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WO2021070200A3 - Stable compositions of (7as,2's)-2-oxoclopidogrel and its pharmaceutical salts - Google Patents

Stable compositions of (7as,2's)-2-oxoclopidogrel and its pharmaceutical salts Download PDF

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Publication number
WO2021070200A3
WO2021070200A3 PCT/IN2020/050865 IN2020050865W WO2021070200A3 WO 2021070200 A3 WO2021070200 A3 WO 2021070200A3 IN 2020050865 W IN2020050865 W IN 2020050865W WO 2021070200 A3 WO2021070200 A3 WO 2021070200A3
Authority
WO
WIPO (PCT)
Prior art keywords
oxoclopidogrel
stable
stable compositions
pharmaceutical salts
salts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IN2020/050865
Other languages
French (fr)
Other versions
WO2021070200A2 (en
Inventor
Ashok Kumar
Dharmendra Singh
Thankachen BYJU
Mukesh Gupta
Arpana Mathur
Dinesh BHADRA
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ipca Laboratories Ltd
Original Assignee
Ipca Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ipca Laboratories Ltd filed Critical Ipca Laboratories Ltd
Publication of WO2021070200A2 publication Critical patent/WO2021070200A2/en
Publication of WO2021070200A3 publication Critical patent/WO2021070200A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention discloses stable oral pharmaceutical composition containing therapeutically effective amount of (7aS,2'S)-2-oxoclopidogrel and/or its salts or derivatives, in combination with pharmaceutically acceptable adjuvants or carriers. More particularly, the present invention discloses highly pure (7aS,2'S)-2-oxoclopidogrel and/or its salts, processes for manufacturing pure and stable (7aS,2'S)-2-oxoclopidogrel and stable compositions having a shelf-life of at least one year or more.
PCT/IN2020/050865 2019-10-08 2020-10-08 Stable compositions of (7as,2's)-2-oxoclopidogrel and its pharmaceutical salts Ceased WO2021070200A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN201921022792 2019-10-08
IN201921022792 2019-10-08

Publications (2)

Publication Number Publication Date
WO2021070200A2 WO2021070200A2 (en) 2021-04-15
WO2021070200A3 true WO2021070200A3 (en) 2021-07-01

Family

ID=75437322

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2020/050865 Ceased WO2021070200A2 (en) 2019-10-08 2020-10-08 Stable compositions of (7as,2's)-2-oxoclopidogrel and its pharmaceutical salts

Country Status (1)

Country Link
WO (1) WO2021070200A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115518066A (en) * 2022-06-17 2022-12-27 成都施贝康生物医药科技有限公司 Pharmaceutical composition for treating anticoagulation and application
CN115327004B (en) * 2022-08-12 2024-01-26 成都施贝康生物医药科技有限公司 Method for detecting clopidogrel oxide crude product
CN115327005B (en) * 2022-08-12 2024-01-26 成都施贝康生物医药科技有限公司 Method for detecting clopidogrel oxide related substances
CN115656394A (en) * 2022-08-12 2023-01-31 成都施贝康生物医药科技有限公司 A method for detecting related substances of oxidized clopidogrel
CN115327003B (en) * 2022-08-12 2024-03-12 成都施贝康生物医药科技有限公司 Method for detecting clopidogrel oxide related substances
CN116262116A (en) * 2022-12-02 2023-06-16 成都施贝康生物医药科技有限公司 A kind of solid preparation containing oxyclopidogrel and preparation method thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120329763A1 (en) * 2011-06-27 2012-12-27 Ashok Kumar Anti-thrombotic compounds
US20150011583A1 (en) * 2010-02-02 2015-01-08 Jiangsu Vcare Pharmatech Co., Ltd. Optically active 2-hydroxy tetrahydrothienopyridine derivatives, preparation method and use in manufacture of medicament thereof
US20170334853A1 (en) * 2013-01-09 2017-11-23 The Regents Of The University Of Michigan Mixed disulfide conjugates of thienopyridine compounds and uses thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20150011583A1 (en) * 2010-02-02 2015-01-08 Jiangsu Vcare Pharmatech Co., Ltd. Optically active 2-hydroxy tetrahydrothienopyridine derivatives, preparation method and use in manufacture of medicament thereof
US20120329763A1 (en) * 2011-06-27 2012-12-27 Ashok Kumar Anti-thrombotic compounds
US20170334853A1 (en) * 2013-01-09 2017-11-23 The Regents Of The University Of Michigan Mixed disulfide conjugates of thienopyridine compounds and uses thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
QIU ZHIXIA, LI NING, SONG LING, LU YANG, JING JING, PAREKHA HARENDRA S., GAO WENCHAO, TIAN FENGJIE, WANG XIN, REN SHUANGXIA, CHEN : "Contributions of Intestine and Plasma to the Presystemic Bioconversion of Vicagrel, an Acetate of Clopidogrel", PHARMACEUTICAL RESEARCH, vol. 31, no. 1, 1 January 2014 (2014-01-01), pages 238 - 251, XP055834803, ISSN: 0724-8741, DOI: 10.1007/s11095-013-1158-5 *

Also Published As

Publication number Publication date
WO2021070200A2 (en) 2021-04-15

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