WO2021069034A1 - Container and method for transporting sterilised items and for removal in an isolator, and combination of an isolator and a container docked thereon - Google Patents

Abstract

The invention relates to a container (10) for transporting sterilised items and for removing the items in a clean room (12) of an isolator (14), comprising an opening (26) and a container-side part (18) of a rapid transfer port system, which comprises a container lid (20) for closing the opening and means for docking the container on a complementary isolator-side part (16) of the rapid transfer port system, and having an item receptacle (30) that can be moved along a linear guide (34). According to the invention, at least one ferromagnetic and/or permanently magnetic body (62) is mounted on the item receptacle (30), which body is arranged in the vicinity of a circumferential wall (22) of the container and can be moved, in parallel with the linear guide, by means of at least one magnet (64) or ferromagnet which is moved outside the container linearly along the circumferential wall and contactlessly acts on the body (62) through the circumferential wall by means of magnetic attraction forces, in order to move the item receptacle at least partially into the clean room without being engaged in the isolator.

Description

Containers and methods for transporting sterile goods and for removal in an isolator, as well as a combination of isolator and docked container

The invention relates to a container according to the preamble of claim 1, a combination of an insulator and such a container docked on the insulator according to the preamble of claim 12, and a method according to the preamble of claim 14.

In the pharmaceutical industry and in laboratories, isolators are often required which enclose a clean room, the term isolator in the context of this patent application also being intended to include RABS systems.

[03] In order to feed sterile goods into the interior of an isolator, a so-called rapid transfer port (RTP) system is usually used, through which the goods contained in the sterile interior of a container are channeled into the isolator.

The sterile material can be, for example, rubber or plastic stoppers for vials or infusion bottles, which are cleaned and sterilized outside the isolator and, after being introduced into the isolator, are fed to a machine for closing the vials or infusion bottles inside the clean room . The cleaning and sterilization of such goods can take place in a treatment device, such as it is described, for example, in EP 2 823828 A1 of the applicant.

[05] The sterile goods can, however, also be exchangeable or format parts that are to be installed in the machines, for example, when the format is changed within the clean room.

In the first-mentioned case, the cleaned and sterilized items can be transferred directly from a treatment container used in the treatment device to the isolator. In the latter case, the container with the pre-cleaned material is moved through an autoclave during transport to the isolator in order to sterilize the material inside the container. The container has an opening through which the material is introduced into the container and removed from the container.

The RTP system is used to transfer the sterile material from the sterile interior of the container into the sterile clean room of the isolator without contact with a non-sterile environment. The RTP system comprises a container-side part attached to the opening of the container, which is usually referred to as the beta part, and a complementary isolator-side part attached to the insulator, which is usually referred to as the alpha part. Before the goods are transferred, the container with the container-side part is docked or mechanically coupled to the isolator-side part. The container-side part comprises an annular flange arranged in front of the opening of the container with an inserted seal, a container lid which tightly closes the opening during transport, and docking means for docking on the isolator-side part. The isolator-side part comprises a port opening which is surrounded by an annular flange with an inserted seal, a port door which tightly closes the port opening and can only be opened when the container is docked, and docking means complementary to the docking means of the container, which on the one hand ensure mechanical locking of the two ring flanges and, on the other hand, mechanical locking of the container lid with the port door. Where the container can be rotated around the central axis of the port opening in the docked state, this can be done, for example, by rotating the container.

[09] When the closure cover is locked to the port door, opposing non-sterile surfaces of the closure cover and the port door are pressed against one another in a sealing manner or enclosed tightly between the port door and the closure cover. The port door and the container lid are then moved together in the locked state into an open position inside the isolator in order to release the opening and the port opening for transferring the sterile material from the container into the clean room. In RTP systems with port door operation from the clean room side, an operator grips one inside the clean room by means of a glove Operating handle of the port door to move it into the open position in which it is usually located to the side of the port opening. In RTP systems with external operation of the port door, the operator outside of the clean room actuates a mechanism in the wall of the isolator that moves the port door into the open position. After the removal of the goods from the container, the port door and the container lid are moved back together again into a closed position in order to first close the opening and the port opening, then to unlock the two ring flanges as well as the closure lid and the port door and finally the container by unlocking and Separate the two parts of the RTP system from the isolator to undock and move away.

[10] DE 102016001027 A1 and WO 2017/129362 A1 by the applicant already disclose a container, a combination and a method of the type mentioned at the beginning. There, the material receptacle consists of a perforated basket that is movable in relation to the container and that receives a pourable material . During transport, the basket is in a transport position inside the closed container. To remove the goods, the basket can be moved along a linear guide into a removal position in which it partially protrudes through the opening into the clean room. This process is carried out by an operator gripping a handle of the basket by means of glove engagement from the clean room and pulling the basket out of the container.

[11] A container with a pull-out receptacle for individual objects, such as spare parts, with one on Slide-in for placing the items on rails is available at http://www.castus.pro/en/gamma-equipment/drawer- and-rail-system /. Here, too, an operator must grasp the insert from the clean room and pull it out of the container in order to remove the objects.

[12] However, since the port door protrudes relatively far into the clean room because of the container cover locked with the port door, it is difficult or even impossible for an operator to grasp the material receptacle by means of glove engagement over the open port door and into the clean room to pull or to move all the way back into the container. This means that in RTP systems with clean room operation of the port door, two glove interventions are required on opposite sides next to the RTP, one to open and close the port door locked with the container lid and the other to pull out or move back the goods pick-up after the Removal of the goods. This in turn leads to an increase in the space required by these RTP systems. In addition, glove interventions in RTP systems should be avoided as far as possible.

[13] Due to the manual movement of the goods pick-up by means of a glove, the degree of automation is also low and the time required to remove the goods is high.

Based on this, the invention is based on the object of providing a container, a combination and a method of the type mentioned at the beginning improve the fact that with RTP systems the number of glove interventions can be kept as small as possible and a higher degree of automation and less time required for removing the goods can be achieved.

To achieve this object, the features in the characterizing part of claims 1, 12 and 14 are proposed according to the invention.

[16] Thereafter, at least one ferromagnetic and / or permanent magnetic body is mounted on the crop receptacle, which is arranged in the vicinity of a circumferential wall of the container and non-contacting by means of at least one outside of the container moved linearly along the circumferential wall and with magnetic forces of attraction through the circumferential wall the body acting magnet or ferromagnet is movable or is moved parallel to the linear guide.

When the ferromagnetic and / or permanent magnetic body and the magnet and / or ferromagnet are opposite on both sides of the peripheral wall so that they attract each other, a state of equilibrium is established in which the magnetic field lines between the body and the magnet are perpendicular to Perimeter wall are aligned. If the state of equilibrium is disturbed, for example by moving the magnet linearly away from the body along the circumferential wall, the magnetic field lines bend. As a result, a driving force acts on the body in the same direction, which tends to restore equilibrium. This driving force causes the body to be in sync with it is moved along with the magnet when the magnetic force of attraction is large enough to overcome frictional forces counteracting the movement and to ensure a stable magnetic coupling. The latter is achieved by maximizing the magnetic attraction force as much as possible and minimizing the spacing as much as possible.

[18] The combination of features according to the invention allows the material pick-up to be moved from the transport position into the removal position and back into the transport position by an operator located outside the isolator without having to intervene in the clean room. As a result, only one glove intervention is required for RTP systems with clean room operation of the port door. In addition, the time required to remove the goods can be reduced and the degree of automation increased by using a stepper motor or a pneumatic or hydraulic cylinder, if necessary, to move the at least one magnet or ferromagnet along the outside of the container.

A preferred embodiment of the invention provides that in a container with two opposite ends and a generally constant container cross-section between the ends, as is usual for the transport of sterile goods to an RTP system, the opening is at one end and the magnetic body is arranged in the vicinity of the other end when the crop receptacle is in the transport position. In this way, the Gutaufnahme can be in its removal position be moved particularly far out of the container and into the clean room by moving the magnetic body along the linear guide up to the vicinity of the opening.

According to a preferred embodiment of the invention, the peripheral wall of the container is made of non-magnetic material, which allows an undisturbed transmission of the magnetic forces of attraction through the wall and thus the moving of the body by the magnetic forces. In principle, the peripheral wall can consist of plastic or metal. It is preferably made of non-magnetic austenitic stainless steel, as this is very easy to sterilize.

A maximum attractive force and thus also a maximum driving force at relatively low costs are achieved if, according to an advantageous embodiment of the invention, the at least one magnet and / or the at least one ferromagnetic and / or permanent magnetic body is a rare earth magnet, preferably one Neodymium (NdFeB) magnets include, since neodymium magnets have very large magnetic forces of attraction and are now available relatively inexpensively. Since the container with the material receptacle and the material is usually sterilized in an autoclave, temperatures of 120 ° C. being exceeded in most cases, it is advantageous to use Nedodymium magnets with the designation SH, UH or EH.

[22] In principle, an electromagnet can also be used as a magnet instead of a permanent magnet, with which very large magnetic forces of attraction can also be achieved.

To achieve great attractive forces, both the at least one magnet and / or the at least one ferromagnetic and / or permanent magnetic body can advantageously comprise one or more pot magnets or yoke magnets with a ferromagnetic pot or yoke, which the magnetic field lines on the of deflects the side of the magnet or body facing away from the peripheral wall to the side adjacent to the peripheral wall.

Since steam is usually fed into the interior of the container during the sterilization of the goods, a further preferred embodiment of the invention provides for the at least one body to be provided with a shell or coating made of a non-rusting material. The body is preferably encased in a thin shell made of stainless steel sheet, which is easier to achieve with a ferromagnetic body, since the arc is not deflected by magnetic field lines during arc welding. A magnetic body, on the other hand, can be chrome-plated or nickel-plated, for example, in order to avoid oxidation and thus also contamination of the goods in the container.

On the other hand, it is advantageous to minimize the frictional forces counteracting the movement of the material receptacle by moving the material receptacle according to a further advantageous embodiment on rollers along the linear guide and the ferro and / or permanent magnetic body is borne by the crop receptacle and is not itself supported against the peripheral wall of the container or the linear guide.

In order to prevent material abrasion caused by friction and thus a possible contamination of the sterile material in the container, the at least one body advantageously always has a small distance from the peripheral wall during the movement along the linear guide, so that between its inside and an opposite surface there is an air gap in the body. This air gap preferably has a thickness of at least 0.5 mm and at most 3 mm in order to keep the distance between the magnet and the body as small as possible and to ensure a stable magnetic coupling during movement.

[27] In order to avoid scratches on the outside of the peripheral wall during use, there should also be a small air gap between the at least one magnet outside the container and the outside of the peripheral wall. Alternatively, however, the magnet could also be provided with a thin friction-reducing layer, e.g. made of PTFE, on its side facing the peripheral wall.

In order to minimize the size and weight of the at least one body without a corresponding decrease in the magnetic forces of attraction, the body advantageously has on its side facing the peripheral wall a surface shape adapted to the cross-sectional shape of the peripheral wall, which in the case of a generally cylindrical container an arc-shaped one Has cross section with a corresponding radius of curvature. If the body contains a plurality of permanent magnets, these are preferably arranged along an arc of a circle on the side of the body adjacent to the peripheral wall.

In principle, a single large rare earth permanent magnet, preferably a neodymium magnet, can be used as a magnet on the outside of the container, opposite to which a single ferromagnetic and / or permanent magnetic body is located inside the container, e.g. in the first mentioned case a single larger one Body made of iron or an iron material or a single large permanent magnet, expediently either a rare earth or ferrite magnet.

However, it was found that the weight of the magnet and / or body can be reduced without impairing the magnetic coupling by arranging a plurality of disc or plate-shaped permanent magnets in the circumferential direction next to one another and / or in the direction of movement on the outside of the container be arranged one behind the other, which are expediently opposite a single ferromagnetic body or a plurality of permanent magnetic bodies in the interior of the container, expediently a corresponding number of disk-shaped or plate-shaped permanent magnets. In the last-mentioned case, the arrangement and magnetization of the opposing permanent magnets are chosen so that the north poles facing the circumferential wall inside the container are opposite the south poles facing the circumferential wall on the outside of the container. Disc-shaped or plate-shaped permanent magnets are referred to here as magnets whose thickness is less than half the diameter or less than half the side dimensions of the magnet in a plane parallel to the peripheral wall.

[31] In particular where the item receptacle has a flat support surface for receiving individual objects, the at least one body is advantageously arranged below the item support, so that more space is available for the item above the support surface. In this case, the at least one magnet or ferromagnet can then be displaced underneath the container. However, the body can also be arranged above the material receptacle and the magnet or ferromagnet can be displaced above the container.

[32] According to a further advantageous embodiment of the invention, the combination of insulator and docked container comprises a table or carriage which carries the container and which is provided with a linear guide for the magnet. In principle, the outside of the peripheral wall can also serve as a linear guide.

In order to ensure a constant distance between the body and the magnet along the path of movement of the material receptacle and the magnet, the at least one magnet is preferably displaceable along a linear guide of the table or trolley The removal position of the goods intake is limited by stops. [34] Where the wall of the isolator is not transparent, it is not easily possible for the operator to determine without looking through a window into the clean room whether the at least one body is inside the at least one during the linear movement of the at least one magnet Container is taken or not. In order to enable such a determination from the outside, a preferred embodiment of the invention provides to make the force of attraction between the body and the magnet so great that the magnet adheres to the outside of the container when the magnet inside the container is opposite the body . If there is no ferromagnetic or permanent magnetic material in front of and behind the body in the direction of movement, the magnet moves away from the peripheral wall. This movement is visible to the operator and indicates that the magnetic coupling is no longer present. Adhesion of the magnet to the peripheral wall is also advantageous because this ensures that the distance between the magnet and the body is always constant during the linear movement.

[35] In the following, the invention is explained in more detail using several exemplary embodiments shown in the drawing.

[36] Figures la to ld show perspective views of a container according to the invention as well as a storage table, wherein FIGS. La and lb show the container with the container lid and FIGS. Lc and ld show the container without the container lid; [37] FIGS. 2a and 2b show enlarged perspective views of the container and the storage table similar to FIGS. 1c and 1d;

[38] FIGS. 3a and 3b show enlarged side views of the container and the storage table corresponding to FIGS.

[39] FIG. 4 shows an enlarged cross-sectional view of the container and part of the storage table along the line IV-IV of FIG. 3a;

[40] FIG. 5a shows an enlarged longitudinal sectional view of the container on the storage table as well as part of an isolator after docking of a container-side part of an RTP system to an isolator-side part, with an item receptacle of the container being in a transport position;

[41] FIG. 5b shows a corresponding longitudinal sectional view, but after a port door and the container lid of the RTP system have been opened, with the item receptacle being in a removal position;

[42] FIG. 6 shows an enlarged cross-sectional view of detail VI in FIG. 4 according to a first exemplary embodiment;

[43] FIG. 7 shows an enlarged cross-sectional view of detail VI in FIG. 4 according to a second exemplary embodiment; [44] FIG. 8 shows an enlarged cross-sectional view of detail VI in FIG. 4 according to a third exemplary embodiment;

[45] FIG. 9 shows an enlarged cross-sectional view of detail VI in FIG. 4 according to a fourth exemplary embodiment;

[46] FIG. 10 shows an enlarged cross-sectional view of detail VI in FIG. 4 according to a fifth exemplary embodiment;

[47] FIG. 11 shows an enlarged cross-sectional view of detail VI in FIG. 4 according to a sixth exemplary embodiment.

The container 10 according to the invention shown in FIGS. 1 to 9 is used for the transport and sterilization of goods, in the present case individual objects, such as exchange or format parts for machines or devices within a clean room 12 of an isolator 14, such as syringes -Filling machines or machines (not shown) for filling and closing infusion bottles or vials. The items previously placed in the container 10 are sterilized inside the container 10 by, for example, feeding superheated steam into the container 10 in an autoclave. The container 10 with the sterile goods is then transported to the isolator 14 in order to dock the container 10 on the isolator 14 and to bring the goods into the clean room 12. In order to prevent any contamination of the sterile material in the container 10 during transport to the isolator 14 and when docking with the isolator 14, the isolator 14 and the container 10 are equipped with a rapid transfer port (RTP) system. The isolator 14 is provided with an isolator-side part 16 of the RTP system, also referred to as an alpha part, while the container 10 is provided with a complementary container-side part 18 of the RTP system, also referred to as a beta part. A suitable Rapid Transfer Port (RTP) system is offered by Getinge-LaCalhene, for example.

As best shown in FIG. 1, the container 10 has a generally cylindrical peripheral wall 22 and is closed at one end by a flat end wall 24, while at the other end it is provided with an opening 26 through which the material can be inserted the container 10 can be introduced and removed from the container 10. The opening 26 is closed by a container lid 20 when the container is transported. At least the peripheral wall 22 consists of an austenitic stainless steel, e.g. of non-magnetic V2A steel. The opening cross-section of the opening 26 corresponds essentially to the inner cross-section of the peripheral wall 22. The container 10 is provided with four legs 28, a pair of which is arranged in the vicinity of the end wall 24 and in the vicinity of the opening 26.

On the end wall 24, the container 10 can have a media connection (not shown) with a filter through which superheated steam is used to sterilize the item can be fed into the interior of the closed container 10.

For transporting and removing the goods, the container 10 is provided with a goods receptacle 30 on which the goods can be placed. In a transport position (FIGS. 2a and 5a), the product receptacle 30 is located completely inside the container 10. When the container lid 20 is open, the product receptacle 30 can be moved along a linear guide 34 parallel to the longitudinal center axis 32 of the container 10 into a removal position in which it is partially protrudes out of the container 10 through the opening 26.

The crop receptacle 30 shown in the drawing consists essentially of a flat plate 36 which is arranged somewhat below the longitudinal center axis 32, its two opposite edges 38 being bent down along the circumferential wall 22. Four pairs of rotatable rollers 40 are attached to each of the two edges 38. In each case one roller 40 of each roller pair rests from above or from below against a narrow side of two guide rails 42 of the linear guide 34 and rolls on this. The parallel guide rails 42 are fastened with one of their broad sides to the ends of the legs 28 projecting inwardly beyond the circumferential wall 22.

As best shown in FIGS. 5a and 5b, the beta portion 18 of the rapid transfer port (RTP) system includes a port 26 surrounding the opening 26 with an end flange 44 of FIG Circumferential wall 22 screwed annular flange 46, an annular seal 48 inserted into the annular flange 46 and the container lid 20, which in the closed state is pressed sealingly with an outer conical peripheral surface against a complementary inner conical peripheral surface of the annular seal 48, around the opening 26 during transport and during the To hermetically seal the sterilization of the goods.

As best shown in FIGS. 5a and 5b, the alpha part 16 of the rapid transfer port (RTP) system comprises a mounting flange 50 which is rigidly connected to a boundary wall 52 of the insulator 14 and has an im The outline of a circular port opening (not visible) surrounds an annular flange 54 which is rotatable in relation to the mounting flange 50, and an annular seal (not visible) inserted into the annular flange 54. The alpha part 16 further comprises a port door 56 pivotably mounted on the mounting flange 50 and having a circular outline.

The alpha part 16 and the beta part 18 also comprise complementary locking devices (not visible) which, when the container 10 is docked, on the one hand for a mutual locking of the two annular flanges 54 and 46 of the alpha part 16 and the beta -Teils 18 and on the other hand for a mutual locking of the container lid 20 and the port door 56. As a result, on the one hand, the container 10 is fixed on the insulator 14 and, on the other hand, the opposite non-sterile surfaces of the two ring flanges 54 and 46 on the one hand and of the port door 56 and the container lid 20 on the other brought into contact with each other and pressed tightly against each other.

In order to dock the container 10 after the sterilization of the goods on the isolator 14 and to feed the goods into the isolator 14, the container 10 is first transported to the isolator 14 (FIG. 1 a), where it is attached to the outside of the isolator 14 with its four legs 28 is placed on a table 58 (Fig. Lb). The height of the table 58, the legs 60 of which can be provided with rollers (not shown), is adapted to the height of the isolator-side alpha part 16 of the rapid transfer port system. During docking, the locking devices of the alpha and beta parts 16, 18 are brought into engagement with one another and the container 10 is fixed on the insulator 14 by rotating the annular flange 54.

Where, instead of the annular flange 54, the container 10 is rotated around the central axis of the port opening for docking, the item receptacle 30 is provided with clamps or other fastening means in order to prevent the item from slipping in relation to the item receptacle when the container 10 is rotated .

[59] After the container 10 has been docked (FIG. 5a), the container lid 20 and the port door 56 are opened together in order to expose the port opening. For this purpose, the insulator 14 is provided in the vicinity of the port opening with a single glove engagement (not shown) protruding into the clean room 12, into which an operator inserts his hand in order to close an unlocking lever 61 of the port door 56 actuate and unlock it. The port door 56 and the container lid 20 are then pivoted together about a vertical pivot axis arranged laterally next to the port opening to one side into the clean room 12, as shown in FIG. 5b.

In order to make it possible in the docked state to partially move the goods receptacle 30 out of the container 10 and into the clean room 12 without an operator reaching into the clean room 12 with the glove and the goods receptacle 30 out of the port opening Has to pull out the container 10, a ferromagnetic and / or permanent magnetic body 62 is attached to the item receptacle 30, which magnet 64 moves linearly along the circumferential wall 22 outside and below the container 10 by means of magnetic forces of attraction through the circumferential wall 22 without contact can move parallel to the linear guide 34 in order to move the item receptacle 30, which is firmly connected to the body 62, out of the transport position into the removal position and, after the removal of the item, back into the transport position.

As best shown in FIGS. 4, 5a and 5b, the body 62 projects downwards over the plate 46 of the crop receptacle 30, wherein it is rigidly connected to the plate 46. The body 62 has an enlarged lower part 66 which extends downward into the immediate vicinity of the peripheral wall 22. The underside of the body 62 adjacent to the circumferential wall 22 is curved in accordance with the curvature of the circumferential wall 22 and is separated by a thin air gap 68 with a constant gap width of 0.5 to 1 mm Perimeter wall 22 separated, as best shown in Figures 6-11.

When the crop receptacle 30 is in the transport position (FIG. 5a), the body 62 is close to the end wall 24. When the crop receptacle 30 is in the removal position (FIG. 5b), the body 30 is close by at the opening 26, but still within the container 10.

As best shown in FIG. 4, the magnet 64 is part of a slide 70 which can be displaced parallel to the horizontal upper side of the table 58 along two round rods 72 serving as linear guides. The ends of the round bars 72 are held by two supports 74 protruding beyond the top of the table, the height of which is adapted to the height of the legs 28 of the container 10. This ensures that the magnet 64 can be displaced below the circumferential wall 22 along the round rods 72, its upper side adjacent to the circumferential wall 22 being curved according to the curvature of the circumferential wall 22 and through a thin air gap 76 with a constant gap width of 0.5 to 1 mm is separated from the peripheral wall 22 after the container 10 has been placed on the table top and a vertical longitudinal center plane of the container 10 has been aligned centrally between the round bars 72 and parallel to them. A handle 78 protruding to one side is used to move the slide 70 along the two round bars 72. In the exemplary embodiments in FIGS. 6 to 10, the body 62 is a single ferromagnetic body 62 made of soft iron, which is enclosed in a casing 80 made of thin, non-magnetic stainless steel sheet.

In the exemplary embodiment in FIG. 6, the magnet 64 is a single cube-shaped neodymium (NdFeB) magnet 82 which is embedded or inserted into the slide 70 made of plastic or metal.

The second embodiment in FIG. 7 differs from the first embodiment in FIG. 6 in that a single cylindrical ferrite magnet 84 is embedded or inserted into the slide 70, the surface of which facing the peripheral wall 22 is in the plane of FIG 7 has a radius of curvature corresponding to the radius of curvature of the peripheral wall 22 in order to move the magnet 84 closer to the peripheral wall 22.

In the third embodiment in FIG. 8, several disk-shaped neodymium (NdFeB) magnets 86 are embedded or inserted into the slide 70 in the circumferential direction and one behind the other in the direction of movement of the slide 70, their end faces largely parallel to the opposite section of the circumferential wall 22 are aligned. The neodymium magnets 86 are aligned in such a way that, opposite to the peripheral wall 22, north poles and south poles alternate both along the peripheral wall 22 and in the direction of movement.

In the fourth embodiment in Fig. 9 are several bar-shaped (NdFeB) magnets 88 with a ferromagnetic yoke 90 made of steel, with a U-shaped cross section, embedded or inserted into the slide 70 in the circumferential direction next to one another. The yoke 90 serves to deflect the magnetic field lines on the side of the magnets 88 facing away from the circumferential wall 22 to the side adjacent to the circumferential wall 22, as a result of which the forces of attraction between the magnets 88 and the body 62 become greater.

In the fifth exemplary embodiment in FIG. 10, an electromagnet 92 with an iron core 94 is inserted into a bore 96 of the slide 70 as a magnet 64. The iron core 94 has a curved end face with a radius of curvature adapted to the radius of curvature of the peripheral wall 22.

In the sixth embodiment in FIG. 11, the permanent and ferromagnetic body 62 comprises several cylindrical neodymium (NdFeB) magnets 100 provided with a ferromagnetic pot 98 made of steel, which are next to one another in the circumferential direction and one behind the other in the direction of movement in the body 62 are inserted or embedded. Corresponding neodymium magnets 102, which comprise a ferromagnetic pot 104 made of steel, are inserted or embedded in the carriage 70. The magnets 100 and 102 are aligned such that north poles of the magnets 102 in the slide 70 are opposite south poles of the magnets 100 in the body 62 and vice versa.

[71] Instead of the pot magnets 100 and 102 in the body 62 and in the slide 70, there can also be cylindrical, disk-shaped or differently shaped permanent magnets be provided. Instead of a single body 62, several separate bodies (not shown) can also be attached to the crop receptacle 30, each of which is acted on by one or more external magnets (not shown).

In principle, a reverse orientation as in the exemplary embodiments of FIGS. 6 to 8 is also possible, by inserting a permanent magnetic body rigidly attached to the crop receptacle 30 with one or more magnets by means of a ferromagnet arranged outside of the container 10, for example by means of a ferromagnetic slide 70 , is moved.

After opening the port door 56 and the container lid 20, the operator moves the slide 70 by means of the handle 78 in the direction of the boundary wall 52 of the insulator 14. The action between the magnet 64 and the body 62 through the peripheral wall 22 without contact Magnetic attraction forces by a magnetic coupling that the body 62 is carried along by the magnet 64 in the direction of the insulator 14. As a result, the crop receptacle 30 also moves along the rails 42 in the direction of the insulator 14, overcoming the rolling friction on the rails 42 given sufficiently large attractive forces. The material receptacle 30 moves through the port opening into its removal position, in which it protrudes a little into the clean room 12, as shown in FIG. 5b. Movement of the crop receptacle 30 beyond this position is prevented by the slide 70 striking against the support 74 adjacent to the insulator 14. After the removal of the item, the slide 70 is moved away from the isolator 14 by the operator until it strikes against the support 74 removed from the isolator 14 and the item receptacle 30 is again in its transport position.

Claims

Patent claims: 1. Container (10) for transporting sterile goods and for Removal of the goods in a clean room (12) of an isolator (14), with an opening (26) and a container-side part (18) of a rapid transfer port system, which has a container lid (20) for closing the opening (26) and means (46) for docking the container (10) to a complementary isolator-side part (16) of the rapid transfer port system, as well as having a material receptacle (30) which is movable in relation to the container (10) and which is located in a The transport position is located entirely within the closed container (10) and, with the container (10) docked and the container lid (20) open, can be moved along a linear guide (34) into a removal position in which it is at least partially through the opening (26) into the clean room ( 12) protrudes, characterized by at least one ferromagnetic and / or permanent magnetic body (62) mounted on the crop receptacle (30), which is arranged in the vicinity of a peripheral wall (22) of the container (10) and by means of at least one outside of the Container (10) linearly moved along the circumferential wall (22) and with magnetic Magnets (64) or ferromagnets acting on the body (62) without contact through the circumferential wall (22) or ferromagnets can be moved parallel to the linear guide (34) in order to move the crop receptacle (30) into the removal position and back without interfering with the insulator (14) to move into the transport position. 2. A container (10) according to claim 1, characterized by two opposite ends and a generally constant container cross-section between the ends, the opening (26) being located at one end and the body (62) near the other end is arranged when the Gutaufnahme (30) in the Transport position is. 3. Container (10) according to claim 1 or 2, characterized in that the peripheral wall (22) consists of a non-magnetic austenitic stainless steel. 4. Container (10) according to one of the preceding claims, characterized in that the at least one body (62) and / or the at least one magnet (64) a Distance from the peripheral wall (22), so that an air gap (68, 76) is present between the peripheral wall (22) and an opposite surface of the body (62) and / or magnet (64). 5. Container (10) according to one of the preceding claims, characterized in that the peripheral wall (22) is cylindrical and that the at least one body (62) and / or the at least one magnet (64) is one of the Has circumferential wall (22) opposite surface with a circular arc-shaped cross section. 6. Container (10) according to one of the preceding claims, characterized in that the at least one body (62) is provided with a casing (80) or coating made of a non-rusting material. 7. Container (10) according to one of claims 1 to 6, characterized in that the at least one body (62) consists of iron or steel. 8. Container (10) according to one of claims 1 to 6, characterized in that the at least one body (62) and / or the at least one magnet (64) consist partially or completely of a permanent magnetic rare earth or ferrite material. 9. Container (10) according to claim 8, characterized in that the permanent magnetic rare earth material of the body (62) comprises at least one neodymium (NdFeB) magnet labeled SH, UH or EH. 10. Container (10) according to one of the preceding claims, characterized in that the at least one ferromagnetic and / or permanent magnetic body (62) and / or the at least one magnet (64) has at least one pot magnet (100, 102) or permanent magnet (88) with a ferromagnetic pot (98, 104) or yoke (90) to create magnetic field lines on the side of the body (62) facing away from the peripheral wall (22) or magnets (64) to deflect the side adjacent to the peripheral wall (22). 11. Container (10) according to one of the preceding claims, characterized in that the at least one body (62) is arranged below the crop receptacle (30). 12. Combination of an isolator (14) with a clean room (12), an isolator-side part (18) of a rapid transfer port system and a container (10) docked thereon according to one of the preceding claims, characterized by at least one outside of the Container (10) linearly on the peripheral wall (22) of the Container (10) along movable magnets (64) or Ferromagnet, which during its linear movement with magnetic forces of attraction through the circumferential wall (22) acts without contact on the at least one ferromagnetic and / or permanent magnetic body (62) in order to move the body (62) parallel to the To carry along the linear guide (34) and to move the crop receptacle (30) into the removal position and back into the transport position without interfering with the isolator (14). 13. Combination according to claim 12, characterized by a table (58) or carriage carrying the container (10) with a linear guide (72) for the at least one magnet (64) or ferromagnet. 14. Method for the transport of sterile goods in one Container (10) which has an opening (26), a container-side part (18) of a rapid transfer port system with a container lid (20) for closing the opening (26) and a movable part with respect to the container (10) Comprises good receptacle (30), as well as for removing the good in a clean room (12) of an isolator (14), which includes a complementary isolator-side part (16) of the rapid transfer port system for docking the container (10), wherein the goods receptacle (30) is in a transport position within the closed container (10) and, with the container (10) docked and the container lid (20) open, is moved along a linear guide (34) into a removal position in which it is at least partially protrudes through the opening (26) into the clean room (12), characterized in that the material receptacle (30) after docking the container (10) and opening the container lid (20) by means of at least one in the vicinity of a peripheral wall (22) of the container (10) at the Gut receiving (30) mounted ferromagnetic and / or permanent magnetic body (62) and by means of at least one outside of the container (10) linearly on the Magnets (64) or ferromagnets that move along the circumferential wall (22) and with magnetic forces of attraction through the circumferential wall (22) contactlessly on the body (62) without engagement in the insulator (14) along the linear guide (34) into the removal position and back is moved into the transport position.