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WO2020218993A1 - A toothpaste - Google Patents

A toothpaste Download PDF

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Publication number
WO2020218993A1
WO2020218993A1 PCT/TR2020/050332 TR2020050332W WO2020218993A1 WO 2020218993 A1 WO2020218993 A1 WO 2020218993A1 TR 2020050332 W TR2020050332 W TR 2020050332W WO 2020218993 A1 WO2020218993 A1 WO 2020218993A1
Authority
WO
WIPO (PCT)
Prior art keywords
phthalocyanine
toothpaste
compounds
azaphthalocyanine
subphthalocyanine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/TR2020/050332
Other languages
French (fr)
Inventor
Mahmut DURMUŞ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nanovasyon Teknolojik Arastirmalar Sanayi Ve Ticaret Ltd Sirketi
Original Assignee
Nanovasyon Teknolojik Arastirmalar Sanayi Ve Ticaret Ltd Sirketi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nanovasyon Teknolojik Arastirmalar Sanayi Ve Ticaret Ltd Sirketi filed Critical Nanovasyon Teknolojik Arastirmalar Sanayi Ve Ticaret Ltd Sirketi
Publication of WO2020218993A1 publication Critical patent/WO2020218993A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/409—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/20—Halogens; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/58—Metal complex; Coordination compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/81—Preparation or application process involves irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0601—Apparatus for use inside the body
    • A61N5/0603—Apparatus for use inside the body for treatment of body cavities
    • A61N2005/0606—Mouth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/062—Photodynamic therapy, i.e. excitation of an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/0624—Apparatus adapted for a specific treatment for eliminating microbes, germs, bacteria on or in the body

Definitions

  • the invention relates to a toothpaste.
  • the invention particularly relates to a toothpaste used in the cosmetic and health sectors, which differs from conventional toothpastes currently in use, with protecting human health by more effectively destroying microorganisms such as bacteria, viruses and microbes that disrupt tooth, gum, palate and oral health.
  • Toothpaste is known as a dentifrice which contains abundant fluorine and calcium. It may be in pasty consistency and have different flavors, but it is generally mentholed, i.e. mint flavored. It origins to tooth cleansing property of miswak plant.
  • antimicrobial substances should be added to toothpastes to ensure more hygenic teeth and oral cleanliness.
  • U.S. Pat. No. 6,056,548 to Wolfgang Neuberger and Walter Cecchetti in 2000 discloses a similar toothpaste containing phthalocyanine derivative compounds as photosensitizer.
  • the technical problems of this toothpaste in said application are listed below. Since the phthalocyanine photosensitizers used in the aforementioned patent do not dissolve in water, it is very difficult to remove the toothpaste from the teeth and mouth after the toothbrushing is completed.
  • the phthalocyanine compounds are in green-blue color, the phthalocyanine compounds used in the aforementioned patent cause color defects that will disrupt the appearance of the teeth by leaving green-blue residues in the teeth at the end of the application.
  • a sensitizer such as Rose Bengal, covalently, ionically bonded to or adsorbed on or immobilized to an organic high polymer or inorganic carrier and the photosensitive oxidation of a-thujene with oxygen is effected by the use of the product to produce the titled compound, an intermediate of perfume components, in high yield.
  • an immobilized sensitizer that is obtained by bonding the above sensitizer to a carrier insoluble in the solvent, such as a styrene-divinylbenzene copolymer covalently bonding with the sensitizer, a strong base anion exchange resin containing rose bengal or eosine immobilized by ion exchange or a silica gel and alumina mixture containing methylene blue adsorbed thereon, is employed.”
  • a method of manufacturing a toothpaste comprising trans-4- hydroperoxy- -zuene is disclosed.
  • the Chinese patent application CN103751029 relates to the subject: "The invention discloses a preparation method and application of a novel tooth whitening repairing agent.
  • a BODIPY (boron fluoride-dipyrromethene) compound is prepared into an aqueous solution with a concentration of 0.1-100 micromol/L, and then ingredients are employed to make the solution into a uniform paste.
  • the BODIPY compound has a structure shown as the specification.
  • the water-soluble BODIPY photodynamic whitening repairing agent provided by the invention has a simple preparation method, is safe and free of toxic or side effect, a BODIPY photosensitizer can achieve a high singlet oxygen quantum yield.
  • the novel tooth whitening repairing agent has good biocompatibility.
  • the tooth whitening repairing agent prepared according to the method provided by the invention is convenient to use, can be operated independently at home, and has strong controllability, and the illumination time can be chosen according to a user's own whitening requirements.
  • the whitening repairing agent not only has no damage to teeth, but also can repair the tooth surface enamel and perform remineralization, thus making the teeth white, smooth, glossy and bright.
  • the novel tooth whitening repairing agent has a broad market application prospect.”
  • the photosensitizer compounds to be used in the new toothpaste proposed by us are completely different from the compounds mentioned in the above patent numbered CN103751029. While the photosensitizers mentioned in the patent numbered CN103751029 absorb the light about 500-600 nm wavelength range, the photosensitizers to be used in the patent proposed by us absorb the light at higher wavelengths. Thus, the photosensitizer compounds in the toothpastes to be prepared with this patent proposed by us will be activated at higher wavelength and therefore lower energy light will be used. This will allow the recommended toothpaste to have less side effects than the photosensitizers indicated in patent CN103751029. Due to the aforementioned disadvantages of other patents, there is a demand to provide a new toothpaste.
  • the object of the present invention is to provide a new toothpaste.
  • Another object of the present invention is to provide a toothpaste for more efficiently destruction of microorganisms such as bacteria, viruses and microbes that impair dental, gum, palate and oral health.
  • Another object of the present invention is to provide a toothpaste in which the photosensitizer residues can be removed by rinsing with water since it has water-soluble structure.
  • Another object of the present invention is to provide a toothpaste in which the phthalocyanine photosensitizer compounds can also be activated by applying light at lower energy or by shortening the light application time.
  • Another object of the present invention is to provide a toothpaste which does not harm teeth, tooth enamel and gum due to application of light at lower energy or shorter duration of light application.
  • Another object of the present invention is to provide a toothpaste which eliminates the necessity of using harmful hydrogen peroxide for removal of the residues.
  • the invention discloses a toothpaste used in the cosmetic and health sectors, which differs from conventional toothpastes currently in use, with protecting human health by more effectively destroying microorganisms such as bacteria, viruses and microbes that disrupt tooth, gum, palate and oral health.
  • the disclosed toothpaste provides a photodynamic antimicrobial activity during use with the light emitted by the toothbrush with LED lamp which can emit light at a certain wavelength and by this way it destroys microorganisms such as bacteria, viruses and microbes and the residuals are removed by rinsing with water.
  • phthalocyanine In addition to phthalocyanine, porphyrin, chlorine, azaphthalocyanine, naphthalocyanine, subphthalocyanine, porphyrazine compounds, etc., which are the same group of compounds, can be used to obtain the phototherapeutic toothpaste.
  • the most important feature of the invention is addition of all of all water-soluble phthalocyanine, porphyrin, chlorine, azaphthalocyanine, naphthalocyanine, subphthalocyanine, porphyrazine, etc. compounds into conventional toothpastes. More hygienic tooth and oral health is provided by activation of these toothpastes containing compounds that exhibit photodynamic activity by a toothbrush that has LED lamp which can emit light at a certain wavelength.
  • said toothpaste comprises all of all water-soluble phthalocyanine, porphyrin, chlorine, azaphthalocyanine, naphthalocyanine, subphthalocyanine, porphyrazine etc. compounds as active ingredient, calcium carbonate, sodium lauryl sulfate, sodium saccharin, water, sorbitol (70% solution), xanthan gum, glycerin, titanium dioxide, aroma, preservative, sodium fluoride (fluoride ion w / v).
  • Photosensitizer wherein all water soluble phthalocyanine, porphyrin, chlorine, azaphthalocyanine, naphthalocyanine, subphthalocyanine, porphyrazine derivatives, etc. (derivatives having carboxylic acid, carboxylic acid salts, sulfonic acid, sulfonic acid salts, quaternized amino derivatives, nonionic water-soluble groups etc. on them) are synthesized by use of all methods described in the literature for synthesis of these compounds (solvent, temperature, reaction time, base type used).

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Birds (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

The invention relates to a toothpaste used in the cosmetic and health sectors, which differs from conventional toothpastes currently in use, with protecting human health by more effectively destroying microorganisms such as bacteria, viruses and microbes that disrupt tooth, gum, palate and oral health.

Description

A TOOTHPASTE
Technical Area
The invention relates to a toothpaste.
The invention particularly relates to a toothpaste used in the cosmetic and health sectors, which differs from conventional toothpastes currently in use, with protecting human health by more effectively destroying microorganisms such as bacteria, viruses and microbes that disrupt tooth, gum, palate and oral health.
Background of the Invention
Toothpaste is known as a dentifrice which contains abundant fluorine and calcium. It may be in pasty consistency and have different flavors, but it is generally mentholed, i.e. mint flavored. It origins to tooth cleansing property of miswak plant.
Conventional toothpastes which are in use in our country and in the world are not sufficient to destroy microorganisms such as bacteria, viruses and microbes that disrupt tooth, gum, palate and oral health.
Taking into consideration that in-mouth and toothbrushes are particularly suitable environments for the growth of microorganisms, antimicrobial substances should be added to toothpastes to ensure more hygenic teeth and oral cleanliness.
For this purpose, U.S. Pat. No. 6,056,548 to Wolfgang Neuberger and Walter Cecchetti in 2000 discloses a similar toothpaste containing phthalocyanine derivative compounds as photosensitizer. The technical problems of this toothpaste in said application are listed below. Since the phthalocyanine photosensitizers used in the aforementioned patent do not dissolve in water, it is very difficult to remove the toothpaste from the teeth and mouth after the toothbrushing is completed.
Since the phthalocyanine compounds are in green-blue color, the phthalocyanine compounds used in the aforementioned patent cause color defects that will disrupt the appearance of the teeth by leaving green-blue residues in the teeth at the end of the application.
Another problem of the toothpaste obtained in the aforementioned patent is; it is obligatory to use harmful hydrogen peroxide (H2O2) which is strong oxidant agent as whitener at the end of application in order to remove the remaining phthalocyanine residues in the teeth by decomposition.
In the said patent, it is recommended to apply light at higher energy or longer application time to remove the photosensitizer residues by decomposition after application. This may cause damage to the healthy tissue presented in mouth and gum.
Due to the aforementioned disadvantages, there is a demand to provide a new toothpaste.
The following statements are mentioned in the Japanese patent application J2PS5675472. "A sensitizer such as Rose Bengal, covalently, ionically bonded to or adsorbed on or immobilized to an organic high polymer or inorganic carrier and the photosensitive oxidation of a-thujene with oxygen is effected by the use of the product to produce the titled compound, an intermediate of perfume components, in high yield. In the production of the objective compound by the photosensitive oxidation of a-thujene in the presence of a photosensitizer such as eosine Y, fluorescenone, chlorophyllin or hematoporphyrin pigment, an immobilized sensitizer that is obtained by bonding the above sensitizer to a carrier insoluble in the solvent, such as a styrene-divinylbenzene copolymer covalently bonding with the sensitizer, a strong base anion exchange resin containing rose bengal or eosine immobilized by ion exchange or a silica gel and alumina mixture containing methylene blue adsorbed thereon, is employed." In this embodiment, a method of manufacturing a toothpaste comprising trans-4- hydroperoxy- -zuene is disclosed.
Also in the literature, the Chinese patent application CN103751029 relates to the subject: "The invention discloses a preparation method and application of a novel tooth whitening repairing agent. Especially, a BODIPY (boron fluoride-dipyrromethene) compound is prepared into an aqueous solution with a concentration of 0.1-100 micromol/L, and then ingredients are employed to make the solution into a uniform paste. Specifica lly, the BODIPY compound has a structure shown as the specification. Experiments prove that the water-soluble BODIPY photodynamic whitening repairing agent provided by the invention has a simple preparation method, is safe and free of toxic or side effect, a BODIPY photosensitizer can achieve a high singlet oxygen quantum yield. With good water solubility, the novel tooth whitening repairing agent has good biocompatibility. The tooth whitening repairing agent prepared according to the method provided by the invention is convenient to use, can be operated independently at home, and has strong controllability, and the illumination time can be chosen according to a user's own whitening requirements. The whitening repairing agent not only has no damage to teeth, but also can repair the tooth surface enamel and perform remineralization, thus making the teeth white, smooth, glossy and bright. Thus, the novel tooth whitening repairing agent has a broad market application prospect."
In this application, a method of manufacturing a boron-containing water-soluble toothpaste is disclosed.
The photosensitizer compounds to be used in the new toothpaste proposed by us are completely different from the compounds mentioned in the above patent numbered CN103751029. While the photosensitizers mentioned in the patent numbered CN103751029 absorb the light about 500-600 nm wavelength range, the photosensitizers to be used in the patent proposed by us absorb the light at higher wavelengths. Thus, the photosensitizer compounds in the toothpastes to be prepared with this patent proposed by us will be activated at higher wavelength and therefore lower energy light will be used. This will allow the recommended toothpaste to have less side effects than the photosensitizers indicated in patent CN103751029. Due to the aforementioned disadvantages of other patents, there is a demand to provide a new toothpaste.
Disclosure of the Invention
The object of the present invention is to provide a new toothpaste.
Another object of the present invention is to provide a toothpaste for more efficiently destruction of microorganisms such as bacteria, viruses and microbes that impair dental, gum, palate and oral health.
Another object of the present invention is to provide a toothpaste in which the photosensitizer residues can be removed by rinsing with water since it has water-soluble structure.
Another object of the present invention is to provide a toothpaste in which the phthalocyanine photosensitizer compounds can also be activated by applying light at lower energy or by shortening the light application time.
Another object of the present invention is to provide a toothpaste which does not harm teeth, tooth enamel and gum due to application of light at lower energy or shorter duration of light application.
Another object of the present invention is to provide a toothpaste which eliminates the necessity of using harmful hydrogen peroxide for removal of the residues.
Detailed description of the invention
In this detailed description, the said innovation according to the invention is explained by examples which will not have any limiting effect on a better understanding of the subject. The invention discloses a toothpaste used in the cosmetic and health sectors, which differs from conventional toothpastes currently in use, with protecting human health by more effectively destroying microorganisms such as bacteria, viruses and microbes that disrupt tooth, gum, palate and oral health. The disclosed toothpaste provides a photodynamic antimicrobial activity during use with the light emitted by the toothbrush with LED lamp which can emit light at a certain wavelength and by this way it destroys microorganisms such as bacteria, viruses and microbes and the residuals are removed by rinsing with water.
In addition to phthalocyanine, porphyrin, chlorine, azaphthalocyanine, naphthalocyanine, subphthalocyanine, porphyrazine compounds, etc., which are the same group of compounds, can be used to obtain the phototherapeutic toothpaste.
The most important feature of the invention is addition of all of all water-soluble phthalocyanine, porphyrin, chlorine, azaphthalocyanine, naphthalocyanine, subphthalocyanine, porphyrazine, etc. compounds into conventional toothpastes. More hygienic tooth and oral health is provided by activation of these toothpastes containing compounds that exhibit photodynamic activity by a toothbrush that has LED lamp which can emit light at a certain wavelength.
In said toothpaste comprises all of all water-soluble phthalocyanine, porphyrin, chlorine, azaphthalocyanine, naphthalocyanine, subphthalocyanine, porphyrazine etc. compounds as active ingredient, calcium carbonate, sodium lauryl sulfate, sodium saccharin, water, sorbitol (70% solution), xanthan gum, glycerin, titanium dioxide, aroma, preservative, sodium fluoride (fluoride ion w / v).
Photosensitizer wherein all water soluble phthalocyanine, porphyrin, chlorine, azaphthalocyanine, naphthalocyanine, subphthalocyanine, porphyrazine derivatives, etc. (derivatives having carboxylic acid, carboxylic acid salts, sulfonic acid, sulfonic acid salts, quaternized amino derivatives, nonionic water-soluble groups etc. on them) are synthesized by use of all methods described in the literature for synthesis of these compounds (solvent, temperature, reaction time, base type used).

Claims

1. The invention relates to a toothpaste used in the cosmetic and health sectors, which differs from conventional toothpastes currently in use, with protecting human health by more effectively destroying microorganisms such as bacteria, viruses and microbes that disrupt tooth, gum, palate and oral health, characterized in that; said toothpaste includes water-soluble photosensitizers such as phthalocyanine, porphyrin, chlorine, azaphthalocyanine, naphthalocyanine, subphthalocyanine, porphyrazine etc. compounds, and provides photodynamic antimicrobial activity during use with the light emitted by the toothbrush with LED lamp which can emit light at a certain wavelength and by this way it destroys microorganisms such as bacteria, viruses and microbes and the residuals of the toothpaste are removed by rinsing with water.
2. A toothpaste according to Claim 1, characterized by comprising photosensitizers such as phthalocyanine, porphyrin, chlorine, azaphthalocyanine, naphthalocyanine, subphthalocyanine, porphyrazine etc. compounds, calcium carbonate, sodium lauryl sulfate, saccharin sodium, water, sorbitol solution 70%, xanthan gum, glycerin, titanium dioxide, aroma, preservative, sodium fluoride (w / v fluoride ion).
3. A toothpaste according to any one of the preceding Claims, wherein said phthalocyanine, porphyrin, chlorine, azaphthalocyanine, naphthalocyanine, subphthalocyanine, porphyrazine etc. compounds comprise carboxylic acid.
4. A toothpaste according to any one of the preceding Claims, wherein said phthalocyanine, porphyrin, chlorine, azaphthalocyanine, naphthalocyanine, subphthalocyanine, porphyrazine etc. compounds comprise carboxylic acid salts.
5. A toothpaste according to in any one of the preceding Claims, wherein said phthalocyanine, porphyrin, chlorine, azaphthalocyanine, naphthalocyanine, subphthalocyanine, porphyrazine etc. compounds sulphonic acid.
6. A toothpaste according to in any one of the preceding Claims, wherein said phthalocyanine, porphyrin, chlorine, azaphthalocyanine, naphthalocyanine, subphthalocyanine, porphyrazine etc. compounds sulphonic acid salts.
7. A toothpaste according to in any one of the preceding Claims, wherein said phthalocyanine, porphyrin, chlorine, azaphthalocyanine, naphthalocyanine, subphthalocyanine, porphyrazine etc. compounds quaternized amino derivatives.
8. A toothpaste according to in any one of the preceding Claims, wherein said phthalocyanine, porphyrin, chlorine, azaphthalocyanine, naphthalocyanine, subphthalocyanine, porphyrazine etc. compounds nonionic water-soluble groups.
PCT/TR2020/050332 2019-04-25 2020-04-21 A toothpaste Ceased WO2020218993A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
TR2019/06173A TR201906173A2 (en) 2019-04-25 2019-04-25 A TOOTH PASTE
TR2019/06173 2019-04-25

Publications (1)

Publication Number Publication Date
WO2020218993A1 true WO2020218993A1 (en) 2020-10-29

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WO (1) WO2020218993A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112807431A (en) * 2020-12-31 2021-05-18 福建医科大学附属口腔医院 Application of novel zinc phthalocyanine photosensitizer in combination with photodynamic therapy in tooth bleaching

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006022970A1 (en) * 2004-07-22 2006-03-02 Ondine International Ltd. Sonophotodynamic therapy for dental applications
WO2009123575A1 (en) * 2008-04-04 2009-10-08 National University Of Singapore A photosensitising composition and its uses
WO2011084744A1 (en) * 2009-12-21 2011-07-14 Colgate-Palmolive Company Oral care compositions for use with an oral light device

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006022970A1 (en) * 2004-07-22 2006-03-02 Ondine International Ltd. Sonophotodynamic therapy for dental applications
WO2009123575A1 (en) * 2008-04-04 2009-10-08 National University Of Singapore A photosensitising composition and its uses
WO2011084744A1 (en) * 2009-12-21 2011-07-14 Colgate-Palmolive Company Oral care compositions for use with an oral light device

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112807431A (en) * 2020-12-31 2021-05-18 福建医科大学附属口腔医院 Application of novel zinc phthalocyanine photosensitizer in combination with photodynamic therapy in tooth bleaching

Also Published As

Publication number Publication date
TR201906173A2 (en) 2019-05-21

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