WO2021062048A3 - Methods and systems for modulating hepatic gaba production or release to alter food intake in monogastric species - Google Patents
Methods and systems for modulating hepatic gaba production or release to alter food intake in monogastric species Download PDFInfo
- Publication number
- WO2021062048A3 WO2021062048A3 PCT/US2020/052571 US2020052571W WO2021062048A3 WO 2021062048 A3 WO2021062048 A3 WO 2021062048A3 US 2020052571 W US2020052571 W US 2020052571W WO 2021062048 A3 WO2021062048 A3 WO 2021062048A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- gaba
- food intake
- methods
- activity
- release
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/145—Amines having sulfur, e.g. thiurams (>N—C(S)—S—C(S)—N< and >N—C(S)—S—S—C(S)—N<), Sulfinylamines (—N=SO), Sulfonylamines (—N=SO2)
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Obesity (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Child & Adolescent Psychology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Methods and compositions (such as compounds, drugs, molecules, etc,) for modulating food intake, e.g., increasing food intake or reducing food intake, in a monogastric animal species. Certain methods herein feature administering to the animal a composition that depresses hepatic GABA production, depresses GABA release, inhibits expression or activity of GABA transaminase, inhibits expression or activity of particular GABA transporters associated with export of GABA, increases expression or activity of particular GABA transporters associated with GABA re- uptake, etc. The methods may help decrease food intake and subsequently improve weight loss. Certain methods herein may feature administering to the animal a composition that activates hepatic GABA production, activates GABA release, increases expression or activity of GABA transaminase, increases expression or activity of particular GABA transporters associated with export of GABA, decreases expression or activity of particular GABA transporters associated with GABA re-uptake, etc. The methods may help increase food intake, and subsequently help promote weight gain.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2021/025629 WO2021203033A2 (en) | 2020-04-02 | 2021-04-02 | Methods and compositions to alter hepatic gaba release to treat obesity-related conditions |
| US17/937,604 US20230128194A1 (en) | 2017-05-26 | 2022-10-03 | Methods and compositions to alter hepatic gaba release to treat obesity-related conditions |
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962905135P | 2019-09-24 | 2019-09-24 | |
| US62/905,135 | 2019-09-24 | ||
| US201916617108A | 2019-11-26 | 2019-11-26 | |
| US16/617,108 | 2019-11-26 | ||
| US202063004373P | 2020-04-02 | 2020-04-02 | |
| US63/004,373 | 2020-04-02 |
Related Parent Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US2018/034680 Continuation-In-Part WO2018218161A2 (en) | 2017-05-26 | 2018-05-25 | Methods and compositions for regulating glucose homeostasis |
| US16/617,108 Continuation-In-Part US20200163908A1 (en) | 2017-05-26 | 2018-05-25 | Methods and compositions for regulating glucose homeostasis |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US2021/025629 Continuation-In-Part WO2021203033A2 (en) | 2017-05-26 | 2021-04-02 | Methods and compositions to alter hepatic gaba release to treat obesity-related conditions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2021062048A2 WO2021062048A2 (en) | 2021-04-01 |
| WO2021062048A3 true WO2021062048A3 (en) | 2021-06-03 |
Family
ID=75166821
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US2020/052571 Ceased WO2021062048A2 (en) | 2017-05-26 | 2020-09-24 | Methods and systems for modulating hepatic gaba production or release to alter food intake in monogastric species |
Country Status (1)
| Country | Link |
|---|---|
| WO (1) | WO2021062048A2 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114774338B (en) * | 2022-03-29 | 2023-08-08 | 北京航空航天大学 | Probiotics for producing butyric acid, construction method and application thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018218161A2 (en) * | 2017-05-26 | 2018-11-29 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Methods and compositions for regulating glucose homeostasis |
-
2020
- 2020-09-24 WO PCT/US2020/052571 patent/WO2021062048A2/en not_active Ceased
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018218161A2 (en) * | 2017-05-26 | 2018-11-29 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Methods and compositions for regulating glucose homeostasis |
Non-Patent Citations (2)
| Title |
|---|
| KAKEHASHI, A ET AL.: "Valerian Inhibits Rat Hepatocarcinogenesis by Activating GABA(A) Receptor-Mediated Signaling", PLOS ONE, vol. 9, no. 11, 24 November 2014 (2014-11-24), pages 1 - 21, XP055829681, DOI: 10.1371/journal.pone.0113610 * |
| ROH, YS ET AL.: "G-Aminobutyric acid promotes methionine-choline deficient diet-induced nonalcoholic steatohepatitis", THE JOURNAL OF BIOMEDICAL RESEARCH, vol. 31, no. 1, 2017, pages 65 - 73, XP055829680, DOI: 10.7555/JBR.31.2016K0007 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2021062048A2 (en) | 2021-04-01 |
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