pumps (A4), three-way valve (A5) and a fluid dispensing / recirculation reservoir (A6); - recirculating subsystem II (B), containing: a fluid dispensing / recirculating reservoir (A6); connection pipes from the dispensing / recirculation reservoir to the pump (B1); a recirculation pump (B2); pressure sensor (B3); Mounting bracket; microfluidic circuit (B3); piping to transport fluids from the pump to the microfluidic circuit; pipelines for the transport of fluids that circulate through the microfluidic circuit to the dispensing / recirculation reservoir containing at least one three-way valve (B4); fluid dispensing tubing in the final product reservoir (B5) connected to one of the valve pathways (B4); - Support for assembly of subsystems I and II; 2. "Microfluidic micromixer circuit", according to claim 1, characterized by being structured bi or three-dimensionally (one or more layers) and generating a mixture of fluids in the microchannels, comprising: - microchannel walls, the bottom and cover bases of the micro mixer (2A) are formed by ceramic sheets cut into at least four forming layers and subjected to sintering; - microchannel structure having at least one main inlet and one outlet (2A), which can optionally contain fluid inlet and outlet fluid connections; - main body of the micro-mixer structured with channels that have at least one division and junction of the channels in a sequential manner (2A), which are repeated periodically at least once in the horizontal and vertical direction of the microfluidic circuit, creating structures of bi or three-dimensional channels , containing at least two units, preferably seven units of these channel structures (2B) promoting the mixture of fluids; - microchannel network structure, which distributes fluids to at least two units in parallel of micro mixers, having at least one main inlet and one outlet (2B); - dispensing pumps, piping of the fluid connections in the dispensing / dosing and recirculation circuit; - Mounting bracket to fix the dispensing pumps, piping of the fluid connections in the dispensing / dosing and recirculation system; 3. "Microfluidic multiprocessor device", according to claims 1 or 2, characterized in that the mounting bracket is made of resistant and inert material, has connections for the microfluidic circuit and has at least one input and an output connected to the microfluidic circuit; 4. “Microfluidic multiprocessor device”, according to claims 1 and 2, characterized by pumps that can be of the solenoid, gear, diaphragm, peristaltic type that act in the dispensing / dosing process and in the recirculation of fluids by the multiprocessor microfluidic; 5. "Microfluidic multiprocessor device", according to claims 2 and 4, characterized in that the pumps for dispensing / dosing fluids are of the solenoid type (A1) and the recirculation pump is of the gear type (B2); and the fixing bracket is made of stainless steel; 6. “Microfluidic micro-mixer circuit”, according to claim 2, characterized in that the microchannels are built with materials resistant to pressure, are inert to chemical solvents, resistant to pressure and temperature, hydrophilic and are reusable; 7. “Microfluidic micro mixer circuit”, according to claim 6, characterized by the microchannels being constructed with LTCC (Low Temperature Co-fired Ceramics) and / or HTCC (High Temperature Co-fired Ceramics) green ceramic sheets submitted to a process sintering by means of thermal heating; 8. “Microfluidic micro mixer circuit”, according to claim 2, characterized by being a three-dimensional microchannel geometry, having at least two divisions and recombination on the x, y and z axes; 9. “Microfluidic micromixer circuit”, according to claim 8, characterized by containing a structure of microchannels with at least two divisions and recombination in three-dimensional axes having at least two repetitions of each basic unit; 10. “Microfluidic micro mixer circuit”, according to claim 9, characterized by containing a microchannel structure with seven repetitive units; 11. “Microfluidic micromixer circuit”, according to claim 2, characterized by being composed of microchannels in parallel, forming a microchannel distribution network with homogeneous fluid speed and reduced pressure loss between the micromixer units; 12. "Microfluidic micromixer circuit" according to claim 2 or 7 to 11, characterized in that the structures of the microchannels are structured in at least four layers, in LTCC (Low Temperature Co-fired Ceramic) green ceramic sheets, being cut out in laser cutting, the structures of the microchannels are aligned and stacked forming the three-dimensional microchannels with smooth bottom bases and a cover with holes for fluid inlets and outlets; 13. "Microfluidic micro-mixer circuit" according to claim 12, characterized in that the set of layers of green ceramic sheets in LTCC is subjected to a sintering process by means of thermal heating; 14. "Microfluidic micro-mixer circuit" according to claim 13, characterized in that the set of layers of green ceramic sheets in LTCC is subjected to a process of thermal sintering; 15. Use of the “Microfluidic multiprocessor device”, according to claims 1 and 3 to 6, characterized by being used for any process that needs to promote the dispensing and / or dosing of fluids, including a fluid recirculation process, passing through a microfluidic circuit; 16. Use of the “Microfluidic micro-mixer circuit” according to claims 2 and 7 to 13, characterized by being used for any process that requires the mixing of fluids, generating a homogeneous mixture by means of recirculations; 17. Use of the “Microfluidic micro-mixer circuit”, according to claim 15, characterized by promoting the mixing of fluids as cosmetic products with values of difference of shades with the standards within the expected limit of resolution.