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WO2021054270A1 - Bouchon - Google Patents

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Publication number
WO2021054270A1
WO2021054270A1 PCT/JP2020/034624 JP2020034624W WO2021054270A1 WO 2021054270 A1 WO2021054270 A1 WO 2021054270A1 JP 2020034624 W JP2020034624 W JP 2020034624W WO 2021054270 A1 WO2021054270 A1 WO 2021054270A1
Authority
WO
WIPO (PCT)
Prior art keywords
plug
less
elastomer resin
weight
plug body
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2020/034624
Other languages
English (en)
Japanese (ja)
Inventor
嵩也 内山
健 川上
川口　泰広
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tokuyama Sekisui Co Ltd
Sekisui Medical Co Ltd
Original Assignee
Tokuyama Sekisui Co Ltd
Sekisui Medical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tokuyama Sekisui Co Ltd, Sekisui Medical Co Ltd filed Critical Tokuyama Sekisui Co Ltd
Priority to JP2021516830A priority Critical patent/JP6904629B1/ja
Publication of WO2021054270A1 publication Critical patent/WO2021054270A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D51/00—Closures not otherwise provided for
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J9/00—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof
    • C08J9/32—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof from compositions containing microballoons, e.g. syntactic foams

Definitions

  • the present invention relates to a plug containing an elastomer resin.
  • Containers such as blood collection tubes and infusion bags, in which a needle is pierced through a plug and the liquid is injected inside or taken out through the pierced needle, are widely used.
  • a plug body formed of a thermoplastic elastomer resin or the like is widely used as a plug body used by piercing a needle.
  • An object of the present invention is to provide a plug body capable of reducing piercing resistance and pull-out resistance.
  • a plug containing an elastomeric resin and a foam of effervescent particles.
  • the plug further comprises air bubbles formed by a chemical foaming agent.
  • the effervescent particles are thermally expandable microcapsules.
  • the volume average diameter of the foamable particles is 35 ⁇ m or less.
  • the elastomer resin is a thermoplastic elastomer resin.
  • the ratio of the specific gravity of the plug body to the specific gravity of the elastomer resin is 0.5 or more and 0.95 or less.
  • the porosity is 10% or more and 40% or less.
  • the plug body according to the present invention is preferably a medical plug body.
  • the stopper according to the present invention is preferably a stopper for a vial containing a reagent.
  • the plug body according to the present invention contains an elastomer resin and a foam of foamable particles, the penetration resistance and the pull-out resistance can be reduced.
  • the plug body according to the present invention contains an elastomer resin and a foam of effervescent particles.
  • the plug body according to the present invention contains bubbles formed by effervescent particles.
  • the plug body according to the present invention has a plurality of air bubbles inside.
  • the plug body according to the present invention is a foam molded body.
  • the plug body according to the present invention has the above configuration, the piercing resistance and the pull-out resistance can be reduced. Therefore, it is possible to reduce the burden on the operator at the time of piercing and pulling out, and it is possible to improve the work efficiency. Further, since the plug body according to the present invention has the above-mentioned configuration, it is possible to maintain a high gas barrier property. Therefore, deterioration of the contents contained in the container provided with the stopper can be suppressed. Further, in the plug body according to the present invention, the amount of the elastomer resin used can be reduced, so that the manufacturing cost can be suppressed.
  • the plug body according to the present invention is formed by foam-molding a molding material containing an elastomer resin and foamable particles, or by molding a molding material containing an elastomer resin and foamed particles (foamed particles) of foamable particles.
  • the stopper according to the present invention is preferably a foamed molded product of a molding material containing an elastomer resin and foamable particles.
  • the plug body and the molding material include an elastomer resin. Therefore, the plug body is a rubber plug. Only one type of the above-mentioned elastomer resin may be used, or two or more types may be used in combination.
  • elastomer resin examples include thermosetting elastomer resins and thermoplastic elastomer resins.
  • thermocurable elastomer resin is not particularly limited, and examples thereof include isoprene rubber, butyl rubber, butadiene rubber, styrene-butadiene copolymer rubber, natural rubber, isoprene / isoprene rubber, neoprene rubber, and silicon rubber.
  • thermoplastic elastomer resin is not particularly limited, and examples thereof include an olefin-based elastomer resin, a styrene-based elastomer resin, an ester-based elastomer resin, an amide-based elastomer resin, and a urethane-based elastomer resin.
  • the elastomer resin is preferably the thermoplastic elastomer resin.
  • the content of the elastomer resin in 100% by weight of the molding material is preferably 85% by weight or more, more preferably 90% by weight or more, preferably 99% by weight or less, and more preferably 98% by weight or less.
  • the content of the elastomer resin is not less than the above lower limit and not more than the above upper limit, the penetration resistance and the pull-out resistance can be further reduced, and a well-foamed plug can be obtained.
  • the effervescent particles are particles that can be effervescent.
  • foamable particles By foaming the foamable particles, foamed particles which are foams of the foamable particles can be obtained.
  • Foamable particles may be foamed by using the heat generated during molding of the plug to form the plug, or the plug may be formed by mixing foams (foamed particles) of foamable particles that have been foamed in a separate step in advance. It may be molded.
  • the foamable particles By using the foamable particles, a foamed structure can be formed in the plug body. Only one kind of the effervescent particles may be used, or two or more kinds may be used in combination.
  • the foamable particles are preferably heat-expandable microcapsules. Therefore, it is preferable that the bubbles are formed by the heat-expanded foam of the heat-expandable microcapsules.
  • the heat-expandable microcapsules are substances that expand when heated. By thermally expanding and foaming the heat-expandable microcapsules, a heat-expandable foam of the heat-expandable microcapsules is formed.
  • the heat-expandable microcapsules preferably have an outer shell and a leavening agent contained in the outer shell.
  • the outer shell is preferably a polymer, more preferably a thermoplastic polymer.
  • the polymer may be a homopolymer of a monomer or a copolymer.
  • the above-mentioned monomer is not particularly limited, and examples thereof include a nitrile-based monomer, a (meth) acrylate-based monomer, a vinyl chloride monomer, and a vinylidene chloride monomer.
  • examples of the nitrile-based monomer include acrylonitrile, metaacrylonitrile, ⁇ -chloroacrylonitrile, ⁇ -ethoxyacrylonitrile, and fumarnitrile. Only one kind of the above-mentioned monomer may be used, or two or more kinds thereof may be used in combination.
  • the monomer is preferably the above-mentioned nitrile-based monomer, and more preferably acrylonitrile or metaacrylonitrile.
  • the heat-expandable microcapsules preferably have a certain degree of heat resistance.
  • the outer shell of the heat-expandable microcapsules is an acrylonitrile polymer, a polymer of a nitrile compound, a polymer of a carboxylic acid compound, a polymer of an amide compound, or It is preferably a polymer of a compound having a cyclic skeleton in the side chain.
  • the polymer of the nitrile compound and the polymer of the carboxylic acid compound are preferably a copolymer of the nitrile compound and the carboxylic acid compound.
  • the outer shell of the heat-expandable microcapsules is more preferably an acrylonitrile polymer.
  • the expansion agent is preferably a volatile expansion agent, and more preferably a low boiling point organic compound. Only one type of the above-mentioned leavening agent may be used, or two or more types may be used in combination.
  • the leavening agent examples include hydrocarbons, chlorofluorocarbons and tetraalkylsilanes, and pyrolytic compounds.
  • the thermally decomposable compound is a compound that is thermally decomposed by heating and becomes gaseous.
  • hydrocarbon examples include propane, propylene, n-butane, isobutane, butene, isobutane, n-pentane, isopentane, neopentane, hexane, heptane, octane, and isooctane.
  • chlorofluorocarbon examples include CCl 3 F, CCl 2 F 2 , CCl F 3 , and CCl F 2- CClF 2 .
  • tetraalkylsilane examples include chlorofluorocarbon, tetramethylsilane, trimethylethylsilane, trimethylisopropylsilane, and trimethyl-n-propylsilane.
  • the content of the expansion agent in 100% by weight of the thermal expansion microcapsules is preferably 1% by weight or more, more preferably 10% by weight or more, preferably 99% by weight. Below, it is more preferably 50% by weight or less, still more preferably 25% by weight or less.
  • the content of the leavening agent is at least the above lower limit, the deterioration of the leavening performance due to the thickness of the outer shell can be effectively suppressed.
  • the content of the leavening agent is not more than the above upper limit, the strength of the outer shell becomes high, and poor expansion such as rupture and shrinkage of the outer shell is less likely to occur.
  • the volume mean diameter of the effervescent particles is preferably 1 ⁇ m or more, more preferably 5 ⁇ m or more, still more preferably 10 ⁇ m or more, particularly preferably 15 ⁇ m or more, preferably 100 ⁇ m or less, more preferably 50 ⁇ m or less, still more preferably 40 ⁇ m or less. It is more preferably 35 ⁇ m or less, and particularly preferably 30 ⁇ m or less.
  • foaming is promoted and bubbles having an appropriate size are formed, so that the penetration resistance and the pull-out resistance of the obtained plug can be further reduced.
  • the volume average diameter is not more than the above upper limit, a plug body having a small bubble diameter can be obtained, the strength of the plug body can be improved, and the penetration resistance and the pull-out resistance of the plug body can be varied. It can be made smaller. Further, when the volume average diameter is not more than the upper limit, the gas barrier property can be maintained high.
  • the volume average diameter of the effervescent particles is the average diameter measured on a volume basis, and is the value of the median diameter (D50) which is 50%.
  • the volume mean diameter can be measured by a laser diffraction / scattering method or the like.
  • the maximum foaming temperature of the effervescent particles is preferably 165 ° C. or higher, more preferably 170 ° C. or higher, still more preferably 175 ° C. or higher, particularly preferably 180 ° C. or higher, preferably 200 ° C. or lower, and more preferably 190 ° C. or lower. is there.
  • the maximum foaming temperature is equal to or higher than the lower limit and lower than the upper limit, the foaming property can be improved and the specific gravity of the obtained plug can be reduced.
  • the maximum foaming temperature means the temperature at which the diameter of the foamable particles becomes the maximum (maximum displacement amount) when the diameter of the foamable particles is measured while heating from room temperature.
  • a commercially available product may be used as the foamable particles.
  • Commercially available products of the foamable particles include Advancel series manufactured by Sekisui Chemical Co., Ltd. (volume average diameter before expansion: Advansel EM306, Advansel EM307, Advansel EM403, Advansel EM406, Advansel EMH204, etc.).
  • Kureha Microsphere Series manufactured by KUREHA volume average diameter before expansion 10 ⁇ m to 50 ⁇ m: M330, M430, H750, H850, H1110, etc.
  • Matsumoto Microsphere registered trademark
  • the content of the foamable particles with respect to 100 parts by weight of the elastomer resin is preferably 0.5 parts by weight or more, more preferably 1 part by weight or more, still more preferably 2 parts by weight or more, and particularly preferably 3. It is more than parts by weight, preferably 10 parts by weight or less, more preferably 8 parts by weight or less, still more preferably 6 parts by weight or less, and particularly preferably 4 parts by weight or less.
  • the content of the effervescent particles is not less than the above lower limit and not more than the above upper limit, a well-foamed plug can be obtained, and as a result, the penetration resistance and the pull-out resistance can be further reduced.
  • the content of the foamable particles in 100% by weight of the molding material is preferably 0.5% by weight or more, more preferably 1% by weight or more, still more preferably 2% by weight or more, preferably 10% by weight or less. It is preferably 8% by weight or less, more preferably 6% by weight or less.
  • the molding material may contain a chemical foaming agent.
  • a foamed structure can be formed in the plug body. Therefore, the plug body may contain air bubbles formed by a chemical foaming agent.
  • the plug body preferably further contains bubbles formed by a chemical foaming agent. Only one kind of the chemical foaming agent may be used, or two or more kinds thereof may be used in combination.
  • the penetration resistance and the pull-out resistance can be reduced to some extent.
  • the piercing resistance and the pull-out resistance tend to vary depending on the position where the needle is pierced. Therefore, the piercing resistance and the pull-out resistance may increase depending on the position where the needle is pierced.
  • the gas barrier property may be lowered in this plug body.
  • the molding material contains a chemical foaming agent
  • the penetration resistance and the pull-out resistance can be reduced, and their variations can be reduced, and further, the gas barrier can be reduced. You can improve your sexuality.
  • the chemical foaming agent is not particularly limited, and conventionally known chemical foaming agents can be used.
  • the chemical foaming agent is preferably a chemical foaming agent that is in powder form at 25 ° C.
  • Examples of the chemical foaming agent include a thermal decomposition type chemical foaming agent and a reactive chemical foaming agent.
  • Examples of the thermal decomposition type chemical foaming agent include an organic thermal decomposition type foaming agent and an inorganic thermal decomposition type foaming agent.
  • Examples of the reactive chemical foaming agent include an organic reactive chemical foaming agent and an inorganic reactive chemical foaming agent.
  • organic pyrolytic foaming agent examples include azodicarbonamide (ADCA), N, N'-dinitrosopentamethylenetetramine (DPT), and 4,4'-oxybisbenzenesulfonylhydrazide (OBSH). ..
  • ADCA azodicarbonamide
  • DPT N, N'-dinitrosopentamethylenetetramine
  • OBSH 4,4'-oxybisbenzenesulfonylhydrazide
  • Examples of the inorganic pyrolyzable foaming agent include hydrogen carbonate, carbonate, and a mixture of hydrogen carbonate and an organic acid salt.
  • the chemical foaming agent is preferably the thermal decomposition type chemical foaming agent.
  • the weight ratio of the content of the foaming particles to the content of the chemical foaming agent in the molding material is preferably 0.2 or more, more preferably 2 or more, preferably 30 or less, and more preferably 5 or less.
  • the weight ratio content of effervescent particles / content of chemical foaming agent
  • a well-foamed plug can be obtained, and as a result, piercing resistance and withdrawal can be obtained. The resistance can be further reduced.
  • the content of the chemical foaming agent in 100% by weight of the molding material is preferably 0.1% by weight or more, more preferably 0.5% by weight or more, preferably 0.5% by weight or more. Is 2.5% by weight or less, more preferably 1.0% by weight or less.
  • the content of the chemical foaming agent is not less than the above lower limit and not more than the above upper limit, a well-foamed plug can be obtained, and as a result, the penetration resistance and the pull-out resistance can be further reduced.
  • the total content of the foamable particles and the chemical foaming agent with respect to 100 parts by weight of the elastomer resin is preferably 0.5 parts by weight or more, more preferably 1. More than parts by weight, more preferably 2 parts by weight or more, particularly preferably 3 parts by weight or more, preferably 10 parts by weight or less, more preferably 8 parts by weight or less, still more preferably 6 parts by weight or less, particularly preferably 4 parts by weight or less. Is. When the total content is not less than the above lower limit and not more than the above upper limit, a well-foamed plug can be obtained, and as a result, the penetration resistance and the pull-out resistance can be further reduced.
  • the plug body and the molding material may contain various additives such as a colorant and an inorganic substance.
  • the inorganic substance include silica and the like. Only one kind of the above-mentioned additive may be used, or two or more kinds thereof may be used in combination.
  • the ratio of the specific gravity of the plug to the specific gravity of the elastomer resin is preferably 0.5 or more, more preferably 0.6 or more, and even more preferably 0.65 or more. , More preferably 0.66 or more, and particularly preferably 0.69 or more.
  • the ratio of the specific gravity of the plug to the specific gravity of the elastomer resin is preferably 0.95 or less, more preferably 0.9 or less, still more preferably 0.85 or less. Particularly preferably, it is 0.8 or less.
  • the porosity of the plug is preferably 10% or more, more preferably 20% or more, preferably 40% or less, more preferably 35% or less, still more preferably 30% or less.
  • the porosity is at least the above lower limit, the penetration resistance and the pull-out resistance can be further reduced.
  • the porosity is not more than the upper limit, the gas barrier property can be maintained high.
  • the porosity of the plug body is the ratio of the area occupied by the air gap to 100% of the cross-sectional area of the plug body observed using a scanning electron microscope.
  • the average value of the bubble diameter in the plug body is preferably 70 ⁇ m or more, more preferably 80 ⁇ m or more, preferably 150 ⁇ m or less, and more preferably 120 ⁇ m or less.
  • the average value of the bubble diameter is not less than the above lower limit and not more than the above upper limit, both weight reduction and strength can be improved, and the penetration resistance and the pull-out resistance can be further reduced. Furthermore, the gas barrier property can be maintained high.
  • the coefficient of variation (CV value) of the bubble diameter in the plug body is preferably 40% or less, more preferably 30% or less.
  • CV value coefficient of variation of the bubble diameter
  • the coefficient of variation of the bubble diameter is not more than the above upper limit, the penetration resistance and the pull-out resistance can be further reduced.
  • a physical foaming agent such as water or carbon dioxide is used, it is difficult to reduce the coefficient of variation of the bubble diameter.
  • the coefficient of variation (CV value) can be measured as follows.
  • CV value (%) ( ⁇ / X) x 100 ⁇ : Standard deviation of bubble diameter X: Average value of bubble diameter
  • the average value and coefficient of variation of the bubble diameter can be obtained by measuring at least 20 bubble diameters using a scanning electron microscope.
  • the bubble diameter is obtained as a particle diameter equivalent to a circle.
  • the manufacturing method of the plug body is not particularly limited. Examples of the method for manufacturing the plug body include the following methods (1) and (2).
  • a molding material containing the above-mentioned elastomer resin, the above-mentioned expandable particles (heat-expandable microcapsules), a chemical foaming agent or the like to be blended as needed, is equal to or higher than the foaming start temperature of the heat-expandable microcapsules. How to mold at the temperature of.
  • the method of injecting into a mold and molding may be a supercritical foaming method.
  • the method (1) described above is preferable.
  • the shape of the stopper is not particularly limited.
  • the shape of the stopper can be appropriately changed according to the target container.
  • the stopper is attached to the opening of the container body.
  • the container includes the container body and a plug body attached to the opening of the container body.
  • Examples of the container body include a tube, a flexible packaging bag, a vial, and the like. Inside the main body of the container, for example, contents such as a composition for separating serum or plasma, a chemical solution, and a reagent are stored.
  • the stopper is preferably a stopper through which a needle is pierced in order to take out the contents contained in the container body or inject the liquid into the container body.
  • the plug body may be a plug body through which the needle does not penetrate.
  • the above plug body is preferably a medical plug body.
  • the medical plug include a blood collection tube plug, an infusion bag plug, a lyophilized vial plug, an injection vial plug, and the like.
  • the stopper is a stopper for a vial containing a reagent.
  • the reagent is, for example, a liquid reagent, a freezing reagent, or a lyophilization reagent.
  • a needle is pierced through the plug to remove the liquid reagent from the vial or to dissolve the lyophilized reagent in the vial.
  • the container includes a blood collection tube body, the above-mentioned plug body (medical plug body) attached to the opening of the blood collection tube body, and a serum or plasma separation composition contained inside the blood collection tube body. It is preferable that the blood collection tube is provided with.
  • the container contains an infusion bag body such as a flexible packaging bag, the above-mentioned plug body (medical plug body) attached to the opening of the infusion bag body, and a chemical solution contained inside the infusion bag body. It is preferable that the infusion bag is provided.
  • the container is a drug vial comprising a vial, the above-mentioned stopper (medical stopper) attached to the opening of the vial, and a lyophilized preparation or injection solution contained inside the vial. Is preferable.
  • the container is preferably a reagent vial including a vial, the above-mentioned stopper attached to the opening of the vial, and a reagent housed inside the vial.
  • Thermally expandable microcapsules 1 ("Advancel EM306” manufactured by Sekisui Chemical Co., Ltd., volume average diameter (before expansion): 25 ⁇ m, foaming start temperature: 140 ° C., maximum foaming temperature: 178 ° C.)
  • Thermally expandable microcapsules 2 (“Advancel EM406” manufactured by Sekisui Chemical Co., Ltd., volume average diameter (before expansion): 29 ⁇ m, foaming start temperature: 145 ° C, maximum foaming temperature: 185 ° C)
  • Thermally expandable microcapsules 3 (“Advancel EM307” manufactured by Sekisui Chemical Co., Ltd., volume average diameter (before expansion): 40 ⁇ m, foaming start temperature: 122 ° C., maximum foaming temperature: 172 ° C.)
  • Thermally expandable microcapsules 4 (Sekisui Chemical Co., Ltd. "Advancel EMH204" volume average diameter (before expansion): 40 ⁇ m, foam
  • Example 1 After kneading 97 parts by weight of the elastomer resin with an open roll (clearance: 0.3 mm and roll temperature 110 ° C. to 120 ° C.) for 3 minutes, add 3 parts by weight of the heat-expandable microcapsules 1 and knead for 2 minutes. Then, a molding material was obtained. The obtained molding material was molded into a sheet to obtain a first molded product.
  • 60 parts by weight of the first molded product was introduced into a mold (length 150 mm ⁇ width 90 mm ⁇ thickness 6 mm), and the conditions were a temperature of 185 ° C., preheating for 3 minutes, pressurization for 2 minutes, and 200 kg / cm 2 using a press machine. After pressing at 25 ° C. for 3 minutes, a second sheet-shaped molded product (evaluation sample) was obtained.
  • Example 2 to 8 and Comparative Example 1 A second molded product (evaluation sample) was obtained in the same manner as in Example 1 except that the compounding composition of the molding material was changed as shown in Tables 1 and 2.
  • the vertical direction is configured.
  • One of the sides to be used was set as the first side, and one of the sides constituting the horizontal direction was set as the second side, and the following five points were selected.
  • First location 35 mm inside from the first side and 25 mm inside from the second side.
  • Second location 70 mm inside from the first side and 50 mm inside from the second side.
  • Third location 35 mm inside from the first side and 75 mm inside from the second side.
  • Fourth location 70 mm inside from the first side and 90 mm inside from the second side.
  • Fifth location A position 35 mm inside from the first side and a position 115 mm inside from the second side.
  • a tensile tester manufactured by Yasuda Seiki Seisakusho Co., Ltd.
  • a needle Tumoro's "Blood Collection Needle S", 21G x 11/2
  • the piercing resistance when pierced under the condition of minutes and the withdrawal resistance when pierced under the condition of pulling speed of 200 mm / min were measured.
  • the average value and standard deviation of the piercing resistance and the pull-out resistance at these five points were calculated.
  • the obtained evaluation sample was cut into a length of 60 mm, a width of 60 mm, and a thickness of 0.5 mm to prepare a test piece.
  • oxygen as the test gas, the gas permeability was measured according to the differential pressure method of JIS K7126, and the oxygen permeability coefficient was calculated.
  • the test temperature was 23 ⁇ 1 ° C.
  • Tables 1 and 2 show the configuration and results.
  • Examples 1 to 8 and Comparative Example 1 the sheet-shaped molded product was evaluated. Even when the plug is prepared using the molding material having the same composition as that of Examples 1 to 8 and Comparative Example 1, the same results as those of Examples 1 to 8 and Comparative Example 1 can be obtained.

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Mechanical Engineering (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Materials Engineering (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Manufacture Of Porous Articles, And Recovery And Treatment Of Waste Products (AREA)
  • Wrappers (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Closures For Containers (AREA)

Abstract

L'invention concerne un bouchon capable de réduire la résistance à la perforation et la résistance à l'extraction. Un bouchon selon la présente invention comprend une résine élastomère et un objet en mousse à base de particules moussantes.
PCT/JP2020/034624 2019-09-18 2020-09-14 Bouchon Ceased WO2021054270A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2021516830A JP6904629B1 (ja) 2019-09-18 2020-09-14 栓体

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2019-169344 2019-09-18
JP2019169344 2019-09-18

Publications (1)

Publication Number Publication Date
WO2021054270A1 true WO2021054270A1 (fr) 2021-03-25

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2020/034624 Ceased WO2021054270A1 (fr) 2019-09-18 2020-09-14 Bouchon

Country Status (2)

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JP (1) JP6904629B1 (fr)
WO (1) WO2021054270A1 (fr)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003503288A (ja) * 1999-07-05 2003-01-28 クレイトン・ポリマーズ・リサーチ・ベー・ベー 合成ボトル栓
WO2011040585A1 (fr) * 2009-09-30 2011-04-07 株式会社クラレ Bouchon de récipient comprenant un article produit par moulage de mousse
JP2012025944A (ja) * 2010-06-22 2012-02-09 Mitsubishi Chemicals Corp 医療用ゴム栓
JP2014069852A (ja) * 2012-09-28 2014-04-21 Kyoraku Co Ltd 薬液容器および栓体

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003503288A (ja) * 1999-07-05 2003-01-28 クレイトン・ポリマーズ・リサーチ・ベー・ベー 合成ボトル栓
WO2011040585A1 (fr) * 2009-09-30 2011-04-07 株式会社クラレ Bouchon de récipient comprenant un article produit par moulage de mousse
JP2012025944A (ja) * 2010-06-22 2012-02-09 Mitsubishi Chemicals Corp 医療用ゴム栓
JP2014069852A (ja) * 2012-09-28 2014-04-21 Kyoraku Co Ltd 薬液容器および栓体

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